Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study

Ahmed Fawzy; Ishaq A. Zaafarany; Fahd A. Tirkistani; Basim H. Asghar

doi:doi:10.11648/j.ab.20160405.12

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Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study

Ahmed Fawzy, Ishaq A. Zaafarany, Fahd A. Tirkistani, Basim H. Asghar

Published in Advances in Biochemistry (Volume 4, Issue 5)

Received: 28 August 2016 Accepted: 5 September 2016 Published: 18 October 2016

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Abstract

The kinetics of oxidations of atropine (ATR) by permanganate ion in both perchloric and sulfuric acid solutions was studied using spectrophotometric technique at a constant ionic strength of 1.2 moldm^-3 and at 25°C. In both acids, the reactions showed a first order dependence with respect to [permanganate], whereas the orders with respect to [ATR] and [H⁺] were found to be less than unity. The effect of acid concentration suggests that the reactions were acid-catalyzed. Variation of either ionic strength or dielectric constant of the medium had no effect significantly on the oxidation rates. The reactions mechanism adequately describing the kinetic results was proposed. In both acids, the main oxidation products of atropine were identified by spectral and chemical analyses as tropine and phenylmalonic acid. Under comparable experimental conditions, the oxidation rate of atropine in sulfuric acid was approximately three times higher than that in perchloric acid. The reactions constants involved in the different steps of the reactions mechanism have been evaluated. With admiration to the rate-limiting step of these reactions, the activation parameters have been evaluated and discussed.

Published in	Advances in Biochemistry (Volume 4, Issue 5)
DOI	10.11648/j.ab.20160405.12
Page(s)	58-65
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Atropine, Permanganate, Oxidation, Kinetics, Mechanism

References

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Ahmed Fawzy, Ishaq A. Zaafarany, Fahd A. Tirkistani, Basim H. Asghar. (2016). Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study. Advances in Biochemistry, 4(5), 58-65. https://doi.org/10.11648/j.ab.20160405.12

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ACS Style

Ahmed Fawzy; Ishaq A. Zaafarany; Fahd A. Tirkistani; Basim H. Asghar. Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study. Adv. Biochem. 2016, 4(5), 58-65. doi: 10.11648/j.ab.20160405.12

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AMA Style

Ahmed Fawzy, Ishaq A. Zaafarany, Fahd A. Tirkistani, Basim H. Asghar. Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study. Adv Biochem. 2016;4(5):58-65. doi: 10.11648/j.ab.20160405.12

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@article{10.11648/j.ab.20160405.12,
  author = {Ahmed Fawzy and Ishaq A. Zaafarany and Fahd A. Tirkistani and Basim H. Asghar},
  title = {Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study},
  journal = {Advances in Biochemistry},
  volume = {4},
  number = {5},
  pages = {58-65},
  doi = {10.11648/j.ab.20160405.12},
  url = {https://doi.org/10.11648/j.ab.20160405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20160405.12},
  abstract = {The kinetics of oxidations of atropine (ATR) by permanganate ion in both perchloric and sulfuric acid solutions was studied using spectrophotometric technique at a constant ionic strength of 1.2 moldm-3 and at 25°C. In both acids, the reactions showed a first order dependence with respect to [permanganate], whereas the orders with respect to [ATR] and [H+] were found to be less than unity. The effect of acid concentration suggests that the reactions were acid-catalyzed. Variation of either ionic strength or dielectric constant of the medium had no effect significantly on the oxidation rates. The reactions mechanism adequately describing the kinetic results was proposed. In both acids, the main oxidation products of atropine were identified by spectral and chemical analyses as tropine and phenylmalonic acid. Under comparable experimental conditions, the oxidation rate of atropine in sulfuric acid was approximately three times higher than that in perchloric acid. The reactions constants involved in the different steps of the reactions mechanism have been evaluated. With admiration to the rate-limiting step of these reactions, the activation parameters have been evaluated and discussed.},
 year = {2016}
}

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TY - JOUR
T1 - Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study
AU - Ahmed Fawzy
AU - Ishaq A. Zaafarany
AU - Fahd A. Tirkistani
AU - Basim H. Asghar
Y1 - 2016/10/18
PY - 2016
N1 - https://doi.org/10.11648/j.ab.20160405.12
DO - 10.11648/j.ab.20160405.12
T2 - Advances in Biochemistry
JF - Advances in Biochemistry
JO - Advances in Biochemistry
SP - 58
EP - 65
PB - Science Publishing Group
SN - 2329-0862
UR - https://doi.org/10.11648/j.ab.20160405.12
AB - The kinetics of oxidations of atropine (ATR) by permanganate ion in both perchloric and sulfuric acid solutions was studied using spectrophotometric technique at a constant ionic strength of 1.2 moldm-3 and at 25°C. In both acids, the reactions showed a first order dependence with respect to [permanganate], whereas the orders with respect to [ATR] and [H+] were found to be less than unity. The effect of acid concentration suggests that the reactions were acid-catalyzed. Variation of either ionic strength or dielectric constant of the medium had no effect significantly on the oxidation rates. The reactions mechanism adequately describing the kinetic results was proposed. In both acids, the main oxidation products of atropine were identified by spectral and chemical analyses as tropine and phenylmalonic acid. Under comparable experimental conditions, the oxidation rate of atropine in sulfuric acid was approximately three times higher than that in perchloric acid. The reactions constants involved in the different steps of the reactions mechanism have been evaluated. With admiration to the rate-limiting step of these reactions, the activation parameters have been evaluated and discussed.
VL - 4
IS - 5
ER -

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Author Information

Ahmed Fawzy

Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia
Ishaq A. Zaafarany

Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia
Fahd A. Tirkistani

Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia
Basim H. Asghar

Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia

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APA Style

Ahmed Fawzy, Ishaq A. Zaafarany, Fahd A. Tirkistani, Basim H. Asghar. (2016). Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study. Advances in Biochemistry, 4(5), 58-65. https://doi.org/10.11648/j.ab.20160405.12

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ACS Style

Ahmed Fawzy; Ishaq A. Zaafarany; Fahd A. Tirkistani; Basim H. Asghar. Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study. Adv. Biochem. 2016, 4(5), 58-65. doi: 10.11648/j.ab.20160405.12

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AMA Style

Ahmed Fawzy, Ishaq A. Zaafarany, Fahd A. Tirkistani, Basim H. Asghar. Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study. Adv Biochem. 2016;4(5):58-65. doi: 10.11648/j.ab.20160405.12

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@article{10.11648/j.ab.20160405.12,
  author = {Ahmed Fawzy and Ishaq A. Zaafarany and Fahd A. Tirkistani and Basim H. Asghar},
  title = {Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study},
  journal = {Advances in Biochemistry},
  volume = {4},
  number = {5},
  pages = {58-65},
  doi = {10.11648/j.ab.20160405.12},
  url = {https://doi.org/10.11648/j.ab.20160405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20160405.12},
  abstract = {The kinetics of oxidations of atropine (ATR) by permanganate ion in both perchloric and sulfuric acid solutions was studied using spectrophotometric technique at a constant ionic strength of 1.2 moldm-3 and at 25°C. In both acids, the reactions showed a first order dependence with respect to [permanganate], whereas the orders with respect to [ATR] and [H+] were found to be less than unity. The effect of acid concentration suggests that the reactions were acid-catalyzed. Variation of either ionic strength or dielectric constant of the medium had no effect significantly on the oxidation rates. The reactions mechanism adequately describing the kinetic results was proposed. In both acids, the main oxidation products of atropine were identified by spectral and chemical analyses as tropine and phenylmalonic acid. Under comparable experimental conditions, the oxidation rate of atropine in sulfuric acid was approximately three times higher than that in perchloric acid. The reactions constants involved in the different steps of the reactions mechanism have been evaluated. With admiration to the rate-limiting step of these reactions, the activation parameters have been evaluated and discussed.},
 year = {2016}
}

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