Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia

Tayu Nigusie Abebe

doi:doi:10.11648/j.plm.20200401.11

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Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia

Tayu Nigusie Abebe

Published in Pathology and Laboratory Medicine (Volume 4, Issue 1)

Received: 12 December 2019 Accepted: 23 December 2019 Published: 8 April 2020

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Abstract

Human immune deficiency virus (HIV) is a major cause of infant and childhood mortality and morbidity; without treatment about 50% of them will succumb to HIV/AIDS before the age of two years. HIV infected children should start ART in order to reduce AIDS related morbidity and mortality, or to improve their survival time. Effective therapies and reduced AIDS related morbidity and mortality have shifted the focus in pediatric human immune deﬁciency virus (HIV) from minimizing short-term disease progression to maintaining optimal long-term health. The main purpose of this study was to evaluate the predictors of longitudinal CD4 cell progression of HIV infected children who were under ART. The study considered a cohort of 201 HIV infected children who were aged 15 years or younger and those were on ART from October 1, 2013 to March 30, 2017 at Adama Referral Hospital and Medical College. To analyze the data we employed exploratory data analysis and linear mixed effect model. The result from linear mixed effect model reviled that observation time, age, WHO clinical stage, history of TB, and functional status had significantly associated with mean change in the square root of CD4 cell count, and they are the predictor of longitudinal CD4 cell change.

Published in	Pathology and Laboratory Medicine (Volume 4, Issue 1)
DOI	10.11648/j.plm.20200401.11
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

CD4 Cell Count, HIV/AIDS, Linear Mixed Effect Model

References

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APA Style

Tayu Nigusie Abebe. (2020). Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia. Pathology and Laboratory Medicine, 4(1), 1-6. https://doi.org/10.11648/j.plm.20200401.11

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ACS Style

Tayu Nigusie Abebe. Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia. Pathol. Lab. Med. 2020, 4(1), 1-6. doi: 10.11648/j.plm.20200401.11

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AMA Style

Tayu Nigusie Abebe. Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia. Pathol Lab Med. 2020;4(1):1-6. doi: 10.11648/j.plm.20200401.11

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@article{10.11648/j.plm.20200401.11,
  author = {Tayu Nigusie Abebe},
  title = {Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia},
  journal = {Pathology and Laboratory Medicine},
  volume = {4},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.plm.20200401.11},
  url = {https://doi.org/10.11648/j.plm.20200401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.plm.20200401.11},
  abstract = {Human immune deficiency virus (HIV) is a major cause of infant and childhood mortality and morbidity; without treatment about 50% of them will succumb to HIV/AIDS before the age of two years. HIV infected children should start ART in order to reduce AIDS related morbidity and mortality, or to improve their survival time. Effective therapies and reduced AIDS related morbidity and mortality have shifted the focus in pediatric human immune deﬁciency virus (HIV) from minimizing short-term disease progression to maintaining optimal long-term health. The main purpose of this study was to evaluate the predictors of longitudinal CD4 cell progression of HIV infected children who were under ART. The study considered a cohort of 201 HIV infected children who were aged 15 years or younger and those were on ART from October 1, 2013 to March 30, 2017 at Adama Referral Hospital and Medical College. To analyze the data we employed exploratory data analysis and linear mixed effect model. The result from linear mixed effect model reviled that observation time, age, WHO clinical stage, history of TB, and functional status had significantly associated with mean change in the square root of CD4 cell count, and they are the predictor of longitudinal CD4 cell change.},
 year = {2020}
}

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TY  - JOUR
T1  - Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia
AU  - Tayu Nigusie Abebe
Y1  - 2020/04/08
PY  - 2020
N1  - https://doi.org/10.11648/j.plm.20200401.11
DO  - 10.11648/j.plm.20200401.11
T2  - Pathology and Laboratory Medicine
JF  - Pathology and Laboratory Medicine
JO  - Pathology and Laboratory Medicine
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2640-4478
UR  - https://doi.org/10.11648/j.plm.20200401.11
AB  - Human immune deficiency virus (HIV) is a major cause of infant and childhood mortality and morbidity; without treatment about 50% of them will succumb to HIV/AIDS before the age of two years. HIV infected children should start ART in order to reduce AIDS related morbidity and mortality, or to improve their survival time. Effective therapies and reduced AIDS related morbidity and mortality have shifted the focus in pediatric human immune deﬁciency virus (HIV) from minimizing short-term disease progression to maintaining optimal long-term health. The main purpose of this study was to evaluate the predictors of longitudinal CD4 cell progression of HIV infected children who were under ART. The study considered a cohort of 201 HIV infected children who were aged 15 years or younger and those were on ART from October 1, 2013 to March 30, 2017 at Adama Referral Hospital and Medical College. To analyze the data we employed exploratory data analysis and linear mixed effect model. The result from linear mixed effect model reviled that observation time, age, WHO clinical stage, history of TB, and functional status had significantly associated with mean change in the square root of CD4 cell count, and they are the predictor of longitudinal CD4 cell change.
VL  - 4
IS  - 1
ER  -

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Author Information

Tayu Nigusie Abebe

Department of Statistics, Bule Hora University, Bule Hora, Ethiopia

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APA Style

Tayu Nigusie Abebe. (2020). Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia. Pathology and Laboratory Medicine, 4(1), 1-6. https://doi.org/10.11648/j.plm.20200401.11

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ACS Style

Tayu Nigusie Abebe. Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia. Pathol. Lab. Med. 2020, 4(1), 1-6. doi: 10.11648/j.plm.20200401.11

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AMA Style

Tayu Nigusie Abebe. Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia. Pathol Lab Med. 2020;4(1):1-6. doi: 10.11648/j.plm.20200401.11

Copy | Download

@article{10.11648/j.plm.20200401.11,
  author = {Tayu Nigusie Abebe},
  title = {Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia},
  journal = {Pathology and Laboratory Medicine},
  volume = {4},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.plm.20200401.11},
  url = {https://doi.org/10.11648/j.plm.20200401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.plm.20200401.11},
  abstract = {Human immune deficiency virus (HIV) is a major cause of infant and childhood mortality and morbidity; without treatment about 50% of them will succumb to HIV/AIDS before the age of two years. HIV infected children should start ART in order to reduce AIDS related morbidity and mortality, or to improve their survival time. Effective therapies and reduced AIDS related morbidity and mortality have shifted the focus in pediatric human immune deﬁciency virus (HIV) from minimizing short-term disease progression to maintaining optimal long-term health. The main purpose of this study was to evaluate the predictors of longitudinal CD4 cell progression of HIV infected children who were under ART. The study considered a cohort of 201 HIV infected children who were aged 15 years or younger and those were on ART from October 1, 2013 to March 30, 2017 at Adama Referral Hospital and Medical College. To analyze the data we employed exploratory data analysis and linear mixed effect model. The result from linear mixed effect model reviled that observation time, age, WHO clinical stage, history of TB, and functional status had significantly associated with mean change in the square root of CD4 cell count, and they are the predictor of longitudinal CD4 cell change.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia
AU  - Tayu Nigusie Abebe
Y1  - 2020/04/08
PY  - 2020
N1  - https://doi.org/10.11648/j.plm.20200401.11
DO  - 10.11648/j.plm.20200401.11
T2  - Pathology and Laboratory Medicine
JF  - Pathology and Laboratory Medicine
JO  - Pathology and Laboratory Medicine
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2640-4478
UR  - https://doi.org/10.11648/j.plm.20200401.11
AB  - Human immune deficiency virus (HIV) is a major cause of infant and childhood mortality and morbidity; without treatment about 50% of them will succumb to HIV/AIDS before the age of two years. HIV infected children should start ART in order to reduce AIDS related morbidity and mortality, or to improve their survival time. Effective therapies and reduced AIDS related morbidity and mortality have shifted the focus in pediatric human immune deﬁciency virus (HIV) from minimizing short-term disease progression to maintaining optimal long-term health. The main purpose of this study was to evaluate the predictors of longitudinal CD4 cell progression of HIV infected children who were under ART. The study considered a cohort of 201 HIV infected children who were aged 15 years or younger and those were on ART from October 1, 2013 to March 30, 2017 at Adama Referral Hospital and Medical College. To analyze the data we employed exploratory data analysis and linear mixed effect model. The result from linear mixed effect model reviled that observation time, age, WHO clinical stage, history of TB, and functional status had significantly associated with mean change in the square root of CD4 cell count, and they are the predictor of longitudinal CD4 cell change.
VL  - 4
IS  - 1
ER  -

Copy | Download