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Evaluation of Nitric Oxide and Some Biochemical Changes in Type 2 Diabetic Patients in Hilla City

Received: 18 July 2014     Accepted: 28 July 2014     Published: 10 August 2014
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Abstract

The study was conducted on fifty seven of type 2 diabetic patients and thirty one apparently healthy control subject. Blood samples obtained from all subjects from Marjan Medical City and AL-Hilla Teaching Hospital in Babylon Province. The aim of this study to evaluate the differences of oxidant (nitric oxide and malonyldialdehyde), antioxidant enzyme (superoxide dismutase), trace elements (copper and zinc) and lipid profile in sera of type 2 diabetic patients and the control group. The results of present study reveal a significant increase in nitric oxide, malonyldialdehyde, copper, glucose, total cholesterol, TG, VLDL-cholesterol and LDL-cholesterol concentration in sera of type 2 diabetic patients when compared to those of the control group. Also this study show significant decrease in superoxide dismutase and zinc concentration in sera of type 2 diabetic patients when compared to those of the control group. The study concluded that type 2 diabetic patients is associated with increase oxidative stress. The increase of nitric oxide, malonyldialdehyde and copper concentration and decrease of super oxide dismutase and zinc concentration may contribute in the development of complications in diabetic patients.

Published in Advances in Biochemistry (Volume 2, Issue 4)
DOI 10.11648/j.ab.20140204.11
Page(s) 50-54
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Diabetes Mullets, Nitric Oxide, Malonyldialdehyde, Superoxide Dismutase, Trace Elements

References
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[7] Skrha J., Sindelka G., Kvasnic'ka J., et al. (1999): Insulin action and fibrinolysis influenced by vitamin E in obese Type 2 diabetes mellitus Prague, Czech Republic, Diabet. Res. Clin. Pract.; 44: 27-33.
[8] Paterson J., Pettegrew A., Dominiczak M., et al. (1991): Screening for hyperlipidaemia in diabetes mellitus. Relation to glycemic control. Ann Clin Biochem.; 28: 254-258.
[9] Alderton K., Cooper E. and Knowles G. (2001): Nitric oxide synthases: structure, function and inhibition. Biochem J. 357: 593-615.
[10] 10. Dong M., Shi Y., Cheng Q., et al. (2001): Increased nitric oxide in peritoneal fluid from women with idiopathic infertility and endometriosis .J Reprod. Med. 46: 887-891.
[11] Opara E. (2002): Oxidative stress, micronutrients, diabetes mellitus and its complications. J R Soc Health. 122 (1): 28-34.
[12] Khanna R., Kumar R., Asthana R., et al. (2009): Role of trace elements and antioxidants in free radical mediated injury in neonates. MASAUM Journal of Basic and Applied Sciences. 3 (1): 543-547.
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[20] Perreault M. and Marette A. (2001): Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med. 7: 1138-1143.
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Cite This Article
  • APA Style

    Mufeed Jalil Ewadh, Nibras Yahya Al-Khafaji. (2014). Evaluation of Nitric Oxide and Some Biochemical Changes in Type 2 Diabetic Patients in Hilla City. Advances in Biochemistry, 2(4), 50-54. https://doi.org/10.11648/j.ab.20140204.11

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    ACS Style

    Mufeed Jalil Ewadh; Nibras Yahya Al-Khafaji. Evaluation of Nitric Oxide and Some Biochemical Changes in Type 2 Diabetic Patients in Hilla City. Adv. Biochem. 2014, 2(4), 50-54. doi: 10.11648/j.ab.20140204.11

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    AMA Style

    Mufeed Jalil Ewadh, Nibras Yahya Al-Khafaji. Evaluation of Nitric Oxide and Some Biochemical Changes in Type 2 Diabetic Patients in Hilla City. Adv Biochem. 2014;2(4):50-54. doi: 10.11648/j.ab.20140204.11

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  • @article{10.11648/j.ab.20140204.11,
      author = {Mufeed Jalil Ewadh and Nibras Yahya Al-Khafaji},
      title = {Evaluation of Nitric Oxide and Some Biochemical Changes in Type 2 Diabetic Patients in Hilla City},
      journal = {Advances in Biochemistry},
      volume = {2},
      number = {4},
      pages = {50-54},
      doi = {10.11648/j.ab.20140204.11},
      url = {https://doi.org/10.11648/j.ab.20140204.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20140204.11},
      abstract = {The study was conducted on fifty seven of type 2 diabetic patients and thirty one apparently healthy control subject. Blood samples obtained from all subjects from Marjan Medical City and AL-Hilla Teaching Hospital in Babylon Province. The aim of this study to evaluate the differences of oxidant (nitric oxide and malonyldialdehyde), antioxidant enzyme (superoxide dismutase), trace elements (copper and zinc) and lipid profile in sera of type 2 diabetic patients and the control group. The results of present study reveal a significant increase in nitric oxide, malonyldialdehyde, copper, glucose, total cholesterol, TG, VLDL-cholesterol and LDL-cholesterol concentration in sera of type 2 diabetic patients when compared to those of the control group. Also this study show significant decrease in superoxide dismutase and zinc concentration in sera of type 2 diabetic patients when compared to those of the control group. The study concluded that type 2 diabetic patients is associated with increase oxidative stress. The increase of nitric oxide, malonyldialdehyde and copper concentration and decrease of super oxide dismutase and zinc concentration may contribute in the development of complications in diabetic patients.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Evaluation of Nitric Oxide and Some Biochemical Changes in Type 2 Diabetic Patients in Hilla City
    AU  - Mufeed Jalil Ewadh
    AU  - Nibras Yahya Al-Khafaji
    Y1  - 2014/08/10
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ab.20140204.11
    DO  - 10.11648/j.ab.20140204.11
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
    SP  - 50
    EP  - 54
    PB  - Science Publishing Group
    SN  - 2329-0862
    UR  - https://doi.org/10.11648/j.ab.20140204.11
    AB  - The study was conducted on fifty seven of type 2 diabetic patients and thirty one apparently healthy control subject. Blood samples obtained from all subjects from Marjan Medical City and AL-Hilla Teaching Hospital in Babylon Province. The aim of this study to evaluate the differences of oxidant (nitric oxide and malonyldialdehyde), antioxidant enzyme (superoxide dismutase), trace elements (copper and zinc) and lipid profile in sera of type 2 diabetic patients and the control group. The results of present study reveal a significant increase in nitric oxide, malonyldialdehyde, copper, glucose, total cholesterol, TG, VLDL-cholesterol and LDL-cholesterol concentration in sera of type 2 diabetic patients when compared to those of the control group. Also this study show significant decrease in superoxide dismutase and zinc concentration in sera of type 2 diabetic patients when compared to those of the control group. The study concluded that type 2 diabetic patients is associated with increase oxidative stress. The increase of nitric oxide, malonyldialdehyde and copper concentration and decrease of super oxide dismutase and zinc concentration may contribute in the development of complications in diabetic patients.
    VL  - 2
    IS  - 4
    ER  - 

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Author Information
  • Babylon University, College of Medicine, Department of Biochemistry, Hilla, Iraq

  • Babylon University, College of Medicine, Department of Biochemistry, Hilla, Iraq

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