Introduction: The placenta is the highly specialized organ of pregnancy that supports the normal growth and development of the fetus. During intrauterine fetal life placenta is the main metabolic, respiratory, excretory, and endocrine organ. Histologic features of normal placenta are differing according to the trimester of pregnancy. COVID-19 infection affects placenta and fetal membrane. Pregnant women with COVID-19 positive result in placental hyperfusion defects in maternal vessels and oxygenation in the intervillous space affecting perinatal outcome. Methods: Systematic reviews, meta-analysis, cross sectional and cohort studies were obtained through searches on PubMed, Medline, Science Direct, Google Scholar, library genesis, Scopus and Web of Science. Key words used for searching are “placenta”, “COVID-19”, “placenta development”, and “placenta histopathology”. Result: Total of 16 articles were included in this review. Many articles are reviewed whether the COVID-19 affects placenta histology and pregnancy adverse outcome in intrauterine life. Finally article which fulfills inclusion criteria are identified and reviewed. Review indicated that histopathologic features of placenta and adverse pregnancy outcome in COVID-19 confirmed pregnant women briefly. Conclusion: COVID-19 affects the placenta during pregnancy. Histopathologic findings of placenta in pregnant women with confirmed COVID-19 positive are fibrin deposition, micro classification, thrombus, avascular villi, infraction, and villous edema. Most common pregnancy adverse outcome are preterm birth, miscarriage and still birth.
| Published in | Pathology and Laboratory Medicine (Volume 7, Issue 1) |
| DOI | 10.11648/j.plm.20230701.12 |
| Page(s) | 4-11 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Used for Searching Are “Placenta”, “COVID-19”, “Placenta Development”, “COVID-19 on Pregnancy”, “Placenta Histopathology”
| [1] | Moore K and PT. The Developing Human: Clinically Oriented Embryology. 9th ed. 2013. |
| [2] | Turco MY, Moffett A. Development of the human placenta. Dev. 2019; 146 (22): 1–14. |
| [3] | Gude NM, Roberts CT, Kalionis B, King RG. Growth and function of the normal human placenta. Thromb Res. 2004; 114 (5–6 SPEC. ISS.): 397–407. |
| [4] | Furukawa S, Kuroda Y, Sugiyama A. A comparison of the histological structure of the placenta in experimental animals. J Toxicol Pathol. 2014; 27 (1): 11–8. |
| [5] | Sood R, Zehnder JL, Druzin ML, Brown PO. Gene expression patterns in human placenta. Proc Natl Acad Sci U S A. 2006; 103 (14): 5478–83. |
| [6] | Monique Rainford M. The Anatomy of the Placenta. verywell Heal. 2020; |
| [7] | Huppertz B. The anatomy of the normal placenta. J Clin Pathol. 2008; 61 (12): 1296–302. |
| [8] | Prieto GR, Ottone NE, Bianchi H. Morphological features of the human placenta and its free chorionic villi in normal pregnancies and those with diabetes and high blood pressure. Literature review. Int J Morphol. 2018; 36 (4): 1183–92. |
| [9] | Bergsjø P. Pathology of the Human Placenta. Vol. 80, Acta Obstetricia et Gynecologica Scandinavica. 2001. 674-675 p. |
| [10] | Verma S, Carter EB. SARS-CoV2 and pregnancy : An invisible enemy? 2020; (July): 1–6. |
| [11] | Penfield CA, Brubaker SG, Limaye MA, Lighter J, Ratner AJ, Thomas KM, et al. Detection of severe acute respiratory syndrome coronavirus 2 in placental and fetal membrane samples. Am J Obstet Gynecol MFM. 2020; 2 (3): 100133. |
| [12] | Avagliano L, Massa V, Bulfamante G Pietro, Hos- SP. Histology of Human Placenta. SM Gr. 2016; 1–15. |
| [13] | Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES, Goldstein JA. Placental Pathology in COVID-19. Am J Clin Pathol. 2020; 154 (1): 23–32. |
| [14] | SARS-CoV-2 : a storm is raging. 2020; 130 (5): 32217834. |
| [15] | Pulinx B, Kieffer D, Michiels I, Petermans S, Strybol D, Delvaux S, et al. Vertical transmission of SARS-CoV-2 infection and preterm birth. Eur J Clin Microbiol Infect Dis. 2020; 39 (12): 2441–5. |
| [16] | Mohamed Khosroshahi L, Rezaei N. Dysregulation of the immune response in coronavirus disease 2019. Cell Biol Int. 2021; 45 (4): 702–7. |
| [17] | Rad HS, Röhl J, Stylianou N, Allenby MC, Bazaz SR, Warkiani ME, et al. The Effects of COVID-19 on the Placenta During Pregnancy. Front Immunol. 2021; 12 (September): 1–29. |
| [18] | Wong YP, Khong TY, Tan GC. The effects of COVID-19 on placenta and pregnancy: What do we know so far? Diagnostics. 2021; 11 (1): 1–20. |
| [19] | Orvos JM. Maternal COVID-19 infection and placental abnormality FDA approves flu vaccine for children as young as 6 months. 2020; 19–21. |
| [20] | Hecht JL, Quade B, Deshpande V, Mino-Kenudson M, Ting DT, Desai N, et al. SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers. Mod Pathol. 2020. |
| [21] | Garrido-Pontnou M, Navarro A, Camacho J, Crispi F, Alguacil-Guillén M, Moreno-Baró A, et al. Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise. Mod Pathol [Internet]. 2021; 34 (9): 1704–9. Available from: http://dx.doi.org/10.1038/s41379-021-00827-5 |
| [22] | Rebutini PZ, Zanchettin AC, Stonoga ETS, Prá DMM, de Oliveira ALP, Dezidério F da S, et al. Association Between COVID-19 Pregnant Women Symptoms Severity and Placental Morphologic Features. Front Immunol. 2021; 12 (May): 1–30. |
| [23] | Hosier H, Farhadian SF, Morotti RA, Deshmukh U, Lu- A, Campbell KH, et al. SARS – CoV-2 infection of the placenta. 2020; 1–13. |
| [24] | Poisson TM, Jr GP. Case Reports in Women ’ s Health Placental pathology and fetal demise at 35 weeks of gestation in a woman with SARS-CoV-2 infection : A case report. Case Reports Women’s Heal [Internet]. 2021; 30: e00289. Available from: https://doi.org/10.1016/j.crwh.2021.e00289 |
| [25] | Singh N, Buckley T, Shertz W. Placental Pathology in COVID-19 : Case Series in a Community Hospital Setting. 2021; 13 (1): 1–6. |
| [26] | Smithgall MC, Liu-jarin X, Hamele-bena D, Mourad M, Debelenko L, Chen X, et al. Third-trimester placentas of severe acute respiratory histomorphology, including viral immunohistochemistry and in-situ hybridization. 2020; 2: 994–9. |
| [27] | Levitan D, London V, Jr RAM, Mann JD, Cheng K, Silver M, et al. Histologic and Immunohistochemical Evaluation of 65 Placentas From Women With Polymerase Chain Reaction – Proven Severe Acute Respiratory Syndrome. 2021; 145 (June). |
| [28] | Schwartz DA. Placental Pathology of COVID-19 with and without Fetal and Neonatal Infection : Trophoblast Necrosis and Chronic Histiocytic Intervillositis as Risk Factors for Transplacental Transmission of SARS-CoV-2. 2020. |
| [29] | Bertero L, Borella F, Botta G, Carosso A, Cosma S, Bovetti M, et al. Placenta histopathology in SARS-CoV-2 infection : analysis of a consecutive series and comparison with control cohorts. 2021; 715–28. |
| [30] | Flores-Pliego A, Miranda J, Vega-Torreblanca S, Valdespino-Vázquez Y, Helguera-Repetto C, Espejel-Nuñez A, et al. Molecular insights into the thrombotic and microvascular injury in placental endothelium of women with mild or severe COVID-19. Cells. 2021; 10 (2): 1–21. |
| [31] | Kotlar B, Gerson E, Petrillo S, Langer A, Tiemeier H. The impact of the COVID-19 pandemic on maternal and perinatal health: a scoping review. Reprod Health. 2021; 18 (1): 1–22. |
| [32] | Hodžić J, Muračević B, Štimjanin H, Iriškić R, Husika M. Pregnancy outcomes of COVID-19 positive pregnant women at the Cantonal Hospital Zenica, Bosnia and Herzegovina. Med Glas (Zenica) [Internet]. 2021; 19 (1): 28–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/34486362 |
| [33] | Singh V, Choudhary A, Datta MR, Ray A. Maternal and Neonatal Outcomes of COVID-19 in Pregnancy: A Single-Centre Observational Study. Cureus. 2021; 13 (2): 64–5. |
| [34] | Kazemi SN, Hajikhani B, Didar H, Hosseini SS, Haddadi S, Khalili F, et al. COVID-19 and cause of pregnancy loss during the pandemic: A systematic review. PLoS One. 2021; 16 (8 August): 2–7. |
| [35] | Patberg ET, Adams T, Rekawek P, Vahanian SA, Akerman M, Hernandez A, et al. Coronavirus disease 2019 infection and placental histopathology in women delivering at term. Am J Obstet Gynecol. 2021; 224 (4): 382. e1-382. e18. |
APA Style
Gutu Belay. (2023). Article Review on Histopathologic Features of Placenta and Adverse Outcome in Pregnant Women with COVID-19 Positive. Pathology and Laboratory Medicine, 7(1), 4-11. https://doi.org/10.11648/j.plm.20230701.12
ACS Style
Gutu Belay. Article Review on Histopathologic Features of Placenta and Adverse Outcome in Pregnant Women with COVID-19 Positive. Pathol. Lab. Med. 2023, 7(1), 4-11. doi: 10.11648/j.plm.20230701.12
AMA Style
Gutu Belay. Article Review on Histopathologic Features of Placenta and Adverse Outcome in Pregnant Women with COVID-19 Positive. Pathol Lab Med. 2023;7(1):4-11. doi: 10.11648/j.plm.20230701.12
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Download@article{10.11648/j.plm.20230701.12,
author = {Gutu Belay},
title = {Article Review on Histopathologic Features of Placenta and Adverse Outcome in Pregnant Women with COVID-19 Positive},
journal = {Pathology and Laboratory Medicine},
volume = {7},
number = {1},
pages = {4-11},
doi = {10.11648/j.plm.20230701.12},
url = {https://doi.org/10.11648/j.plm.20230701.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.plm.20230701.12},
abstract = {Introduction: The placenta is the highly specialized organ of pregnancy that supports the normal growth and development of the fetus. During intrauterine fetal life placenta is the main metabolic, respiratory, excretory, and endocrine organ. Histologic features of normal placenta are differing according to the trimester of pregnancy. COVID-19 infection affects placenta and fetal membrane. Pregnant women with COVID-19 positive result in placental hyperfusion defects in maternal vessels and oxygenation in the intervillous space affecting perinatal outcome. Methods: Systematic reviews, meta-analysis, cross sectional and cohort studies were obtained through searches on PubMed, Medline, Science Direct, Google Scholar, library genesis, Scopus and Web of Science. Key words used for searching are “placenta”, “COVID-19”, “placenta development”, and “placenta histopathology”. Result: Total of 16 articles were included in this review. Many articles are reviewed whether the COVID-19 affects placenta histology and pregnancy adverse outcome in intrauterine life. Finally article which fulfills inclusion criteria are identified and reviewed. Review indicated that histopathologic features of placenta and adverse pregnancy outcome in COVID-19 confirmed pregnant women briefly. Conclusion: COVID-19 affects the placenta during pregnancy. Histopathologic findings of placenta in pregnant women with confirmed COVID-19 positive are fibrin deposition, micro classification, thrombus, avascular villi, infraction, and villous edema. Most common pregnancy adverse outcome are preterm birth, miscarriage and still birth.},
year = {2023}
}
TY - JOUR T1 - Article Review on Histopathologic Features of Placenta and Adverse Outcome in Pregnant Women with COVID-19 Positive AU - Gutu Belay Y1 - 2023/05/25 PY - 2023 N1 - https://doi.org/10.11648/j.plm.20230701.12 DO - 10.11648/j.plm.20230701.12 T2 - Pathology and Laboratory Medicine JF - Pathology and Laboratory Medicine JO - Pathology and Laboratory Medicine SP - 4 EP - 11 PB - Science Publishing Group SN - 2640-4478 UR - https://doi.org/10.11648/j.plm.20230701.12 AB - Introduction: The placenta is the highly specialized organ of pregnancy that supports the normal growth and development of the fetus. During intrauterine fetal life placenta is the main metabolic, respiratory, excretory, and endocrine organ. Histologic features of normal placenta are differing according to the trimester of pregnancy. COVID-19 infection affects placenta and fetal membrane. Pregnant women with COVID-19 positive result in placental hyperfusion defects in maternal vessels and oxygenation in the intervillous space affecting perinatal outcome. Methods: Systematic reviews, meta-analysis, cross sectional and cohort studies were obtained through searches on PubMed, Medline, Science Direct, Google Scholar, library genesis, Scopus and Web of Science. Key words used for searching are “placenta”, “COVID-19”, “placenta development”, and “placenta histopathology”. Result: Total of 16 articles were included in this review. Many articles are reviewed whether the COVID-19 affects placenta histology and pregnancy adverse outcome in intrauterine life. Finally article which fulfills inclusion criteria are identified and reviewed. Review indicated that histopathologic features of placenta and adverse pregnancy outcome in COVID-19 confirmed pregnant women briefly. Conclusion: COVID-19 affects the placenta during pregnancy. Histopathologic findings of placenta in pregnant women with confirmed COVID-19 positive are fibrin deposition, micro classification, thrombus, avascular villi, infraction, and villous edema. Most common pregnancy adverse outcome are preterm birth, miscarriage and still birth. VL - 7 IS - 1 ER -
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