The Effect of Curcumin on the Acute Wound Healing of Mice

Armansjah Dara Sjahruddin; Anis IrawanAnwar; Farida Tabri; Khairuddin Djawad; Dasril Daud; Gemini Alam

doi:doi:10.11648/j.ajcem.20150304.20

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The Effect of Curcumin on the Acute Wound Healing of Mice

Armansjah Dara Sjahruddin, Anis IrawanAnwar, Farida Tabri, Khairuddin Djawad, Dasril Daud, Gemini Alam

Published in American Journal of Clinical and Experimental Medicine (Volume 3, Issue 4)

Received: 5 June 2015 Accepted: 18 June 2015 Published: 7 July 2015

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Abstract

Background: The study aimed to compare the effectiveness of curcumin 0.5% and 5% by Natrium Chloride (NaCl) 0.9% in the acute wound healing of mice. Methods: This study was conducted at the Animal Laboratory and at the Department of Anatomical Pathology, Medical Faculty Hasanuddin University in Makassar, by using an experimental study. The samples consisted of 30 mice observed by the change of clinical and histopathological manifestations. Result: The study reveal that there was no significant difference between the application of curcumin 5% and Natrium Chloride 0.9% in the healing wound. After seven days the length of significant reepithelization was p=0.026 between curcumin 0.5% and Natrium Chloride 0.9%. After the seventh day of treatment the density of polymorpho nuclear (PMN) and macrophages was not significant (p<0.05) in all three groups. Statistically, the thickness of fibroblast was significant, between Natrium Chloride 0.9% and curcumin 0.5% (p=0.049), curcumin 5% (p=0.006) after the treatment on day seven. Conclusions: The use of application topical curcumin is not better than the NaCl 0.9% in acute wound healing in mice.

Published in	American Journal of Clinical and Experimental Medicine (Volume 3, Issue 4)
DOI	10.11648/j.ajcem.20150304.20
Page(s)	189-193
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Clinical Manifestation, Curcumin, Histopathology, Natrium Chloride, Wound Healing

References

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[2]	Lazarus, G.S., Cooper, D.M., Knighton, D.R., Percoraro, R.E., Rodeheaver, G., Robson, M.C. Definitions and guidelines for assessment of wounds and evaluation of healing. Wound Repair Regen.1994; 2: 165-70
[3]	Lee, H., Li, Y., Phillips, T., Woodley, D.T. Wound healing. In Roenigk, R. K., Ratz, J.L., Roenigk, H.H, eds. Roenigk’s Dermatologic Surgery.2007; Informa healthcare: New York.
[4]	Chin, G.A., Diegelmann, R.F., Schultz, G.S. Cellular and Molecular regulation of wound healing. In Falabella, A. F., Kirsner, R. S (eds). Wound healing.2005; Taylor and Francis: Boca.
[5]	Utami, A.N. Perbandingan Efek Anti Inflamasi Kurcumin 1% dalam Vehikulum Krim dan Salep pada Kulit Mencit yang Telah Disinari Sinar Ultraviolet. Journal Tesis. FKUI: Jakarta.
[6]	Purohit, S.K., Solanki, R., Madhur, V., Madhur, M. Evaluation of Wound Healing Activity of Ethanolic Extract of Curcuma Longa Rhizomes in Male Albino Rats. Asian J. Pharm. Res. 2013; 3(2): 79-81.
[7]	Mani, H., Sidhu, G.S., Gaddipati, J.P., Seth, P., Maheshwari, R.K. Curcumin Differentially Regulates TGF-β1, its Reseptors and Nitric Oxide Synthase During Impaired Wound Healing. BioFactors. 2002; 16: 29-43.
[8]	Fagraeus A. 1949. Influence of sodium chloride on growth of staphylococci and some other bacteria. ActaPeth Micro Scand. 26:655-65.
[9]	Neysens P, Messens W, Vuyst LD. 2003. Effect of sodium chloride on growth and bacteriocin production by Lactobacillus amylovorusDCE 471. Int J Food Micro 88:29-30.
[10]	World Health Organization. 2013. The International Pharmacopoeia.
[11]	Young SR, Dyson M, Lang S, Osborn C. 2001. Comparison of the effects of semi-occlusive polyurethane dressings and hydrocolloid dressing on dermal repair: 1. Cellular changes. J Invest Dermatol 97:586-92.
[12]	Vogt, P. M., Andree, C., Breuing, K., Liu, P. Y., et al. 1995. Dry, moist, and wet skin wound repair. Ann Plas Surg. 34: 493-500
[13]	Eming, S.A., 2012. Biology of Wound Healing. In BologniaJ.L., Jorizzo, J.L.,Schaffer, J.V (eds). Dermatology. Elsevier limited.
[14]	Fonder, M. A., Lazarus, G. S., Cowan, D. A., Aronson-Cook, B., Kohli, A. R., Mamelak, A. J. 2008. Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings.J Am Acad. 58: 185-206
[15]	Leong, M., Phillips, LG. 2012. Wound healing. In Townsend, CM., Beauchamp, RD., Evers, M., Mattox, KL (eds). Sabiston Textbook of Surgery. Saunders.

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APA Style

Armansjah Dara Sjahruddin, Anis IrawanAnwar, Farida Tabri, Khairuddin Djawad, Dasril Daud, et al. (2015). The Effect of Curcumin on the Acute Wound Healing of Mice. American Journal of Clinical and Experimental Medicine, 3(4), 189-193. https://doi.org/10.11648/j.ajcem.20150304.20

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ACS Style

Armansjah Dara Sjahruddin; Anis IrawanAnwar; Farida Tabri; Khairuddin Djawad; Dasril Daud, et al. The Effect of Curcumin on the Acute Wound Healing of Mice. Am. J. Clin. Exp. Med. 2015, 3(4), 189-193. doi: 10.11648/j.ajcem.20150304.20

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AMA Style

Armansjah Dara Sjahruddin, Anis IrawanAnwar, Farida Tabri, Khairuddin Djawad, Dasril Daud, et al. The Effect of Curcumin on the Acute Wound Healing of Mice. Am J Clin Exp Med. 2015;3(4):189-193. doi: 10.11648/j.ajcem.20150304.20

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@article{10.11648/j.ajcem.20150304.20,
  author = {Armansjah Dara Sjahruddin and Anis IrawanAnwar and Farida Tabri and Khairuddin Djawad and Dasril Daud and Gemini Alam},
  title = {The Effect of Curcumin on the Acute Wound Healing of Mice},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {4},
  pages = {189-193},
  doi = {10.11648/j.ajcem.20150304.20},
  url = {https://doi.org/10.11648/j.ajcem.20150304.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150304.20},
  abstract = {Background: The study aimed to compare the effectiveness of curcumin 0.5% and 5% by Natrium Chloride (NaCl) 0.9% in the acute wound healing of mice. Methods: This study was conducted at the Animal Laboratory and at the Department of Anatomical Pathology, Medical Faculty Hasanuddin University in Makassar, by using an experimental study. The samples consisted of 30 mice observed by the change of clinical and histopathological manifestations. Result: The study reveal that there was no significant difference between the application of curcumin 5% and Natrium Chloride 0.9% in the healing wound. After seven days the length of significant reepithelization was p=0.026 between curcumin 0.5% and Natrium Chloride 0.9%. After the seventh day of treatment the density of polymorpho nuclear (PMN) and macrophages was not significant (p<0.05) in all three groups. Statistically, the thickness of fibroblast was significant, between Natrium Chloride 0.9% and curcumin 0.5% (p=0.049), curcumin 5% (p=0.006) after the treatment on day seven. Conclusions: The use of application topical curcumin is not better than the NaCl 0.9% in acute wound healing in mice.},
 year = {2015}
}

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TY  - JOUR
T1  - The Effect of Curcumin on the Acute Wound Healing of Mice
AU  - Armansjah Dara Sjahruddin
AU  - Anis IrawanAnwar
AU  - Farida Tabri
AU  - Khairuddin Djawad
AU  - Dasril Daud
AU  - Gemini Alam
Y1  - 2015/07/07
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150304.20
DO  - 10.11648/j.ajcem.20150304.20
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 189
EP  - 193
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150304.20
AB  - Background: The study aimed to compare the effectiveness of curcumin 0.5% and 5% by Natrium Chloride (NaCl) 0.9% in the acute wound healing of mice. Methods: This study was conducted at the Animal Laboratory and at the Department of Anatomical Pathology, Medical Faculty Hasanuddin University in Makassar, by using an experimental study. The samples consisted of 30 mice observed by the change of clinical and histopathological manifestations. Result: The study reveal that there was no significant difference between the application of curcumin 5% and Natrium Chloride 0.9% in the healing wound. After seven days the length of significant reepithelization was p=0.026 between curcumin 0.5% and Natrium Chloride 0.9%. After the seventh day of treatment the density of polymorpho nuclear (PMN) and macrophages was not significant (p<0.05) in all three groups. Statistically, the thickness of fibroblast was significant, between Natrium Chloride 0.9% and curcumin 0.5% (p=0.049), curcumin 5% (p=0.006) after the treatment on day seven. Conclusions: The use of application topical curcumin is not better than the NaCl 0.9% in acute wound healing in mice.
VL  - 3
IS  - 4
ER  -

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Author Information

Armansjah Dara Sjahruddin

Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, South Sulawesi, Indonesia
Anis IrawanAnwar

Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, South Sulawesi, Indonesia
Farida Tabri

Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, South Sulawesi, Indonesia
Khairuddin Djawad

Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, South Sulawesi, Indonesia
Dasril Daud

Pediatric Department, Medical Faculty Hasanuddin University, Makassar, South Sulawesi, Indonesia
Gemini Alam

Pharmacy Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia

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APA Style

Armansjah Dara Sjahruddin, Anis IrawanAnwar, Farida Tabri, Khairuddin Djawad, Dasril Daud, et al. (2015). The Effect of Curcumin on the Acute Wound Healing of Mice. American Journal of Clinical and Experimental Medicine, 3(4), 189-193. https://doi.org/10.11648/j.ajcem.20150304.20

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ACS Style

Armansjah Dara Sjahruddin; Anis IrawanAnwar; Farida Tabri; Khairuddin Djawad; Dasril Daud, et al. The Effect of Curcumin on the Acute Wound Healing of Mice. Am. J. Clin. Exp. Med. 2015, 3(4), 189-193. doi: 10.11648/j.ajcem.20150304.20

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AMA Style

Armansjah Dara Sjahruddin, Anis IrawanAnwar, Farida Tabri, Khairuddin Djawad, Dasril Daud, et al. The Effect of Curcumin on the Acute Wound Healing of Mice. Am J Clin Exp Med. 2015;3(4):189-193. doi: 10.11648/j.ajcem.20150304.20

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@article{10.11648/j.ajcem.20150304.20,
  author = {Armansjah Dara Sjahruddin and Anis IrawanAnwar and Farida Tabri and Khairuddin Djawad and Dasril Daud and Gemini Alam},
  title = {The Effect of Curcumin on the Acute Wound Healing of Mice},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {4},
  pages = {189-193},
  doi = {10.11648/j.ajcem.20150304.20},
  url = {https://doi.org/10.11648/j.ajcem.20150304.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150304.20},
  abstract = {Background: The study aimed to compare the effectiveness of curcumin 0.5% and 5% by Natrium Chloride (NaCl) 0.9% in the acute wound healing of mice. Methods: This study was conducted at the Animal Laboratory and at the Department of Anatomical Pathology, Medical Faculty Hasanuddin University in Makassar, by using an experimental study. The samples consisted of 30 mice observed by the change of clinical and histopathological manifestations. Result: The study reveal that there was no significant difference between the application of curcumin 5% and Natrium Chloride 0.9% in the healing wound. After seven days the length of significant reepithelization was p=0.026 between curcumin 0.5% and Natrium Chloride 0.9%. After the seventh day of treatment the density of polymorpho nuclear (PMN) and macrophages was not significant (p<0.05) in all three groups. Statistically, the thickness of fibroblast was significant, between Natrium Chloride 0.9% and curcumin 0.5% (p=0.049), curcumin 5% (p=0.006) after the treatment on day seven. Conclusions: The use of application topical curcumin is not better than the NaCl 0.9% in acute wound healing in mice.},
 year = {2015}
}

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TY  - JOUR
T1  - The Effect of Curcumin on the Acute Wound Healing of Mice
AU  - Armansjah Dara Sjahruddin
AU  - Anis IrawanAnwar
AU  - Farida Tabri
AU  - Khairuddin Djawad
AU  - Dasril Daud
AU  - Gemini Alam
Y1  - 2015/07/07
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150304.20
DO  - 10.11648/j.ajcem.20150304.20
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 189
EP  - 193
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150304.20
AB  - Background: The study aimed to compare the effectiveness of curcumin 0.5% and 5% by Natrium Chloride (NaCl) 0.9% in the acute wound healing of mice. Methods: This study was conducted at the Animal Laboratory and at the Department of Anatomical Pathology, Medical Faculty Hasanuddin University in Makassar, by using an experimental study. The samples consisted of 30 mice observed by the change of clinical and histopathological manifestations. Result: The study reveal that there was no significant difference between the application of curcumin 5% and Natrium Chloride 0.9% in the healing wound. After seven days the length of significant reepithelization was p=0.026 between curcumin 0.5% and Natrium Chloride 0.9%. After the seventh day of treatment the density of polymorpho nuclear (PMN) and macrophages was not significant (p<0.05) in all three groups. Statistically, the thickness of fibroblast was significant, between Natrium Chloride 0.9% and curcumin 0.5% (p=0.049), curcumin 5% (p=0.006) after the treatment on day seven. Conclusions: The use of application topical curcumin is not better than the NaCl 0.9% in acute wound healing in mice.
VL  - 3
IS  - 4
ER  -

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