Dementia is an illness of the brain in which there is deterioration in a person's cognitive abilities. This interferes with one's ability to carry out everyday tasks and maintain social autonomy by adversely affecting memory, behavior, reasoning, and social capacities. The study reviewed the epidemiological literature on dementia and its risk factors as well as the several midlife strategies for lowering the risk of dementia. This is with a view to explore the midlife strategies in lowering the risk factors of dementia among adults in the United Kingdom. The study adopted reviews of literature carried out systematically. The specifications described in the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)” were followed in reviewing the literature to ensure a comprehensive and transparent methodology. Literature search was conducted systematically in scientific databases to identify empirical studies that are pertinent. The comprehensive search strategy aimed to retrieve as many relevant studies as possible within the scope of the review. It employed a combination of keywords related to dementia risk factors, behavioral and psychological impacts, older people, and the UK context. The search terms were adapted to fit the specific requirements of each database, ensuring optimal retrieval of relevant literature. In total, 16 publications were included in the study after the eligibility of these articles was verified. By leveraging the potential advantages of internet-based, individualised health prevention measures, both the general public and primary care providers become more aware of dementia as well as help to solve the issue. Dementia and various cognitive impairments have been repeatedly associated to high blood pressure. Recent findings support the idea that decreasing blood pressure in middle age is an important strategy for preventing dementia in old age. Education has a protective impact and that the majority of previously investigated risk factors including physical inactivity, diabetes, air pollution, hearing loss, hypertension, obesity, social isolation, depression, and smoking increase the incidence of dementia. People who adhered to the MedDiet the best had a 23% reduced risk of dementia than those who adhered the least. The study concluded that significant modifiable risk variables, particularly socioeconomic and lifestyle factors, were more strongly associated with dementia and contributed to higher attributable fractions of dementia cases.
Published in | Journal of Family Medicine and Health Care (Volume 10, Issue 3) |
DOI | 10.11648/j.jfmhc.20241003.14 |
Page(s) | 67-84 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Dementia, Midlife, Risk Factors, Analysis, Adults, United Kingdom
[1] | Arvanitakis Z, Bennett DA. What Is Dementia? JAMA. 2019 Nov 5; 322(17): 1728. |
[2] |
Alzheimer’s Disease International, Wimo A, Ali GC, Guerchet M, Prince M, Prina M, et al. ADI - World Alzheimer Report 2015. Available from:
https://www.alzint.org/resource/world-alzheimer-report-2015/ [Accessed 7 Jun. 2023] |
[3] |
Alzheimer’s Disease International, Gauthier S., Rosa-Neto P., Morais J., Webster C. - World Alzheimer Report 2021. Alzheimer’s Disease International (ADI). Available from:
https://www.alzint.org/resource/world-alzheimer-report-2021/ [Accessed 7 Jun. 2023] |
[4] | Nichols E, Vos T. The estimation of the global prevalence of dementia from 1990-2019 and forecasted prevalence through 2050: An analysis for the Global Burden of Disease (GBD) study 2019. Alzheimer’s & Dementia. 2021 Dec; 17(S10). |
[5] | Mirzaei G, Adeli H. Machine learning techniques for diagnosis of alzheimer disease, mild cognitive disorder, and other types of dementia. Biomedical Signal Processing and Control. 2022 Feb; 72: 103293. |
[6] | Wolters FJ, Ikram MA. Epidemiology of Vascular Dementia. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019 Aug; 39(8): 1542–9. |
[7] |
Alzheimer Society of Canada. About dementia. Available from:
https://alzheimer.ca/en/about-dementia [Accessed 7 Jun. 2023]. |
[8] | Olney NT, Spina S, Miller BL. Frontotemporal Dementia. Neurologic Clinics. 2017 May; 35(2): 339–74. |
[9] |
Alzheimer’s Disease International, Patterson C. ADI - World Alzheimer Report 2018. Available from:
https://www.alzint.org/resource/world-alzheimer-report-2018/ [Accessed 7 Jun. 2023]. |
[10] |
England PH. Health matters: midlife approaches to reduce dementia risk. Available from:
https://www.gov.uk/government/publications/health-matters-midlife-approaches-to-reduce-dementia-risk/health-matters-midlife-approaches-to-reduce- dementia-risk [Accessed 7 Jun. 2023]. |
[11] | Pedroza P, Miller-Petrie MK, Chen C, Chakrabarti S, Chapin A, Hay S, et al. Global and regional spending on dementia care from 2000–2019 and expected future health spending scenarios from 2020–2050: An economic modelling exercise. eClinicalMedicine. 2022 Mar; 45: 101337. |
[12] | Cations M, Radisic G, Crotty M, Laver KE. What does the general public understand about prevention and treatment of dementia? A systematic review of population-based surveys. PLOS ONE. 2018 Apr 19; 13(4): e0196085. |
[13] | Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. The Lancet. 2017 Dec; 390(10113): 2673–734. |
[14] | Ferreira M do C, Abreu MJ, Machado C, Santos B, Machado Á, Costa AS. Neuropsychiatric Profile in Early Versus Late Onset Alzheimer’s Disease. American Journal of Alzheimer’s Disease & amp; Other Dementiasr. 2017 Dec 6; 33(2): 93–9. |
[15] |
World Health Organization: WHO. Dementia. World Health Organization: Available from:
https://www.who.int/news-room/fact-sheets/detail/dementia [Accessed 7 Jun. 2023]. |
[16] | Ranganathan P, Aggarwal R. Study designs: Part 7 – Systematic reviews. Perspectives in Clinical Research. 2020; 11(2): 97. |
[17] |
LibGuides at Edith Cowan University, Systematic Reviews: Levels of evidence and study design. Available from:
https://ecu.au.libguides.com/systematic-reviews/levels-of-evidence [Accessed 7 Jun. 2023]. |
[18] |
National Library of Medicine, Behavioral And Psychological Symptoms In Dementia (BPSD). Available from:
https://www.ncbi.nlm.nih.gov/books/NBK551552/ [Accessed 7 Jun. 2023] |
[19] | Goudriaan I, van Boekel LC, Verbiest ME, van Hoof J, Luijkx KG. Dementia Enlightened?! A Systematic Literature Review of the Influence of Indoor Environmental Light on the Health of Older Persons with Dementia in Long-Term Care Facilities. Clinical Interventions in Aging. 2021 May; Volume 16: 909–37. |
[20] | Bramer WM, Rethlefsen ML, Kleijnen J, Franco OH. Optimal database combinations for literature searches in systematic reviews: a prospective exploratory study. Systematic Reviews. 2017 Dec; 6(1). |
[21] | Berwald S, Roche M, Adelman S, Mukadam N, Livingston G. Black African and Caribbean British Communities’ Perceptions of Memory Problems: “We Don’t Do Dementia.” PLOS ONE. 2016 Apr 5; 11(4): e0151878. |
[22] | Bosco A, Jones KA, Di Lorito C, Stephan BCM, Orrell M, Oliveira D. Changing lifestyle for dementia risk reduction: Inductive content analysis of a national UK survey. PLOS ONE. 2020 May 15; 15(5): e0233039. |
[23] | Chen H, Cao Y, Ma Y, Zong G, Yuan C. Age- and sex-specific modifiable risk factor profiles of dementia: evidence from the UK Biobank [Internet]. Research Square Platform LLC; 2021 Nov [cited 2024 Jul 17]. Available from: |
[24] | Eggink E, Hafdi M, Hoevenaar-Blom MP, Song M, Andrieu S, Barnes LE, et al. Prevention of dementia using mobile phone applications (PRODEMOS): protocol for an international randomised controlled trial. BMJ Open. 2021 Jun; 11(6): e049762. |
[25] | Elwood P, Galante J, Pickering J, Palmer S, Bayer A, Ben-Shlomo Y, et al. Healthy Lifestyles Reduce the Incidence of Chronic Diseases and Dementia: Evidence from the Caerphilly Cohort Study. PLoS ONE. 2013 Dec 9; 8(12): e81877. |
[26] | Gong J, Harris K, Peters SAE, Woodward M. Sex differences in the association between major cardiovascular risk factors in midlife and dementia: a cohort study using data from the UK Biobank. BMC Medicine. 2021 May 19; 19(1). |
[27] | Malik R, Georgakis MK, Neitzel J, Rannikmäe K, Ewers M, Seshadri S, et al. Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank. Alzheimer’s & Dementia. 2021 Mar 22; 17(9): 1422–31. |
[28] | Mukadam N, Marston L, Lewis G, Livingston G. Risk factors, ethnicity and dementia: A UK Biobank prospective cohort study of White, South Asian and Black participants. PLOS ONE. 2022 Oct 12; 17(10): e0275309. |
[29] | O’Donnell CA, Browne S, Pierce M, McConnachie A, Deckers K, van Boxtel MPJ, et al. Reducing dementia risk by targeting modifiable risk factors in mid-life: study protocol for the Innovative Midlife Intervention for Dementia Deterrence (In-MINDD) randomised controlled feasibility trial. Pilot and Feasibility Studies. 2015 Nov17; 1(1). |
[30] | Oliveira D, Aubeeluck A, Stupple E, Kim S, Orrell M. Factor and reliability analysis of a brief scale to measure motivation to change lifestyle for dementia risk reduction in the UK: the MOCHAD-10. Health and Quality of Life Outcomes. 2019 May 2; 17(1). |
[31] | Oliveira D, Knight H, Jones KA, Ogollah R, Orrell M. Motivation and willingness to increase physical activity for dementia risk reduction: Cross-Sectional UK survey with people aged 50 and over. Aging & Mental Health. 2021 Oct 4; 26(9): 1899–908. |
[32] | Qizilbash N, Gregson J, Johnson ME, Pearce N, Douglas I, Wing K, et al. BMI and risk of dementia in two million people over two decades: a retrospective cohort study. The Lancet Diabetes & amp; Endocrinology. 2015 Jun; 3(6): 431–6. |
[33] | Rosato M, Leavey G, Cooper J, De Cock P, Devine P. Factors associated with public knowledge of and attitudes to dementia: A cross-sectional study. PLOS ONE. 2019 Feb 28; 14(2): e0210543. |
[34] | Shannon OM, Lee V, Bundy R, Gillings R, Jennings A, Stephan B, et al. Feasibility and acceptability of a multi-domain intervention to increase Mediterranean diet adherence and physical activity in older UK adults at risk of dementia: protocol for the MedEx-UK randomised controlled trial. BMJ Open. 2021 Feb; 11(2): e042823. |
[35] | Shannon OM, Ranson JM, Gregory S, Macpherson H, Milte C, Lentjes M, et al. Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study. BMC Medicine. 2023 Mar 14; 21(1). |
[36] | Wotton CJ, Goldacre MJ. Associations between specific autoimmune diseases and subsequent dementia: retrospective record-linkage cohort study, UK. Journal of Epidemiology and Community Health. 2017 Mar 1; 71(6): 576–83. |
[37] | Hong QN, Fàbregues S, Bartlett G, Boardman F, Cargo M, Dagenais P, et al. The Mixed Methods Appraisal Tool (MMAT) version 2018 for information professionals and researchers. Education for Information. 2018 Dec 18; 34(4): 285–91. |
[38] | Booth AM, Wright KE, Outhwaite H. Centre for Reviews and Dissemination databases: Value, content, and developments. International Journal of Technology Assessment in Health Care. 2010 Oct; 26(4): 470–2. |
[39] |
Schmitt J. LibGuides: Evidence-Based Practice (EBP): Inclusion & Exclusion Criteria [Internet]. St Louis. Available from:
https://libguides.umsl.edu/ebp/selection-criteria [Accessed 7 Jun. 2023]. |
[40] | George-Carey R, Adeloye A, Chan KY, Paul A, Kolčić I, Campbell H, Rudan I. An estimate of the prevalence of dementia in Africa: A systematic analysis. J Glob Health 2013; 2: 020401corr1. Journal of Global Health. 2012 Dec; 2(2). |
[41] | Hughes D, Judge C, Murphy R, Loughlin E, Costello M, Whiteley W, et al. Association of Blood Pressure Lowering With Incident Dementia or Cognitive Impairment. JAMA. 2020 May 19; 323(19): 1934. |
[42] | Veldsman M, Tai XY, Nichols T, Smith S, Peixoto J, Manohar S, et al. Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing. Nature Communications. 2020 Sep 7; 11(1). |
[43] | Gilsanz P, Mayeda ER, Glymour MM, Quesenberry CP, Mungas DM, DeCarli C, et al. Female sex, early-onset hypertension, and risk of dementia. Neurology. 2017 Oct 31; 89(18): 1886–93. |
[44] | Pankratz VS, Roberts RO, Mielke MM, Knopman DS, Jack CR Jr, Geda YE, et al. Predicting the risk of mild cognitive impairment in the Mayo Clinic Study of Aging. Neurology. 2015 Apr 7; 84(14): 1433–42. |
[45] | Hébert R, Lindsay J, Verreault R, Rockwood K, Hill G, Dubois MF. Vascular Dementia. Stroke. 2000 Jul; 31(7): 1487–93. |
[46] | Deegan BM, Sorond FA, Galica A, Lipsitz LA, O’Laighin G, Serrador JM. Elderly Women Regulate Brain Blood Flow Better Than Men Do. Stroke. 2011 Jul; 42(7): 1988–93. |
[47] | Wolters FJ, Zonneveld HI, Hofman A, van der Lugt A, Koudstaal PJ, Vernooij MW, et al. Cerebral Perfusion and the Risk of Dementia. Circulation. 2017 Aug 22; 136(8): 719–28. |
[48] | Williamson JD, Pajewski NM, Auchus AP, Bryan RN, Chelune G, Cheung AK, et al. Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia. JAMA. 2019 Feb 12; 321(6): 553. |
[49] | Abell JG, Kivimäki M, Dugravot A, Tabak AG, Fayosse A, Shipley M, et al. Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension. European Heart Journal. 2018 Jun 12; 39(33): 3119–25. |
[50] | McGrath ER, Beiser AS, DeCarli C, Plourde KL, Vasan RS, Greenberg SM, et al. Blood pressure from mid- to late life and risk of incident dementia. Neurology. 2017 Dec 12; 89(24): 2447–54. |
[51] | Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet. 2020 Aug; 396(10248): 413–46. |
[52] | Zhong G, Wang Y, Zhang Y, Guo JJ, Zhao Y. Smoking Is Associated with an Increased Risk of Dementia: A Meta-Analysis of Prospective Cohort Studies with Investigation of Potential Effect Modifiers. PLOS ONE. 2015 Mar 12; 10(3): e0118333. |
[53] | Chatterjee S, Peters SAE, Woodward M, Mejia Arango S, Batty GD, Beckett N, et al. Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia. Diabetes Care. 2015 Dec 17; 39(2): 300–7. |
[54] | Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age. PLOS Medicine. 2015 Mar 31; 12(3): e1001779. |
[55] | Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice. 2019 Nov; 157: 107843. |
[56] | Biessels GJ, Whitmer RA. Cognitive dysfunction in diabetes: how to implement emerging guidelines. Diabetologia. 2019 Aug 16; 63(1): 3–9. |
[57] | Letellier N, Gutierrez L, Carrière I, Gabelle A, Dartigues J, Dufouil C, et al. Sex- specific association between neighborhood characteristics and dementia: The Three-City cohort. Alzheimer’s & Dementia. 2017 Nov; 14(4): 473–82. |
[58] | Russ TC, Stamatakis E, Hamer M, Starr JM, Kivimäki M, Batty GD. Socioeconomic status as a risk factor for dementia death: individual participant meta-analysis of 86 508 men and women from the UK. British Journal of Psychiatry. 2013 Jul; 203(1): 10–7. |
[59] | Kivipelto M, Håkansson K. A Rare Success against Alzheimer’s. Scientific American Mind. 2018 Feb 13; 27(1s): 106–11. |
[60] | Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. The Lancet. 2015 Jun; 385(9984): 2255–63. |
[61] | Glynn RW, Shelley E, Lawlor BA. Public knowledge and understanding of dementia—evidence from a national survey in Ireland. Age and Ageing. 2017 May 22; 46(5): 865–9. |
[62] | McParland P, Devine P, Innes A, Gayle V. Dementia knowledge and attitudes of the general public in Northern Ireland: an analysis of national survey data. International Psychogeriatrics. 2012 May 17; 24(10): 1600–13. |
[63] | Cahill S, Pierce M, Werner P, Darley A, Bobersky A. A Systematic Review of the Public’s Knowledge and Understanding of Alzheimer’s Disease and Dementia. Alzheimer Disease & Associated Disorders. 2015 Jul; 29(3): 255–75. |
[64] | Sabia S, Fayosse A, Dumurgier J, Dugravot A, Akbaraly T, Britton A, et al. Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study. BMJ. 2018 Aug 1; k2927. |
[65] | Rosenberg A, Coley N, Soulier A, Kulmala J, Soininen H, Andrieu S, et al. Experiences of dementia and attitude towards prevention: a qualitative study among older adults participating in a prevention trial. BMC Geriatrics. 2020 Mar 12; 20(1). |
[66] | Wansink B, Pope L. When do gain-framed health messages work better than fear appeals? Nutrition Reviews. 2014 Dec 17; 73(1): 4–11. |
[67] | Rothman AJ, Bartels RD, Wlaschin J, Salovey P. The Strategic Use of Gain- and Loss-Framed Messages to Promote Healthy Behavior: How Theory Can Inform Practice. Journal of Communication. 2006 Aug 1; 56(suppl_1): S202–20. |
[68] | Naughton P, McCarthy SN, McCarthy MB. The creation of a healthy eating motivation score and its association with food choice and physical activity in a cross sectional sample of Irish adults. International Journal of Behavioral Nutrition and Physical Activity. 2015 Jun 6; 12(1). |
[69] | Smith BJ, Ali S, Quach H. The motivation and actions of Australians concerning brain health and dementia risk reduction. Health Promotion Journal of Australia. 2015 Jul 27; 26(2): 115–21. |
[70] | Lovell GP, El Ansari W, Parker JK. Perceived Exercise Benefits and Barriers of Non-Exercising Female University Students in the United Kingdom. International Journal of Environmental Research and Public Health. 2010 Mar 1; 7(3): 784–98. |
[71] | Rasinaho M, Hirvensalo M, Leinonen R, Lintunen T, Rantanen T. Motives for and Barriers to Physical Activity among Older Adults with Mobility Limitations. Journal of Aging and Physical Activity. 2007 Jan; 15(1): 90–102. |
[72] | Moschny A, Platen P, Klaaßen-Mielke R, Trampisch U, Hinrichs T. Barriers to physical activity in older adults in Germany: a cross-sectional study. International Journal of Behavioral Nutrition and Physical Activity. 2011; 8(1): 121. |
[73] | Beydoun MA, Beydoun HA, Gamaldo AA, Teel A, Zonderman AB, Wang Y. Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis. BMC Public Health. 2014 Jun 24; 14(1). |
[74] | Xu W, Qiu C, Gatz M, Pedersen NL, Johansson B, Fratiglioni L. Mid- and Late-Life Diabetes in Relation to the Risk of Dementia. Diabetes. 2009 Jan 1; 58(1): 71–7. |
[75] | Gąsecki D, Kwarciany M, Nyka W, Narkiewicz K. Hypertension, Brain Damage and Cognitive Decline. Current Hypertension Reports. 2013 Oct 23; 15(6): 547–58. |
[76] | Brettschneider J, Tredici KD, Lee VMY, Trojanowski JQ. Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nature Reviews Neuroscience. 2015 Jan 15; 16(2): 109–20. |
[77] | The Lancet Neurology. Dementia warning for the Asia-Pacific region. The Lancet Neurology. 2015 Jan; 14(1): 1. |
[78] | Emmerzaal TL, Kiliaan AJ, Gustafson DR. 2003-2013: A Decade of Body Mass Index, Alzheimer’s Disease, and Dementia. Journal of Alzheimer’s Disease. 2014 Dec 2; 43(3): 739–55. |
[79] | Xu WL, Atti AR, Gatz M, Pedersen NL, Johansson B, Fratiglioni L. Midlife overweight and obesity increase late-life dementia risk. Neurology. 2011 May 3; 76(18): 1568–74. |
[80] | Whitmer RA, Gustafson DR, Barrett-Connor E, Haan MN, Gunderson EP, Yaffe K. Central obesity and increased risk of dementia more than three decades later. Neurology. 2008 Sep 30; 71(14): 1057–64. |
[81] | Ravona-Springer R, Schnaider-Beeri M, Goldbourt U. Body weight variability in midlife and risk for dementia in old age. Neurology. 2013 Apr 30; 80(18): 1677–83. |
[82] | Strand BH, Langballe EM, Hjellvik V, Handal M, Næss Ø, Knudsen GP, et al. Midlife vascular risk factors and their association with dementia deaths: Results from a Norwegian prospective study followed up for 35years. Journal of the Neurological Sciences. 2013 Jan; 324(1–2): 124–30. |
[83] | Solomon A, Kivipelto M, Wolozin B, Zhou J, Whitmer RA. Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later. Dementia and Geriatric Cognitive Disorders. 2009; 28(1): 75–80. |
[84] | Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. The Lancet Neurology. 2014 Aug; 13(8): 788–94. |
[85] | Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, et al. Vitamin D and the risk of dementia and Alzheimer disease. Neurology. 2014 Sep 2; 83(10): 920–8. |
[86] | Devore EE, Grodstein F, van Rooij FJA, Hofman A, Stampfer MJ, Witteman JCM, et al. Dietary Antioxidants and Long-term Risk of Dementia. Archives of Neurology. 2010 Jul 1; 67(7). |
[87] | Limongi F, Siviero P, Bozanic A, Noale M, Veronese N, Maggi S. The Effect of Adherence to the Mediterranean Diet on Late-Life Cognitive Disorders: A Systematic Review. Journal of the American Medical Directors Association. 2020 Oct; 21(10): 1402–9. |
[88] | Andreu-Reinón ME, Chirlaque MD, Gavrila D, Amiano P, Mar J, Tainta M, et al. Mediterranean Diet and Risk of Dementia and Alzheimer’s Disease in the EPIC-Spain Dementia Cohort Study. Nutrients. 2021 Feb 22; 13(2): 700. |
[89] | Chiuve SE, McCullough ML, Sacks FM, Rimm EB. Healthy Lifestyle Factors in the Primary Prevention of Coronary Heart Disease Among Men. Circulation. 2006 Jul 11; 114(2): 160–7. |
[90] | Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary Prevention of Coronary Heart Disease in Women through Diet and Lifestyle. New England Journal of Medicine. 2000 Jul 6; 343(1): 16–22. |
[91] | Khaw KT, Wareham N, Bingham S, Welch A, Luben R, Day N. Combined Impact of Health Behaviours and Mortality in Men and Women: The EPIC-Norfolk Prospective Population Study. PLoS Medicine. 2008 Jan 8; 5(1): e12. |
[92] | Chakravarty EF, Hubert HB, Krishnan E, Bruce BB, Lingala VB, Fries JF. Lifestyle Risk Factors Predict Disability and Death in Healthy Aging Adults. The American Journal of Medicine. 2012 Feb; 125(2): 190–7. |
[93] | Ford ES, Zhao G, Tsai J, Li C. Low-Risk Lifestyle Behaviors and All-Cause Mortality: Findings From the National Health and Nutrition Examination Survey III Mortality Study. American Journal of Public Health. 2011 Oct; 101(10): 1922–9. |
[94] | Kvaavik E. Influence of Individual and Combined Health Behaviors on Total and Cause-Specific Mortality in Men and Women. Archives of Internal Medicine. 2010 Apr 26; 170(8): 711. |
[95] | Buchman AS, Boyle PA, Yu L, Shah RC, Wilson RS, Bennett DA. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology. 2012 Apr 24; 78(17): 1323–9. |
[96] | Gow AJ, Bastin ME, Muñoz Maniega S, Valdés Hernández MC, Morris Z, Murray C, et al. Neuroprotective lifestyles and the aging brain. Neurology. 2012 Oct 23; 79(17): 1802–8. |
[97] | Iwasa H, Yoshida Y, Kai I, Suzuki T, Kim H, Yoshida H. Leisure activities and cognitive function in elderly community-dwelling individuals in Japan: A 5-year prospective cohort study. Journal of Psychosomatic Research. 2012 Feb; 72(2): 159–64. |
[98] | Ruscheweyh R, Willemer C, Krüger K, Duning T, Warnecke T, Sommer J, et al. Physical activity and memory functions: An interventional study. Neurobiology of Aging. 2011 Jul; 32(7): 1304–19. |
[99] | Hagger-Johnson G, Sabia S, Brunner EJ, Shipley M, Bobak M, Marmot M, et al. Combined impact of smoking and heavy alcohol use on cognitive decline in early old age: Whitehall II prospective cohort study. British Journal of Psychiatry. 2013 Aug; 203(2): 120–5. |
[100] | Singh-Manoux A, Czernichow S, Elbaz A, Dugravot A, Sabia S, Hagger-Johnson G, et al. Obesity phenotypes in midlife and cognition in early old age. Neurology. 2012 Aug 21; 79(8): 755–62. |
[101] | Gelber RP, Petrovitch H, Masaki KH, Abbott RD, Ross GW, Launer LJ, et al. Lifestyle and the Risk of Dementia in Japanese-American Men. Journal of the American Geriatrics Society. 2011 Dec 28; 60(1): 118–23. |
[102] | Alexopoulos P, Richter-Schmidinger T, Horn M, Maus S, Reichel M, Sidiropoulos C, et al. Hippocampal Volume Differences Between Healthy Young Apolipoprotein E ε2 and ε4 Carriers. Journal of Alzheimer’s Disease. 2011 Sep 9; 26(2): 207–10. |
[103] | Vrijsen J, Abu-Hanna A, de Rooij SE, Smidt N. Association between dementia parental family history and mid-life modifiable risk factors for dementia: a cross-sectional study using propensity score matching within the Lifelines cohort. BMJ Open. 2021 Dec; 11(12): e049918. |
[104] | Brayne C, Gao L, Dewey M, Matthews FE. Dementia before Death in Ageing Societies— The Promise of Prevention and the Reality. PLoS Medicine. 2006 Oct 31; 3(10): e397. |
[105] | Milne R, Diaz A, Badger S, Bunnik E, Fauria K, Wells K. At, with and beyond risk: expectations of living with the possibility of future dementia. Sociology of Health & Illness. 2018 Apr 16; 40(6): 969–87. |
[106] | Sindi S, Kåreholt I, Eskelinen M, Hooshmand B, Lehtisalo J, Soininen H, et al. Healthy Dietary Changes in Midlife Are Associated with Reduced Dementia Risk Later in Life. Nutrients. 2018 Nov 3; 10(11): 1649. |
[107] | Cisek-Woźniak A, Mruczyk K, Wójciak RW. The Association between Physical Activity and Selected Parameters of Psychological Status and Dementia in Older Women. International Journal of Environmental Research and Public Health. 2021 Jul 15; 18(14): 7549. |
[108] | Lafortune L, Martin S, Kelly S, Kuhn I, Remes O, Cowan A, et al. Behavioural Risk Factors in Mid-Life Associated with Successful Ageing, Disability, Dementia and Frailty in Later Life: A Rapid Systematic Review. PLOS ONE. 2016 Feb 4; 11(2): e0144405. |
APA Style
Ayandeyi, K. F., Shaha, S., Chilaka, M. (2024). Analysis of Midlife Approaches to Reduce the Risk Factors of Dementia Among Adults in the United Kingdom. Journal of Family Medicine and Health Care, 10(3), 67-84. https://doi.org/10.11648/j.jfmhc.20241003.14
ACS Style
Ayandeyi, K. F.; Shaha, S.; Chilaka, M. Analysis of Midlife Approaches to Reduce the Risk Factors of Dementia Among Adults in the United Kingdom. J. Fam. Med. Health Care 2024, 10(3), 67-84. doi: 10.11648/j.jfmhc.20241003.14
AMA Style
Ayandeyi KF, Shaha S, Chilaka M. Analysis of Midlife Approaches to Reduce the Risk Factors of Dementia Among Adults in the United Kingdom. J Fam Med Health Care. 2024;10(3):67-84. doi: 10.11648/j.jfmhc.20241003.14
@article{10.11648/j.jfmhc.20241003.14, author = {Kehinde Francisca Ayandeyi and Sabita Shaha and Marcus Chilaka}, title = {Analysis of Midlife Approaches to Reduce the Risk Factors of Dementia Among Adults in the United Kingdom }, journal = {Journal of Family Medicine and Health Care}, volume = {10}, number = {3}, pages = {67-84}, doi = {10.11648/j.jfmhc.20241003.14}, url = {https://doi.org/10.11648/j.jfmhc.20241003.14}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20241003.14}, abstract = {Dementia is an illness of the brain in which there is deterioration in a person's cognitive abilities. This interferes with one's ability to carry out everyday tasks and maintain social autonomy by adversely affecting memory, behavior, reasoning, and social capacities. The study reviewed the epidemiological literature on dementia and its risk factors as well as the several midlife strategies for lowering the risk of dementia. This is with a view to explore the midlife strategies in lowering the risk factors of dementia among adults in the United Kingdom. The study adopted reviews of literature carried out systematically. The specifications described in the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)” were followed in reviewing the literature to ensure a comprehensive and transparent methodology. Literature search was conducted systematically in scientific databases to identify empirical studies that are pertinent. The comprehensive search strategy aimed to retrieve as many relevant studies as possible within the scope of the review. It employed a combination of keywords related to dementia risk factors, behavioral and psychological impacts, older people, and the UK context. The search terms were adapted to fit the specific requirements of each database, ensuring optimal retrieval of relevant literature. In total, 16 publications were included in the study after the eligibility of these articles was verified. By leveraging the potential advantages of internet-based, individualised health prevention measures, both the general public and primary care providers become more aware of dementia as well as help to solve the issue. Dementia and various cognitive impairments have been repeatedly associated to high blood pressure. Recent findings support the idea that decreasing blood pressure in middle age is an important strategy for preventing dementia in old age. Education has a protective impact and that the majority of previously investigated risk factors including physical inactivity, diabetes, air pollution, hearing loss, hypertension, obesity, social isolation, depression, and smoking increase the incidence of dementia. People who adhered to the MedDiet the best had a 23% reduced risk of dementia than those who adhered the least. The study concluded that significant modifiable risk variables, particularly socioeconomic and lifestyle factors, were more strongly associated with dementia and contributed to higher attributable fractions of dementia cases. }, year = {2024} }
TY - JOUR T1 - Analysis of Midlife Approaches to Reduce the Risk Factors of Dementia Among Adults in the United Kingdom AU - Kehinde Francisca Ayandeyi AU - Sabita Shaha AU - Marcus Chilaka Y1 - 2024/09/29 PY - 2024 N1 - https://doi.org/10.11648/j.jfmhc.20241003.14 DO - 10.11648/j.jfmhc.20241003.14 T2 - Journal of Family Medicine and Health Care JF - Journal of Family Medicine and Health Care JO - Journal of Family Medicine and Health Care SP - 67 EP - 84 PB - Science Publishing Group SN - 2469-8342 UR - https://doi.org/10.11648/j.jfmhc.20241003.14 AB - Dementia is an illness of the brain in which there is deterioration in a person's cognitive abilities. This interferes with one's ability to carry out everyday tasks and maintain social autonomy by adversely affecting memory, behavior, reasoning, and social capacities. The study reviewed the epidemiological literature on dementia and its risk factors as well as the several midlife strategies for lowering the risk of dementia. This is with a view to explore the midlife strategies in lowering the risk factors of dementia among adults in the United Kingdom. The study adopted reviews of literature carried out systematically. The specifications described in the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)” were followed in reviewing the literature to ensure a comprehensive and transparent methodology. Literature search was conducted systematically in scientific databases to identify empirical studies that are pertinent. The comprehensive search strategy aimed to retrieve as many relevant studies as possible within the scope of the review. It employed a combination of keywords related to dementia risk factors, behavioral and psychological impacts, older people, and the UK context. The search terms were adapted to fit the specific requirements of each database, ensuring optimal retrieval of relevant literature. In total, 16 publications were included in the study after the eligibility of these articles was verified. By leveraging the potential advantages of internet-based, individualised health prevention measures, both the general public and primary care providers become more aware of dementia as well as help to solve the issue. Dementia and various cognitive impairments have been repeatedly associated to high blood pressure. Recent findings support the idea that decreasing blood pressure in middle age is an important strategy for preventing dementia in old age. Education has a protective impact and that the majority of previously investigated risk factors including physical inactivity, diabetes, air pollution, hearing loss, hypertension, obesity, social isolation, depression, and smoking increase the incidence of dementia. People who adhered to the MedDiet the best had a 23% reduced risk of dementia than those who adhered the least. The study concluded that significant modifiable risk variables, particularly socioeconomic and lifestyle factors, were more strongly associated with dementia and contributed to higher attributable fractions of dementia cases. VL - 10 IS - 3 ER -