Aim of the study was to evaluate the importance of the combined use of fine needle aspiration cytology (FNAC) and cell-block in the diagnosis of different breast lesions. Patient and methods: This study was a prospective study of 310 cases (301 females and 9 males) with breast swelling, coming to cytopathology unit, faculty of medicine, Zagazig University. FNAC and cell-block were performed. Cytological findings of smears and cell-blocks were correlated to histopathological results. Results: Most of cases were diagnosed as benign lesions or normal findings. The majority of FNAC samples was diagnosed as fibrocystic disease (160 cases, 51.6%), followed by fibroadenoma in 54 cases (17.4%). Positive cases for malignancy, including non-Hodgkin lymphoma and false negative cases were encountered in 50 cases (16.1%). Studying the histopathological results showed that true positive cases by FNAC and cell-block were 47 in number (15.16%) and true negative ones were 247 cases (82.90%). False positive cases were 3 in number (0.96%) and false negative ones were also 3 cases (0.96%). Sensitivity was 94% and specificity was 98%. Positive predictive and negative predictive values were 94% and 98%, respectively. False positive and false negative rates were 1.15% and 6% respectively. Total accuracy was 98%. Conclusion: It is advised to perform cell-blocks for each case of breast FNAC to decrease the pitfalls and to improve the diagnosis and management of breast lumps.
| Published in | American Journal of Biomedical and Life Sciences (Volume 2, Issue 1) |
| DOI | 10.11648/j.ajbls.20140201.12 |
| Page(s) | 8-17 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2013. Published by Science Publishing Group |
Breast, Histology, Pathology, FNAC, Cell-Block
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APA Style
Raafat Awad Hegazy, Abdelmonem Awad Hegazy, Fathy Ahmed Fetouh, Samir Ibrahim. (2013). Fine Needle Aspiration Cytology and Cell-Block Study of Various Breast Lumps. American Journal of Biomedical and Life Sciences, 2(1), 8-17. https://doi.org/10.11648/j.ajbls.20140201.12
ACS Style
Raafat Awad Hegazy; Abdelmonem Awad Hegazy; Fathy Ahmed Fetouh; Samir Ibrahim. Fine Needle Aspiration Cytology and Cell-Block Study of Various Breast Lumps. Am. J. Biomed. Life Sci. 2013, 2(1), 8-17. doi: 10.11648/j.ajbls.20140201.12
AMA Style
Raafat Awad Hegazy, Abdelmonem Awad Hegazy, Fathy Ahmed Fetouh, Samir Ibrahim. Fine Needle Aspiration Cytology and Cell-Block Study of Various Breast Lumps. Am J Biomed Life Sci. 2013;2(1):8-17. doi: 10.11648/j.ajbls.20140201.12
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Download@article{10.11648/j.ajbls.20140201.12,
author = {Raafat Awad Hegazy and Abdelmonem Awad Hegazy and Fathy Ahmed Fetouh and Samir Ibrahim},
title = {Fine Needle Aspiration Cytology and Cell-Block Study of Various Breast Lumps},
journal = {American Journal of Biomedical and Life Sciences},
volume = {2},
number = {1},
pages = {8-17},
doi = {10.11648/j.ajbls.20140201.12},
url = {https://doi.org/10.11648/j.ajbls.20140201.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20140201.12},
abstract = {Aim of the study was to evaluate the importance of the combined use of fine needle aspiration cytology (FNAC) and cell-block in the diagnosis of different breast lesions. Patient and methods: This study was a prospective study of 310 cases (301 females and 9 males) with breast swelling, coming to cytopathology unit, faculty of medicine, Zagazig University. FNAC and cell-block were performed. Cytological findings of smears and cell-blocks were correlated to histopathological results. Results: Most of cases were diagnosed as benign lesions or normal findings. The majority of FNAC samples was diagnosed as fibrocystic disease (160 cases, 51.6%), followed by fibroadenoma in 54 cases (17.4%). Positive cases for malignancy, including non-Hodgkin lymphoma and false negative cases were encountered in 50 cases (16.1%). Studying the histopathological results showed that true positive cases by FNAC and cell-block were 47 in number (15.16%) and true negative ones were 247 cases (82.90%). False positive cases were 3 in number (0.96%) and false negative ones were also 3 cases (0.96%). Sensitivity was 94% and specificity was 98%. Positive predictive and negative predictive values were 94% and 98%, respectively. False positive and false negative rates were 1.15% and 6% respectively. Total accuracy was 98%. Conclusion: It is advised to perform cell-blocks for each case of breast FNAC to decrease the pitfalls and to improve the diagnosis and management of breast lumps.},
year = {2013}
}
TY - JOUR T1 - Fine Needle Aspiration Cytology and Cell-Block Study of Various Breast Lumps AU - Raafat Awad Hegazy AU - Abdelmonem Awad Hegazy AU - Fathy Ahmed Fetouh AU - Samir Ibrahim Y1 - 2013/12/30 PY - 2013 N1 - https://doi.org/10.11648/j.ajbls.20140201.12 DO - 10.11648/j.ajbls.20140201.12 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 8 EP - 17 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20140201.12 AB - Aim of the study was to evaluate the importance of the combined use of fine needle aspiration cytology (FNAC) and cell-block in the diagnosis of different breast lesions. Patient and methods: This study was a prospective study of 310 cases (301 females and 9 males) with breast swelling, coming to cytopathology unit, faculty of medicine, Zagazig University. FNAC and cell-block were performed. Cytological findings of smears and cell-blocks were correlated to histopathological results. Results: Most of cases were diagnosed as benign lesions or normal findings. The majority of FNAC samples was diagnosed as fibrocystic disease (160 cases, 51.6%), followed by fibroadenoma in 54 cases (17.4%). Positive cases for malignancy, including non-Hodgkin lymphoma and false negative cases were encountered in 50 cases (16.1%). Studying the histopathological results showed that true positive cases by FNAC and cell-block were 47 in number (15.16%) and true negative ones were 247 cases (82.90%). False positive cases were 3 in number (0.96%) and false negative ones were also 3 cases (0.96%). Sensitivity was 94% and specificity was 98%. Positive predictive and negative predictive values were 94% and 98%, respectively. False positive and false negative rates were 1.15% and 6% respectively. Total accuracy was 98%. Conclusion: It is advised to perform cell-blocks for each case of breast FNAC to decrease the pitfalls and to improve the diagnosis and management of breast lumps. VL - 2 IS - 1 ER -
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