| Peer-Reviewed

Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status

Received: 28 November 2020     Published: 18 January 2021
Views:       Downloads:
Abstract

Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (P<0.05), while the urinary iodine level of HT-B group was negatively correlated with the serum FT3 and TT4 (P<0.05), and positively correlated with TSH (P<0.05). Along with the progression of HT disease, the levels of serum TPOAb and TGAb increased successively, and there were significant differences among each group (P<0.01). The serum TSH level of high TPOAb group and high TgAb group were respectively higher than those of low TPOAb group, low TgAb group and the control group, the levels of FT3 and FT4 were respectively lower than the low TPOAb group and low TGAb group, but there were no statistically significant on the differences between the FT3 of low TgAb and the levels of T3 and T4 of the control group, high TPOAb group, high TGAb group, low TPOAb group and low TGAb group. Conclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.

Published in American Journal of Biomedical and Life Sciences (Volume 9, Issue 1)
DOI 10.11648/j.ajbls.20210901.12
Page(s) 10-19
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Median Urinary Iodine, Thyroid Hormone, Thyroid Autoantibody, Thyroid Disease, Hashimoto's Thyroiditis

References
[1] Xiang Guangda. Clinical Thyroidology [M]. People's Medical Publishing House, 2013: 200.
[2] Hu S, Rayman MP. Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis [J]. Thyroid. 2017, 27 (5): 597-610. doi: 10.1089/thy.2016.0635.
[3] Brčić L, Barić A, Gračan S, et al. Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis [J]. Sci Rep. 2019, 9 (1): 5360. doi: 10.1038/s41598-019.
[4] Zhang Yong xuan. Analysis of the diagnostic value of serum TPO AB, TG AB and TRAb levels in Graves' disease and Hashimoto's thyroiditis [J]. Sichuan J anatomy, 2020, 28 (3): 173-174.
[5] Ma L, Chen YQ, Du J. et al. Correlations between thyroid autoantibodies and thyroid function in patients with newly-diagnosed Hashimoto’s thyroiditis [J]. Chin J Mode Med, 2018, 28 (17): 94-97.
[6] Zhang BJ, Zhang J, Li DX. Role of Antithyroid Antibody in Autoimmune Thyroid Disease [J]. China Pharmacist 2020, 23 (11): 2261-2265.
[7] Chinese Guidelines for the Diagnosis and Treatment of Thyroid Diseases-thyroiditis formulated by the Society of Endocrinology, Chinese Medical Association [J]. Chin J inter Med, 2008, 47 (9): 784-788.
[8] Organization W H, UNICEF. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 2nd ed. [J]. Geneva Switzerland Who Department of Nutrition for Health & Development, 2001.
[9] Zhang Yaping, Yan Yuqin, Liu Liejun, et al. Determination of iodine in urine by ammonium persulfate digestion low arsenic cerium catalytic spectrophotometric method [J]. Chinese Journal of endemic diseases, 2013, 32 (1): 95-100.
[10] Rohner F, Zimmermann M, Jooste P, et al. Biomarkers of nutrition for development--iodine review [J]. J Nutr, 2014, 144 (8): 1322S-1342S.
[11] Chinese Guidelines for the Diagnosis and Treatment of Thyroid Diseases-Iodine deficiency disorders formulated by the Society of Endocrinology, Chinese Medical Association [J]. Chin J inter Med, 2008, 47 (8): 689-690.
[12] Shan ZY, Teng WP, Li YM, et al. Comparative epidemiologic study on the prevalence of iodine-induced hypothyroidism [J]. Chinese Journal of Endocrinology and Metabolism, 2001, 17 (2): 71-74.
[13] Teng WP, Shan ZY, Teng XC, et al. Effect of iodine intake on thyroid diseases in China [J]. N Ensl J Med, 2006, 354 (26): 2783-2793.
[14] Li Yushu, Jin Ying, Teng Weiping, et al. Epidemiological study of thyroid autoantibodies in different areas of iodine intake [J]. Shanghai Journal of immunology, 2002, 22: 91-95.
[15] Guan H, Li C, Li Y, et al. High iodine intake is a risk factor of post-partum thyroiditis: result of a survey from Shenyang, China [J] J Endocrinol Invest [J]. 2005, 28 (10): 876-881.
[16] Wang Peihua, Zhou Yonglin, Zhang Qinglan, et al. Prevalence of hypothyroidism in residents of iodine excess areas [J]. Chinese Journal of endemic diseases, 2007, 26 (6): 669-672.
[17] Wu Zhifeng, Liang Yuan, Chen Xiaojing. Investigation of urinary iodine in patients with thyroid diseases [J]. Youjiang Medical Journal, 2010, 38 (2): 188-189.
[18] Huang Shuyu, Yan Yimin, Wu Min, et al. Analysis of urinary iodine level of newly diagnosed thyroid disease patients in Xiaogan area [J]. Guangzhou trace element science, 2015, 22 (1): 24-27.
[19] Xue Limin, Liu Geling, Yang Xiaolin, et al. The significance of urinary iodine determination in thyroid diseases [J]. Journal of clinical medical literature, 2017, 4 (43): 8371-8372.
[20] Wang Fengling, Hou Zhenjiang, Liu Yuzhi, et al. Evaluation and analysis of iodine nutritional status in patients with thyroid dysfunction [J]. Chinese medicine guide, 2018, 15 (25): 64-67.
[21] Laurberg P, Cerqueira C, Ovesen L, et al. Iodine intake as a determinant of thyroid disorders in populations [J]. Best Pract Res Clin Endocrinol Metab, 2010, 24 (1): 13-27. doi: 10.1016/j.beem.2009.08.013.
[22] Wang Yijun, Zhou Wei, Yang Chunxiang. The relationship between iodine nutritional status and thyroid disease in the elderly [J]. Journal of Integrated Chinese and Western Medicine on cardiovascular disease, 2018, B6 (5): 98-99.
[23] Na buqi, Zhang Xiaoling, Wang Shuyi, et al. Analysis of thyroid function under different iodine nutritional status [J]. Chinese Journal of endemic diseases, 2019, 38 (3): 235-238.
[24] Ren Yanting, Jia Qingzhen, Zhang Xiangdong, et al. Investigation on thyroid disease of women of childbearing age in different iodine intake areas of Shanxi Province [J]. Chinese Journal of epidemiology, 2014, 35 (1): 45-48.
[25] Wang Xinling, rezwanguli•Usman, Ma Fuhui, et al. Analysis of thyroid function, thyroid autoantibodies and urinary iodine changes of permanent residents in Urumqi, Xinjiang [J]. Chinese Journal of epidemiology, 2015, 36 (8): 811-814 DOI: 10.3760/cma.j.issn.0254-6450.2015.08.
[26] Song Xiangxin, Guo Yanying, Ma Xiaoqing. Analysis of thyroid function and iodine nutritional status of Uygur and Han patients in Xinjiang [J]. Hainan Medical. 2016. 27 (24): 3994-3997.
[27] Brčić L, Barić A, Gračan S, et al. Association of established thyroid peroxidase autoantibody (TPOAb) genetic variants with Hashimoto's thyroiditis [J]. Autoimmunity. 2016; 49 (7) 480-485. doi: 10.1080/08916934.
[28] Wang YG, Yan SL, Zhao SH, et al. Correlation of Hashimoto’s thyroiditis with urine iodine level among the coastal districts in Shandong Province [J]. Chinese Journal of Endocrinology and Metabolism, 2004, 20 (4): 337-338.
[29] Zhang Zhihong, Zhang Jinmin, Lian Wenjuan. Study on the relationship between urinary iodine level and Hashimoto's thyroiditis [J]. Basic medicine forum, 2015, 19 (12): 1599-1601.
[30] Li Honghai, Qu Shujun, Li Guangping, et al. Study on urinary iodine level of patients with thyroid disease in Tangshan area [J]. Chinese Journal of health inspection, 2017, 27 (7): 1038-1040.
[31] Zhang Dandan, Shi Nan, Zhang Yan, et al. Correlation between iodine nutrition and SOD, IP-10 and thyroid hormone levels in elderly patients with Hashimoto's thyroiditis [J]. Journal of Chongqing Medical University, 2019, 44 (3): 347-351.
[32] Jin Xin, Shang Xuemei, Chen Haibo, et al. Dynamic changes and significance of regulatory T cells and Th17 cells in peripheral blood of Hashimoto's thyroiditis [J]. Journal of clinical and experimental medicine, 2018, 17 (19): 2092-2094.
[33] Wang Fengling, Hou Zhenjiang, Liu Yuzhi, et al. Study on the relationship between iodine nutrition level and hypothyroidism [J]. Medical review, 2019, 25 (3): 608-611.
[34] Teng XC, Shi X, Shi XG, Shan ZY, et al. Safe range of iodine intake levels: a comparative study of thyroid diseases in three women population cohorts with slightly different iodine intake levels [J]. Biol Trace Elem Res, 2008, 121 (1): 23-30. doi: 10.1007/s12011-007-8036-0. Epub 2007 Oct 20.
[35] Asik M, Gunes F, Binnetoglu E, et al. Decrease in TSH levels after lactose restriction in Hashimoto’s thyroiditis patients with lactose intolerance [J]. Endocrine, 2014, 46: 279-284.
[36] Latrofa F, Fiore E, Rago T, et al. Iodine contributes to thyroid autoimmunity in humans by unmasking a cryptic epitope on thyroglobulin [J]. J Clin Endocrinol Metab, 2013, 98 (11): E1768-1774.
[37] Gong Q, Li X, Gong Q, et al. Hashimoto’s thyroiditis could be secondary to vitiligo: the possibility of antigen crossover and oxidative stress between the two diseases [J]. Arch Dermatol Res, 2016, 308 (4): 277-281.
[38] Gabalec1 F, Srbova L, Nova M, et al. Impact of Hashimoto’s thyroiditis, TSH levels, and anti-thyroid antibody positivity on differentiated thyroid carcinoma incidence [J]. Endokrynol Pol, 2016, 67 (1): 48-53.
[39] Liang Xiuzhen, Wang Jing, Yang Xiaoqiong, et al. Diagnostic value of thyroid autoantibodies in Hashimoto's thyroiditis: a Meta analysis [J]. International Journal of laboratory medicine, 2018, 39 (10): 1206-1210.
[40] Kolypetri P, Carayanniotis G. Apoptosis of NOD. H2 h4 thyrocytes by low concentrations of iodide is associated with impaired control of oxidative stress [J]. Thyroid. 2014, 24 (7): 1170-1178. doi: 10.1089/thy.
[41] Miranda DM, Massom JN, Catarino RM, et al. Impact of nutritional iodine optimization on rates of thyroid hypoechogenicity and autoimmune thyroiditis: a cross-sectional, comparative study [J]. Thyroid. 2015, 25 (1): 118-124.
[42] Teng XC, Shan ZY, Chen YY, et al. More than adequate iodine intake may increase subclinical hypothyroidism and autoimmune thyroiditis: a cross-sectional study based on two Chinese communities with different iodine intake levels [J]. Eur J Endocrinol, 2011, 164 (6): 943-950.
[43] Sundick RS, Herdegen DM, Brown TR, et al. The incorporation of dietary iodine into thyroglobulin increases its immunogenicity [J]. Endocrinology, 1987, 120 (5): 2078-2084. doi: 10.1210/endo-120-5-2078.
[44] Guo XW, Liu Y, Zhai LP, et al. Effects of excessive iodine intake on school-age children's health in high water iodine areas [J]. Chinese Journal of Control of Endemic Diseases, 2013, 28 (3): 161-165.
[45] Sha Liping, Wang Ting, Lu Qingling, et al. Study on the correlation between iodine nutrition level and thyroid disease in Ningxia [J]. Chinese Journal of Endocrinol Metab, may, 2018, 34 (5): 394-397.
[46] Zhang YQ, Chen MW, Wang YM, et al. Characteristics of thyroid autoantibodies and influencing factors among adult population in Hefei Area [J]. Chinese General Practice, 2019, 22 (24): 2991-2995.
[47] Moulopoulos DS, Koutras DA, Mantzos J, et al. The relation of serum T4 and TSH with the urinary iodine excretion [J]. J Endocrinol Invest, 1988, 11 (6): 437-439.
[48] Tian Yan, Liu Jingfang, Tang Xulei, et al. Study on the relationship between iodine nutritional status and TSH, thyroid autoantibodies and thyroid nodules in Gansu Province [J]. Acta nutrica Sinica, 2019, 41 (3): 248-252.
[49] Ma Ling, Chen Yuqiong, Du Juan, et al. Correlation analysis of Hashimoto's thyroiditis autoantibody and thyroid function [J]. Chinese Journal of modern medicine, Journal of Pharmaceutical University, 2018, 28 (17): 94-97.
[50] Fang Lu, Zhu wufei, Liao Xiangyu, et al. Analysis of age, gender distribution and autoimmune antibody level in Hashimoto's thyroiditis [J]. Journal of microcirculation, 2020, 30 (1): 69-72.
[51] Zhu Xudong. Correlation analysis of serum TPOAb, TGAb levels and disease condition in Hashimoto's thyroiditis [J]. 2018, 33 (10): 903-906.
[52] Li Yushu, Zhao Dong, Shan Zhongyan, et al. Epidemiological study of thyroid autoantibodies in different iodine intake areas [J]. Chinese Journal of Endocrinology and metabolism, 2006, 22 (6): 518-522.
[53] Li SM, Xu XL, He YT. Diagnostic and treatment signifi cance of physical examination for postoperative thyroid carcinoma patients and its effect on their hospitalization expenses [J]. Chinese General Practice, 2014, 17 (28): 3353-3355.
Cite This Article
  • APA Style

    Li Hongyan, Ma Jinqun, Wang Cuicui, Liu Jianfeng, Chen Yunxia, et al. (2021). Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status. American Journal of Biomedical and Life Sciences, 9(1), 10-19. https://doi.org/10.11648/j.ajbls.20210901.12

    Copy | Download

    ACS Style

    Li Hongyan; Ma Jinqun; Wang Cuicui; Liu Jianfeng; Chen Yunxia, et al. Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status. Am. J. Biomed. Life Sci. 2021, 9(1), 10-19. doi: 10.11648/j.ajbls.20210901.12

    Copy | Download

    AMA Style

    Li Hongyan, Ma Jinqun, Wang Cuicui, Liu Jianfeng, Chen Yunxia, et al. Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status. Am J Biomed Life Sci. 2021;9(1):10-19. doi: 10.11648/j.ajbls.20210901.12

    Copy | Download

  • @article{10.11648/j.ajbls.20210901.12,
      author = {Li Hongyan and Ma Jinqun and Wang Cuicui and Liu Jianfeng and Chen Yunxia and Liu Chunyan and Hou Zhenjiang},
      title = {Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {9},
      number = {1},
      pages = {10-19},
      doi = {10.11648/j.ajbls.20210901.12},
      url = {https://doi.org/10.11648/j.ajbls.20210901.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210901.12},
      abstract = {Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (PPPPConclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.},
     year = {2021}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status
    AU  - Li Hongyan
    AU  - Ma Jinqun
    AU  - Wang Cuicui
    AU  - Liu Jianfeng
    AU  - Chen Yunxia
    AU  - Liu Chunyan
    AU  - Hou Zhenjiang
    Y1  - 2021/01/18
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajbls.20210901.12
    DO  - 10.11648/j.ajbls.20210901.12
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
    SP  - 10
    EP  - 19
    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.20210901.12
    AB  - Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (PPPPConclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.
    VL  - 9
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

  • Cangzhou People's Hospital Endocrinology, Cangzhou, China

  • Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

  • Cangzhou People's Hospital Endocrinology, Cangzhou, China

  • Cangzhou People's Hospital Endocrinology, Cangzhou, China

  • Cangzhou People's Hospital Endocrinology, Cangzhou, China

  • Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China

  • Sections