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Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder

Received: 12 November 2013     Accepted: 28 November 2014     Published: 27 November 2014
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Abstract

Bile acids as characteristic compounds of human and animal bile are major endogenous products of cholesterol and play very important roles in cholesterol homeostasis, lipid absorption and production of bile flow. At present, bile acids are useful biomarkers and signaling molecules for the diagnosis or treatment of many diseases in clinic. Various analytical methods, from overall to individual, qualitative to quantitative, have been developed for the determination of bile acids in biomedical samples and even bile-based medicinal materials. The most precious and commonly-used bile-based traditional animal medicines are cow-bezoar (CB) and bear bile powder (BBP), which regard bile acids as the main bioactive constituents and have extensive use for treating many diseases since thousands of years ago. However, extensive consumption of CB and BBP make their natural resource scarcity and price valuableness. Currently, artificial, in-vitro cultured substitutes and even worse adulterants or counterfeits mix in the medicine market and they have seriously compromised the therapeutic effects of these two traditional medicines. To guarantee the long-term development of ethnodrugs, many analytical approaches have been utilized in quality control of CB and BBP. In this paper, various analytical methods of bile acids are summarized and compared with each other.

Published in American Journal of Applied Chemistry (Volume 2, Issue 6)
DOI 10.11648/j.ajac.20140206.11
Page(s) 96-104
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Bile Acids, Analytical Methods, Cow-Bezoar, Bear Bile Powder, Quality Control

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    Xiaoyuan Niu, Ying Xu, Qiaoling Yang, Xiaowen Tang, Li Yang, et al. (2014). Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder. American Journal of Applied Chemistry, 2(6), 96-104. https://doi.org/10.11648/j.ajac.20140206.11

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    Xiaoyuan Niu; Ying Xu; Qiaoling Yang; Xiaowen Tang; Li Yang, et al. Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder. Am. J. Appl. Chem. 2014, 2(6), 96-104. doi: 10.11648/j.ajac.20140206.11

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    Xiaoyuan Niu, Ying Xu, Qiaoling Yang, Xiaowen Tang, Li Yang, et al. Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder. Am J Appl Chem. 2014;2(6):96-104. doi: 10.11648/j.ajac.20140206.11

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  • @article{10.11648/j.ajac.20140206.11,
      author = {Xiaoyuan Niu and Ying Xu and Qiaoling Yang and Xiaowen Tang and Li Yang and Zhengtao Wang},
      title = {Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder},
      journal = {American Journal of Applied Chemistry},
      volume = {2},
      number = {6},
      pages = {96-104},
      doi = {10.11648/j.ajac.20140206.11},
      url = {https://doi.org/10.11648/j.ajac.20140206.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20140206.11},
      abstract = {Bile acids as characteristic compounds of human and animal bile are major endogenous products of cholesterol and play very important roles in cholesterol homeostasis, lipid absorption and production of bile flow. At present, bile acids are useful biomarkers and signaling molecules for the diagnosis or treatment of many diseases in clinic. Various analytical methods, from overall to individual, qualitative to quantitative, have been developed for the determination of bile acids in biomedical samples and even bile-based medicinal materials. The most precious and commonly-used bile-based traditional animal medicines are cow-bezoar (CB) and bear bile powder (BBP), which regard bile acids as the main bioactive constituents and have extensive use for treating many diseases since thousands of years ago. However, extensive consumption of CB and BBP make their natural resource scarcity and price valuableness. Currently, artificial, in-vitro cultured substitutes and even worse adulterants or counterfeits mix in the medicine market and they have seriously compromised the therapeutic effects of these two traditional medicines. To guarantee the long-term development of ethnodrugs, many analytical approaches have been utilized in quality control of CB and BBP. In this paper, various analytical methods of bile acids are summarized and compared with each other.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder
    AU  - Xiaoyuan Niu
    AU  - Ying Xu
    AU  - Qiaoling Yang
    AU  - Xiaowen Tang
    AU  - Li Yang
    AU  - Zhengtao Wang
    Y1  - 2014/11/27
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajac.20140206.11
    DO  - 10.11648/j.ajac.20140206.11
    T2  - American Journal of Applied Chemistry
    JF  - American Journal of Applied Chemistry
    JO  - American Journal of Applied Chemistry
    SP  - 96
    EP  - 104
    PB  - Science Publishing Group
    SN  - 2330-8745
    UR  - https://doi.org/10.11648/j.ajac.20140206.11
    AB  - Bile acids as characteristic compounds of human and animal bile are major endogenous products of cholesterol and play very important roles in cholesterol homeostasis, lipid absorption and production of bile flow. At present, bile acids are useful biomarkers and signaling molecules for the diagnosis or treatment of many diseases in clinic. Various analytical methods, from overall to individual, qualitative to quantitative, have been developed for the determination of bile acids in biomedical samples and even bile-based medicinal materials. The most precious and commonly-used bile-based traditional animal medicines are cow-bezoar (CB) and bear bile powder (BBP), which regard bile acids as the main bioactive constituents and have extensive use for treating many diseases since thousands of years ago. However, extensive consumption of CB and BBP make their natural resource scarcity and price valuableness. Currently, artificial, in-vitro cultured substitutes and even worse adulterants or counterfeits mix in the medicine market and they have seriously compromised the therapeutic effects of these two traditional medicines. To guarantee the long-term development of ethnodrugs, many analytical approaches have been utilized in quality control of CB and BBP. In this paper, various analytical methods of bile acids are summarized and compared with each other.
    VL  - 2
    IS  - 6
    ER  - 

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Author Information
  • The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

  • The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

  • The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

  • The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

  • The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

  • The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

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