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Synthesis, Characterization and Study of Antimicrobial Activity of Mn(II) and Ni(II) Complexes with Schiff Base Derived from 2-Hydroxy-benzaldehyde and 1-Naphthylamine

Received: 20 April 2023     Accepted: 9 May 2023     Published: 6 July 2023
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Abstract

The Schiff base; 2-hydroxybenzalidene-1-naphthylamine and its Mn(II) and Ni(II) complexes were synthesized and characterized using, conductivity measurement, magnetic susceptibility, elemental analyses, melting point/decomposition temperature, electronic spectral analyses, infrared spectral analysis and solubility test. The Schiff base and its metal complexes were tested for antimicrobial activity. The molar conductance values range (6.52 – 23.1 Ω-1cm2mol-1) revealed non-electrolytic nature of the complexes. The magnetic susceptibility values; 5.91 BM indicated Mn(II) complex as paramagnetic while –Ve indicated Ni(II) complex as diamagnetic. The elemental analyses results revealed slight differences between calculated and observed percentages of values of C, H, and N, which is in line with the proposed structures of the synthesized compounds. The high decomposition temperature range (201 – 223°C) indicated good stability of the complexes. The infrared spectra analysis results suggested that the Schiff base behave as bidentate ligand coordinates to metal ion via azomethine nitrogen and phenolic oxygen. The antimicrobial activity of the Schiff base and its metal complexes were carried out using agar well diffusion method against two bacteria strains; (Salmonella typhi and streptococcus pneumoniae) and two fungal isolates; (Aspergillus fumigatus and Rhizopus species). The results revealed that the Schiff base and its metal complexes exhibited moderate antimicrobial activity as compared with the standard drugs; (Gentamycin and Nystatin).

Published in American Journal of Applied Chemistry (Volume 11, Issue 3)
DOI 10.11648/j.ajac.20231103.13
Page(s) 86-94
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Schiff Base, Complexes, 2-hydroxybenzaldehyde, 1-naphthylamine, Antimicrobial Activity

References
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[2] Akmal, S. G., Mohsen, S. A., Atiat, S. B. and Said, M. T. (2007), Synthesis, characterization and biological activity of some platinum (II) complexes with Schiff bases derived from salicylaldehyde, 2-furaldehyde and phenylenediamine, Spectrochimica Acta Part A 67, 114-121.
[3] Bhausaheb, K. M., Anil, S. K. and Trimbak K. C. (2013), Formation of N-Salicylidene-p-chloroaniline; a kinetic Study ActaChim pharm. Indica 4 (1): 40-46.
[4] Chaudhary, N. K. (2013) Synthesis and medicinal use of Metal Complexes of Schiff bases, a multidisciplinary Journal of Science, Technology and Mathematics. 9 (1): 75-80.
[5] Devesh, K. (2014). Review on biological important mixed ligand Complexes and their Application. Asian journal of Biochemical and Pharmaceutical Research issue. 1 (4): 22-135.
[6] Gomathi, V. and Selvameena, R. (2014), Synthesis, spectral characterization and antimicrobial screening of novel Schiff bases from sulfa drugs, International Journal of Pharmacy and Pharmaceutical Sciences, 6 (1).
[7] Ibrahim, A. K., Yusuf, B. A. and Hamisu, A. (2017), Synthesis, Characterization and Antimicrobial Studies of Cu(II) and Zn(II) Complexes with the Schiff base N-salicylidene-4-chloroaniline, ChemSearch Journal, 8 (2): 68-74.
[8] Ignat, L. (2012), Complexes of some Transition Metal with Ketone and azomethinic derivatives of Ketones. PhD Thesis University of Bucharest Romania 2 (1): 256-285.
[9] Jai, D., Suman, D. and Ashwani, K. (2016), Synthesis, antibacterial evaluation and QSAR analysis of Schiff base complexes derived from [2,2′-(ethylenedioxy)bis(ethylamine)] and aromatic aldehyde, Journal of Royal Society of Chemistry, (7): 932.
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[12] Matangi, S., Pragathi, J., Ushaiah and Gyanakumari, C. (2012), Synthesis¸ structural characterization, molecular modeling and antimicrobial studies of transition metal complexes of Schiff base ligand derived from 5-chlorosalicylaldehyde and 2-(2-aminophenyl) 1H-benzimidazole, Journal of Chemical and Pharmaceutical Research, 2012, 4 (3): 1553-1561.
[13] Moamens R and Ibrahim, M. (2013), Spectroscopic, Structural and Electrical Conductivity studies of Cu(II), Ni(II) and C(II) Complexes derived from 4-acetylpyridine with thiosemicarbazide. International journal of Electrochemical Science. 1 (8): 9898-9917.
[14] Nagajothi, A., Kiruthika, A., Chitra, S. and Parameswari, K. (2013) Fe(III) Complexes with Schiff base ligand: Synthesis, Characterization, Antimicrobial Studies, Research Journal of Chemical Sciences, 3 (2), 35-43.
[15] Naila, A. b., Rashid, S., Rashmi, S., Rahul, G., Shankardutt, P., Kabita, S., Chavan, R. P. and Satu, T. C. (2015), Synthesis and characterization of novel Schiff’s base Ni(II) and Fe(III) & its complexes with its anti-bacterial activity, International Journal of chemical societies, 3 (4): 39-41.
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    Ibrahim Kani Aminu, Abdulwaris Abdullahi Daura. (2023). Synthesis, Characterization and Study of Antimicrobial Activity of Mn(II) and Ni(II) Complexes with Schiff Base Derived from 2-Hydroxy-benzaldehyde and 1-Naphthylamine. American Journal of Applied Chemistry, 11(3), 86-94. https://doi.org/10.11648/j.ajac.20231103.13

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    ACS Style

    Ibrahim Kani Aminu; Abdulwaris Abdullahi Daura. Synthesis, Characterization and Study of Antimicrobial Activity of Mn(II) and Ni(II) Complexes with Schiff Base Derived from 2-Hydroxy-benzaldehyde and 1-Naphthylamine. Am. J. Appl. Chem. 2023, 11(3), 86-94. doi: 10.11648/j.ajac.20231103.13

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    AMA Style

    Ibrahim Kani Aminu, Abdulwaris Abdullahi Daura. Synthesis, Characterization and Study of Antimicrobial Activity of Mn(II) and Ni(II) Complexes with Schiff Base Derived from 2-Hydroxy-benzaldehyde and 1-Naphthylamine. Am J Appl Chem. 2023;11(3):86-94. doi: 10.11648/j.ajac.20231103.13

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  • @article{10.11648/j.ajac.20231103.13,
      author = {Ibrahim Kani Aminu and Abdulwaris Abdullahi Daura},
      title = {Synthesis, Characterization and Study of Antimicrobial Activity of Mn(II) and Ni(II) Complexes with Schiff Base Derived from 2-Hydroxy-benzaldehyde and 1-Naphthylamine},
      journal = {American Journal of Applied Chemistry},
      volume = {11},
      number = {3},
      pages = {86-94},
      doi = {10.11648/j.ajac.20231103.13},
      url = {https://doi.org/10.11648/j.ajac.20231103.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20231103.13},
      abstract = {The Schiff base; 2-hydroxybenzalidene-1-naphthylamine and its Mn(II) and Ni(II) complexes were synthesized and characterized using, conductivity measurement, magnetic susceptibility, elemental analyses, melting point/decomposition temperature, electronic spectral analyses, infrared spectral analysis and solubility test. The Schiff base and its metal complexes were tested for antimicrobial activity. The molar conductance values range (6.52 – 23.1 Ω-1cm2mol-1) revealed non-electrolytic nature of the complexes. The magnetic susceptibility values; 5.91 BM indicated Mn(II) complex as paramagnetic while –Ve indicated Ni(II) complex as diamagnetic. The elemental analyses results revealed slight differences between calculated and observed percentages of values of C, H, and N, which is in line with the proposed structures of the synthesized compounds. The high decomposition temperature range (201 – 223°C) indicated good stability of the complexes. The infrared spectra analysis results suggested that the Schiff base behave as bidentate ligand coordinates to metal ion via azomethine nitrogen and phenolic oxygen. The antimicrobial activity of the Schiff base and its metal complexes were carried out using agar well diffusion method against two bacteria strains; (Salmonella typhi and streptococcus pneumoniae) and two fungal isolates; (Aspergillus fumigatus and Rhizopus species). The results revealed that the Schiff base and its metal complexes exhibited moderate antimicrobial activity as compared with the standard drugs; (Gentamycin and Nystatin).},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Synthesis, Characterization and Study of Antimicrobial Activity of Mn(II) and Ni(II) Complexes with Schiff Base Derived from 2-Hydroxy-benzaldehyde and 1-Naphthylamine
    AU  - Ibrahim Kani Aminu
    AU  - Abdulwaris Abdullahi Daura
    Y1  - 2023/07/06
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ajac.20231103.13
    DO  - 10.11648/j.ajac.20231103.13
    T2  - American Journal of Applied Chemistry
    JF  - American Journal of Applied Chemistry
    JO  - American Journal of Applied Chemistry
    SP  - 86
    EP  - 94
    PB  - Science Publishing Group
    SN  - 2330-8745
    UR  - https://doi.org/10.11648/j.ajac.20231103.13
    AB  - The Schiff base; 2-hydroxybenzalidene-1-naphthylamine and its Mn(II) and Ni(II) complexes were synthesized and characterized using, conductivity measurement, magnetic susceptibility, elemental analyses, melting point/decomposition temperature, electronic spectral analyses, infrared spectral analysis and solubility test. The Schiff base and its metal complexes were tested for antimicrobial activity. The molar conductance values range (6.52 – 23.1 Ω-1cm2mol-1) revealed non-electrolytic nature of the complexes. The magnetic susceptibility values; 5.91 BM indicated Mn(II) complex as paramagnetic while –Ve indicated Ni(II) complex as diamagnetic. The elemental analyses results revealed slight differences between calculated and observed percentages of values of C, H, and N, which is in line with the proposed structures of the synthesized compounds. The high decomposition temperature range (201 – 223°C) indicated good stability of the complexes. The infrared spectra analysis results suggested that the Schiff base behave as bidentate ligand coordinates to metal ion via azomethine nitrogen and phenolic oxygen. The antimicrobial activity of the Schiff base and its metal complexes were carried out using agar well diffusion method against two bacteria strains; (Salmonella typhi and streptococcus pneumoniae) and two fungal isolates; (Aspergillus fumigatus and Rhizopus species). The results revealed that the Schiff base and its metal complexes exhibited moderate antimicrobial activity as compared with the standard drugs; (Gentamycin and Nystatin).
    VL  - 11
    IS  - 3
    ER  - 

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Author Information
  • Department of Pure and Industrial Chemistry, Bayero University, Kano, Nigeria

  • Mechanical Engineering Department, Usman Danfodiyo University, Sokoto, Nigeria

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