Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with <i>Plasmodium falciparum</i> in Katsina State, Nigeria

Bello Ibrahim; Abdulsalami Mohammed Sani; Bulus Timothy

doi:doi:10.11648/j.ab.20160406.11

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Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with Plasmodium falciparum in Katsina State, Nigeria

Bello Ibrahim, Abdulsalami Mohammed Sani, Bulus Timothy

Published in Advances in Biochemistry (Volume 4, Issue 6)

Received: 22 August 2016 Accepted: 8 September 2016 Published: 15 November 2016

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Abstract

About 96 million people having Glucose-6-phosphate dehydrogenase (G6PD) deficiency worldwide are known to reside in malaria endemic countries and this G6PD-deficiency has been shown to protect against malaria infection, a disease which affect mostly children less than 5 years of age. This study was prompted by the paucity of scientific information on G6PD deficiency for malaria-infected children in Nigeria and so it was designed to determine the prevalence of G6PD deficiency among children (aged 0-5 years) infected with Plasmodium falciparum in Katsina State, a North-western region of Nigeria. A total of 200 blood samples were collected from children with Plasmodium falciparum malaria attending the six selected hospitals located across the three senatorial zones of the state from March 2015 to May 2015. Children’s inform consent was obtained, their socio-demographic information and clinical presentations were also taken with the aid of structured questionnaire. G6PD deficiency was detected qualitatively using G6PD screening test. Thirty two (16%) samples were G6PD deficient and were significantly associated (p<0.05) with malaria. Higher prevalence was observed among male children (62.5%) compared with their female counterpart (37.5%). Prevalence rates of 31.25%, 25.00%, 18.75% and 12.50% were seen in children of 1, 2, 3, 4 and 5 years old respectively. These conditions reach life-threatening scenarios for all G6PD deficiency patients with different genetic variants. Hence, individuals that are required to use antimalaria drugs should be screened very carefully for their tendency to have G6PD deficiency. For effective control and treatment, either a reliable test for detecting G6PD deficiency or an anti-malaria drug that can be safely given to G6PD deficiency patients is required. The need for training paediatricians on routine screening of children for G6PD deficiency in developing countries in order to avoid cases of drug-induced anaemia associated with malaria treatment need to be taken into consideration.

Published in	Advances in Biochemistry (Volume 4, Issue 6)
DOI	10.11648/j.ab.20160406.11
Page(s)	66-73
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD), Plasmodium Falciparum, Malaria, Children, Katsina State, Nigeria

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APA Style

Bello Ibrahim, Abdulsalami Mohammed Sani, Bulus Timothy. (2016). Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with Plasmodium falciparum in Katsina State, Nigeria. Advances in Biochemistry, 4(6), 66-73. https://doi.org/10.11648/j.ab.20160406.11

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ACS Style

Bello Ibrahim; Abdulsalami Mohammed Sani; Bulus Timothy. Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with Plasmodium falciparum in Katsina State, Nigeria. Adv. Biochem. 2016, 4(6), 66-73. doi: 10.11648/j.ab.20160406.11

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AMA Style

Bello Ibrahim, Abdulsalami Mohammed Sani, Bulus Timothy. Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with Plasmodium falciparum in Katsina State, Nigeria. Adv Biochem. 2016;4(6):66-73. doi: 10.11648/j.ab.20160406.11

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@article{10.11648/j.ab.20160406.11,
  author = {Bello Ibrahim and Abdulsalami Mohammed Sani and Bulus Timothy},
  title = {Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with Plasmodium falciparum in Katsina State, Nigeria},
  journal = {Advances in Biochemistry},
  volume = {4},
  number = {6},
  pages = {66-73},
  doi = {10.11648/j.ab.20160406.11},
  url = {https://doi.org/10.11648/j.ab.20160406.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20160406.11},
  abstract = {About 96 million people having Glucose-6-phosphate dehydrogenase (G6PD) deficiency worldwide are known to reside in malaria endemic countries and this G6PD-deficiency has been shown to protect against malaria infection, a disease which affect mostly children less than 5 years of age. This study was prompted by the paucity of scientific information on G6PD deficiency for malaria-infected children in Nigeria and so it was designed to determine the prevalence of G6PD deficiency among children (aged 0-5 years) infected with Plasmodium falciparum in Katsina State, a North-western region of Nigeria. A total of 200 blood samples were collected from children with Plasmodium falciparum malaria attending the six selected hospitals located across the three senatorial zones of the state from March 2015 to May 2015. Children’s inform consent was obtained, their socio-demographic information and clinical presentations were also taken with the aid of structured questionnaire. G6PD deficiency was detected qualitatively using G6PD screening test. Thirty two (16%) samples were G6PD deficient and were significantly associated (p<0.05) with malaria. Higher prevalence was observed among male children (62.5%) compared with their female counterpart (37.5%). Prevalence rates of 31.25%, 25.00%, 18.75% and 12.50% were seen in children of 1, 2, 3, 4 and 5 years old respectively. These conditions reach life-threatening scenarios for all G6PD deficiency patients with different genetic variants. Hence, individuals that are required to use antimalaria drugs should be screened very carefully for their tendency to have G6PD deficiency. For effective control and treatment, either a reliable test for detecting G6PD deficiency or an anti-malaria drug that can be safely given to G6PD deficiency patients is required. The need for training paediatricians on routine screening of children for G6PD deficiency in developing countries in order to avoid cases of drug-induced anaemia associated with malaria treatment need to be taken into consideration.},
 year = {2016}
}

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TY  - JOUR
T1  - Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with Plasmodium falciparum in Katsina State, Nigeria
AU  - Bello Ibrahim
AU  - Abdulsalami Mohammed Sani
AU  - Bulus Timothy
Y1  - 2016/11/15
PY  - 2016
N1  - https://doi.org/10.11648/j.ab.20160406.11
DO  - 10.11648/j.ab.20160406.11
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 66
EP  - 73
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20160406.11
AB  - About 96 million people having Glucose-6-phosphate dehydrogenase (G6PD) deficiency worldwide are known to reside in malaria endemic countries and this G6PD-deficiency has been shown to protect against malaria infection, a disease which affect mostly children less than 5 years of age. This study was prompted by the paucity of scientific information on G6PD deficiency for malaria-infected children in Nigeria and so it was designed to determine the prevalence of G6PD deficiency among children (aged 0-5 years) infected with Plasmodium falciparum in Katsina State, a North-western region of Nigeria. A total of 200 blood samples were collected from children with Plasmodium falciparum malaria attending the six selected hospitals located across the three senatorial zones of the state from March 2015 to May 2015. Children’s inform consent was obtained, their socio-demographic information and clinical presentations were also taken with the aid of structured questionnaire. G6PD deficiency was detected qualitatively using G6PD screening test. Thirty two (16%) samples were G6PD deficient and were significantly associated (p<0.05) with malaria. Higher prevalence was observed among male children (62.5%) compared with their female counterpart (37.5%). Prevalence rates of 31.25%, 25.00%, 18.75% and 12.50% were seen in children of 1, 2, 3, 4 and 5 years old respectively. These conditions reach life-threatening scenarios for all G6PD deficiency patients with different genetic variants. Hence, individuals that are required to use antimalaria drugs should be screened very carefully for their tendency to have G6PD deficiency. For effective control and treatment, either a reliable test for detecting G6PD deficiency or an anti-malaria drug that can be safely given to G6PD deficiency patients is required. The need for training paediatricians on routine screening of children for G6PD deficiency in developing countries in order to avoid cases of drug-induced anaemia associated with malaria treatment need to be taken into consideration.
VL  - 4
IS  - 6
ER  -

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Author Information

Bello Ibrahim

National Biotechnology Development Agency, Abuja, Nigeria
Abdulsalami Mohammed Sani

Department of Biological Sciences, Nigerian Defence Academy, Kaduna, Nigeria
Bulus Timothy

Department of Biochemistry, Kaduna State University, Kaduna, Nigeria

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Bello Ibrahim, Abdulsalami Mohammed Sani, Bulus Timothy. (2016). Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with Plasmodium falciparum in Katsina State, Nigeria. Advances in Biochemistry, 4(6), 66-73. https://doi.org/10.11648/j.ab.20160406.11

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ACS Style

Bello Ibrahim; Abdulsalami Mohammed Sani; Bulus Timothy. Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with Plasmodium falciparum in Katsina State, Nigeria. Adv. Biochem. 2016, 4(6), 66-73. doi: 10.11648/j.ab.20160406.11

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AMA Style

Bello Ibrahim, Abdulsalami Mohammed Sani, Bulus Timothy. Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with Plasmodium falciparum in Katsina State, Nigeria. Adv Biochem. 2016;4(6):66-73. doi: 10.11648/j.ab.20160406.11

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@article{10.11648/j.ab.20160406.11,
  author = {Bello Ibrahim and Abdulsalami Mohammed Sani and Bulus Timothy},
  title = {Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with Plasmodium falciparum in Katsina State, Nigeria},
  journal = {Advances in Biochemistry},
  volume = {4},
  number = {6},
  pages = {66-73},
  doi = {10.11648/j.ab.20160406.11},
  url = {https://doi.org/10.11648/j.ab.20160406.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20160406.11},
  abstract = {About 96 million people having Glucose-6-phosphate dehydrogenase (G6PD) deficiency worldwide are known to reside in malaria endemic countries and this G6PD-deficiency has been shown to protect against malaria infection, a disease which affect mostly children less than 5 years of age. This study was prompted by the paucity of scientific information on G6PD deficiency for malaria-infected children in Nigeria and so it was designed to determine the prevalence of G6PD deficiency among children (aged 0-5 years) infected with Plasmodium falciparum in Katsina State, a North-western region of Nigeria. A total of 200 blood samples were collected from children with Plasmodium falciparum malaria attending the six selected hospitals located across the three senatorial zones of the state from March 2015 to May 2015. Children’s inform consent was obtained, their socio-demographic information and clinical presentations were also taken with the aid of structured questionnaire. G6PD deficiency was detected qualitatively using G6PD screening test. Thirty two (16%) samples were G6PD deficient and were significantly associated (p<0.05) with malaria. Higher prevalence was observed among male children (62.5%) compared with their female counterpart (37.5%). Prevalence rates of 31.25%, 25.00%, 18.75% and 12.50% were seen in children of 1, 2, 3, 4 and 5 years old respectively. These conditions reach life-threatening scenarios for all G6PD deficiency patients with different genetic variants. Hence, individuals that are required to use antimalaria drugs should be screened very carefully for their tendency to have G6PD deficiency. For effective control and treatment, either a reliable test for detecting G6PD deficiency or an anti-malaria drug that can be safely given to G6PD deficiency patients is required. The need for training paediatricians on routine screening of children for G6PD deficiency in developing countries in order to avoid cases of drug-induced anaemia associated with malaria treatment need to be taken into consideration.},
 year = {2016}
}

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TY  - JOUR
T1  - Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency Among Children Aged 0-5 Years Infected with Plasmodium falciparum in Katsina State, Nigeria
AU  - Bello Ibrahim
AU  - Abdulsalami Mohammed Sani
AU  - Bulus Timothy
Y1  - 2016/11/15
PY  - 2016
N1  - https://doi.org/10.11648/j.ab.20160406.11
DO  - 10.11648/j.ab.20160406.11
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 66
EP  - 73
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20160406.11
AB  - About 96 million people having Glucose-6-phosphate dehydrogenase (G6PD) deficiency worldwide are known to reside in malaria endemic countries and this G6PD-deficiency has been shown to protect against malaria infection, a disease which affect mostly children less than 5 years of age. This study was prompted by the paucity of scientific information on G6PD deficiency for malaria-infected children in Nigeria and so it was designed to determine the prevalence of G6PD deficiency among children (aged 0-5 years) infected with Plasmodium falciparum in Katsina State, a North-western region of Nigeria. A total of 200 blood samples were collected from children with Plasmodium falciparum malaria attending the six selected hospitals located across the three senatorial zones of the state from March 2015 to May 2015. Children’s inform consent was obtained, their socio-demographic information and clinical presentations were also taken with the aid of structured questionnaire. G6PD deficiency was detected qualitatively using G6PD screening test. Thirty two (16%) samples were G6PD deficient and were significantly associated (p<0.05) with malaria. Higher prevalence was observed among male children (62.5%) compared with their female counterpart (37.5%). Prevalence rates of 31.25%, 25.00%, 18.75% and 12.50% were seen in children of 1, 2, 3, 4 and 5 years old respectively. These conditions reach life-threatening scenarios for all G6PD deficiency patients with different genetic variants. Hence, individuals that are required to use antimalaria drugs should be screened very carefully for their tendency to have G6PD deficiency. For effective control and treatment, either a reliable test for detecting G6PD deficiency or an anti-malaria drug that can be safely given to G6PD deficiency patients is required. The need for training paediatricians on routine screening of children for G6PD deficiency in developing countries in order to avoid cases of drug-induced anaemia associated with malaria treatment need to be taken into consideration.
VL  - 4
IS  - 6
ER  -

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