Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat

Oluwole Israel Oyewole; Tolulope Olufunmilayo Akinbamijo; Oluwabukola Joy Omoboriowo; Naomi Ubongabasi Ukana

doi:doi:10.11648/j.ab.20150302.12

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Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat

Oluwole Israel Oyewole, Tolulope Olufunmilayo Akinbamijo, Oluwabukola Joy Omoboriowo, Naomi Ubongabasi Ukana

Published in Advances in Biochemistry (Volume 3, Issue 2)

Received: 8 July 2015 Accepted: 28 July 2015 Published: 5 August 2015

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Abstract

The protective role of aqueous root extract of Musa paradisiaca on arsenic chloride-induced oxidative damage in the liver and kidney of albino rats was investigated in this study. Twenty four albino rats were grouped in to four (A, B, C and D). Group A served as the control and received distilled water while B, C and D were administered 10 mg/kg bw of arsenic chloride weekly. Groups C and D were treated with 200 and 500 mg/kg bw of aqueous extract of Musa paradisiaca roots respectively for 28 days while group B was left untreated. Phytochemical screening carried out on the root powder indicated the presence of tannins, terpenoids, steroids, sarponins, cardiac glycosides and flavonoids. Arsenic chloride induced a significant elevation in aminotransferases (ALT and AST), ALP and total bilirubin and reduction in serum protein and albumin indicating derangement of liver function. Significant elevation of serum creatinine, urea, uric acid, blood urea nitrogen and electrolytes levels were also recorded in arsenic intoxicated rats indicating disruption of kidney function. Histological examination of the kidney and liver of arsenic intoxicated rats also indicated significant alteration in tissue architecture and morphology. There was significant increase in the liver and kidney weight index in arsenic treated groups compared to the control indicating tissue inflammation. Treatment of rats with different doses of Musa paradisiaca root extract significantly (P<0.05) normalized liver and kidney functions while it also restored normal tissue histology at the end of the experiment. It can be concluded that Musa paradisiaca contain bioactive constituents capable of protecting the living system against arsenic-induced disruption of liver and kidney functions in rats.

Published in	Advances in Biochemistry (Volume 3, Issue 2)
DOI	10.11648/j.ab.20150302.12
Page(s)	30-34
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Musa paradisiaca, Arsenic Chloride, Liver Function, Kidney Function

References

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Oluwole Israel Oyewole, Tolulope Olufunmilayo Akinbamijo, Oluwabukola Joy Omoboriowo, Naomi Ubongabasi Ukana. (2015). Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat. Advances in Biochemistry, 3(2), 30-34. https://doi.org/10.11648/j.ab.20150302.12

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ACS Style

Oluwole Israel Oyewole; Tolulope Olufunmilayo Akinbamijo; Oluwabukola Joy Omoboriowo; Naomi Ubongabasi Ukana. Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat. Adv. Biochem. 2015, 3(2), 30-34. doi: 10.11648/j.ab.20150302.12

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AMA Style

Oluwole Israel Oyewole, Tolulope Olufunmilayo Akinbamijo, Oluwabukola Joy Omoboriowo, Naomi Ubongabasi Ukana. Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat. Adv Biochem. 2015;3(2):30-34. doi: 10.11648/j.ab.20150302.12

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@article{10.11648/j.ab.20150302.12,
  author = {Oluwole Israel Oyewole and Tolulope Olufunmilayo Akinbamijo and Oluwabukola Joy Omoboriowo and Naomi Ubongabasi Ukana},
  title = {Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat},
  journal = {Advances in Biochemistry},
  volume = {3},
  number = {2},
  pages = {30-34},
  doi = {10.11648/j.ab.20150302.12},
  url = {https://doi.org/10.11648/j.ab.20150302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20150302.12},
  abstract = {The protective role of aqueous root extract of Musa paradisiaca on arsenic chloride-induced oxidative damage in the liver and kidney of albino rats was investigated in this study. Twenty four albino rats were grouped in to four (A, B, C and D). Group A served as the control and received distilled water while B, C and D were administered 10 mg/kg bw of arsenic chloride weekly. Groups C and D were treated with 200 and 500 mg/kg bw of aqueous extract of Musa paradisiaca roots respectively for 28 days while group B was left untreated. Phytochemical screening carried out on the root powder indicated the presence of tannins, terpenoids, steroids, sarponins, cardiac glycosides and flavonoids. Arsenic chloride induced a significant elevation in aminotransferases (ALT and AST), ALP and total bilirubin and reduction in serum protein and albumin indicating derangement of liver function. Significant elevation of serum creatinine, urea, uric acid, blood urea nitrogen and electrolytes levels were also recorded in arsenic intoxicated rats indicating disruption of kidney function. Histological examination of the kidney and liver of arsenic intoxicated rats also indicated significant alteration in tissue architecture and morphology. There was significant increase in the liver and kidney weight index in arsenic treated groups compared to the control indicating tissue inflammation. Treatment of rats with different doses of Musa paradisiaca root extract significantly (P<0.05) normalized liver and kidney functions while it also restored normal tissue histology at the end of the experiment. It can be concluded that Musa paradisiaca contain bioactive constituents capable of protecting the living system against arsenic-induced disruption of liver and kidney functions in rats.},
 year = {2015}
}

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TY  - JOUR
T1  - Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat
AU  - Oluwole Israel Oyewole
AU  - Tolulope Olufunmilayo Akinbamijo
AU  - Oluwabukola Joy Omoboriowo
AU  - Naomi Ubongabasi Ukana
Y1  - 2015/08/05
PY  - 2015
N1  - https://doi.org/10.11648/j.ab.20150302.12
DO  - 10.11648/j.ab.20150302.12
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 30
EP  - 34
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20150302.12
AB  - The protective role of aqueous root extract of Musa paradisiaca on arsenic chloride-induced oxidative damage in the liver and kidney of albino rats was investigated in this study. Twenty four albino rats were grouped in to four (A, B, C and D). Group A served as the control and received distilled water while B, C and D were administered 10 mg/kg bw of arsenic chloride weekly. Groups C and D were treated with 200 and 500 mg/kg bw of aqueous extract of Musa paradisiaca roots respectively for 28 days while group B was left untreated. Phytochemical screening carried out on the root powder indicated the presence of tannins, terpenoids, steroids, sarponins, cardiac glycosides and flavonoids. Arsenic chloride induced a significant elevation in aminotransferases (ALT and AST), ALP and total bilirubin and reduction in serum protein and albumin indicating derangement of liver function. Significant elevation of serum creatinine, urea, uric acid, blood urea nitrogen and electrolytes levels were also recorded in arsenic intoxicated rats indicating disruption of kidney function. Histological examination of the kidney and liver of arsenic intoxicated rats also indicated significant alteration in tissue architecture and morphology. There was significant increase in the liver and kidney weight index in arsenic treated groups compared to the control indicating tissue inflammation. Treatment of rats with different doses of Musa paradisiaca root extract significantly (P<0.05) normalized liver and kidney functions while it also restored normal tissue histology at the end of the experiment. It can be concluded that Musa paradisiaca contain bioactive constituents capable of protecting the living system against arsenic-induced disruption of liver and kidney functions in rats.
VL  - 3
IS  - 2
ER  -

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Author Information

Oluwole Israel Oyewole

Department of Biochemistry, Osun State University, Osogbo, Nigeria
Tolulope Olufunmilayo Akinbamijo

Department of Biochemistry, Federal University of Technology, Akure, Nigeria
Oluwabukola Joy Omoboriowo

Department of Biochemistry, Osun State University, Osogbo, Nigeria
Naomi Ubongabasi Ukana

Department of Biochemistry, Osun State University, Osogbo, Nigeria

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APA Style

Oluwole Israel Oyewole, Tolulope Olufunmilayo Akinbamijo, Oluwabukola Joy Omoboriowo, Naomi Ubongabasi Ukana. (2015). Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat. Advances in Biochemistry, 3(2), 30-34. https://doi.org/10.11648/j.ab.20150302.12

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ACS Style

Oluwole Israel Oyewole; Tolulope Olufunmilayo Akinbamijo; Oluwabukola Joy Omoboriowo; Naomi Ubongabasi Ukana. Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat. Adv. Biochem. 2015, 3(2), 30-34. doi: 10.11648/j.ab.20150302.12

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AMA Style

Oluwole Israel Oyewole, Tolulope Olufunmilayo Akinbamijo, Oluwabukola Joy Omoboriowo, Naomi Ubongabasi Ukana. Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat. Adv Biochem. 2015;3(2):30-34. doi: 10.11648/j.ab.20150302.12

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@article{10.11648/j.ab.20150302.12,
  author = {Oluwole Israel Oyewole and Tolulope Olufunmilayo Akinbamijo and Oluwabukola Joy Omoboriowo and Naomi Ubongabasi Ukana},
  title = {Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat},
  journal = {Advances in Biochemistry},
  volume = {3},
  number = {2},
  pages = {30-34},
  doi = {10.11648/j.ab.20150302.12},
  url = {https://doi.org/10.11648/j.ab.20150302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20150302.12},
  abstract = {The protective role of aqueous root extract of Musa paradisiaca on arsenic chloride-induced oxidative damage in the liver and kidney of albino rats was investigated in this study. Twenty four albino rats were grouped in to four (A, B, C and D). Group A served as the control and received distilled water while B, C and D were administered 10 mg/kg bw of arsenic chloride weekly. Groups C and D were treated with 200 and 500 mg/kg bw of aqueous extract of Musa paradisiaca roots respectively for 28 days while group B was left untreated. Phytochemical screening carried out on the root powder indicated the presence of tannins, terpenoids, steroids, sarponins, cardiac glycosides and flavonoids. Arsenic chloride induced a significant elevation in aminotransferases (ALT and AST), ALP and total bilirubin and reduction in serum protein and albumin indicating derangement of liver function. Significant elevation of serum creatinine, urea, uric acid, blood urea nitrogen and electrolytes levels were also recorded in arsenic intoxicated rats indicating disruption of kidney function. Histological examination of the kidney and liver of arsenic intoxicated rats also indicated significant alteration in tissue architecture and morphology. There was significant increase in the liver and kidney weight index in arsenic treated groups compared to the control indicating tissue inflammation. Treatment of rats with different doses of Musa paradisiaca root extract significantly (P<0.05) normalized liver and kidney functions while it also restored normal tissue histology at the end of the experiment. It can be concluded that Musa paradisiaca contain bioactive constituents capable of protecting the living system against arsenic-induced disruption of liver and kidney functions in rats.},
 year = {2015}
}

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TY  - JOUR
T1  - Hepatorenal Protective Activities of Plantain Root (Musa paradisiaca) on Arsenic-induced Oxidative Damage in Rat
AU  - Oluwole Israel Oyewole
AU  - Tolulope Olufunmilayo Akinbamijo
AU  - Oluwabukola Joy Omoboriowo
AU  - Naomi Ubongabasi Ukana
Y1  - 2015/08/05
PY  - 2015
N1  - https://doi.org/10.11648/j.ab.20150302.12
DO  - 10.11648/j.ab.20150302.12
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 30
EP  - 34
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20150302.12
AB  - The protective role of aqueous root extract of Musa paradisiaca on arsenic chloride-induced oxidative damage in the liver and kidney of albino rats was investigated in this study. Twenty four albino rats were grouped in to four (A, B, C and D). Group A served as the control and received distilled water while B, C and D were administered 10 mg/kg bw of arsenic chloride weekly. Groups C and D were treated with 200 and 500 mg/kg bw of aqueous extract of Musa paradisiaca roots respectively for 28 days while group B was left untreated. Phytochemical screening carried out on the root powder indicated the presence of tannins, terpenoids, steroids, sarponins, cardiac glycosides and flavonoids. Arsenic chloride induced a significant elevation in aminotransferases (ALT and AST), ALP and total bilirubin and reduction in serum protein and albumin indicating derangement of liver function. Significant elevation of serum creatinine, urea, uric acid, blood urea nitrogen and electrolytes levels were also recorded in arsenic intoxicated rats indicating disruption of kidney function. Histological examination of the kidney and liver of arsenic intoxicated rats also indicated significant alteration in tissue architecture and morphology. There was significant increase in the liver and kidney weight index in arsenic treated groups compared to the control indicating tissue inflammation. Treatment of rats with different doses of Musa paradisiaca root extract significantly (P<0.05) normalized liver and kidney functions while it also restored normal tissue histology at the end of the experiment. It can be concluded that Musa paradisiaca contain bioactive constituents capable of protecting the living system against arsenic-induced disruption of liver and kidney functions in rats.
VL  - 3
IS  - 2
ER  -

Copy | Download