Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou

Shen Chao; Liu Na; Ji Libin; Yang Guiran

doi:doi:10.11648/j.ajbls.20241201.13

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Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou

Shen Chao, Liu Na, Ji Libin, Yang Guiran^*

Published in American Journal of Biomedical and Life Sciences (Volume 12, Issue 1)

Received: 9 January 2024 Accepted: 31 January 2024 Published: 29 February 2024

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Abstract

Objective: To analyze the differences in the expression of thyroid autoantibodies and thyroid-stimulating hormone in people with thyroid disease in the high iodine area of Cangzhou City. Methods A total of 90 patients with thyroid disease from high iodine area of Cangzhou City were enrolled, including 30 patients with hypothyroidism, 30 patients with goiter and 30 patients with thyroid cancer. A total of 30 healthy patients at the same time and in the same region were selected as the control. The subjects were divided into four groups: hypothyroidism group, Goiter group, Thyroid cancer group, and control group. The TSH levels and thyroid autoantibody levels of the four groups were analyzed. Results Compared with the control group, the levels of thyroid autoantibodies in the hypothyroidism, Goiter group and thyroid cancer group were significantly higher (P<0.05), and compared with the control group, the TSH levels in the hypothyroidism group and the thyroid cancer group were higher, and the TSH levels in the Goiter group were lower (P<0.05). Conclusion: Thyroid autoantibodies and thyroid-stimulating hormone are differentially expressed in different types of thyroid diseases in the high iodine area of Cangzhou City, which can be used as reference indicators for the identification and diagnosis of different types of thyroid diseases.

Published in	American Journal of Biomedical and Life Sciences (Volume 12, Issue 1)
DOI	10.11648/j.ajbls.20241201.13
Page(s)	12-15
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Thyroid Autoantibodies, Thyroid-Stimulating Hormone, Different Types of Thyroid Diseases

References

[1]	Yang J. The significance of thyroid antibody detection in the diagnosis of thyroid function [J]. Journal of Contemporary Clinical Medicine, 2023, 36(05): 75-77.
[2]	Wang Yiwei. The value of serum TpoAb, LC3, TgAb and TSH levels in the early diagnosis of thyroid diseases [J]. China Health Engineering, 2021, 20(04): 642~643.
[3]	Luo Shuiguang, Song Han, Huang Haishen et al. The role of thyroxine, thyroid stimulating hormone combined with thyroglobulin antibody and thyroid peroxidase antibody in the evaluation of thyroid diseases [J]. Journal of Guangdong Medical University, 2022, 40(06): 645-649.
[4]	Liu Zhidong, Miao Haiting. Significance of TSH, TPOAb, TRAb, TG-Ab and other antibody detection in the diagnosis of thyroid diseases [J]. Wisdom of health, 2022, 8 (16): 5-8. https://doi.org/10.19335/j.carolcarrollnki.2096-1219.2022.16.002
[5]	Zhang J. Value analysis of thyroid stimulating hormone, anti-thyroid peroxidase antibody and anti-thyroglobulin antibody in diagnosis of thyroid diseases [J]. Heilongjiang Medical Journal, 2020, 44(02): 230-232.
[6]	Wang Tinghuai. Physiology [M]. Beijing: People's Medical Publishing House, 2018: 379.
[7]	Wu Feng Size, Jian Danling, Qiu Sijia, et al. Study on the relationship between thyroid disease and iodized salt consumption in coastal areas of Fujian Province [J]. South China J Prev M, 2019, 45(04): 341~345.
[8]	Duan Xinjie, Wang Jun, Wang Zixiao, et al. Research progress on the relationship between environmental endocrine disruptors and thyroid diseases [J]. Journal of Nanjing Medical University (Natural Science Edition), 2023, 43(3): 427~431.
[9]	Li Y, Ba J, Chen B, et al. Efficacy and Safety of Long-Term Universal Salt Iodiztion on Thyroid Disorders: Epidemiological Evidence from 31 Provinces of Mainland China [J]. Thyroid, 2019, 30(4): 568-579.
[10]	Xu Rui, Li Yanguo, Zhou Yuan, et al. Investigation on the geographical distribution of iodine in drinking water in Cangzhou City [J]. Modern Journal of Preventive Medicine, 2019, 46(10): 1895~1897, 1909.
[11]	Wang Mian. Iodine nutritional status and thyroid disease [J]. Clinical Focus, 2016, 31(3): 272~276.
[12]	Zhou Wen, Tan Jing, Huang Li-Chang. The value of thyroid stimulating hormone and thyroid autoantibody detection in the diagnosis and prognosis of hyperthyroidism [J]. Primary Medicine Forum, 2023, 27(22): 109-111. https://doi.org/10.19435/j.1672-1721.2023.22.036
[13]	Zhang Yaqin, Chen Mingwei, Wang Youmin, et al. Study on the characteristics and influencing factors of thyroid autoantibodies in Hefei population [J]. Chinese Journal of General Practice, 2019, 22(24): 2991~2995.
[14]	DUAN J, KANG T, DENG T, et al. Exposure to DBP and high iodine aggravates autoimmune thyroid disease through increasing the levels of IL-17 and thyroid binding globulin in Wistar rats [J]. Toxicol Sci, 2018, 163(1): 196~205.
[15]	MIRANDA D M, MASSOM J N, CATARINO R M, et al. Impact of nutritional iodine optimization on rates of thyroid hypoechogenicity and autoimmune thyroiditis: a cross-sectional, comparative study [J]. Thyroid, 2015, 25(1): 118~124.
[16]	Li Aiying. Clinical value of TSH, TPOAb, TRAb and TG-Ab combined detection in the diagnosis of autoimmune thyroid diseases [J]. China Practical Medicine, 2021, 16(10): 102~104.

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APA Style

Chao, S., Na, L., Libin, J., Guiran, Y. (2024). Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou. American Journal of Biomedical and Life Sciences, 12(1), 12-15. https://doi.org/10.11648/j.ajbls.20241201.13

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ACS Style

Chao, S.; Na, L.; Libin, J.; Guiran, Y. Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou. Am. J. Biomed. Life Sci. 2024, 12(1), 12-15. doi: 10.11648/j.ajbls.20241201.13

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AMA Style

Chao S, Na L, Libin J, Guiran Y. Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou. Am J Biomed Life Sci. 2024;12(1):12-15. doi: 10.11648/j.ajbls.20241201.13

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@article{10.11648/j.ajbls.20241201.13,
  author = {Shen Chao and Liu Na and Ji Libin and Yang Guiran},
  title = {Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {12},
  number = {1},
  pages = {12-15},
  doi = {10.11648/j.ajbls.20241201.13},
  url = {https://doi.org/10.11648/j.ajbls.20241201.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20241201.13},
  abstract = {Objective: To analyze the differences in the expression of thyroid autoantibodies and thyroid-stimulating hormone in people with thyroid disease in the high iodine area of Cangzhou City. Methods A total of 90 patients with thyroid disease from high iodine area of Cangzhou City were enrolled, including 30 patients with hypothyroidism, 30 patients with goiter and 30 patients with thyroid cancer. A total of 30 healthy patients at the same time and in the same region were selected as the control. The subjects were divided into four groups: hypothyroidism group, Goiter group, Thyroid cancer group, and control group. The TSH levels and thyroid autoantibody levels of the four groups were analyzed. Results Compared with the control group, the levels of thyroid autoantibodies in the hypothyroidism, Goiter group and thyroid cancer group were significantly higher (P<0.05), and compared with the control group, the TSH levels in the hypothyroidism group and the thyroid cancer group were higher, and the TSH levels in the Goiter group were lower (P<0.05). Conclusion: Thyroid autoantibodies and thyroid-stimulating hormone are differentially expressed in different types of thyroid diseases in the high iodine area of Cangzhou City, which can be used as reference indicators for the identification and diagnosis of different types of thyroid diseases.
},
 year = {2024}
}

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TY  - JOUR
T1  - Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou
AU  - Shen Chao
AU  - Liu Na
AU  - Ji Libin
AU  - Yang Guiran
Y1  - 2024/02/29
PY  - 2024
N1  - https://doi.org/10.11648/j.ajbls.20241201.13
DO  - 10.11648/j.ajbls.20241201.13
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 12
EP  - 15
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20241201.13
AB  - Objective: To analyze the differences in the expression of thyroid autoantibodies and thyroid-stimulating hormone in people with thyroid disease in the high iodine area of Cangzhou City. Methods A total of 90 patients with thyroid disease from high iodine area of Cangzhou City were enrolled, including 30 patients with hypothyroidism, 30 patients with goiter and 30 patients with thyroid cancer. A total of 30 healthy patients at the same time and in the same region were selected as the control. The subjects were divided into four groups: hypothyroidism group, Goiter group, Thyroid cancer group, and control group. The TSH levels and thyroid autoantibody levels of the four groups were analyzed. Results Compared with the control group, the levels of thyroid autoantibodies in the hypothyroidism, Goiter group and thyroid cancer group were significantly higher (P<0.05), and compared with the control group, the TSH levels in the hypothyroidism group and the thyroid cancer group were higher, and the TSH levels in the Goiter group were lower (P<0.05). Conclusion: Thyroid autoantibodies and thyroid-stimulating hormone are differentially expressed in different types of thyroid diseases in the high iodine area of Cangzhou City, which can be used as reference indicators for the identification and diagnosis of different types of thyroid diseases.

VL  - 12
IS  - 1
ER  -

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Author Information

Shen Chao

Office of Clinical Laboratory, Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Liu Na

Department of Public Courses, Cangzhou Thyroid Disease Engineering technology Center Thyroid Basic Laboratory Cangzhou Medical College, Cangzhou, China
Ji Libin

Department of Traditional Chinese Medicine, Cangzhou Medical College, Cangzhou, China
Yang Guiran

Office of Clinical Laboratory, Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

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Plain Text BibTeX RIS

APA Style

Chao, S., Na, L., Libin, J., Guiran, Y. (2024). Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou. American Journal of Biomedical and Life Sciences, 12(1), 12-15. https://doi.org/10.11648/j.ajbls.20241201.13

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ACS Style

Chao, S.; Na, L.; Libin, J.; Guiran, Y. Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou. Am. J. Biomed. Life Sci. 2024, 12(1), 12-15. doi: 10.11648/j.ajbls.20241201.13

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AMA Style

Chao S, Na L, Libin J, Guiran Y. Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou. Am J Biomed Life Sci. 2024;12(1):12-15. doi: 10.11648/j.ajbls.20241201.13

Copy | Download

@article{10.11648/j.ajbls.20241201.13,
  author = {Shen Chao and Liu Na and Ji Libin and Yang Guiran},
  title = {Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {12},
  number = {1},
  pages = {12-15},
  doi = {10.11648/j.ajbls.20241201.13},
  url = {https://doi.org/10.11648/j.ajbls.20241201.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20241201.13},
  abstract = {Objective: To analyze the differences in the expression of thyroid autoantibodies and thyroid-stimulating hormone in people with thyroid disease in the high iodine area of Cangzhou City. Methods A total of 90 patients with thyroid disease from high iodine area of Cangzhou City were enrolled, including 30 patients with hypothyroidism, 30 patients with goiter and 30 patients with thyroid cancer. A total of 30 healthy patients at the same time and in the same region were selected as the control. The subjects were divided into four groups: hypothyroidism group, Goiter group, Thyroid cancer group, and control group. The TSH levels and thyroid autoantibody levels of the four groups were analyzed. Results Compared with the control group, the levels of thyroid autoantibodies in the hypothyroidism, Goiter group and thyroid cancer group were significantly higher (P<0.05), and compared with the control group, the TSH levels in the hypothyroidism group and the thyroid cancer group were higher, and the TSH levels in the Goiter group were lower (P<0.05). Conclusion: Thyroid autoantibodies and thyroid-stimulating hormone are differentially expressed in different types of thyroid diseases in the high iodine area of Cangzhou City, which can be used as reference indicators for the identification and diagnosis of different types of thyroid diseases.
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - Analysis of Thyroid Autoantibodies and Thyroid Stimulating Hormone Expression in Patients with Thyroid Diseases in High Iodine Areas of Cangzhou
AU  - Shen Chao
AU  - Liu Na
AU  - Ji Libin
AU  - Yang Guiran
Y1  - 2024/02/29
PY  - 2024
N1  - https://doi.org/10.11648/j.ajbls.20241201.13
DO  - 10.11648/j.ajbls.20241201.13
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 12
EP  - 15
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20241201.13
AB  - Objective: To analyze the differences in the expression of thyroid autoantibodies and thyroid-stimulating hormone in people with thyroid disease in the high iodine area of Cangzhou City. Methods A total of 90 patients with thyroid disease from high iodine area of Cangzhou City were enrolled, including 30 patients with hypothyroidism, 30 patients with goiter and 30 patients with thyroid cancer. A total of 30 healthy patients at the same time and in the same region were selected as the control. The subjects were divided into four groups: hypothyroidism group, Goiter group, Thyroid cancer group, and control group. The TSH levels and thyroid autoantibody levels of the four groups were analyzed. Results Compared with the control group, the levels of thyroid autoantibodies in the hypothyroidism, Goiter group and thyroid cancer group were significantly higher (P<0.05), and compared with the control group, the TSH levels in the hypothyroidism group and the thyroid cancer group were higher, and the TSH levels in the Goiter group were lower (P<0.05). Conclusion: Thyroid autoantibodies and thyroid-stimulating hormone are differentially expressed in different types of thyroid diseases in the high iodine area of Cangzhou City, which can be used as reference indicators for the identification and diagnosis of different types of thyroid diseases.

VL  - 12
IS  - 1
ER  -

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