The integrity of the cardiac cells and muscles is essential for quality of life. The sinoatrial node cells are the definitive cells of cardiac electrophysiology. They are the primary source of action potentials. Lamentably, the question of ion currents that generate the much needed cardiac action potentials is yet to be resolved. The nagging issue of the presence or otherwise of the sodium ion (Na+) in the sino-atrial node cells may cast doubts at the propriety of clinical measures that target some cardiac events. Some literatures suggest the presence of the said ion at the periphery of the sino-atrial node while contending that it is totally absent in the node centre. Other literatures hold that it is present the entire sino-atrial node. In the light of these, this paper proposed a refined model equation of the cardiac sino-atrial node membrane current. The node centre, known to be the origin of cardiac action potential, was given a bit closer look. Physiological delay arising from the flow of a class of calcium ion current (L-Type calcium current), the bastion of the sino-atrial node centre action potential, was also considered. Ostensibly, the timing of specific ion currents during action potentials may furnish some clues on cardiac conditions.
| Published in | Mathematics Letters (Volume 4, Issue 4) |
| DOI | 10.11648/j.ml.20180404.11 |
| Page(s) | 59-66 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Action Potentials, Cardiac, Delay, Ion Channels, Mathematical, Equations, Periodic, Physiological
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APA Style
Nzerem Francis Egenti, Ugorji Hycinth Chimezie. (2019). Cardiac Electrophysiology: The Sinoatrial Node in Focus. Mathematics Letters, 4(4), 59-66. https://doi.org/10.11648/j.ml.20180404.11
ACS Style
Nzerem Francis Egenti; Ugorji Hycinth Chimezie. Cardiac Electrophysiology: The Sinoatrial Node in Focus. Math. Lett. 2019, 4(4), 59-66. doi: 10.11648/j.ml.20180404.11
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Download@article{10.11648/j.ml.20180404.11,
author = {Nzerem Francis Egenti and Ugorji Hycinth Chimezie},
title = {Cardiac Electrophysiology: The Sinoatrial Node in Focus},
journal = {Mathematics Letters},
volume = {4},
number = {4},
pages = {59-66},
doi = {10.11648/j.ml.20180404.11},
url = {https://doi.org/10.11648/j.ml.20180404.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ml.20180404.11},
abstract = {The integrity of the cardiac cells and muscles is essential for quality of life. The sinoatrial node cells are the definitive cells of cardiac electrophysiology. They are the primary source of action potentials. Lamentably, the question of ion currents that generate the much needed cardiac action potentials is yet to be resolved. The nagging issue of the presence or otherwise of the sodium ion (Na+) in the sino-atrial node cells may cast doubts at the propriety of clinical measures that target some cardiac events. Some literatures suggest the presence of the said ion at the periphery of the sino-atrial node while contending that it is totally absent in the node centre. Other literatures hold that it is present the entire sino-atrial node. In the light of these, this paper proposed a refined model equation of the cardiac sino-atrial node membrane current. The node centre, known to be the origin of cardiac action potential, was given a bit closer look. Physiological delay arising from the flow of a class of calcium ion current (L-Type calcium current), the bastion of the sino-atrial node centre action potential, was also considered. Ostensibly, the timing of specific ion currents during action potentials may furnish some clues on cardiac conditions.},
year = {2019}
}
TY - JOUR T1 - Cardiac Electrophysiology: The Sinoatrial Node in Focus AU - Nzerem Francis Egenti AU - Ugorji Hycinth Chimezie Y1 - 2019/01/03 PY - 2019 N1 - https://doi.org/10.11648/j.ml.20180404.11 DO - 10.11648/j.ml.20180404.11 T2 - Mathematics Letters JF - Mathematics Letters JO - Mathematics Letters SP - 59 EP - 66 PB - Science Publishing Group SN - 2575-5056 UR - https://doi.org/10.11648/j.ml.20180404.11 AB - The integrity of the cardiac cells and muscles is essential for quality of life. The sinoatrial node cells are the definitive cells of cardiac electrophysiology. They are the primary source of action potentials. Lamentably, the question of ion currents that generate the much needed cardiac action potentials is yet to be resolved. The nagging issue of the presence or otherwise of the sodium ion (Na+) in the sino-atrial node cells may cast doubts at the propriety of clinical measures that target some cardiac events. Some literatures suggest the presence of the said ion at the periphery of the sino-atrial node while contending that it is totally absent in the node centre. Other literatures hold that it is present the entire sino-atrial node. In the light of these, this paper proposed a refined model equation of the cardiac sino-atrial node membrane current. The node centre, known to be the origin of cardiac action potential, was given a bit closer look. Physiological delay arising from the flow of a class of calcium ion current (L-Type calcium current), the bastion of the sino-atrial node centre action potential, was also considered. Ostensibly, the timing of specific ion currents during action potentials may furnish some clues on cardiac conditions. VL - 4 IS - 4 ER -
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