Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing

Nagwan Ahmed Bahgat; Waleed Syed

doi:doi:10.11648/j.jgo.20221002.13

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Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing

Nagwan Ahmed Bahgat, Waleed Syed

Published in Journal of Gynecology and Obstetrics (Volume 10, Issue 2)

Received: 6 February 2022 Accepted: 25 February 2022 Published: 9 March 2022

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Abstract

Patients with recurrent implantation failure had to be extensively studied to find way to achieve clinical pregnancy, it is well known that defects in the embryo or the endometrium or the alteration between both could be the reason. Exclusion of the possibilities of embryo abnormalities could help us to concentrate on the endometrial factors of failure. In this study we concentrated on endometrial receptivity displacement as a factor of implantation failure in patients with recurrent unexplained IVF failure. This is done through studying gene expression of endometrium in those cases to determine the receptivity timing and the window of implantation. Through retrospective study of 93 patients with recurrent implantation failure who underwent endometrial receptivity array testing, we found that the incidence of non-receptive endometrium in such cases was 45% 38 patients of 83 which is higher than other studies in the same field. Prevalence of pre receptive endometrium in those cases more than post receptive, Indicates the need to more exposure to Progesterone to achieve receptivity. Polycystic ovarian syndrome patients included in this study showed also high incidence of non-receptive endometrium10 out of 11patients (90.9%). In conclusion personalized embryo transfer according to ERA test could be useful to this category of patients. However larger studies are needed in the same group of patient

Published in	Journal of Gynecology and Obstetrics (Volume 10, Issue 2)
DOI	10.11648/j.jgo.20221002.13
Page(s)	69-74
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Implantation, Implantation Failure, Array Test

References

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APA Style

Nagwan Ahmed Bahgat, Waleed Syed. (2022). Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing. Journal of Gynecology and Obstetrics, 10(2), 69-74. https://doi.org/10.11648/j.jgo.20221002.13

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ACS Style

Nagwan Ahmed Bahgat; Waleed Syed. Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing. J. Gynecol. Obstet. 2022, 10(2), 69-74. doi: 10.11648/j.jgo.20221002.13

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AMA Style

Nagwan Ahmed Bahgat, Waleed Syed. Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing. J Gynecol Obstet. 2022;10(2):69-74. doi: 10.11648/j.jgo.20221002.13

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@article{10.11648/j.jgo.20221002.13,
  author = {Nagwan Ahmed Bahgat and Waleed Syed},
  title = {Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {10},
  number = {2},
  pages = {69-74},
  doi = {10.11648/j.jgo.20221002.13},
  url = {https://doi.org/10.11648/j.jgo.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20221002.13},
  abstract = {Patients with recurrent implantation failure had to be extensively studied to find way to achieve clinical pregnancy, it is well known that defects in the embryo or the endometrium or the alteration between both could be the reason. Exclusion of the possibilities of embryo abnormalities could help us to concentrate on the endometrial factors of failure. In this study we concentrated on endometrial receptivity displacement as a factor of implantation failure in patients with recurrent unexplained IVF failure. This is done through studying gene expression of endometrium in those cases to determine the receptivity timing and the window of implantation. Through retrospective study of 93 patients with recurrent implantation failure who underwent endometrial receptivity array testing, we found that the incidence of non-receptive endometrium in such cases was 45% 38 patients of 83 which is higher than other studies in the same field. Prevalence of pre receptive endometrium in those cases more than post receptive, Indicates the need to more exposure to Progesterone to achieve receptivity. Polycystic ovarian syndrome patients included in this study showed also high incidence of non-receptive endometrium10 out of 11patients (90.9%). In conclusion personalized embryo transfer according to ERA test could be useful to this category of patients. However larger studies are needed in the same group of patient},
 year = {2022}
}

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TY  - JOUR
T1  - Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing
AU  - Nagwan Ahmed Bahgat
AU  - Waleed Syed
Y1  - 2022/03/09
PY  - 2022
N1  - https://doi.org/10.11648/j.jgo.20221002.13
DO  - 10.11648/j.jgo.20221002.13
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 69
EP  - 74
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20221002.13
AB  - Patients with recurrent implantation failure had to be extensively studied to find way to achieve clinical pregnancy, it is well known that defects in the embryo or the endometrium or the alteration between both could be the reason. Exclusion of the possibilities of embryo abnormalities could help us to concentrate on the endometrial factors of failure. In this study we concentrated on endometrial receptivity displacement as a factor of implantation failure in patients with recurrent unexplained IVF failure. This is done through studying gene expression of endometrium in those cases to determine the receptivity timing and the window of implantation. Through retrospective study of 93 patients with recurrent implantation failure who underwent endometrial receptivity array testing, we found that the incidence of non-receptive endometrium in such cases was 45% 38 patients of 83 which is higher than other studies in the same field. Prevalence of pre receptive endometrium in those cases more than post receptive, Indicates the need to more exposure to Progesterone to achieve receptivity. Polycystic ovarian syndrome patients included in this study showed also high incidence of non-receptive endometrium10 out of 11patients (90.9%). In conclusion personalized embryo transfer according to ERA test could be useful to this category of patients. However larger studies are needed in the same group of patient
VL  - 10
IS  - 2
ER  -

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Author Information

Nagwan Ahmed Bahgat

Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt
Waleed Syed

Health Plus Fertility Center, Health Plus Group, Abu Dhabi, United Arab Emirates

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APA Style

Nagwan Ahmed Bahgat, Waleed Syed. (2022). Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing. Journal of Gynecology and Obstetrics, 10(2), 69-74. https://doi.org/10.11648/j.jgo.20221002.13

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ACS Style

Nagwan Ahmed Bahgat; Waleed Syed. Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing. J. Gynecol. Obstet. 2022, 10(2), 69-74. doi: 10.11648/j.jgo.20221002.13

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AMA Style

Nagwan Ahmed Bahgat, Waleed Syed. Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing. J Gynecol Obstet. 2022;10(2):69-74. doi: 10.11648/j.jgo.20221002.13

Copy | Download

@article{10.11648/j.jgo.20221002.13,
  author = {Nagwan Ahmed Bahgat and Waleed Syed},
  title = {Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {10},
  number = {2},
  pages = {69-74},
  doi = {10.11648/j.jgo.20221002.13},
  url = {https://doi.org/10.11648/j.jgo.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20221002.13},
  abstract = {Patients with recurrent implantation failure had to be extensively studied to find way to achieve clinical pregnancy, it is well known that defects in the embryo or the endometrium or the alteration between both could be the reason. Exclusion of the possibilities of embryo abnormalities could help us to concentrate on the endometrial factors of failure. In this study we concentrated on endometrial receptivity displacement as a factor of implantation failure in patients with recurrent unexplained IVF failure. This is done through studying gene expression of endometrium in those cases to determine the receptivity timing and the window of implantation. Through retrospective study of 93 patients with recurrent implantation failure who underwent endometrial receptivity array testing, we found that the incidence of non-receptive endometrium in such cases was 45% 38 patients of 83 which is higher than other studies in the same field. Prevalence of pre receptive endometrium in those cases more than post receptive, Indicates the need to more exposure to Progesterone to achieve receptivity. Polycystic ovarian syndrome patients included in this study showed also high incidence of non-receptive endometrium10 out of 11patients (90.9%). In conclusion personalized embryo transfer according to ERA test could be useful to this category of patients. However larger studies are needed in the same group of patient},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Displacement of Window of Implantation in Cases of Unexplained Recurrent Implantation Failure as Detected by Endometrial Receptivity Array Testing
AU  - Nagwan Ahmed Bahgat
AU  - Waleed Syed
Y1  - 2022/03/09
PY  - 2022
N1  - https://doi.org/10.11648/j.jgo.20221002.13
DO  - 10.11648/j.jgo.20221002.13
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 69
EP  - 74
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20221002.13
AB  - Patients with recurrent implantation failure had to be extensively studied to find way to achieve clinical pregnancy, it is well known that defects in the embryo or the endometrium or the alteration between both could be the reason. Exclusion of the possibilities of embryo abnormalities could help us to concentrate on the endometrial factors of failure. In this study we concentrated on endometrial receptivity displacement as a factor of implantation failure in patients with recurrent unexplained IVF failure. This is done through studying gene expression of endometrium in those cases to determine the receptivity timing and the window of implantation. Through retrospective study of 93 patients with recurrent implantation failure who underwent endometrial receptivity array testing, we found that the incidence of non-receptive endometrium in such cases was 45% 38 patients of 83 which is higher than other studies in the same field. Prevalence of pre receptive endometrium in those cases more than post receptive, Indicates the need to more exposure to Progesterone to achieve receptivity. Polycystic ovarian syndrome patients included in this study showed also high incidence of non-receptive endometrium10 out of 11patients (90.9%). In conclusion personalized embryo transfer according to ERA test could be useful to this category of patients. However larger studies are needed in the same group of patient
VL  - 10
IS  - 2
ER  -

Copy | Download