Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients

Nurhayati Edison; Safruddin Amin; Khairuddin Djawad; Raden Satriono; Yohanes Widodo; Marianti A. Manggau

doi:doi:10.11648/j.ajcem.20160406.13

| Peer-Reviewed

Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients

Nurhayati Edison, Safruddin Amin, Khairuddin Djawad, Raden Satriono, Yohanes Widodo, Marianti A. Manggau

Published in American Journal of Clinical and Experimental Medicine (Volume 4, Issue 6)

Received: 16 September 2016 Accepted: 28 September 2016 Published: 10 November 2016

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Acne vulgaris (AV) is the most common skin disease, including in Indonesia. This research aims to determine the effectivity of preovulation phase autologous serum application in patients with moderate-severe AV. This research was conducted in Makassar, South Sulawesi. Thirteen patient samples with moderate-severe AV who have met the inclusion criteria were taken from Dr. Wahidin Sudirohusodo General Hospital, Public Senior High School, and Medical Faculty of Hasanuddin University Laboratory. The method used is clinical trial. The examination was done by observing the clinical manifestations, sebum level using 815 sebumeter, and estradiol level examination. All patiens were given the same autologous serum treatment which is applied once a day every night and followed-up on day 21 and day 42. The data were processed using paired t test and Fisher’s exact test. The result showed that there were improvements in clinical manifestation and decreased sebum level after autologous serum application (p < 0.05) on day 21 compared to day 1, on day 42 compared to day 21, and day 42 compared to day 1. Preovulation estradiol level were higher than the estradiol level on menstruation or in lutheal phase (p < 0.05). There were no significant relationship between routine activity, familial history, peanuts, chocolate, spicy and oily food consumption, wearing cosmetics, stress, and squeezing pimples (trauma) with number of acne lesion and sebum level (p < 0.05).

Published in	American Journal of Clinical and Experimental Medicine (Volume 4, Issue 6)
DOI	10.11648/j.ajcem.20160406.13
Page(s)	170-178
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Moderate to Severe Acne Vulgaris, Autologous Serum, Estradiol

References

[1]	Anwar, A. I, Tata Laksana Akne Vulgaris Makassar. Dua Satu Pree, 2013.
[2]	Bowe, W. P. & Shalita, A. R, Introduction: Epidemiology, Cost, And Psychosocial Implications. In: Shalita, A. R., Rosso, J. Q. D. & Webster, G. F. (Eds.) Acne Vulgaris. New York: Informa Healhcare. 2011.
[3]	Zaenglein, A. L., Graber, E. M. & Thiboutot, D. M, Acne Vulgaris And Acneiform Eruptions. In: Goldsmith, L. A., Katz, S. I., Gilchrest, B. A., Paller, A. S., Leffell, D. J. & Wolff, K. (Eds.) Fitzpatrick's Dermatology In General Medicine. 8 Th Ed. New York: Mc Graw Hill. 2012.
[4]	James, W. D., Berger, T. G. & Elston, D. M, Andrews' Diseases Of The Skin Clinical Dermatology "Acne" Philadelphia, Saudres Elsevier. 2006.
[5]	Tahir, C. M, Pathogenesis Of Acne Vulgaris: Simplified. J Pakistan Association Of Dermatologists, 2010. 20: p. 93-7
[6]	George, R., Clarke, S. & Thiboutot, D, Hormonal Therapy For Acne. Semin Cutan Med Surg, 2008: 27: p. 188-96
[7]	Knor, T, The Pathogenesis Of Acne. Acta Dermatovenerol Croat, 2005. 13: p. 44-9.
[8]	Balachandrudu, B., Niveditadevi, V. & Rani, T. P, Hormon Pathogenesis Of Acne- Simplified. Inter J Scient Study, 2015. 3: p. 183-185.
[9]	Shaw, J. C, Acne Efffect Of Hormones On Pathogenesis And Management. Am J Clin Dermatol, 2002. 3: p. 571-578.
[10]	Hanafiah, M. J, Haid Dan Siklusnya, In: Wiknjosastro, H., Saifuddin, A. B. & Rachimhadhi, T. (Eds.) Ilmu Kandungan Tridasa Printer, Jakarta: Yayasan Bima Pustaka Sarwono Prawirohardji. 2007.
[11]	Jacoeb, T. Z, Endokrinologi Reproduksi Pada Wanita, In: Wiknjosastro, H., Saifuddin, A. B. & Rachimhadhi, T. (Eds.) Ilmu Kandungan Tridasa Printer, Jakarta: Yayasan Bima Pustaka Sarwono Prawirohardji. 2007.
[12]	Gruber, C. J., Tschugguel, W., Schneeberger, C. & Huber, J. C, Production And Actions Of Estrogens. N Engl J Med, 2002. 346: p. 340-52.
[13]	Thiboutot, D. & Chen, W, Update And Future Of Hormonal Therapy. Dermatol, 2003. 206: p. 57-67.
[14]	Ebede, T. L., Arch, E. L. & Berson, D, Hormonal Treatment Of Acne In Women. J Clin Aesthetic Dermatol, 2009. 12: p. 16-22.
[15]	Lakshmi, C, Hormone Therapy In Acne. Ind J Dermatol-Venereo And Lepro, 2013. 79: p. 322-36.
[16]	Baumann, M, Acne. In: Bauman L & Wwisberg E (Eds). Cosmetic dermatology principles and practice. New York, The McGraw-Hill Companies. 2002.
[17]	Gollnick, H. & Cunliffe, W, Management Of Acne A Report From A Global Alliance To Improve. Jaad, 2003. 49: p. S1-5.
[18]	Preneau S, Dreno B, Female acne – a different subtype of teenager acne? JEADV, 2011. 26: p. 277-82.
[19]	Harper, J. C, Hormonal Therapy For Acne Using Oral Contraceptive Pills. Semin Cutan Med Surg, 2005. 24: p. 103-106.
[20]	Geerling, G., MacLennan, S., Hartwig, D, Autologous serum eye drops for ocular surface disorders. Br J Ophthalmol, 2004. 88: p. 1467-74.
[21]	Poon, A. C., Geerling, G., Dart, J. K., Fraenkel, G. E., Daniels, J. T, Autologous serum eyedrops for dry eyes and epithelial defects: clinical and in vitro toxicity studies. Br J Ophthalmol, 2001. 85 (10): p. 1188-97.
[22]	Ilham, Pengujian tetes mata serum autolog sebagai antibakteri dan inflamasi pada penyakit permukaan okuler. Makassar, Universitas Hasanuddin. 2011.
[23]	Tsubota, K., Goto, E., Fujita, H., Ono, M., Inoue, H., Saito, I., et al, Treatment of dry eye by autlogous serum application in Sjogren's syndrome. Br J Dermatol, 1999. 83: p. 390-5.

Cite This Article

Plain Text BibTeX RIS

APA Style

Nurhayati Edison, Safruddin Amin, Khairuddin Djawad, Raden Satriono, Yohanes Widodo, et al. (2016). Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients. American Journal of Clinical and Experimental Medicine, 4(6), 170-178. https://doi.org/10.11648/j.ajcem.20160406.13

Copy | Download

ACS Style

Nurhayati Edison; Safruddin Amin; Khairuddin Djawad; Raden Satriono; Yohanes Widodo, et al. Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients. Am. J. Clin. Exp. Med. 2016, 4(6), 170-178. doi: 10.11648/j.ajcem.20160406.13

Copy | Download

AMA Style

Nurhayati Edison, Safruddin Amin, Khairuddin Djawad, Raden Satriono, Yohanes Widodo, et al. Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients. Am J Clin Exp Med. 2016;4(6):170-178. doi: 10.11648/j.ajcem.20160406.13

Copy | Download

@article{10.11648/j.ajcem.20160406.13,
  author = {Nurhayati Edison and Safruddin Amin and Khairuddin Djawad and Raden Satriono and Yohanes Widodo and Marianti A. Manggau},
  title = {Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {6},
  pages = {170-178},
  doi = {10.11648/j.ajcem.20160406.13},
  url = {https://doi.org/10.11648/j.ajcem.20160406.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160406.13},
  abstract = {Acne vulgaris (AV) is the most common skin disease, including in Indonesia. This research aims to determine the effectivity of preovulation phase autologous serum application in patients with moderate-severe AV. This research was conducted in Makassar, South Sulawesi. Thirteen patient samples with moderate-severe AV who have met the inclusion criteria were taken from Dr. Wahidin Sudirohusodo General Hospital, Public Senior High School, and Medical Faculty of Hasanuddin University Laboratory. The method used is clinical trial. The examination was done by observing the clinical manifestations, sebum level using 815 sebumeter, and estradiol level examination. All patiens were given the same autologous serum treatment which is applied once a day every night and followed-up on day 21 and day 42. The data were processed using paired t test and Fisher’s exact test. The result showed that there were improvements in clinical manifestation and decreased sebum level after autologous serum application (p < 0.05) on day 21 compared to day 1, on day 42 compared to day 21, and day 42 compared to day 1. Preovulation estradiol level were higher than the estradiol level on menstruation or in lutheal phase (p < 0.05). There were no significant relationship between routine activity, familial history, peanuts, chocolate, spicy and oily food consumption, wearing cosmetics, stress, and squeezing pimples (trauma) with number of acne lesion and sebum level (p < 0.05).},
 year = {2016}
}

Copy | Download

TY - JOUR
T1 - Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients
AU - Nurhayati Edison
AU - Safruddin Amin
AU - Khairuddin Djawad
AU - Raden Satriono
AU - Yohanes Widodo
AU - Marianti A. Manggau
Y1 - 2016/11/10
PY - 2016
N1 - https://doi.org/10.11648/j.ajcem.20160406.13
DO - 10.11648/j.ajcem.20160406.13
T2 - American Journal of Clinical and Experimental Medicine
JF - American Journal of Clinical and Experimental Medicine
JO - American Journal of Clinical and Experimental Medicine
SP - 170
EP - 178
PB - Science Publishing Group
SN - 2330-8133
UR - https://doi.org/10.11648/j.ajcem.20160406.13
AB - Acne vulgaris (AV) is the most common skin disease, including in Indonesia. This research aims to determine the effectivity of preovulation phase autologous serum application in patients with moderate-severe AV. This research was conducted in Makassar, South Sulawesi. Thirteen patient samples with moderate-severe AV who have met the inclusion criteria were taken from Dr. Wahidin Sudirohusodo General Hospital, Public Senior High School, and Medical Faculty of Hasanuddin University Laboratory. The method used is clinical trial. The examination was done by observing the clinical manifestations, sebum level using 815 sebumeter, and estradiol level examination. All patiens were given the same autologous serum treatment which is applied once a day every night and followed-up on day 21 and day 42. The data were processed using paired t test and Fisher’s exact test. The result showed that there were improvements in clinical manifestation and decreased sebum level after autologous serum application (p < 0.05) on day 21 compared to day 1, on day 42 compared to day 21, and day 42 compared to day 1. Preovulation estradiol level were higher than the estradiol level on menstruation or in lutheal phase (p < 0.05). There were no significant relationship between routine activity, familial history, peanuts, chocolate, spicy and oily food consumption, wearing cosmetics, stress, and squeezing pimples (trauma) with number of acne lesion and sebum level (p < 0.05).
VL - 4
IS - 6
ER -

Copy | Download

Author Information

Nurhayati Edison

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Safruddin Amin

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Khairuddin Djawad

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Raden Satriono

Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Yohanes Widodo

Department of Dermatology and Venereology, Medical Faculty, Gadjah Mada University, Jogjakarta, Indonesia
Marianti A. Manggau

Department of Pharmacy, Hasanuddin University, Makassar, Indonesia

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Nurhayati Edison, Safruddin Amin, Khairuddin Djawad, Raden Satriono, Yohanes Widodo, et al. (2016). Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients. American Journal of Clinical and Experimental Medicine, 4(6), 170-178. https://doi.org/10.11648/j.ajcem.20160406.13

Copy | Download

ACS Style

Nurhayati Edison; Safruddin Amin; Khairuddin Djawad; Raden Satriono; Yohanes Widodo, et al. Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients. Am. J. Clin. Exp. Med. 2016, 4(6), 170-178. doi: 10.11648/j.ajcem.20160406.13

Copy | Download

AMA Style

Nurhayati Edison, Safruddin Amin, Khairuddin Djawad, Raden Satriono, Yohanes Widodo, et al. Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients. Am J Clin Exp Med. 2016;4(6):170-178. doi: 10.11648/j.ajcem.20160406.13

Copy | Download

@article{10.11648/j.ajcem.20160406.13,
  author = {Nurhayati Edison and Safruddin Amin and Khairuddin Djawad and Raden Satriono and Yohanes Widodo and Marianti A. Manggau},
  title = {Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {6},
  pages = {170-178},
  doi = {10.11648/j.ajcem.20160406.13},
  url = {https://doi.org/10.11648/j.ajcem.20160406.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160406.13},
  abstract = {Acne vulgaris (AV) is the most common skin disease, including in Indonesia. This research aims to determine the effectivity of preovulation phase autologous serum application in patients with moderate-severe AV. This research was conducted in Makassar, South Sulawesi. Thirteen patient samples with moderate-severe AV who have met the inclusion criteria were taken from Dr. Wahidin Sudirohusodo General Hospital, Public Senior High School, and Medical Faculty of Hasanuddin University Laboratory. The method used is clinical trial. The examination was done by observing the clinical manifestations, sebum level using 815 sebumeter, and estradiol level examination. All patiens were given the same autologous serum treatment which is applied once a day every night and followed-up on day 21 and day 42. The data were processed using paired t test and Fisher’s exact test. The result showed that there were improvements in clinical manifestation and decreased sebum level after autologous serum application (p < 0.05) on day 21 compared to day 1, on day 42 compared to day 21, and day 42 compared to day 1. Preovulation estradiol level were higher than the estradiol level on menstruation or in lutheal phase (p < 0.05). There were no significant relationship between routine activity, familial history, peanuts, chocolate, spicy and oily food consumption, wearing cosmetics, stress, and squeezing pimples (trauma) with number of acne lesion and sebum level (p < 0.05).},
 year = {2016}
}

Copy | Download