Ultraviolet (UV) plays an important role in the pathogenesis of melasma. Ultraviolet rays can cause lipid peroxidation in cell membranes that trigger the generation of free radicals that can stimulate melanocytes to produce many melanin. Malondialdehyde (MDA) is the end product of lipid peroxidation in the body. MDA is an important indicator of lipid peroxidation. There are a lot of research has been done in linking MDA to the severity of melasma. But there has not yet any research connecting it with sun exposure in patients with melasma. This study aims to find out the relationship between MDA serum levels and the duration of sun exposure; and Melasma Area and Severity Index (MASI) scores in patients with melasma. The research method was the case control study. It used 84 samples divided into two groups: a melasma group consisting of 42 people and a control group consisting of 42 people. The examination was performed with anamnesis, questionnaires, duration score of sun exposure, physical examination and the assessment of MDA serum levels with Thiobutiric acid-reactive substance test reaction. The data were analysed using independent t test, Mann Whitney, and Spearman correlation test. The results show that there is a significant correlation between the levels of MDA with the duration of sun exposure, but the duration of sun exposure is not associated with MASI score. It means that MDA levels are not significantly associated with MASI scores. Free radicals are significantly associated with the duration of sun exposure, but the severity of melasma is not affected by the duration of sun exposure. The severity level of melasma is still much influenced by some other risk factors associated with the pathogenesis of melasma.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 4, Issue 3) |
| DOI | 10.11648/j.ajcem.20160403.16 |
| Page(s) | 68-75 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2016. Published by Science Publishing Group |
Length Sun Exposure, Melasma, Malondialdehyde, MASI Scores
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APA Style
Fadlina Zainuddin, Anis Irawan Anwar, Khairuddin Djawad, Arifin Seweng, Rizalinda Sjahril, et al. (2016). The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar. American Journal of Clinical and Experimental Medicine, 4(3), 68-75. https://doi.org/10.11648/j.ajcem.20160403.16
ACS Style
Fadlina Zainuddin; Anis Irawan Anwar; Khairuddin Djawad; Arifin Seweng; Rizalinda Sjahril, et al. The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar. Am. J. Clin. Exp. Med. 2016, 4(3), 68-75. doi: 10.11648/j.ajcem.20160403.16
AMA Style
Fadlina Zainuddin, Anis Irawan Anwar, Khairuddin Djawad, Arifin Seweng, Rizalinda Sjahril, et al. The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar. Am J Clin Exp Med. 2016;4(3):68-75. doi: 10.11648/j.ajcem.20160403.16
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Download@article{10.11648/j.ajcem.20160403.16,
author = {Fadlina Zainuddin and Anis Irawan Anwar and Khairuddin Djawad and Arifin Seweng and Rizalinda Sjahril and Anni Adriani},
title = {The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {4},
number = {3},
pages = {68-75},
doi = {10.11648/j.ajcem.20160403.16},
url = {https://doi.org/10.11648/j.ajcem.20160403.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160403.16},
abstract = {Ultraviolet (UV) plays an important role in the pathogenesis of melasma. Ultraviolet rays can cause lipid peroxidation in cell membranes that trigger the generation of free radicals that can stimulate melanocytes to produce many melanin. Malondialdehyde (MDA) is the end product of lipid peroxidation in the body. MDA is an important indicator of lipid peroxidation. There are a lot of research has been done in linking MDA to the severity of melasma. But there has not yet any research connecting it with sun exposure in patients with melasma. This study aims to find out the relationship between MDA serum levels and the duration of sun exposure; and Melasma Area and Severity Index (MASI) scores in patients with melasma. The research method was the case control study. It used 84 samples divided into two groups: a melasma group consisting of 42 people and a control group consisting of 42 people. The examination was performed with anamnesis, questionnaires, duration score of sun exposure, physical examination and the assessment of MDA serum levels with Thiobutiric acid-reactive substance test reaction. The data were analysed using independent t test, Mann Whitney, and Spearman correlation test. The results show that there is a significant correlation between the levels of MDA with the duration of sun exposure, but the duration of sun exposure is not associated with MASI score. It means that MDA levels are not significantly associated with MASI scores. Free radicals are significantly associated with the duration of sun exposure, but the severity of melasma is not affected by the duration of sun exposure. The severity level of melasma is still much influenced by some other risk factors associated with the pathogenesis of melasma.},
year = {2016}
}
TY - JOUR T1 - The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar AU - Fadlina Zainuddin AU - Anis Irawan Anwar AU - Khairuddin Djawad AU - Arifin Seweng AU - Rizalinda Sjahril AU - Anni Adriani Y1 - 2016/05/13 PY - 2016 N1 - https://doi.org/10.11648/j.ajcem.20160403.16 DO - 10.11648/j.ajcem.20160403.16 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 68 EP - 75 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20160403.16 AB - Ultraviolet (UV) plays an important role in the pathogenesis of melasma. Ultraviolet rays can cause lipid peroxidation in cell membranes that trigger the generation of free radicals that can stimulate melanocytes to produce many melanin. Malondialdehyde (MDA) is the end product of lipid peroxidation in the body. MDA is an important indicator of lipid peroxidation. There are a lot of research has been done in linking MDA to the severity of melasma. But there has not yet any research connecting it with sun exposure in patients with melasma. This study aims to find out the relationship between MDA serum levels and the duration of sun exposure; and Melasma Area and Severity Index (MASI) scores in patients with melasma. The research method was the case control study. It used 84 samples divided into two groups: a melasma group consisting of 42 people and a control group consisting of 42 people. The examination was performed with anamnesis, questionnaires, duration score of sun exposure, physical examination and the assessment of MDA serum levels with Thiobutiric acid-reactive substance test reaction. The data were analysed using independent t test, Mann Whitney, and Spearman correlation test. The results show that there is a significant correlation between the levels of MDA with the duration of sun exposure, but the duration of sun exposure is not associated with MASI score. It means that MDA levels are not significantly associated with MASI scores. Free radicals are significantly associated with the duration of sun exposure, but the severity of melasma is not affected by the duration of sun exposure. The severity level of melasma is still much influenced by some other risk factors associated with the pathogenesis of melasma. VL - 4 IS - 3 ER -
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