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The Possible Role of GPI-Ceruloplasmin in Hypoxia De Novo Creation and Maintenance

Received: 30 May 2013     Published: 30 June 2013
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Abstract

Ceruloplasmin is a member of the multicopper oxidases family (MCOs), multidomain proteins capable of oxidizing many structurally unrelated compounds reducing oxygen to water. While MCOs show great oxidative versatility, they can only transfer electrons to molecular oxygen, which is the obligate electron acceptor. Therefore, MCOs should also be considered as ‘‘O2 consuming enzymes’’. The glycosylphosphatidylinositol anchored ceruloplasmin (GPI-Cp) isoform present on the surface of the plasma membrane, does not seem to be involved in copper and iron metabolism. Since hypoxia is also a common feature of many rapidly growing solid tumors, we postulate that the regulation of GPI-Cp could be the molecular event in the creation and the maintenance of hypoxia in tumor cells. By inhibiting the GPI-Cp expression, it would appear possible to attempt to overcome tumor hypoxia, thus improving the efficiency of radiotherapy.

Published in Advances in Biochemistry (Volume 1, Issue 2)
DOI 10.11648/j.ab.20130102.13
Page(s) 22-27
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Hypoxia, Glycosylphosphatidylinositol-Ceruloplasmin, Multicopper Oxidases, Oxygen-Consuming Enzyme, Tumor

References
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    Roberto Arrigoni. (2013). The Possible Role of GPI-Ceruloplasmin in Hypoxia De Novo Creation and Maintenance. Advances in Biochemistry, 1(2), 22-27. https://doi.org/10.11648/j.ab.20130102.13

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    Roberto Arrigoni. The Possible Role of GPI-Ceruloplasmin in Hypoxia De Novo Creation and Maintenance. Adv. Biochem. 2013, 1(2), 22-27. doi: 10.11648/j.ab.20130102.13

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    AMA Style

    Roberto Arrigoni. The Possible Role of GPI-Ceruloplasmin in Hypoxia De Novo Creation and Maintenance. Adv Biochem. 2013;1(2):22-27. doi: 10.11648/j.ab.20130102.13

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  • @article{10.11648/j.ab.20130102.13,
      author = {Roberto Arrigoni},
      title = {The Possible Role of GPI-Ceruloplasmin in Hypoxia De Novo Creation and Maintenance},
      journal = {Advances in Biochemistry},
      volume = {1},
      number = {2},
      pages = {22-27},
      doi = {10.11648/j.ab.20130102.13},
      url = {https://doi.org/10.11648/j.ab.20130102.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20130102.13},
      abstract = {Ceruloplasmin is a member of the multicopper oxidases family (MCOs), multidomain proteins capable of oxidizing many structurally unrelated compounds reducing oxygen to water. While MCOs show great oxidative versatility, they can only transfer electrons to molecular oxygen, which is the obligate electron acceptor. Therefore, MCOs should also be considered as ‘‘O2 consuming enzymes’’. The glycosylphosphatidylinositol anchored ceruloplasmin (GPI-Cp) isoform present on the surface of the plasma membrane, does not seem to be involved in copper and iron metabolism. Since hypoxia is also a common feature of many rapidly growing solid tumors, we postulate that the regulation of GPI-Cp could be the molecular event in the creation and the maintenance of hypoxia in tumor cells. By inhibiting the GPI-Cp expression, it would appear possible to attempt to overcome tumor hypoxia, thus improving the efficiency of radiotherapy.},
     year = {2013}
    }
    

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    T1  - The Possible Role of GPI-Ceruloplasmin in Hypoxia De Novo Creation and Maintenance
    AU  - Roberto Arrigoni
    Y1  - 2013/06/30
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    N1  - https://doi.org/10.11648/j.ab.20130102.13
    DO  - 10.11648/j.ab.20130102.13
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
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    UR  - https://doi.org/10.11648/j.ab.20130102.13
    AB  - Ceruloplasmin is a member of the multicopper oxidases family (MCOs), multidomain proteins capable of oxidizing many structurally unrelated compounds reducing oxygen to water. While MCOs show great oxidative versatility, they can only transfer electrons to molecular oxygen, which is the obligate electron acceptor. Therefore, MCOs should also be considered as ‘‘O2 consuming enzymes’’. The glycosylphosphatidylinositol anchored ceruloplasmin (GPI-Cp) isoform present on the surface of the plasma membrane, does not seem to be involved in copper and iron metabolism. Since hypoxia is also a common feature of many rapidly growing solid tumors, we postulate that the regulation of GPI-Cp could be the molecular event in the creation and the maintenance of hypoxia in tumor cells. By inhibiting the GPI-Cp expression, it would appear possible to attempt to overcome tumor hypoxia, thus improving the efficiency of radiotherapy.
    VL  - 1
    IS  - 2
    ER  - 

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Author Information
  • Department of Biosciences, Biotechnologies and Biopharmaceutics, Laboratory of Biochemistry and Molecular Biology, University of Bari

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