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Effect of Dry Garlic Powder on Plasma Lipid Profile and Enzyme Activities in Some Tissues of Hypercholesterolemic Rats

Received: 3 May 2013     Accepted: 27 June 2014     Published: 20 July 2014
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Abstract

The effect of garlic powder at 5% and 10% level on plasma lipid profile was investigated in hypercholesterolemic rats. Male albino rats were fed a diet containing 20% fat and 1% cholesterol for two weeks to provoke hypercholesterolemia. The hypercholesterolemic rats were divided into three groups B, C and D. Group A rats were fed with normal diet, Group B were maintained on the hyper diet, Group C were fed hyper diet +5% garlic powder, Group D were fed hyper diet with +10% garlic powder. They were maintained on this diet for four weeks. Results showed that the plasma total cholesterol and LDL-C was significantly reduced in the treated groups (C and D) compared to the hypercholesterolemic control (Group B), while the HDL-C was significantly increased (P<0.05). Also plasma enzyme activities of Aspartate and Alanine Aminotransferases (AST. ALT) and Alkaline Phosphatase (ALP) showed a slight decrease in the treated rats. It is concluded that consumption of dry garlic powder at the level used in this study could be beneficial on the plasma lipid profile in hypercholesterolemia.

Published in Advances in Biochemistry (Volume 2, Issue 3)
DOI 10.11648/j.ab.20140203.12
Page(s) 45-49
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Hypercholesterolemia, Aminotransferases, Lipid Profile

References
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    Ajayi O. B., Ajayi D. D. (2014). Effect of Dry Garlic Powder on Plasma Lipid Profile and Enzyme Activities in Some Tissues of Hypercholesterolemic Rats. Advances in Biochemistry, 2(3), 45-49. https://doi.org/10.11648/j.ab.20140203.12

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    ACS Style

    Ajayi O. B.; Ajayi D. D. Effect of Dry Garlic Powder on Plasma Lipid Profile and Enzyme Activities in Some Tissues of Hypercholesterolemic Rats. Adv. Biochem. 2014, 2(3), 45-49. doi: 10.11648/j.ab.20140203.12

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    AMA Style

    Ajayi O. B., Ajayi D. D. Effect of Dry Garlic Powder on Plasma Lipid Profile and Enzyme Activities in Some Tissues of Hypercholesterolemic Rats. Adv Biochem. 2014;2(3):45-49. doi: 10.11648/j.ab.20140203.12

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  • @article{10.11648/j.ab.20140203.12,
      author = {Ajayi O. B. and Ajayi D. D.},
      title = {Effect of Dry Garlic Powder on Plasma Lipid Profile and Enzyme Activities in Some Tissues of Hypercholesterolemic Rats},
      journal = {Advances in Biochemistry},
      volume = {2},
      number = {3},
      pages = {45-49},
      doi = {10.11648/j.ab.20140203.12},
      url = {https://doi.org/10.11648/j.ab.20140203.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20140203.12},
      abstract = {The effect of garlic powder at 5% and 10% level on plasma lipid profile was investigated in hypercholesterolemic rats. Male albino rats were fed a diet containing 20% fat and 1% cholesterol for two weeks to provoke hypercholesterolemia. The hypercholesterolemic rats were divided into three groups B, C and D. Group A rats were fed with normal diet, Group B were maintained on the hyper diet, Group C were fed hyper diet +5% garlic powder, Group D were fed hyper diet with +10% garlic powder. They were maintained on this diet for four weeks. Results showed that the plasma total cholesterol and LDL-C was significantly reduced in the treated groups (C and D) compared to the hypercholesterolemic control (Group B), while the HDL-C was significantly increased (P<0.05). Also plasma enzyme activities of Aspartate and Alanine Aminotransferases (AST. ALT) and Alkaline Phosphatase (ALP) showed a slight decrease in the treated rats. It is concluded that consumption of dry garlic powder at the level used in this study could be beneficial on the plasma lipid profile in hypercholesterolemia.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Effect of Dry Garlic Powder on Plasma Lipid Profile and Enzyme Activities in Some Tissues of Hypercholesterolemic Rats
    AU  - Ajayi O. B.
    AU  - Ajayi D. D.
    Y1  - 2014/07/20
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ab.20140203.12
    DO  - 10.11648/j.ab.20140203.12
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
    SP  - 45
    EP  - 49
    PB  - Science Publishing Group
    SN  - 2329-0862
    UR  - https://doi.org/10.11648/j.ab.20140203.12
    AB  - The effect of garlic powder at 5% and 10% level on plasma lipid profile was investigated in hypercholesterolemic rats. Male albino rats were fed a diet containing 20% fat and 1% cholesterol for two weeks to provoke hypercholesterolemia. The hypercholesterolemic rats were divided into three groups B, C and D. Group A rats were fed with normal diet, Group B were maintained on the hyper diet, Group C were fed hyper diet +5% garlic powder, Group D were fed hyper diet with +10% garlic powder. They were maintained on this diet for four weeks. Results showed that the plasma total cholesterol and LDL-C was significantly reduced in the treated groups (C and D) compared to the hypercholesterolemic control (Group B), while the HDL-C was significantly increased (P<0.05). Also plasma enzyme activities of Aspartate and Alanine Aminotransferases (AST. ALT) and Alkaline Phosphatase (ALP) showed a slight decrease in the treated rats. It is concluded that consumption of dry garlic powder at the level used in this study could be beneficial on the plasma lipid profile in hypercholesterolemia.
    VL  - 2
    IS  - 3
    ER  - 

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Author Information
  • Biochemistry department, Ekiti State University, Ado Ekiti, Ekiti State, Nigeria

  • Department of Chemical Pathology, Ekiti State University Teaching Hospital, Ado Ekiti, Ekiti State, Nigeria

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