The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes)

Ma’arifah Nadjar; Farida Ilyas; Safruddin Amin; Farida Tabri; R. Satriono; Rizalinda Sjahrir

doi:doi:10.11648/j.ajcem.20160403.17

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The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes)

Ma’arifah Nadjar, Farida Ilyas, Safruddin Amin, Farida Tabri, R. Satriono, Rizalinda Sjahrir

Published in American Journal of Clinical and Experimental Medicine (Volume 4, Issue 3)

Received: 30 March 2016 Accepted: 9 May 2016 Published: 28 May 2016

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Abstract

Topical tretinoin is used by the dermatolovenereologist and aesthetic physicians in patients with mild acne vulgaris, so it is necessary to be investigated. The aim of the study was to assess the effectiveness of benzoyl peroxide gel compared to tretinoin gel on persons with mild acne vulgaris and identify Propionibacterium acnes in patients with mild acne vulgaris. The research method was a clinical trial, double blind randomization. Patients with mild acne vulgaris were randomized in to 2 groups, each group was examined for clinical manifestations (comedone, papules or pustules) examination with sebumeter 815 and Polymerase Chain Reaction, every night each group was treated with benzoyl peroxide 5% gel and tretinoin 0.05% gel in the application, and followed-up in the days of the week 2, 4 and 6. Data were processed with Mann-Whitney test and Chi-Square Test. The results indicated benzoyl peroxide 5% gel and tretinoin 0.05% gel have the same effectiveness in patients with mild acne vulgaris. But, benzoyl peroxide 5% gel decreased blackheads faster compared to papules or pustules with 0.05% tretinoin gel. of sebum. There was no difference in levels of decrease between benzoyl peroxide 5% gel and tretinoin 0.05% gel. Propionibacterium acnes were found in patients with mild acne vulgaris before the treatment of benzoyl peroxide 5% gel and tretinoin 0.05% gel, although not found in all samples.

Published in	American Journal of Clinical and Experimental Medicine (Volume 4, Issue 3)
DOI	10.11648/j.ajcem.20160403.17
Page(s)	76-80
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Mild Acne Vulgaris, Benzoyl Peroxide 5% Gel, Tretinoin 0.05% Gel

References

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[2]	Zaenglein, A. L. Thiboutot, D. M. Acne vulgaris. Dermatology. J. L. Bolognia, J. L. Jorizzo and J. V. Schaffer. USA, elsevier. 2011; 36: 545-559.
[3]	Benner N. & Sammons D. Overview of the treatment of acne vulgaris. Osteophatic Fam Physician J. 2013; 5: 185-190.
[4]	Layton A. M. Disorders of the Sebaceous Glands. Burns T. Breathnach S, Cox N, Griffiths C, editors. Rook's Textbook of Dermatology. 8th ed. Wiley-Blackwell. 2010. p. 42. 17-42.55.
[5]	Kraft, J., Freiman, A. Management of Acne. Canadian Medical Association J. 2011; 183 (7): 430-435.
[6]	Koo, E, B., Petersen, T, D, Kimball, A. B. Meta-Analysis Comparing Efficacy Of Antibiotics Versus Oral Contraceptives In Acne Vulgaris. J Am Acad Dermatol. 2014; 1-9.
[7]	Gollnick H. & Cunliffe W. Management of acne are report from a global alliance to improve outcome in acne. J Am Acad Dermatol. 2003; 49: S1-38.
[8]	Achermann Y. et al. Propionibacterium acnes: from Commensal to Opportunistic Biofilm-Associated Implant Pathogen. Clinical Microbiology Reviews J. 2014; 27: 419–440.
[9]	Ramanathan S. and Hebert A. A. Management of acne vulgaris. J pediatr Health Care. 2011; 25: 332-337.
[10]	Eichenfield L. F. et al. Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne. Acad Pe J. 2013; 131, 163-182.
[11]	Pappas, A., Johnsen, S., Liu, C. J. Eisinger, M. Sebum analysis Of Individuals with and without Acne. Dermato-endocrinology. 2009; 1: 3. 157-161.
[12]	Wolff K. et al. Topical tretinoin, Fitzpatrick's Dermatology in General Medicine, Ac. 2008; 3789-3797.
[13]	Malhotra N, et al. Real World Acne Therapy in Primary Care. Dermatol J. 2012; 5: 29-43.
[14]	Liao DC. Management of Acne. Fam J Pract. 2003; 52: 43.
[15]	Ramdani R, 1 Sibero, H. T. Treatment for Acne Vulgaris. J Majority. 2015; 4: 87-95.
[16]	Tsatsou F. & Christos. C. Z Acne vulgaris. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. M. G. Lebwohi, W. R. Heymann, J. B.-. jones and I. Coulson. New York, Elsevier. 3. 2014. 6-11.

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APA Style

Ma’arifah Nadjar, Farida Ilyas, Safruddin Amin, Farida Tabri, R. Satriono, et al. (2016). The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes). American Journal of Clinical and Experimental Medicine, 4(3), 76-80. https://doi.org/10.11648/j.ajcem.20160403.17

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ACS Style

Ma’arifah Nadjar; Farida Ilyas; Safruddin Amin; Farida Tabri; R. Satriono, et al. The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes). Am. J. Clin. Exp. Med. 2016, 4(3), 76-80. doi: 10.11648/j.ajcem.20160403.17

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AMA Style

Ma’arifah Nadjar, Farida Ilyas, Safruddin Amin, Farida Tabri, R. Satriono, et al. The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes). Am J Clin Exp Med. 2016;4(3):76-80. doi: 10.11648/j.ajcem.20160403.17

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@article{10.11648/j.ajcem.20160403.17,
  author = {Ma’arifah Nadjar and Farida Ilyas and Safruddin Amin and Farida Tabri and R. Satriono and Rizalinda Sjahrir},
  title = {The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes)},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {3},
  pages = {76-80},
  doi = {10.11648/j.ajcem.20160403.17},
  url = {https://doi.org/10.11648/j.ajcem.20160403.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160403.17},
  abstract = {Topical tretinoin is used by the dermatolovenereologist and aesthetic physicians in patients with mild acne vulgaris, so it is necessary to be investigated. The aim of the study was to assess the effectiveness of benzoyl peroxide gel compared to tretinoin gel on persons with mild acne vulgaris and identify Propionibacterium acnes in patients with mild acne vulgaris. The research method was a clinical trial, double blind randomization. Patients with mild acne vulgaris were randomized in to 2 groups, each group was examined for clinical manifestations (comedone, papules or pustules) examination with sebumeter 815 and Polymerase Chain Reaction, every night each group was treated with benzoyl peroxide 5% gel and tretinoin 0.05% gel in the application, and followed-up in the days of the week 2, 4 and 6. Data were processed with Mann-Whitney test and Chi-Square Test. The results indicated benzoyl peroxide 5% gel and tretinoin 0.05% gel have the same effectiveness in patients with mild acne vulgaris. But, benzoyl peroxide 5% gel decreased blackheads faster compared to papules or pustules with 0.05% tretinoin gel. of sebum. There was no difference in levels of decrease between benzoyl peroxide 5% gel and tretinoin 0.05% gel. Propionibacterium acnes were found in patients with mild acne vulgaris before the treatment of benzoyl peroxide 5% gel and tretinoin 0.05% gel, although not found in all samples.},
 year = {2016}
}

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TY - JOUR
T1 - The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes)
AU - Ma’arifah Nadjar
AU - Farida Ilyas
AU - Safruddin Amin
AU - Farida Tabri
AU - R. Satriono
AU - Rizalinda Sjahrir
Y1 - 2016/05/28
PY - 2016
N1 - https://doi.org/10.11648/j.ajcem.20160403.17
DO - 10.11648/j.ajcem.20160403.17
T2 - American Journal of Clinical and Experimental Medicine
JF - American Journal of Clinical and Experimental Medicine
JO - American Journal of Clinical and Experimental Medicine
SP - 76
EP - 80
PB - Science Publishing Group
SN - 2330-8133
UR - https://doi.org/10.11648/j.ajcem.20160403.17
AB - Topical tretinoin is used by the dermatolovenereologist and aesthetic physicians in patients with mild acne vulgaris, so it is necessary to be investigated. The aim of the study was to assess the effectiveness of benzoyl peroxide gel compared to tretinoin gel on persons with mild acne vulgaris and identify Propionibacterium acnes in patients with mild acne vulgaris. The research method was a clinical trial, double blind randomization. Patients with mild acne vulgaris were randomized in to 2 groups, each group was examined for clinical manifestations (comedone, papules or pustules) examination with sebumeter 815 and Polymerase Chain Reaction, every night each group was treated with benzoyl peroxide 5% gel and tretinoin 0.05% gel in the application, and followed-up in the days of the week 2, 4 and 6. Data were processed with Mann-Whitney test and Chi-Square Test. The results indicated benzoyl peroxide 5% gel and tretinoin 0.05% gel have the same effectiveness in patients with mild acne vulgaris. But, benzoyl peroxide 5% gel decreased blackheads faster compared to papules or pustules with 0.05% tretinoin gel. of sebum. There was no difference in levels of decrease between benzoyl peroxide 5% gel and tretinoin 0.05% gel. Propionibacterium acnes were found in patients with mild acne vulgaris before the treatment of benzoyl peroxide 5% gel and tretinoin 0.05% gel, although not found in all samples.
VL - 4
IS - 3
ER -

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Author Information

Ma’arifah Nadjar

Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Farida Ilyas

Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Safruddin Amin

Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Farida Tabri

Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
R. Satriono

Pediatric Departement, Medical Faculty Hasanuddin University, Makassar, Indonesia
Rizalinda Sjahrir

Microbiology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia

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APA Style

Ma’arifah Nadjar, Farida Ilyas, Safruddin Amin, Farida Tabri, R. Satriono, et al. (2016). The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes). American Journal of Clinical and Experimental Medicine, 4(3), 76-80. https://doi.org/10.11648/j.ajcem.20160403.17

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ACS Style

Ma’arifah Nadjar; Farida Ilyas; Safruddin Amin; Farida Tabri; R. Satriono, et al. The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes). Am. J. Clin. Exp. Med. 2016, 4(3), 76-80. doi: 10.11648/j.ajcem.20160403.17

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AMA Style

Ma’arifah Nadjar, Farida Ilyas, Safruddin Amin, Farida Tabri, R. Satriono, et al. The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes). Am J Clin Exp Med. 2016;4(3):76-80. doi: 10.11648/j.ajcem.20160403.17

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@article{10.11648/j.ajcem.20160403.17,
  author = {Ma’arifah Nadjar and Farida Ilyas and Safruddin Amin and Farida Tabri and R. Satriono and Rizalinda Sjahrir},
  title = {The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes)},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {3},
  pages = {76-80},
  doi = {10.11648/j.ajcem.20160403.17},
  url = {https://doi.org/10.11648/j.ajcem.20160403.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160403.17},
  abstract = {Topical tretinoin is used by the dermatolovenereologist and aesthetic physicians in patients with mild acne vulgaris, so it is necessary to be investigated. The aim of the study was to assess the effectiveness of benzoyl peroxide gel compared to tretinoin gel on persons with mild acne vulgaris and identify Propionibacterium acnes in patients with mild acne vulgaris. The research method was a clinical trial, double blind randomization. Patients with mild acne vulgaris were randomized in to 2 groups, each group was examined for clinical manifestations (comedone, papules or pustules) examination with sebumeter 815 and Polymerase Chain Reaction, every night each group was treated with benzoyl peroxide 5% gel and tretinoin 0.05% gel in the application, and followed-up in the days of the week 2, 4 and 6. Data were processed with Mann-Whitney test and Chi-Square Test. The results indicated benzoyl peroxide 5% gel and tretinoin 0.05% gel have the same effectiveness in patients with mild acne vulgaris. But, benzoyl peroxide 5% gel decreased blackheads faster compared to papules or pustules with 0.05% tretinoin gel. of sebum. There was no difference in levels of decrease between benzoyl peroxide 5% gel and tretinoin 0.05% gel. Propionibacterium acnes were found in patients with mild acne vulgaris before the treatment of benzoyl peroxide 5% gel and tretinoin 0.05% gel, although not found in all samples.},
 year = {2016}
}

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