The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy

Arif Risdianto Karim; Muh Dali Amiruddin; Farida Tabri; R. Satriono; Mochammad Hatta; Marianti Manggau

doi:doi:10.11648/j.ajcem.20150304.17

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The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy

Arif Risdianto Karim, Muh Dali Amiruddin, Farida Tabri, R. Satriono, Mochammad Hatta, Marianti Manggau

Published in American Journal of Clinical and Experimental Medicine (Volume 3, Issue 4)

Received: 27 May 2015 Accepted: 6 June 2015 Published: 25 June 2015

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Abstract

Background: This reserach aimed to determine the correlation between the morphology index and IgM anti PGL-1, and the mutations in gyrA genes in order to detect ofloxacin resistance in the patients with multibacillary (MB) leprosy. Methods: This research was conducted in Dr. Wahidin Sudirohusodo General Hospital and its network hospitals in Makassar using the cohort retrospective design. The research sample comprised 21 patients with MB leprosy who had completed the ROM treatment regimens, and whose bacterial index (BI), morphology index (MI), IgM anti PGL-1 antibody, PCR, and sequencing, skin lesion number, and treatment regularity had been examined. Result: The research revealed that all the samples did not undergo any mutations of the gyrA genes which was responsible for the ofloxacin resistance; however, there was a correlation between BI and the IgM anti PGL-1 antibody, and between IgM anti PGL-1 antibody and the number of the skin lesions. Conclusions: There was no samples found to undergo the mutations of gyrA genes, this could be used as the reference to assess the correlation between the morphology index and the IgM anti PGL-1 antibody with the mutations of the gyrA genes.

Published in	American Journal of Clinical and Experimental Medicine (Volume 3, Issue 4)
DOI	10.11648/j.ajcem.20150304.17
Page(s)	167-171
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

gyrA Genes, Morphology Index, IgM Anti PGL-1 Antibody, Ofloxacin Resistance

References

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[5]	Cambau, E., Perani, E., Guilemin, I., Jamet, P., Ji, B. Multidrug-Resistance to Dapson, Rifampicin, and Ofloxacin in Mycobacterium Leprae. The Lancet. 1997; 349: 103-4.
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[9]	Noordeen, S. Epidemiology of Leprosy. In: Hastings, R.C. and Opromella, D.V.A., eds. Leprosy. 1994. Churchil Livingstone: New York.
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APA Style

Arif Risdianto Karim, Muh Dali Amiruddin, Farida Tabri, R. Satriono, Mochammad Hatta, et al. (2015). The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy. American Journal of Clinical and Experimental Medicine, 3(4), 167-171. https://doi.org/10.11648/j.ajcem.20150304.17

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ACS Style

Arif Risdianto Karim; Muh Dali Amiruddin; Farida Tabri; R. Satriono; Mochammad Hatta, et al. The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy. Am. J. Clin. Exp. Med. 2015, 3(4), 167-171. doi: 10.11648/j.ajcem.20150304.17

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AMA Style

Arif Risdianto Karim, Muh Dali Amiruddin, Farida Tabri, R. Satriono, Mochammad Hatta, et al. The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy. Am J Clin Exp Med. 2015;3(4):167-171. doi: 10.11648/j.ajcem.20150304.17

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@article{10.11648/j.ajcem.20150304.17,
  author = {Arif Risdianto Karim and Muh Dali Amiruddin and Farida Tabri and R. Satriono and Mochammad Hatta and Marianti Manggau},
  title = {The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {4},
  pages = {167-171},
  doi = {10.11648/j.ajcem.20150304.17},
  url = {https://doi.org/10.11648/j.ajcem.20150304.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150304.17},
  abstract = {Background: This reserach aimed to determine the correlation between the morphology index and IgM anti PGL-1, and the mutations in gyrA genes in order to detect ofloxacin resistance in the patients with multibacillary (MB) leprosy. Methods: This research was conducted in Dr. Wahidin Sudirohusodo General Hospital and its network hospitals in Makassar using the cohort retrospective design. The research sample comprised 21 patients with MB leprosy who had completed the ROM treatment regimens, and whose bacterial index (BI), morphology index (MI), IgM anti PGL-1 antibody, PCR, and sequencing, skin lesion number, and treatment regularity had been examined. Result: The research revealed that all the samples did not undergo any mutations of the gyrA genes which was responsible for the ofloxacin resistance; however, there was a correlation between BI and the IgM anti PGL-1 antibody, and between IgM anti PGL-1 antibody and the number of the skin lesions. Conclusions: There was no samples found to undergo the mutations of gyrA genes, this could be used as the reference to assess the correlation between the morphology index and the IgM anti PGL-1 antibody with the mutations of the gyrA genes.},
 year = {2015}
}

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TY  - JOUR
T1  - The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy
AU  - Arif Risdianto Karim
AU  - Muh Dali Amiruddin
AU  - Farida Tabri
AU  - R. Satriono
AU  - Mochammad Hatta
AU  - Marianti Manggau
Y1  - 2015/06/25
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150304.17
DO  - 10.11648/j.ajcem.20150304.17
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 167
EP  - 171
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150304.17
AB  - Background: This reserach aimed to determine the correlation between the morphology index and IgM anti PGL-1, and the mutations in gyrA genes in order to detect ofloxacin resistance in the patients with multibacillary (MB) leprosy. Methods: This research was conducted in Dr. Wahidin Sudirohusodo General Hospital and its network hospitals in Makassar using the cohort retrospective design. The research sample comprised 21 patients with MB leprosy who had completed the ROM treatment regimens, and whose bacterial index (BI), morphology index (MI), IgM anti PGL-1 antibody, PCR, and sequencing, skin lesion number, and treatment regularity had been examined. Result: The research revealed that all the samples did not undergo any mutations of the gyrA genes which was responsible for the ofloxacin resistance; however, there was a correlation between BI and the IgM anti PGL-1 antibody, and between IgM anti PGL-1 antibody and the number of the skin lesions. Conclusions: There was no samples found to undergo the mutations of gyrA genes, this could be used as the reference to assess the correlation between the morphology index and the IgM anti PGL-1 antibody with the mutations of the gyrA genes.
VL  - 3
IS  - 4
ER  -

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Author Information

Arif Risdianto Karim

Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Muh Dali Amiruddin

Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Farida Tabri

Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
R. Satriono

Pediatric Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Mochammad Hatta

Microbiology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Marianti Manggau

Pharmacy Faculty Hasanuddin University, Makassar, Indonesia

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APA Style

Arif Risdianto Karim, Muh Dali Amiruddin, Farida Tabri, R. Satriono, Mochammad Hatta, et al. (2015). The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy. American Journal of Clinical and Experimental Medicine, 3(4), 167-171. https://doi.org/10.11648/j.ajcem.20150304.17

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ACS Style

Arif Risdianto Karim; Muh Dali Amiruddin; Farida Tabri; R. Satriono; Mochammad Hatta, et al. The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy. Am. J. Clin. Exp. Med. 2015, 3(4), 167-171. doi: 10.11648/j.ajcem.20150304.17

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AMA Style

Arif Risdianto Karim, Muh Dali Amiruddin, Farida Tabri, R. Satriono, Mochammad Hatta, et al. The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy. Am J Clin Exp Med. 2015;3(4):167-171. doi: 10.11648/j.ajcem.20150304.17

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@article{10.11648/j.ajcem.20150304.17,
  author = {Arif Risdianto Karim and Muh Dali Amiruddin and Farida Tabri and R. Satriono and Mochammad Hatta and Marianti Manggau},
  title = {The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {4},
  pages = {167-171},
  doi = {10.11648/j.ajcem.20150304.17},
  url = {https://doi.org/10.11648/j.ajcem.20150304.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150304.17},
  abstract = {Background: This reserach aimed to determine the correlation between the morphology index and IgM anti PGL-1, and the mutations in gyrA genes in order to detect ofloxacin resistance in the patients with multibacillary (MB) leprosy. Methods: This research was conducted in Dr. Wahidin Sudirohusodo General Hospital and its network hospitals in Makassar using the cohort retrospective design. The research sample comprised 21 patients with MB leprosy who had completed the ROM treatment regimens, and whose bacterial index (BI), morphology index (MI), IgM anti PGL-1 antibody, PCR, and sequencing, skin lesion number, and treatment regularity had been examined. Result: The research revealed that all the samples did not undergo any mutations of the gyrA genes which was responsible for the ofloxacin resistance; however, there was a correlation between BI and the IgM anti PGL-1 antibody, and between IgM anti PGL-1 antibody and the number of the skin lesions. Conclusions: There was no samples found to undergo the mutations of gyrA genes, this could be used as the reference to assess the correlation between the morphology index and the IgM anti PGL-1 antibody with the mutations of the gyrA genes.},
 year = {2015}
}

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TY  - JOUR
T1  - The Analysis of the Mycobacterium Leprae Resistance Against Ofloxacin After the Rifampicin Ofloxacin Minocycline (ROM) Therapy
AU  - Arif Risdianto Karim
AU  - Muh Dali Amiruddin
AU  - Farida Tabri
AU  - R. Satriono
AU  - Mochammad Hatta
AU  - Marianti Manggau
Y1  - 2015/06/25
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150304.17
DO  - 10.11648/j.ajcem.20150304.17
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 167
EP  - 171
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150304.17
AB  - Background: This reserach aimed to determine the correlation between the morphology index and IgM anti PGL-1, and the mutations in gyrA genes in order to detect ofloxacin resistance in the patients with multibacillary (MB) leprosy. Methods: This research was conducted in Dr. Wahidin Sudirohusodo General Hospital and its network hospitals in Makassar using the cohort retrospective design. The research sample comprised 21 patients with MB leprosy who had completed the ROM treatment regimens, and whose bacterial index (BI), morphology index (MI), IgM anti PGL-1 antibody, PCR, and sequencing, skin lesion number, and treatment regularity had been examined. Result: The research revealed that all the samples did not undergo any mutations of the gyrA genes which was responsible for the ofloxacin resistance; however, there was a correlation between BI and the IgM anti PGL-1 antibody, and between IgM anti PGL-1 antibody and the number of the skin lesions. Conclusions: There was no samples found to undergo the mutations of gyrA genes, this could be used as the reference to assess the correlation between the morphology index and the IgM anti PGL-1 antibody with the mutations of the gyrA genes.
VL  - 3
IS  - 4
ER  -

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