A patient (age 75, male) with diffuse peritonitis (cecum rupture resulted from tumor obturation) was hospitalized and underwent emergency surgery. He was hypotensive (norepinephrine 0.56 mg/kg*min) and exhibited multiple organ failure syndrome (SOFA=10), so a septic shock diagnosis was concluded. Standard of care treatment didn’t result in improvement of his condition and so he was subjected to extracorporeal hemoperfusion with Efferon LPS adsorber. Efferon LPS is single-use therapeutic device, certified in Russia, a cartridge with selective adsorbent polymeric beads, which provide simultaneous lipopolysaccharide (LPS) and cytokines adsorption (“multimodal” action). Two conclusive hemoperfusions led to quick improvements in hemodynamic parameters and improvement of patient’s condition. IL-6 serum level dropped from 1640 to 480 pG/mL, followed by subsequent decrease down to 350 pG/mL within next few days. Procalcitonin levels dropped from 98 nG/mL down to 5 nG/mL. Significant decrease in CD14+ blood monocytes also was noted during each hemoperfusion session. The patient stayed in ICU for 8 days. He has survived and was discharged on day 24 in satisfactory condition. Extracorporeal sequestration of LPS, cytokines and which is extremely important CD14+ monocytes from the bloodstream can dampen the systemic inflammation’s crippling action in patients with sepsis. Efferon LPS hemoperfusion is prominent option for extracorporeal treatment of septic shock.
| Published in | World Journal of Medical Case Reports (Volume 2, Issue 3) |
| DOI | 10.11648/j.wjmcr.20210203.14 |
| Page(s) | 46-50 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
LPS-selective Hemoperfusion, Anti-cytokine Hemoperfusion, Sepsis, Septic Shock, СD14+ Monocytes, Procalcitonin, IL-6
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APA Style
Mikhail Ivanovich Gromov, Ludmila Pavlovna Pivovarova, Irina Viktorovna Osipova, Olga Borisovna Ariskina, Alexey Valerievich Fedorov. (2021). Use a Novel Hemoperfusion Cartridge Efferon LPS for Simultaneous Adsorption of Cytokines and Endotoxin in Septic Shock: A Case Report. World Journal of Medical Case Reports, 2(3), 46-50. https://doi.org/10.11648/j.wjmcr.20210203.14
ACS Style
Mikhail Ivanovich Gromov; Ludmila Pavlovna Pivovarova; Irina Viktorovna Osipova; Olga Borisovna Ariskina; Alexey Valerievich Fedorov. Use a Novel Hemoperfusion Cartridge Efferon LPS for Simultaneous Adsorption of Cytokines and Endotoxin in Septic Shock: A Case Report. World J. Med. Case Rep. 2021, 2(3), 46-50. doi: 10.11648/j.wjmcr.20210203.14
AMA Style
Mikhail Ivanovich Gromov, Ludmila Pavlovna Pivovarova, Irina Viktorovna Osipova, Olga Borisovna Ariskina, Alexey Valerievich Fedorov. Use a Novel Hemoperfusion Cartridge Efferon LPS for Simultaneous Adsorption of Cytokines and Endotoxin in Septic Shock: A Case Report. World J Med Case Rep. 2021;2(3):46-50. doi: 10.11648/j.wjmcr.20210203.14
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Download@article{10.11648/j.wjmcr.20210203.14,
author = {Mikhail Ivanovich Gromov and Ludmila Pavlovna Pivovarova and Irina Viktorovna Osipova and Olga Borisovna Ariskina and Alexey Valerievich Fedorov},
title = {Use a Novel Hemoperfusion Cartridge Efferon LPS for Simultaneous Adsorption of Cytokines and Endotoxin in Septic Shock: A Case Report},
journal = {World Journal of Medical Case Reports},
volume = {2},
number = {3},
pages = {46-50},
doi = {10.11648/j.wjmcr.20210203.14},
url = {https://doi.org/10.11648/j.wjmcr.20210203.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjmcr.20210203.14},
abstract = {A patient (age 75, male) with diffuse peritonitis (cecum rupture resulted from tumor obturation) was hospitalized and underwent emergency surgery. He was hypotensive (norepinephrine 0.56 mg/kg*min) and exhibited multiple organ failure syndrome (SOFA=10), so a septic shock diagnosis was concluded. Standard of care treatment didn’t result in improvement of his condition and so he was subjected to extracorporeal hemoperfusion with Efferon LPS adsorber. Efferon LPS is single-use therapeutic device, certified in Russia, a cartridge with selective adsorbent polymeric beads, which provide simultaneous lipopolysaccharide (LPS) and cytokines adsorption (“multimodal” action). Two conclusive hemoperfusions led to quick improvements in hemodynamic parameters and improvement of patient’s condition. IL-6 serum level dropped from 1640 to 480 pG/mL, followed by subsequent decrease down to 350 pG/mL within next few days. Procalcitonin levels dropped from 98 nG/mL down to 5 nG/mL. Significant decrease in CD14+ blood monocytes also was noted during each hemoperfusion session. The patient stayed in ICU for 8 days. He has survived and was discharged on day 24 in satisfactory condition. Extracorporeal sequestration of LPS, cytokines and which is extremely important CD14+ monocytes from the bloodstream can dampen the systemic inflammation’s crippling action in patients with sepsis. Efferon LPS hemoperfusion is prominent option for extracorporeal treatment of septic shock.},
year = {2021}
}
TY - JOUR T1 - Use a Novel Hemoperfusion Cartridge Efferon LPS for Simultaneous Adsorption of Cytokines and Endotoxin in Septic Shock: A Case Report AU - Mikhail Ivanovich Gromov AU - Ludmila Pavlovna Pivovarova AU - Irina Viktorovna Osipova AU - Olga Borisovna Ariskina AU - Alexey Valerievich Fedorov Y1 - 2021/08/27 PY - 2021 N1 - https://doi.org/10.11648/j.wjmcr.20210203.14 DO - 10.11648/j.wjmcr.20210203.14 T2 - World Journal of Medical Case Reports JF - World Journal of Medical Case Reports JO - World Journal of Medical Case Reports SP - 46 EP - 50 PB - Science Publishing Group SN - 2994-726X UR - https://doi.org/10.11648/j.wjmcr.20210203.14 AB - A patient (age 75, male) with diffuse peritonitis (cecum rupture resulted from tumor obturation) was hospitalized and underwent emergency surgery. He was hypotensive (norepinephrine 0.56 mg/kg*min) and exhibited multiple organ failure syndrome (SOFA=10), so a septic shock diagnosis was concluded. Standard of care treatment didn’t result in improvement of his condition and so he was subjected to extracorporeal hemoperfusion with Efferon LPS adsorber. Efferon LPS is single-use therapeutic device, certified in Russia, a cartridge with selective adsorbent polymeric beads, which provide simultaneous lipopolysaccharide (LPS) and cytokines adsorption (“multimodal” action). Two conclusive hemoperfusions led to quick improvements in hemodynamic parameters and improvement of patient’s condition. IL-6 serum level dropped from 1640 to 480 pG/mL, followed by subsequent decrease down to 350 pG/mL within next few days. Procalcitonin levels dropped from 98 nG/mL down to 5 nG/mL. Significant decrease in CD14+ blood monocytes also was noted during each hemoperfusion session. The patient stayed in ICU for 8 days. He has survived and was discharged on day 24 in satisfactory condition. Extracorporeal sequestration of LPS, cytokines and which is extremely important CD14+ monocytes from the bloodstream can dampen the systemic inflammation’s crippling action in patients with sepsis. Efferon LPS hemoperfusion is prominent option for extracorporeal treatment of septic shock. VL - 2 IS - 3 ER -
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