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Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase

Received: 23 November 2014     Accepted: 9 December 2014     Published: 19 December 2014
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Abstract

The content of C-reactive protein (CRP), interleukin-1 (IL-1), endothelin -1(E-1), soluble adhesion molecules of vascular endothelium-1 (sVCAM-1) and soluble molecules of intercellular adhesion -1 (sICAM-1 ) in peripheral blood of patients suffering from neurologic syndromes of dorsolumbar osteochondrosis (lumbalgia, lumboishialgia, lumbosacral radiculupathy) in recrudescence phase was investigated. CRP concentration in blood serum was determined by highly sensitive quantitative method (hs-CRP), based on the reaction of immunoprecipitation with reagent sets “Thermoscientific” firm, USA. Endothelin-1, sVCAM-1, sICAM-1 content in blood serum was determined by means of immunoenzymometric analysis method. The research was carried out with standard diagnostic reagent set of the “BioMedica”, “Bender MedSystem»” (BMS201, BMS 232) firm, (Austria), and the apparatus “Multiscan” of the Labsystem firm (Finland). Statistically significant (p < 0,05) concentration increase of C-reactive protein, interleukin-1 (IL-1), endothelin -1, sVCAM-1 and sICAM-1 in peripheral blood serum in patients having lumbosacral radiculopathy in comparison with the test-group and with groups of patients suffering from syndromes of lumbalgia and lumboishialgia was found out.

Published in Advances in Biochemistry (Volume 2, Issue 6)
DOI 10.11648/j.ab.20140206.13
Page(s) 95-102
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

C-Reactive Protein (hs-CRP), Interleukin-1 (IL-1), Endothelin – 1 (E-1), Lumbosacral Radiculopathies, Soluble Adhesion Molecules of Vascular Endothelium - 1 (sVCAM-1), Lumbalgia (Lumbodynia), Soluble Molecules of Intercellular Adhesion - 1 (sICAM-1), Lumboishialgia

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  • APA Style

    Marina Goryacheva, Grigori Shumakher, Liliya Kostyuchenko, Larisa Tsybirova, Peter Veselovsky, et al. (2014). Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase. Advances in Biochemistry, 2(6), 95-102. https://doi.org/10.11648/j.ab.20140206.13

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    ACS Style

    Marina Goryacheva; Grigori Shumakher; Liliya Kostyuchenko; Larisa Tsybirova; Peter Veselovsky, et al. Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase. Adv. Biochem. 2014, 2(6), 95-102. doi: 10.11648/j.ab.20140206.13

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    AMA Style

    Marina Goryacheva, Grigori Shumakher, Liliya Kostyuchenko, Larisa Tsybirova, Peter Veselovsky, et al. Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase. Adv Biochem. 2014;2(6):95-102. doi: 10.11648/j.ab.20140206.13

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  • @article{10.11648/j.ab.20140206.13,
      author = {Marina Goryacheva and Grigori Shumakher and Liliya Kostyuchenko and Larisa Tsybirova and Peter Veselovsky and Sergey Fedyanin and Alexey Malikov and Oleg Komarov and Andrey Belousov and Maria Bondareva and Ksenia Goryacheva},
      title = {Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase},
      journal = {Advances in Biochemistry},
      volume = {2},
      number = {6},
      pages = {95-102},
      doi = {10.11648/j.ab.20140206.13},
      url = {https://doi.org/10.11648/j.ab.20140206.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20140206.13},
      abstract = {The content of C-reactive protein (CRP), interleukin-1 (IL-1), endothelin -1(E-1), soluble adhesion molecules of vascular endothelium-1 (sVCAM-1) and soluble molecules of intercellular adhesion -1 (sICAM-1 ) in peripheral blood of patients suffering from neurologic syndromes of dorsolumbar osteochondrosis (lumbalgia, lumboishialgia, lumbosacral radiculupathy) in recrudescence phase was investigated. CRP concentration in blood serum was determined by highly sensitive quantitative method (hs-CRP), based on the reaction of immunoprecipitation with reagent sets “Thermoscientific” firm, USA. Endothelin-1, sVCAM-1, sICAM-1 content in blood serum was determined by means of immunoenzymometric analysis method. The research was carried out with standard diagnostic reagent set of the “BioMedica”, “Bender MedSystem»” (BMS201, BMS 232) firm, (Austria), and the apparatus “Multiscan” of the Labsystem firm (Finland). Statistically significant (p < 0,05) concentration increase  of C-reactive protein, interleukin-1 (IL-1), endothelin -1, sVCAM-1 and sICAM-1 in peripheral blood serum in patients having lumbosacral radiculopathy in comparison with the test-group and with groups of patients suffering from syndromes of lumbalgia and lumboishialgia was found out.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase
    AU  - Marina Goryacheva
    AU  - Grigori Shumakher
    AU  - Liliya Kostyuchenko
    AU  - Larisa Tsybirova
    AU  - Peter Veselovsky
    AU  - Sergey Fedyanin
    AU  - Alexey Malikov
    AU  - Oleg Komarov
    AU  - Andrey Belousov
    AU  - Maria Bondareva
    AU  - Ksenia Goryacheva
    Y1  - 2014/12/19
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ab.20140206.13
    DO  - 10.11648/j.ab.20140206.13
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
    SP  - 95
    EP  - 102
    PB  - Science Publishing Group
    SN  - 2329-0862
    UR  - https://doi.org/10.11648/j.ab.20140206.13
    AB  - The content of C-reactive protein (CRP), interleukin-1 (IL-1), endothelin -1(E-1), soluble adhesion molecules of vascular endothelium-1 (sVCAM-1) and soluble molecules of intercellular adhesion -1 (sICAM-1 ) in peripheral blood of patients suffering from neurologic syndromes of dorsolumbar osteochondrosis (lumbalgia, lumboishialgia, lumbosacral radiculupathy) in recrudescence phase was investigated. CRP concentration in blood serum was determined by highly sensitive quantitative method (hs-CRP), based on the reaction of immunoprecipitation with reagent sets “Thermoscientific” firm, USA. Endothelin-1, sVCAM-1, sICAM-1 content in blood serum was determined by means of immunoenzymometric analysis method. The research was carried out with standard diagnostic reagent set of the “BioMedica”, “Bender MedSystem»” (BMS201, BMS 232) firm, (Austria), and the apparatus “Multiscan” of the Labsystem firm (Finland). Statistically significant (p < 0,05) concentration increase  of C-reactive protein, interleukin-1 (IL-1), endothelin -1, sVCAM-1 and sICAM-1 in peripheral blood serum in patients having lumbosacral radiculopathy in comparison with the test-group and with groups of patients suffering from syndromes of lumbalgia and lumboishialgia was found out.
    VL  - 2
    IS  - 6
    ER  - 

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Author Information
  • Chair of Biology of Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia

  • Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia

  • Chair of Therapy delivering the course of Immunology at Altai State University of RF Public Health Care Ministry, Barnaul, Russia

  • Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia

  • Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia

  • Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia

  • Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia

  • Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia

  • Central Scientific-Research Laboratory at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia

  • Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia

  • Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia

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