Background: Generic substitution of a brand of medicine for others, with the hope that they have the same therapeutic effect is difficult for health care providers and consumers. Aim: This study was able to evaluate the authenticity of label claim of eight samples of artemether-lumefantrine and two samples of amoxicillin trihydrate tablets available at Ogige market Nsukka and Ogbete main market, Enugu. Method: The following tests were carried out; hardness, friability, modified disintegration time, wetting time, water absorption ratio and weight uniformity. The compliance of each sample to the United States Pharmacopoeia (USP) requirements were recorded. Results: The friability test showed that all the tablets passed the test with less than 1% friability loss. The mean hardness ranged from 1.65±0.47 to 5.35±0.67 for artemether-lumefantrine tablets, while that of amoxicillin trihydrate tablets ranged from 4.00±0.93 to 6.10±0.91 respectively. The tablet diameter and mean thickness of artemether-lumefantrine tablets ranged from 9.00±1.53 to 11.00±1.0 and 2.00±1.15 to 4.00±1.53 respectively, while that of amoxicillin trihydrate ranged from 8.00±0.9 to 10.00±1.0 and 3.00±2.08 to 4.00±1.53 respectively. The disintegration time of artemether-lumefantrine tablets ranged from 1.50±0.1 to 3.52±0.01 and 2.06±0.02 to 3.30±0.03 for amoxicillin trihydrate respectively. The wetting and water absorption ratio of artemether-lumefantrine ranged from 0.21±0.01 to 4.47±0.01, and 25.66±0.01 to 131.62±0.04 respectively, while that of amoxicillin trihydrate ranged from 1.28±0.01 to 10.00±0.02 and 49.54±0.02 to 75.65±0.03 respectively. The study discovered that several generic brands of artemether-lumefantrine and amoxicillin trihydrate tablets in Nigeria could be sub-standard products.
Published in | World Journal of Medical Case Reports (Volume 3, Issue 4) |
DOI | 10.11648/j.wjmcr.20220304.12 |
Page(s) | 50-55 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Artemether-Lumefantrine, Amoxicillin Trihydrate, Oro-Dispersible Tablets, Malaria, Pneumonia
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APA Style
Ezegbe Chekwube Andrew, Ezegbe Amarachi Grace, Boniface Christian Izuchukwu, Kalu Amarachi Agu, Okorafor Ezinne Chinemerem, et al. (2022). Evaluation of Oro-Dispersible Tablets (Artemether-Lumefantrine and Amoxicillin Trihydrate) Used for Some Common Childhood Diseases (Malaria and Pheumonia). World Journal of Medical Case Reports, 3(4), 50-55. https://doi.org/10.11648/j.wjmcr.20220304.12
ACS Style
Ezegbe Chekwube Andrew; Ezegbe Amarachi Grace; Boniface Christian Izuchukwu; Kalu Amarachi Agu; Okorafor Ezinne Chinemerem, et al. Evaluation of Oro-Dispersible Tablets (Artemether-Lumefantrine and Amoxicillin Trihydrate) Used for Some Common Childhood Diseases (Malaria and Pheumonia). World J. Med. Case Rep. 2022, 3(4), 50-55. doi: 10.11648/j.wjmcr.20220304.12
AMA Style
Ezegbe Chekwube Andrew, Ezegbe Amarachi Grace, Boniface Christian Izuchukwu, Kalu Amarachi Agu, Okorafor Ezinne Chinemerem, et al. Evaluation of Oro-Dispersible Tablets (Artemether-Lumefantrine and Amoxicillin Trihydrate) Used for Some Common Childhood Diseases (Malaria and Pheumonia). World J Med Case Rep. 2022;3(4):50-55. doi: 10.11648/j.wjmcr.20220304.12
@article{10.11648/j.wjmcr.20220304.12, author = {Ezegbe Chekwube Andrew and Ezegbe Amarachi Grace and Boniface Christian Izuchukwu and Kalu Amarachi Agu and Okorafor Ezinne Chinemerem and Godswill Onunkwo}, title = {Evaluation of Oro-Dispersible Tablets (Artemether-Lumefantrine and Amoxicillin Trihydrate) Used for Some Common Childhood Diseases (Malaria and Pheumonia)}, journal = {World Journal of Medical Case Reports}, volume = {3}, number = {4}, pages = {50-55}, doi = {10.11648/j.wjmcr.20220304.12}, url = {https://doi.org/10.11648/j.wjmcr.20220304.12}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjmcr.20220304.12}, abstract = {Background: Generic substitution of a brand of medicine for others, with the hope that they have the same therapeutic effect is difficult for health care providers and consumers. Aim: This study was able to evaluate the authenticity of label claim of eight samples of artemether-lumefantrine and two samples of amoxicillin trihydrate tablets available at Ogige market Nsukka and Ogbete main market, Enugu. Method: The following tests were carried out; hardness, friability, modified disintegration time, wetting time, water absorption ratio and weight uniformity. The compliance of each sample to the United States Pharmacopoeia (USP) requirements were recorded. Results: The friability test showed that all the tablets passed the test with less than 1% friability loss. The mean hardness ranged from 1.65±0.47 to 5.35±0.67 for artemether-lumefantrine tablets, while that of amoxicillin trihydrate tablets ranged from 4.00±0.93 to 6.10±0.91 respectively. The tablet diameter and mean thickness of artemether-lumefantrine tablets ranged from 9.00±1.53 to 11.00±1.0 and 2.00±1.15 to 4.00±1.53 respectively, while that of amoxicillin trihydrate ranged from 8.00±0.9 to 10.00±1.0 and 3.00±2.08 to 4.00±1.53 respectively. The disintegration time of artemether-lumefantrine tablets ranged from 1.50±0.1 to 3.52±0.01 and 2.06±0.02 to 3.30±0.03 for amoxicillin trihydrate respectively. The wetting and water absorption ratio of artemether-lumefantrine ranged from 0.21±0.01 to 4.47±0.01, and 25.66±0.01 to 131.62±0.04 respectively, while that of amoxicillin trihydrate ranged from 1.28±0.01 to 10.00±0.02 and 49.54±0.02 to 75.65±0.03 respectively. The study discovered that several generic brands of artemether-lumefantrine and amoxicillin trihydrate tablets in Nigeria could be sub-standard products.}, year = {2022} }
TY - JOUR T1 - Evaluation of Oro-Dispersible Tablets (Artemether-Lumefantrine and Amoxicillin Trihydrate) Used for Some Common Childhood Diseases (Malaria and Pheumonia) AU - Ezegbe Chekwube Andrew AU - Ezegbe Amarachi Grace AU - Boniface Christian Izuchukwu AU - Kalu Amarachi Agu AU - Okorafor Ezinne Chinemerem AU - Godswill Onunkwo Y1 - 2022/12/29 PY - 2022 N1 - https://doi.org/10.11648/j.wjmcr.20220304.12 DO - 10.11648/j.wjmcr.20220304.12 T2 - World Journal of Medical Case Reports JF - World Journal of Medical Case Reports JO - World Journal of Medical Case Reports SP - 50 EP - 55 PB - Science Publishing Group SN - 2994-726X UR - https://doi.org/10.11648/j.wjmcr.20220304.12 AB - Background: Generic substitution of a brand of medicine for others, with the hope that they have the same therapeutic effect is difficult for health care providers and consumers. Aim: This study was able to evaluate the authenticity of label claim of eight samples of artemether-lumefantrine and two samples of amoxicillin trihydrate tablets available at Ogige market Nsukka and Ogbete main market, Enugu. Method: The following tests were carried out; hardness, friability, modified disintegration time, wetting time, water absorption ratio and weight uniformity. The compliance of each sample to the United States Pharmacopoeia (USP) requirements were recorded. Results: The friability test showed that all the tablets passed the test with less than 1% friability loss. The mean hardness ranged from 1.65±0.47 to 5.35±0.67 for artemether-lumefantrine tablets, while that of amoxicillin trihydrate tablets ranged from 4.00±0.93 to 6.10±0.91 respectively. The tablet diameter and mean thickness of artemether-lumefantrine tablets ranged from 9.00±1.53 to 11.00±1.0 and 2.00±1.15 to 4.00±1.53 respectively, while that of amoxicillin trihydrate ranged from 8.00±0.9 to 10.00±1.0 and 3.00±2.08 to 4.00±1.53 respectively. The disintegration time of artemether-lumefantrine tablets ranged from 1.50±0.1 to 3.52±0.01 and 2.06±0.02 to 3.30±0.03 for amoxicillin trihydrate respectively. The wetting and water absorption ratio of artemether-lumefantrine ranged from 0.21±0.01 to 4.47±0.01, and 25.66±0.01 to 131.62±0.04 respectively, while that of amoxicillin trihydrate ranged from 1.28±0.01 to 10.00±0.02 and 49.54±0.02 to 75.65±0.03 respectively. The study discovered that several generic brands of artemether-lumefantrine and amoxicillin trihydrate tablets in Nigeria could be sub-standard products. VL - 3 IS - 4 ER -