The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes

Iryna Nizhenkovska

doi:doi:10.11648/j.ajcem.20150304.16

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The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes

Iryna Nizhenkovska

Published in American Journal of Clinical and Experimental Medicine (Volume 3, Issue 4)

Received: 23 April 2015 Accepted: 9 May 2015 Published: 25 June 2015

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Abstract

There was carried out research concerning the following metabolic deterioration: the metabolic disorders of nicotinamide nucleotides and such macro-energy compounds as adenyl nucleotides, creatine phosphate and their metabolism enzymes in myocardium tissue in case of anthracycline-induced toxic cardiomyopathy. The results of influence of a new physiologically active compound carbicyl that possesses metabolic effect on bioenergenic processes when used in rats with anthracycline-induced heart failure are presented comparing with other cardiotonic agents of different pharmaceutical classes. This study shows that the administration of a metabolic cardiotonic agent carbicyl to the rats that suffer from adriamycin-induced cardiomyopathy significantly normalizes the state of redox processes in myocardium. Carbicyl normalizes the parameters of mitochondrial function; it decreases the deterioration of energy metabolism in cardiomyocytes; carbicyl increases the content of the oxidized forms of NAD+ and NADH+ coenzymes; and it increases the level of ATP, creatine phosphate and glycogen.

Published in	American Journal of Clinical and Experimental Medicine (Volume 3, Issue 4)
DOI	10.11648/j.ajcem.20150304.16
Page(s)	162-166
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Adriamycin, Carbicyl, Cardiotonic Agents, Cardiomyopathy

References

[1]	Korkushko, O. and Lishnevskaya, V. 2003, J. Blood Circulation and Hemostasis, 1, 8.
[2]	Frolkis, V., Bezrukov, V. and Kulchitskiy, O. 1994, Aging and Experimental Aging Cardiovascular Pathology, Kyiv.
[3]	Nizhenkovskaya, I. 2013, J. Current Topics in Pharmacology, 17(1), 103.
[4]	Shinkai, S. 1985, J. Journal of the D.I. Mendeleev All-union Chemical Society, 30(5), 546.
[5]	Telepneva, V. and Isayeva, I. 1967, J. Medical Chemistry Questions, 13, 242.
[6]	Chmielewski, Yu., Gubskiy, Yu and Zaitseva, S. 1985, Biolodical Chemistry. Practical Work Book, Kyiv.
[7]	Ivashkin, V., Gorbatenkova, O. and Drapkina, O. 2004, J. Clinical Medicine, 82(2), 20.
[8]	Mokhort, N., Horchakova, N. and Hrynevych, A. 1999, Pharmacodynamics and the Search of New Cardiotonic Drugs, Kyiv.
[9]	Boldyrev, A. 1982, J. Biological Sciences, 4, 5.
[10]	Nizhenkovska, I., Gladchuk, A., Yanitska L. 2013, J. Medical Chemistry, 15 (2), 77.
[11]	Saks, V., Javadov, S., Pozyn, E. 1989, Phosphocreatine: biochemical and pharmacological action and clinical use, Moscow.
[12]	Vatutin N., Kalinkina, N., Katynh, E. 1999, J. Ukrainian Journal of Chemotherapy, 2 (32), 11.
[13]	Semenova, L., Nepomnyashchii, L., Semenov, D. 1985, Morphology of heart muscle cells in case of plastic failure, The Scientific Thought, Novosibirsk.

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Iryna Nizhenkovska. (2015). The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes. American Journal of Clinical and Experimental Medicine, 3(4), 162-166. https://doi.org/10.11648/j.ajcem.20150304.16

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ACS Style

Iryna Nizhenkovska. The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes. Am. J. Clin. Exp. Med. 2015, 3(4), 162-166. doi: 10.11648/j.ajcem.20150304.16

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AMA Style

Iryna Nizhenkovska. The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes. Am J Clin Exp Med. 2015;3(4):162-166. doi: 10.11648/j.ajcem.20150304.16

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@article{10.11648/j.ajcem.20150304.16,
  author = {Iryna Nizhenkovska},
  title = {The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {4},
  pages = {162-166},
  doi = {10.11648/j.ajcem.20150304.16},
  url = {https://doi.org/10.11648/j.ajcem.20150304.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150304.16},
  abstract = {There was carried out research concerning the following metabolic deterioration: the metabolic disorders of nicotinamide nucleotides and such macro-energy compounds as adenyl nucleotides, creatine phosphate and their metabolism enzymes in myocardium tissue in case of anthracycline-induced toxic cardiomyopathy. The results of influence of a new physiologically active compound carbicyl that possesses metabolic effect on bioenergenic processes when used in rats with anthracycline-induced heart failure are presented comparing with other cardiotonic agents of different pharmaceutical classes. This study shows that the administration of a metabolic cardiotonic agent carbicyl to the rats that suffer from adriamycin-induced cardiomyopathy significantly normalizes the state of redox processes in myocardium. Carbicyl normalizes the parameters of mitochondrial function; it decreases the deterioration of energy metabolism in cardiomyocytes; carbicyl increases the content of the oxidized forms of NAD+ and NADH+ coenzymes; and it increases the level of ATP, creatine phosphate and glycogen.},
 year = {2015}
}

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TY  - JOUR
T1  - The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes
AU  - Iryna Nizhenkovska
Y1  - 2015/06/25
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150304.16
DO  - 10.11648/j.ajcem.20150304.16
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 162
EP  - 166
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150304.16
AB  - There was carried out research concerning the following metabolic deterioration: the metabolic disorders of nicotinamide nucleotides and such macro-energy compounds as adenyl nucleotides, creatine phosphate and their metabolism enzymes in myocardium tissue in case of anthracycline-induced toxic cardiomyopathy. The results of influence of a new physiologically active compound carbicyl that possesses metabolic effect on bioenergenic processes when used in rats with anthracycline-induced heart failure are presented comparing with other cardiotonic agents of different pharmaceutical classes. This study shows that the administration of a metabolic cardiotonic agent carbicyl to the rats that suffer from adriamycin-induced cardiomyopathy significantly normalizes the state of redox processes in myocardium. Carbicyl normalizes the parameters of mitochondrial function; it decreases the deterioration of energy metabolism in cardiomyocytes; carbicyl increases the content of the oxidized forms of NAD+ and NADH+ coenzymes; and it increases the level of ATP, creatine phosphate and glycogen.
VL  - 3
IS  - 4
ER  -

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Author Information

Iryna Nizhenkovska

The department of pharmaceutical, biological and toxicological chemistry, Pharmaceutical Faculty, Bogomolets National Medical University, Kyiv, Ukraine

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APA Style

Iryna Nizhenkovska. (2015). The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes. American Journal of Clinical and Experimental Medicine, 3(4), 162-166. https://doi.org/10.11648/j.ajcem.20150304.16

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ACS Style

Iryna Nizhenkovska. The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes. Am. J. Clin. Exp. Med. 2015, 3(4), 162-166. doi: 10.11648/j.ajcem.20150304.16

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AMA Style

Iryna Nizhenkovska. The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes. Am J Clin Exp Med. 2015;3(4):162-166. doi: 10.11648/j.ajcem.20150304.16

Copy | Download

@article{10.11648/j.ajcem.20150304.16,
  author = {Iryna Nizhenkovska},
  title = {The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {4},
  pages = {162-166},
  doi = {10.11648/j.ajcem.20150304.16},
  url = {https://doi.org/10.11648/j.ajcem.20150304.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150304.16},
  abstract = {There was carried out research concerning the following metabolic deterioration: the metabolic disorders of nicotinamide nucleotides and such macro-energy compounds as adenyl nucleotides, creatine phosphate and their metabolism enzymes in myocardium tissue in case of anthracycline-induced toxic cardiomyopathy. The results of influence of a new physiologically active compound carbicyl that possesses metabolic effect on bioenergenic processes when used in rats with anthracycline-induced heart failure are presented comparing with other cardiotonic agents of different pharmaceutical classes. This study shows that the administration of a metabolic cardiotonic agent carbicyl to the rats that suffer from adriamycin-induced cardiomyopathy significantly normalizes the state of redox processes in myocardium. Carbicyl normalizes the parameters of mitochondrial function; it decreases the deterioration of energy metabolism in cardiomyocytes; carbicyl increases the content of the oxidized forms of NAD+ and NADH+ coenzymes; and it increases the level of ATP, creatine phosphate and glycogen.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes
AU  - Iryna Nizhenkovska
Y1  - 2015/06/25
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150304.16
DO  - 10.11648/j.ajcem.20150304.16
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 162
EP  - 166
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150304.16
AB  - There was carried out research concerning the following metabolic deterioration: the metabolic disorders of nicotinamide nucleotides and such macro-energy compounds as adenyl nucleotides, creatine phosphate and their metabolism enzymes in myocardium tissue in case of anthracycline-induced toxic cardiomyopathy. The results of influence of a new physiologically active compound carbicyl that possesses metabolic effect on bioenergenic processes when used in rats with anthracycline-induced heart failure are presented comparing with other cardiotonic agents of different pharmaceutical classes. This study shows that the administration of a metabolic cardiotonic agent carbicyl to the rats that suffer from adriamycin-induced cardiomyopathy significantly normalizes the state of redox processes in myocardium. Carbicyl normalizes the parameters of mitochondrial function; it decreases the deterioration of energy metabolism in cardiomyocytes; carbicyl increases the content of the oxidized forms of NAD+ and NADH+ coenzymes; and it increases the level of ATP, creatine phosphate and glycogen.
VL  - 3
IS  - 4
ER  -

Copy | Download