Carmoisine and tartrazine are azo dyes widely used as food colourants. This study examine the effects of oral administration of carmoisine and tartrazine on some biochemical parameters in the heart and kidney of albino rats. Twenty four (24) female albino rats (average weight 140g) were sorted into four groups. Group A received water and served as the control, Group B-250mg/kg bw carmoisine, Group C-250mg/kg bw tartrazine, Group D-co-administered 250mg/kg bw each of carmoisine and tartrazine. The food dyes were administered daily for a period of 21 days. Results obtained showed a significant increase (p<0.05) in the levels of urea, creatinine and electrolytes (Na+, K+ and CO32-) in the serum of rats administered the food dyes compared to control. The colourants also caused significant alterations (p<0.05) in the levels of enzymes (creatine kinase, lactate dehydrogenase, aspartate aminotransferase and alkaline phosphatase) in the serum and heart homogenate of the experimental rats. Histological examination of the renal and cardiac tissues correlate with the biochemical results indicating marked distortions in the kidney and heart of rats administered carmoisine and tartrazine. These results suggest that carmoisine and tartrazine have the tendency of inducing nephrotoxicity and cardiac dysfunction in rats.
| Published in | Advances in Biochemistry (Volume 4, Issue 3) |
| DOI | 10.11648/j.ab.20160403.11 |
| Page(s) | 21-25 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2016. Published by Science Publishing Group |
Carmoisine, Tartrazine, Nephrotoxicity, Heart, Histology
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APA Style
Olu Israel Oyewole, Johnson Olaleye Oladele. (2016). Assessment of Cardiac and Renal Functions in Wistar Albino Rats Administered Carmoisine and Tartrazine. Advances in Biochemistry, 4(3), 21-25. https://doi.org/10.11648/j.ab.20160403.11
ACS Style
Olu Israel Oyewole; Johnson Olaleye Oladele. Assessment of Cardiac and Renal Functions in Wistar Albino Rats Administered Carmoisine and Tartrazine. Adv. Biochem. 2016, 4(3), 21-25. doi: 10.11648/j.ab.20160403.11
AMA Style
Olu Israel Oyewole, Johnson Olaleye Oladele. Assessment of Cardiac and Renal Functions in Wistar Albino Rats Administered Carmoisine and Tartrazine. Adv Biochem. 2016;4(3):21-25. doi: 10.11648/j.ab.20160403.11
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Download@article{10.11648/j.ab.20160403.11,
author = {Olu Israel Oyewole and Johnson Olaleye Oladele},
title = {Assessment of Cardiac and Renal Functions in Wistar Albino Rats Administered Carmoisine and Tartrazine},
journal = {Advances in Biochemistry},
volume = {4},
number = {3},
pages = {21-25},
doi = {10.11648/j.ab.20160403.11},
url = {https://doi.org/10.11648/j.ab.20160403.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20160403.11},
abstract = {Carmoisine and tartrazine are azo dyes widely used as food colourants. This study examine the effects of oral administration of carmoisine and tartrazine on some biochemical parameters in the heart and kidney of albino rats. Twenty four (24) female albino rats (average weight 140g) were sorted into four groups. Group A received water and served as the control, Group B-250mg/kg bw carmoisine, Group C-250mg/kg bw tartrazine, Group D-co-administered 250mg/kg bw each of carmoisine and tartrazine. The food dyes were administered daily for a period of 21 days. Results obtained showed a significant increase (p+, K+ and CO32-) in the serum of rats administered the food dyes compared to control. The colourants also caused significant alterations (p<0.05) in the levels of enzymes (creatine kinase, lactate dehydrogenase, aspartate aminotransferase and alkaline phosphatase) in the serum and heart homogenate of the experimental rats. Histological examination of the renal and cardiac tissues correlate with the biochemical results indicating marked distortions in the kidney and heart of rats administered carmoisine and tartrazine. These results suggest that carmoisine and tartrazine have the tendency of inducing nephrotoxicity and cardiac dysfunction in rats.},
year = {2016}
}
TY - JOUR T1 - Assessment of Cardiac and Renal Functions in Wistar Albino Rats Administered Carmoisine and Tartrazine AU - Olu Israel Oyewole AU - Johnson Olaleye Oladele Y1 - 2016/04/28 PY - 2016 N1 - https://doi.org/10.11648/j.ab.20160403.11 DO - 10.11648/j.ab.20160403.11 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 21 EP - 25 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20160403.11 AB - Carmoisine and tartrazine are azo dyes widely used as food colourants. This study examine the effects of oral administration of carmoisine and tartrazine on some biochemical parameters in the heart and kidney of albino rats. Twenty four (24) female albino rats (average weight 140g) were sorted into four groups. Group A received water and served as the control, Group B-250mg/kg bw carmoisine, Group C-250mg/kg bw tartrazine, Group D-co-administered 250mg/kg bw each of carmoisine and tartrazine. The food dyes were administered daily for a period of 21 days. Results obtained showed a significant increase (p+, K+ and CO32-) in the serum of rats administered the food dyes compared to control. The colourants also caused significant alterations (p<0.05) in the levels of enzymes (creatine kinase, lactate dehydrogenase, aspartate aminotransferase and alkaline phosphatase) in the serum and heart homogenate of the experimental rats. Histological examination of the renal and cardiac tissues correlate with the biochemical results indicating marked distortions in the kidney and heart of rats administered carmoisine and tartrazine. These results suggest that carmoisine and tartrazine have the tendency of inducing nephrotoxicity and cardiac dysfunction in rats. VL - 4 IS - 3 ER -
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