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Lipid Profiles Levels of Type One Diabetics Compared to Controls in Gaza Strip

Received: 24 June 2016     Accepted: 4 July 2016     Published: 21 July 2016
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Abstract

Background: Type 1 diabetes mellitus (T1DM) is a group of metabolic diseases characterized by hyperglycemia resulting from autoimmune destructions of β cells lead to lack or sever reduction in insulin secretion. Coronary heart disease (CHD) is more prevalent among DM patients than other population. Higher risk of CHD is seen in DM patients who are smokers, have lipid abnormalities, obese, and hypertension. Objective: The overall aim of this study is to evaluate serum lipid profiles of patients with T1DM in comparison with age matched controls in Gaza Strip, Palestine. Materials and Methods: This study was a case control started in Jan, 2014 and finished in Sept, 2014. A total of 50 T1DM patients as a cases group and 100 age-matched healthy individuals as a controls group, aged between 3-18 years. Personal & demographic data, and clinical data situation of the study population were taken by interview questionnaire. Anthropometric and biochemical evaluation were carried out. Collected data and biochemical analysis were analyzed using SPSS version 18. Results: There was no statistically differences among the study subjects with respect to age (P=0.729). Regarding to gender, there was a statistically difference among the study subjects with respect to gender (P=0.014). Concerning the body mass index (BMI), the results reported that there was no statistically difference among the study subjects with respect to BMI (P=0.146). Regarding lipid profiles, this research found that the percentage of high serum triglycerides (TGs) levels was significantly higher among diabetic patients than in controls (p=0.001), However both of them have normal TGs levels, generally. Moreover, despite of both of T1DM and controls in generally, have a normal levels of serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), there were no statistically significant differences among both of them according to these biochemical parameters (p>0.05). On the other hand, there was no relationship between the lipid profiles in T1DM patients and the gender, family history and duration of DM, and BMI, except that, elevation of TGs levels was significantly higher in diabetic males as compared to diabetic females (p=0.011). Conclusions: T1DM patients group and control group were appeared with little or no progressing towards the emergence atherosclerosis and coronary risk factors; because, mostly, they were having normal serum TC, LDL-C &, TGs with low or normal BMI.

Published in American Journal of Biomedical and Life Sciences (Volume 4, Issue 4)
DOI 10.11648/j.ajbls.20160404.12
Page(s) 61-68
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Diabetes Mellitus, Lipid Profiles, Coronary Heart Disease, Gaza Strip

References
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[3] A. Altaher, "The Effect of Ramadan Fasting on Biochemical Parameters among Type 2 Diabetic Patients in Gaza Governorate". Master theses, IUG Journal of Natural and Engineering Studies, 21 (1), pp 485-518, 2013.
[4] M. Yassin, H. Altibi, and A. El Shanti, "Biochemical Features of Type 2 Diabetic Patients in Gaza Governorate ", Submitted to the West African Journal of Medicine, 14, pp 580-585, 2009.
[5] M. Fujita, K. Ueno, and A. Hata, "Effect of obesity on incidence of type 2 diabetes declines with age among Japanese women", Experimental Biology and Medicine, 234, pp 750-757, 2009.
[6] Ministry of Health, Palestine Health Information Center, Non Communicable disease. Health Status in Palestine, 2011 (Accessed 25-3- 2014).
[7] American Diabetes Association, Standards of Medical Care in Diabetes. Diabetes Care. 30, pp 4-41, 2013 (Accessed 2-3- 2014).
[8] A. A. Alrabaty, A. A. Alnakshabandi, N. B. Yahya, "The Lipid Profile in Children with Type 1 Diabetes Mellitus in Erbil Governorate", THE IRAQI POSTGRADUATE MEDICAL JOURNAL, 8 (4), 2009.
[9] A. J. Krentz, "Lipoprotein abnormalities and their consequences for patients with type 2 diabetes" Diabetes Obes Metab., 5 (1), pp 19-27, 2003.
[10] Palestinian Medical Relief Society (PMRS) "About Palestinian Medical Relief Society", 2013. http://www.pmrs.ps (Accessed 2-5- 2014).
[11] Ministry of Health (MOH) "Palestinian Clinical Laboratory Tests Guide". Palestinian Health Information Center, Palestine, 2005. (Accessed 20-4- 2014).
[12] World Health Organization, "Obesity and overweight", Fact sheet number 311. Geneva, 2012. http://www.who.int/mediacentre/factsheets/fs311/en/index.html (accessed 10-4-2014).
[13] M. H. Burstein, R. Scholnick, and R. Morfin, " Rapid Method for Isolation of Lipoproteins from Human Serum by Precipitation with Polyanion", Journal of Lipid Research, 11, 583, 1970.
[14] W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge", Clinical Chemistry Journal, 18 (6) pp 499–502, 1972.
[15] M. M. Engler, M. B. Engler, D. M. Daridson and R. E. Slaughter "Cardiovascular disease prevention, knowledge and attitudes of graduate nursing students", Journal of Advanced Nursing, 17: pp 1220-1225, 1992.
[16] N. Khalil "Clinical study of lipid profile in diabetic patients", Middle East Journal of Family Medicine, 4 (5), 2006.
[17] L. P. Oski's, "Pediatrics principles and pediatrics", 4th ed., Philadiliphia, saunders, 2006.
[18] H. William, "Diabetes Mellitus, Type 1". [Online] 2014. Available at www. emedicine.com/ped/topic581.htm (accessed 10-4-2014).
[19] L. M. Naama, M. Kadhim, M. S. Aboud "Lipid profile in children with insulin dependent diabetes mellitus", J Pak Med Assoc., 52, pp 29-34, 2002.
[20] F. Erciyas, T. Fatma, A. Bana, U. Yasemin, "Glycemic control, oxidative stress and lipid profile in children with type 1 diabetes mellitus", Arch Med Res, 35, pp 134-140, 2004.
[21] S. F. Imani, M. Hashmipour, R. Kelishadi, "Lipid profilre of children with type 1 diabetes compared to controls", ARYA Journal, 2, pp 36-38, 2006.
[22] S. Patiakas, N. Kiriakopoulos, C. Gavala, I. Aggos, K. Akritopoulou, P. Akritopoulos, et al. "The lipid profile of patients with diabetes mellitus in Paionia country", Diabetologie und Stoffweechsel, 10, 1055, 2007.
[23] P. Antonio, M. Ana, C. Gemma, G. Gabriel, L. Jose, R. Mercedes, et al. "Prevalence and Phenotypic Distribution of Dyslipidemia in Type 1 Diabetes Mellitus", Arch Intern Med., 160, pp 2756-2762, 2000.
[24] M. Bianga, G. Deja, C. Jarosz, T. Malecka, M. Kalina, M. Grychtol, "Evaluation of selected risk factors of atherosclerosis in children with type 1 hypercholesterolemia", Endocrynol Diabetol Chor Przemiany Wieku Rozw, 12, pp 25-30, 2006.
[25] Ho. Herbert, G. Partica, A. Mary, M. D. Batongbacal, "The lipid profile of Diabetic Patients at the Diabetes Clinic of the Philippine general hospital", Philipp J Intern Med, 38, pp 16-20, 2000.
Cite This Article
  • APA Style

    Akram Mohammed-Refat Altaher, Salem Sami Alewaity, Jalal Ahmed Abu-Touima. (2016). Lipid Profiles Levels of Type One Diabetics Compared to Controls in Gaza Strip. American Journal of Biomedical and Life Sciences, 4(4), 61-68. https://doi.org/10.11648/j.ajbls.20160404.12

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    ACS Style

    Akram Mohammed-Refat Altaher; Salem Sami Alewaity; Jalal Ahmed Abu-Touima. Lipid Profiles Levels of Type One Diabetics Compared to Controls in Gaza Strip. Am. J. Biomed. Life Sci. 2016, 4(4), 61-68. doi: 10.11648/j.ajbls.20160404.12

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    AMA Style

    Akram Mohammed-Refat Altaher, Salem Sami Alewaity, Jalal Ahmed Abu-Touima. Lipid Profiles Levels of Type One Diabetics Compared to Controls in Gaza Strip. Am J Biomed Life Sci. 2016;4(4):61-68. doi: 10.11648/j.ajbls.20160404.12

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  • @article{10.11648/j.ajbls.20160404.12,
      author = {Akram Mohammed-Refat Altaher and Salem Sami Alewaity and Jalal Ahmed Abu-Touima},
      title = {Lipid Profiles Levels of Type One Diabetics Compared to Controls in Gaza Strip},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {4},
      number = {4},
      pages = {61-68},
      doi = {10.11648/j.ajbls.20160404.12},
      url = {https://doi.org/10.11648/j.ajbls.20160404.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20160404.12},
      abstract = {Background: Type 1 diabetes mellitus (T1DM) is a group of metabolic diseases characterized by hyperglycemia resulting from autoimmune destructions of β cells lead to lack or sever reduction in insulin secretion. Coronary heart disease (CHD) is more prevalent among DM patients than other population. Higher risk of CHD is seen in DM patients who are smokers, have lipid abnormalities, obese, and hypertension. Objective: The overall aim of this study is to evaluate serum lipid profiles of patients with T1DM in comparison with age matched controls in Gaza Strip, Palestine. Materials and Methods: This study was a case control started in Jan, 2014 and finished in Sept, 2014. A total of 50 T1DM patients as a cases group and 100 age-matched healthy individuals as a controls group, aged between 3-18 years. Personal & demographic data, and clinical data situation of the study population were taken by interview questionnaire. Anthropometric and biochemical evaluation were carried out. Collected data and biochemical analysis were analyzed using SPSS version 18. Results: There was no statistically differences among the study subjects with respect to age (P=0.729). Regarding to gender, there was a statistically difference among the study subjects with respect to gender (P=0.014). Concerning the body mass index (BMI), the results reported that there was no statistically difference among the study subjects with respect to BMI (P=0.146). Regarding lipid profiles, this research found that the percentage of high serum triglycerides (TGs) levels was significantly higher among diabetic patients than in controls (p=0.001), However both of them have normal TGs levels, generally. Moreover, despite of both of T1DM and controls in generally, have a normal levels of serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), there were no statistically significant differences among both of them according to these biochemical parameters (p>0.05). On the other hand, there was no relationship between the lipid profiles in T1DM patients and the gender, family history and duration of DM, and BMI, except that, elevation of TGs levels was significantly higher in diabetic males as compared to diabetic females (p=0.011). Conclusions: T1DM patients group and control group were appeared with little or no progressing towards the emergence atherosclerosis and coronary risk factors; because, mostly, they were having normal serum TC, LDL-C &, TGs with low or normal BMI.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Lipid Profiles Levels of Type One Diabetics Compared to Controls in Gaza Strip
    AU  - Akram Mohammed-Refat Altaher
    AU  - Salem Sami Alewaity
    AU  - Jalal Ahmed Abu-Touima
    Y1  - 2016/07/21
    PY  - 2016
    N1  - https://doi.org/10.11648/j.ajbls.20160404.12
    DO  - 10.11648/j.ajbls.20160404.12
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
    SP  - 61
    EP  - 68
    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.20160404.12
    AB  - Background: Type 1 diabetes mellitus (T1DM) is a group of metabolic diseases characterized by hyperglycemia resulting from autoimmune destructions of β cells lead to lack or sever reduction in insulin secretion. Coronary heart disease (CHD) is more prevalent among DM patients than other population. Higher risk of CHD is seen in DM patients who are smokers, have lipid abnormalities, obese, and hypertension. Objective: The overall aim of this study is to evaluate serum lipid profiles of patients with T1DM in comparison with age matched controls in Gaza Strip, Palestine. Materials and Methods: This study was a case control started in Jan, 2014 and finished in Sept, 2014. A total of 50 T1DM patients as a cases group and 100 age-matched healthy individuals as a controls group, aged between 3-18 years. Personal & demographic data, and clinical data situation of the study population were taken by interview questionnaire. Anthropometric and biochemical evaluation were carried out. Collected data and biochemical analysis were analyzed using SPSS version 18. Results: There was no statistically differences among the study subjects with respect to age (P=0.729). Regarding to gender, there was a statistically difference among the study subjects with respect to gender (P=0.014). Concerning the body mass index (BMI), the results reported that there was no statistically difference among the study subjects with respect to BMI (P=0.146). Regarding lipid profiles, this research found that the percentage of high serum triglycerides (TGs) levels was significantly higher among diabetic patients than in controls (p=0.001), However both of them have normal TGs levels, generally. Moreover, despite of both of T1DM and controls in generally, have a normal levels of serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), there were no statistically significant differences among both of them according to these biochemical parameters (p>0.05). On the other hand, there was no relationship between the lipid profiles in T1DM patients and the gender, family history and duration of DM, and BMI, except that, elevation of TGs levels was significantly higher in diabetic males as compared to diabetic females (p=0.011). Conclusions: T1DM patients group and control group were appeared with little or no progressing towards the emergence atherosclerosis and coronary risk factors; because, mostly, they were having normal serum TC, LDL-C &, TGs with low or normal BMI.
    VL  - 4
    IS  - 4
    ER  - 

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Author Information
  • Medical Sciences Department, University College of Science and Technology, Gaza Strip, Palestine

  • Medical Sciences Department, University College of Science and Technology, Gaza Strip, Palestine

  • Medical Sciences Department, University College of Science and Technology, Gaza Strip, Palestine

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