Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics

Jianzhang Hou; Yong Li

doi:doi:10.11648/j.ajbls.20200804.18

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Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics

Jianzhang Hou, Yong Li

Published in American Journal of Biomedical and Life Sciences (Volume 8, Issue 4)

Received: 16 July 2020 Published: 25 August 2020

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Abstract

Objective: To explore the value of integrin-linked kinase (ILK) in the diagnosis of gastric cancer, its mechanism of action in the pathogenesis and its influence on tumor metastasis. Methods: Collect 100 cases of gastric cancer diagnosed pathologically, detect the positive expression of ILK, and analyze its biological characteristics. Results: The positive rate of ILK in gastric cancer tissue (57.0%) is significantly higher than that in the control group (12%), and the positive rate of ILK gradually increased with the progress of superficial gastritis, chronic atrophic gastritis with atypical hyperplasia and gastric cancer. The differences between the four groups are statistically significant. There is a significant difference in the positive rate of ILK among well-differentiated, moderately-differentiated, poorly-differentiated and undifferentiated adenocarcinomas (P<0.001). The positive rate (25%) of ILK in the uninvaded serosal layer (T1+T2) is significantly lower than the positive rate (75.0%) in the invaded serosal layer (T3+T4). There is a significant difference in the positive rate of ILK in stage I, II, III and IV (P<0.001). In the localized type (I+II), the positive rate of ILK (24.39%) is significantly lower than that of the invasive type (III+IV) (79.66%). The positive rate of ILK in patients without lymph node metastasis (30.23%) is significantly lower than that of patients with lymph node metastasis (77.19%). Conclusion: The positive rate of ILK in gastric cancer tissue is significantly higher than that in adjacent tissues. The higher the positive rate, the worse the prognosis. ILK is an independent risk factor affecting the prognosis of patients.

Published in	American Journal of Biomedical and Life Sciences (Volume 8, Issue 4)
DOI	10.11648/j.ajbls.20200804.18
Page(s)	119-125
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Gastric Cancer, Degree of Differentiation, Borrmann Classification, TNM Staging, Lymph Node Metastasis, Integrin-Linked Kinase

References

[1]	Ra Fiei E, Mohammadian-Hafshejani A, Towhidi F, et al. Lack of Any relation-ship of Stomach Cancer Incidence and Mortality with development in Asia [J]. Asian Pacific J cancer Prevention, 2016, 17 (8): 3777-3783.
[2]	Lam JK, Chow MY, Zhang Y, et al. siRNA Versus miRNA as Therapeutics for Gene Silencing [J]. Mol Ther Nucleic Acids, 2015, 4 (9): 252.
[3]	Chen WQ, Zheng RS, Zhang SW, et al. Report of Cancer Incidence and Mortality in China, 2012, Chin Canc, 2016, 25 (1): 1-8.
[4]	Li N, Li YF, Wu XF. Advances in biological function of integrin-linked kinase [J]. Life Chem, 2016, 36 (3): 385-389.
[5]	Qiang ZR, Yang GD, Wu J, et al. The role of integrin-linked kinases in tumorigenesis and progression [J]. Chin Clin Onco, 2006, 11 (11): 873-875.
[6]	Department of Medical Administration, Ministry of Health of the People's Republic of China. Guidelines for the Diagnosis and Treatment of Gastric Cancer (2011edition) Chin J Frontiers Med Scie (Electronic Version) 2012, 4 (5): 62-71.
[7]	Song J, Dong SL, Duan JP, et al. Expression of SDF-1/CXCR4 in gastric carcinoma of different Borrmann type and its clinical significances [J]. Chin J Clin (Electronic Edition) 2015, 9 (20): 3691-3695.
[8]	M. B. Amin et al. American Joint Committee on Cáncer A JCC Cáncer Staging M anual, Eighth Edition [J], 2017 203-220.
[9]	Wang G Platt-Higgins A, Carroll J, et al. Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patients [J]. Cancer Res, 2006, 66 (2): 1199-1207.
[10]	Laks S, Meyers MO, Kim HJ. Surveillance for Gastric Cancer [J]. Surg Clin North Am. 2017, 97 (2): 317-331.
[11]	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015 [J]. CA Cancer J Clin. 2016, 66 (2): 115-132.
[12]	Strand MS, Lockhart AC, Fields RC. Genetics of Gastric Cancer [J]. Surg Clin North Am. 2017, 97 (2): 345-370.
[13]	Ilson DH. Current Progress in the Adjuvant Treatment of Gastric Cancer [J]. Surg Oncol Clin N Am. 2017, 26 (2): 225-239.
[14]	Gao J, Zhu J, Li HY, et al. Small interfering RNA targeting integrin-linked kinase inhibited the growth and induced apoptosis in human bladder cancer cells [J]. Int J Biochem Cell Biol. 2011 43 (9): 1294-1304.
[15]	Xiong T, Qu Y, Mu DZ. Integrin-Linked KinaseandIntegrin [J]. J Appl Clin Pedi, 2009, 24 (23): 1848-1851.
[16]	Edwards LA, Shabbits JA, Bally M, et a1. Integrin-linked kinase (ILK) in combination molecular targeting [J]. Cancer Treat Res, 2004, 119 (1): 59-75.
[17]	Ito R, Oue N, Zhu X, et al. Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma [J]. Virchows Arch, 2003, 442 (2): 118-123.
[18]	Zhang FM, Li SS, Li XQ, et a1. Expression and significance of ILK and MMP-9 in gastric cancer invasion and metastasis [J]. Chin J Gastr Hepa, 2015, 24 (1): 95-98.
[19]	Dong L. Expression and significance of Hsp90 and its client protein ILK in gastric cancer and precancerous Iesion [J]. Chin J Integr Trad West Med Dig, 2016, 24 (4): 271-275.
[20]	Hu B, El Hajj N, Sittler S, et al. Gastric cancer: Classification, histology and application of molecular pathology [J]. Gastrointest Oncol, 2012, 3 (3): 251-261.
[21]	Li ZS, Li Q. WHO Classification of Digestive System Tumors in 2010 edition [J]. Chin J Pathol, 2011, 40 (5): 351-354.
[22]	Xie J, Fang J, Jin ML, et al. Advances in pathological typing of gastric cancer [J]. Chin J Prac Inter Medi, 2014, 34 (6): 626-630.
[23]	Hu JK, Chen XZ. Treatment and Prognosis Based on Types and Stages of Gastric Cancer [J]. Chin J Bases Clin General Surg.
[24]	Cao WJ, Li M, LI HJ. Clinical characteristics and prognosis of intestinal- type and diffuse-type gastric cancer [J]. Chin Gene Prac, 2017, 20 (13): 1587-1591.
[25]	Yuan QQ, Ye HZ, Xu LP, et al. Clinicopathological characteristics and prognosis of gastric carcinoma by Lauren classification [J]. Acta Acade Medicinae Wannan, 2016, 35 (6): 544-547.

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APA Style

Jianzhang Hou, Yong Li. (2020). Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics. American Journal of Biomedical and Life Sciences, 8(4), 119-125. https://doi.org/10.11648/j.ajbls.20200804.18

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ACS Style

Jianzhang Hou; Yong Li. Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics. Am. J. Biomed. Life Sci. 2020, 8(4), 119-125. doi: 10.11648/j.ajbls.20200804.18

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AMA Style

Jianzhang Hou, Yong Li. Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics. Am J Biomed Life Sci. 2020;8(4):119-125. doi: 10.11648/j.ajbls.20200804.18

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@article{10.11648/j.ajbls.20200804.18,
  author = {Jianzhang Hou and Yong Li},
  title = {Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {8},
  number = {4},
  pages = {119-125},
  doi = {10.11648/j.ajbls.20200804.18},
  url = {https://doi.org/10.11648/j.ajbls.20200804.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200804.18},
  abstract = {Objective: To explore the value of integrin-linked kinase (ILK) in the diagnosis of gastric cancer, its mechanism of action in the pathogenesis and its influence on tumor metastasis. Methods: Collect 100 cases of gastric cancer diagnosed pathologically, detect the positive expression of ILK, and analyze its biological characteristics. Results: The positive rate of ILK in gastric cancer tissue (57.0%) is significantly higher than that in the control group (12%), and the positive rate of ILK gradually increased with the progress of superficial gastritis, chronic atrophic gastritis with atypical hyperplasia and gastric cancer. The differences between the four groups are statistically significant. There is a significant difference in the positive rate of ILK among well-differentiated, moderately-differentiated, poorly-differentiated and undifferentiated adenocarcinomas (P<0.001). The positive rate (25%) of ILK in the uninvaded serosal layer (T1+T2) is significantly lower than the positive rate (75.0%) in the invaded serosal layer (T3+T4). There is a significant difference in the positive rate of ILK in stage I, II, III and IV (P<0.001). In the localized type (I+II), the positive rate of ILK (24.39%) is significantly lower than that of the invasive type (III+IV) (79.66%). The positive rate of ILK in patients without lymph node metastasis (30.23%) is significantly lower than that of patients with lymph node metastasis (77.19%). Conclusion: The positive rate of ILK in gastric cancer tissue is significantly higher than that in adjacent tissues. The higher the positive rate, the worse the prognosis. ILK is an independent risk factor affecting the prognosis of patients.},
 year = {2020}
}

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TY - JOUR
T1 - Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics
AU - Jianzhang Hou
AU - Yong Li
Y1 - 2020/08/25
PY - 2020
N1 - https://doi.org/10.11648/j.ajbls.20200804.18
DO - 10.11648/j.ajbls.20200804.18
T2 - American Journal of Biomedical and Life Sciences
JF - American Journal of Biomedical and Life Sciences
JO - American Journal of Biomedical and Life Sciences
SP - 119
EP - 125
PB - Science Publishing Group
SN - 2330-880X
UR - https://doi.org/10.11648/j.ajbls.20200804.18
AB - Objective: To explore the value of integrin-linked kinase (ILK) in the diagnosis of gastric cancer, its mechanism of action in the pathogenesis and its influence on tumor metastasis. Methods: Collect 100 cases of gastric cancer diagnosed pathologically, detect the positive expression of ILK, and analyze its biological characteristics. Results: The positive rate of ILK in gastric cancer tissue (57.0%) is significantly higher than that in the control group (12%), and the positive rate of ILK gradually increased with the progress of superficial gastritis, chronic atrophic gastritis with atypical hyperplasia and gastric cancer. The differences between the four groups are statistically significant. There is a significant difference in the positive rate of ILK among well-differentiated, moderately-differentiated, poorly-differentiated and undifferentiated adenocarcinomas (P<0.001). The positive rate (25%) of ILK in the uninvaded serosal layer (T1+T2) is significantly lower than the positive rate (75.0%) in the invaded serosal layer (T3+T4). There is a significant difference in the positive rate of ILK in stage I, II, III and IV (P<0.001). In the localized type (I+II), the positive rate of ILK (24.39%) is significantly lower than that of the invasive type (III+IV) (79.66%). The positive rate of ILK in patients without lymph node metastasis (30.23%) is significantly lower than that of patients with lymph node metastasis (77.19%). Conclusion: The positive rate of ILK in gastric cancer tissue is significantly higher than that in adjacent tissues. The higher the positive rate, the worse the prognosis. ILK is an independent risk factor affecting the prognosis of patients.
VL - 8
IS - 4
ER -

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Author Information

Jianzhang Hou

Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Yong Li

Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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APA Style

Jianzhang Hou, Yong Li. (2020). Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics. American Journal of Biomedical and Life Sciences, 8(4), 119-125. https://doi.org/10.11648/j.ajbls.20200804.18

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ACS Style

Jianzhang Hou; Yong Li. Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics. Am. J. Biomed. Life Sci. 2020, 8(4), 119-125. doi: 10.11648/j.ajbls.20200804.18

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AMA Style

Jianzhang Hou, Yong Li. Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics. Am J Biomed Life Sci. 2020;8(4):119-125. doi: 10.11648/j.ajbls.20200804.18

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@article{10.11648/j.ajbls.20200804.18,
  author = {Jianzhang Hou and Yong Li},
  title = {Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {8},
  number = {4},
  pages = {119-125},
  doi = {10.11648/j.ajbls.20200804.18},
  url = {https://doi.org/10.11648/j.ajbls.20200804.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200804.18},
  abstract = {Objective: To explore the value of integrin-linked kinase (ILK) in the diagnosis of gastric cancer, its mechanism of action in the pathogenesis and its influence on tumor metastasis. Methods: Collect 100 cases of gastric cancer diagnosed pathologically, detect the positive expression of ILK, and analyze its biological characteristics. Results: The positive rate of ILK in gastric cancer tissue (57.0%) is significantly higher than that in the control group (12%), and the positive rate of ILK gradually increased with the progress of superficial gastritis, chronic atrophic gastritis with atypical hyperplasia and gastric cancer. The differences between the four groups are statistically significant. There is a significant difference in the positive rate of ILK among well-differentiated, moderately-differentiated, poorly-differentiated and undifferentiated adenocarcinomas (P<0.001). The positive rate (25%) of ILK in the uninvaded serosal layer (T1+T2) is significantly lower than the positive rate (75.0%) in the invaded serosal layer (T3+T4). There is a significant difference in the positive rate of ILK in stage I, II, III and IV (P<0.001). In the localized type (I+II), the positive rate of ILK (24.39%) is significantly lower than that of the invasive type (III+IV) (79.66%). The positive rate of ILK in patients without lymph node metastasis (30.23%) is significantly lower than that of patients with lymph node metastasis (77.19%). Conclusion: The positive rate of ILK in gastric cancer tissue is significantly higher than that in adjacent tissues. The higher the positive rate, the worse the prognosis. ILK is an independent risk factor affecting the prognosis of patients.},
 year = {2020}
}

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