@article{10.11648/j.aas.20220703.18,
  author = {Serge Bruno Ebong and Calixte Ida Penda and Essangui Same Estelle and Juste Patient Mbebi Enone and Madeleine Mbangue and Samuel Honore Mandengue and Carole Else Eboumbou Moukoko},
  title = {Biological and Immunological Profile of HIV Voluntary Consultants with HCV and Plasmodium Coinfection in One Accredited Treatment Center in Cameroon},
  journal = {Advances in Applied Sciences},
  volume = {7},
  number = {3},
  pages = {84-92},
  doi = {10.11648/j.aas.20220703.18},
  url = {https://doi.org/10.11648/j.aas.20220703.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aas.20220703.18},
  abstract = {Malaria and HIV share common determinants of vulnerability and, HIV/HCV coinfection accelerates the progression to AIDS causing millions of deaths each year worldwide. The aim of the study was to determine epidemiological and immunological profile of HIV in HCV and Plasmodium coinfection context. All adults (≥ 17 years) volunteers for HIV testing and attending the Voluntary Testing Center of Douala Laquintinie Hospital were consecutively recruited over a period of seven months. Anonymous questionnaire was used to explore demographics, circumstances and reasons for testing, knowledge, attitudes, and behaviors. HIV diagnosis were performed using Rapid Diagnostic Test (RDT) and ELISA, whereas RDT were used for HCV and Plasmodium falciparum infection diagnosis. Quantification of HIV-1 specific CD4 and transaminases were based on FACS Count and spectrophotometer respectively. Overall, 25.6%, 6.4% and 24.8% of 125 adults had HIV, HCV and Plasmodium infection respectively. HIV/Plasmodium, HCV/Plasmodium and HIV/HCV coinfection was reported in 9, 2 and 1 consultant(s) respectively. Based on the WHO classification, severe immunosuppression (CD4 count 3) was recorded in HIV and Plasmodium monoinfected individuals: 12.5% and 6.6% respectively. For HIV mono-infected consultants, 12.5% were highly immunocompromised and 43.75% had a CD4 count between 500 and 2000 cells/mm3. Severe immunosuppression was more marked in HIV/Plasmodium (22.2%). HIV and Plasmodium mono-infected patients had higher hyperparasitemia compared to non-infected and the same result was observed with HCV/Plasmodium co-infected patients (42.8%) and HCV/Plasmodium co-infected patients. Severe immunosuppression was recorded in both HIV and Plasmodium monoinfected individuals. This severe immunosuppression was more pronounced in HIV/Plasmodium and HIV/HCV/Plasmodium coinfected patients. HIV and Plasmodium mono-infected patients had more pronounced hypertransaminasemia in women than in men.},
 year = {2022}
}

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TY  - JOUR
T1  - Biological and Immunological Profile of HIV Voluntary Consultants with HCV and Plasmodium Coinfection in One Accredited Treatment Center in Cameroon
AU  - Serge Bruno Ebong
AU  - Calixte Ida Penda
AU  - Essangui Same Estelle
AU  - Juste Patient Mbebi Enone
AU  - Madeleine Mbangue
AU  - Samuel Honore Mandengue
AU  - Carole Else Eboumbou Moukoko
Y1  - 2022/08/24
PY  - 2022
N1  - https://doi.org/10.11648/j.aas.20220703.18
DO  - 10.11648/j.aas.20220703.18
T2  - Advances in Applied Sciences
JF  - Advances in Applied Sciences
JO  - Advances in Applied Sciences
SP  - 84
EP  - 92
PB  - Science Publishing Group
SN  - 2575-1514
UR  - https://doi.org/10.11648/j.aas.20220703.18
AB  - Malaria and HIV share common determinants of vulnerability and, HIV/HCV coinfection accelerates the progression to AIDS causing millions of deaths each year worldwide. The aim of the study was to determine epidemiological and immunological profile of HIV in HCV and Plasmodium coinfection context. All adults (≥ 17 years) volunteers for HIV testing and attending the Voluntary Testing Center of Douala Laquintinie Hospital were consecutively recruited over a period of seven months. Anonymous questionnaire was used to explore demographics, circumstances and reasons for testing, knowledge, attitudes, and behaviors. HIV diagnosis were performed using Rapid Diagnostic Test (RDT) and ELISA, whereas RDT were used for HCV and Plasmodium falciparum infection diagnosis. Quantification of HIV-1 specific CD4 and transaminases were based on FACS Count and spectrophotometer respectively. Overall, 25.6%, 6.4% and 24.8% of 125 adults had HIV, HCV and Plasmodium infection respectively. HIV/Plasmodium, HCV/Plasmodium and HIV/HCV coinfection was reported in 9, 2 and 1 consultant(s) respectively. Based on the WHO classification, severe immunosuppression (CD4 count 3) was recorded in HIV and Plasmodium monoinfected individuals: 12.5% and 6.6% respectively. For HIV mono-infected consultants, 12.5% were highly immunocompromised and 43.75% had a CD4 count between 500 and 2000 cells/mm3. Severe immunosuppression was more marked in HIV/Plasmodium (22.2%). HIV and Plasmodium mono-infected patients had higher hyperparasitemia compared to non-infected and the same result was observed with HCV/Plasmodium co-infected patients (42.8%) and HCV/Plasmodium co-infected patients. Severe immunosuppression was recorded in both HIV and Plasmodium monoinfected individuals. This severe immunosuppression was more pronounced in HIV/Plasmodium and HIV/HCV/Plasmodium coinfected patients. HIV and Plasmodium mono-infected patients had more pronounced hypertransaminasemia in women than in men.
VL  - 7
IS  - 3
ER  - 

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