The Effect of Hypothyroidism on Pulmonary Function in School-age Children

Rahaf Sleman; Ahmed Chreitah; Maamoun Hakim

doi:doi:10.11648/j.jfmhc.20210704.15

| Peer-Reviewed

The Effect of Hypothyroidism on Pulmonary Function in School-age Children

Rahaf Sleman, Ahmed Chreitah, Maamoun Hakim

Published in Journal of Family Medicine and Health Care (Volume 7, Issue 4)

Received: 31 October 2021 Accepted: 23 November 2021 Published: 24 December 2021

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Background: Hypothyroidism is a relative public health problem in pediatric, associated with increased morbidity due to multisystemic impairment including deleterious changes in lung function. Objective: The aim of this study is to assess lung function in children affected by hypothyroidism. In addition to, comparison lung function between clinical and subclinical hypothyroidism. Materials and Methods: An Observational Comparative Cross-Sectional study was conducted in 40 patients with newly diagnosed hypothyroidism and 40 healthy children aged 6-14 years. They are selected from Endocrinology and General Pediatric Clinic, Tishreen University Hospital between August 2020 and August 2021. Weight and height were measured and body mass index BMI was calculated. Blood samples were taken and TSH, FT4 were measured. Results: A total of 80 children, 30 males (37.5%) and 50 females (62.5%) with mean age 10.4±2.1 years were included in the study. Out of the 80 children, 40 (50%) were euthyroidism, 20 (25%) were with subclinical hypothyroidism, and 20 (25%) were with clinical hypothyroidism. BMI was higher in patients with clinical hypothyroidism compared to other groups with significant difference (p: 0.04). A statistically significant decrease in FEV1, FVC, and increase in FEV1/FVC were seen in children with clinical hypothyroidism compared to other children (p: 0.0001). Significant negative correlation was seen between TSH and FEV1 (r:-0.36, p: 0.02), FVC (r:-0.64, p: 0.0001), and positive correlation with FEV1/FVC (r: 0.44, p: 0.004). Positive correlation was found between FT4 and FEV1 (r: 0.88, p: 0.04), FVC (r: 0.49, p: 0.001) and negative correlation with FEV1/FVC (r: -0.43, p: 0.006).

Published in	Journal of Family Medicine and Health Care (Volume 7, Issue 4)
DOI	10.11648/j.jfmhc.20210704.15
Page(s)	108-111
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Hypothyroidism, Pulmonary Function, Body Mass Index

References

[1]	Wassner A (2017). Pediatric hypothyroidism: diagnosis and treatment. Paediatr Drugs. 19: 291-301.
[2]	Diaz A, Lipman D (2014). Hypothyroidism. Pediatr Rev. 35: 336-7.
[3]	Hanley P, Lord K, Bauer A (2016). Thyroid disorders in children and adolescents: a review. JAMA Pediatr. 170: 1008-19.
[4]	Salerno M, Capalbo D, Cerbone M (2016). Subclinical hypothyroidism in childhood –current knowledge and open issues. Nat Rev Endocrinol. 12: 734-746.
[5]	Alexander K. C. Leung, Alexander A. C. Leung (2019) Evaluation and management of the child with hypothyroidism.
[6]	Bona G, Monzani A, De Luca F (2015). Thyroid diseases in childhood: Recent advances from basic science to clinical practice. Springer Switzerland: Springer International. 75-83.
[7]	Yaqub B I, Suhail M, Solepure A B, Daimi BA, Bemat Ishrat Fa, Study of pulmonary function test in hypothyroidism. Indian J Clin Anat Physiol 2018; 5 (3): 394-396
[8]	Siafakas N, Salesiotou V, Bouros D (1992). Respiratory muscle strength in hypothyroidism. Chest. 102: 189-194.
[9]	Cakmak G, Saler T, Demir T (2007). Spirometry in patients with clinical and subclinical hypothyroidism. Tuberk Toraks. 55: 266-270.
[10]	Dombkowski K, Clark S, Wasilevich E (2010). Spirometry use among pediatric primary care physicians. Pediatrics. 126: 682.
[11]	Cole T, Freeman J, Preece M (1995). Body mass index reference curves for the UK. Arch Dis Child. 73: 25-29.
[12]	Gaffin J, Shotola N, Martin T, Phipatanakul W (2010). Clinically useful spirometry in school-aged children: evaluation of the 2007 American Thoracic Society guidelines. J Asthma. 47: 762-7.
[13]	Rasha N Mohammed, Haitham J. kadhumand Ali R Hashim. Spirometry in adult hypothyroid patients: a comparative study “Journal of basic and Clinical Physiology and Pharmacology” (2021) 189-195.
[14]	Valjevac S, Hadzovic –Dzuvo A (2011). Assessment of lung dysfunction with spirometry in patients with thyroid disorders. Acta Inform Med. 19: 16-18.
[15]	Gulay Y, Mine A, Aysen H (2013). Evaluation of respiratory functions in subclinical and clinical hypothyroidism. Journal of Turgut Ozal Medical Center. 20: 8-11.
[16]	Sivaranjani H, Chaitra K (2019). The study of pulmonary function tests in patients with hypothyroidism. Int J Adv Med.: 1774-1778.

Cite This Article

Plain Text BibTeX RIS

APA Style

Rahaf Sleman, Ahmed Chreitah, Maamoun Hakim. (2021). The Effect of Hypothyroidism on Pulmonary Function in School-age Children. Journal of Family Medicine and Health Care, 7(4), 108-111. https://doi.org/10.11648/j.jfmhc.20210704.15

Copy | Download

ACS Style

Rahaf Sleman; Ahmed Chreitah; Maamoun Hakim. The Effect of Hypothyroidism on Pulmonary Function in School-age Children. J. Fam. Med. Health Care 2021, 7(4), 108-111. doi: 10.11648/j.jfmhc.20210704.15

Copy | Download

AMA Style

Rahaf Sleman, Ahmed Chreitah, Maamoun Hakim. The Effect of Hypothyroidism on Pulmonary Function in School-age Children. J Fam Med Health Care. 2021;7(4):108-111. doi: 10.11648/j.jfmhc.20210704.15

Copy | Download

@article{10.11648/j.jfmhc.20210704.15,
  author = {Rahaf Sleman and Ahmed Chreitah and Maamoun Hakim},
  title = {The Effect of Hypothyroidism on Pulmonary Function in School-age Children},
  journal = {Journal of Family Medicine and Health Care},
  volume = {7},
  number = {4},
  pages = {108-111},
  doi = {10.11648/j.jfmhc.20210704.15},
  url = {https://doi.org/10.11648/j.jfmhc.20210704.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20210704.15},
  abstract = {Background: Hypothyroidism is a relative public health problem in pediatric, associated with increased morbidity due to multisystemic impairment including deleterious changes in lung function. Objective: The aim of this study is to assess lung function in children affected by hypothyroidism. In addition to, comparison lung function between clinical and subclinical hypothyroidism. Materials and Methods: An Observational Comparative Cross-Sectional study was conducted in 40 patients with newly diagnosed hypothyroidism and 40 healthy children aged 6-14 years. They are selected from Endocrinology and General Pediatric Clinic, Tishreen University Hospital between August 2020 and August 2021. Weight and height were measured and body mass index BMI was calculated. Blood samples were taken and TSH, FT4 were measured. Results: A total of 80 children, 30 males (37.5%) and 50 females (62.5%) with mean age 10.4±2.1 years were included in the study. Out of the 80 children, 40 (50%) were euthyroidism, 20 (25%) were with subclinical hypothyroidism, and 20 (25%) were with clinical hypothyroidism. BMI was higher in patients with clinical hypothyroidism compared to other groups with significant difference (p: 0.04). A statistically significant decrease in FEV1, FVC, and increase in FEV1/FVC were seen in children with clinical hypothyroidism compared to other children (p: 0.0001). Significant negative correlation was seen between TSH and FEV1 (r:-0.36, p: 0.02), FVC (r:-0.64, p: 0.0001), and positive correlation with FEV1/FVC (r: 0.44, p: 0.004). Positive correlation was found between FT4 and FEV1 (r: 0.88, p: 0.04), FVC (r: 0.49, p: 0.001) and negative correlation with FEV1/FVC (r: -0.43, p: 0.006).},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - The Effect of Hypothyroidism on Pulmonary Function in School-age Children
AU  - Rahaf Sleman
AU  - Ahmed Chreitah
AU  - Maamoun Hakim
Y1  - 2021/12/24
PY  - 2021
N1  - https://doi.org/10.11648/j.jfmhc.20210704.15
DO  - 10.11648/j.jfmhc.20210704.15
T2  - Journal of Family Medicine and Health Care
JF  - Journal of Family Medicine and Health Care
JO  - Journal of Family Medicine and Health Care
SP  - 108
EP  - 111
PB  - Science Publishing Group
SN  - 2469-8342
UR  - https://doi.org/10.11648/j.jfmhc.20210704.15
AB  - Background: Hypothyroidism is a relative public health problem in pediatric, associated with increased morbidity due to multisystemic impairment including deleterious changes in lung function. Objective: The aim of this study is to assess lung function in children affected by hypothyroidism. In addition to, comparison lung function between clinical and subclinical hypothyroidism. Materials and Methods: An Observational Comparative Cross-Sectional study was conducted in 40 patients with newly diagnosed hypothyroidism and 40 healthy children aged 6-14 years. They are selected from Endocrinology and General Pediatric Clinic, Tishreen University Hospital between August 2020 and August 2021. Weight and height were measured and body mass index BMI was calculated. Blood samples were taken and TSH, FT4 were measured. Results: A total of 80 children, 30 males (37.5%) and 50 females (62.5%) with mean age 10.4±2.1 years were included in the study. Out of the 80 children, 40 (50%) were euthyroidism, 20 (25%) were with subclinical hypothyroidism, and 20 (25%) were with clinical hypothyroidism. BMI was higher in patients with clinical hypothyroidism compared to other groups with significant difference (p: 0.04). A statistically significant decrease in FEV1, FVC, and increase in FEV1/FVC were seen in children with clinical hypothyroidism compared to other children (p: 0.0001). Significant negative correlation was seen between TSH and FEV1 (r:-0.36, p: 0.02), FVC (r:-0.64, p: 0.0001), and positive correlation with FEV1/FVC (r: 0.44, p: 0.004). Positive correlation was found between FT4 and FEV1 (r: 0.88, p: 0.04), FVC (r: 0.49, p: 0.001) and negative correlation with FEV1/FVC (r: -0.43, p: 0.006).
VL  - 7
IS  - 4
ER  -

Copy | Download

Author Information

Rahaf Sleman

Faculty of Medicine, Department of Pediatric, Tishreen University, Lattakia, Syria
Ahmed Chreitah

Faculty of Medicine, Department of Pediatric, Tishreen University, Lattakia, Syria
Maamoun Hakim

Faculty of Medicine, Department of Pediatric, Tishreen University, Lattakia, Syria

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Rahaf Sleman, Ahmed Chreitah, Maamoun Hakim. (2021). The Effect of Hypothyroidism on Pulmonary Function in School-age Children. Journal of Family Medicine and Health Care, 7(4), 108-111. https://doi.org/10.11648/j.jfmhc.20210704.15

Copy | Download

ACS Style

Rahaf Sleman; Ahmed Chreitah; Maamoun Hakim. The Effect of Hypothyroidism on Pulmonary Function in School-age Children. J. Fam. Med. Health Care 2021, 7(4), 108-111. doi: 10.11648/j.jfmhc.20210704.15

Copy | Download

AMA Style

Rahaf Sleman, Ahmed Chreitah, Maamoun Hakim. The Effect of Hypothyroidism on Pulmonary Function in School-age Children. J Fam Med Health Care. 2021;7(4):108-111. doi: 10.11648/j.jfmhc.20210704.15

Copy | Download

@article{10.11648/j.jfmhc.20210704.15,
  author = {Rahaf Sleman and Ahmed Chreitah and Maamoun Hakim},
  title = {The Effect of Hypothyroidism on Pulmonary Function in School-age Children},
  journal = {Journal of Family Medicine and Health Care},
  volume = {7},
  number = {4},
  pages = {108-111},
  doi = {10.11648/j.jfmhc.20210704.15},
  url = {https://doi.org/10.11648/j.jfmhc.20210704.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20210704.15},
  abstract = {Background: Hypothyroidism is a relative public health problem in pediatric, associated with increased morbidity due to multisystemic impairment including deleterious changes in lung function. Objective: The aim of this study is to assess lung function in children affected by hypothyroidism. In addition to, comparison lung function between clinical and subclinical hypothyroidism. Materials and Methods: An Observational Comparative Cross-Sectional study was conducted in 40 patients with newly diagnosed hypothyroidism and 40 healthy children aged 6-14 years. They are selected from Endocrinology and General Pediatric Clinic, Tishreen University Hospital between August 2020 and August 2021. Weight and height were measured and body mass index BMI was calculated. Blood samples were taken and TSH, FT4 were measured. Results: A total of 80 children, 30 males (37.5%) and 50 females (62.5%) with mean age 10.4±2.1 years were included in the study. Out of the 80 children, 40 (50%) were euthyroidism, 20 (25%) were with subclinical hypothyroidism, and 20 (25%) were with clinical hypothyroidism. BMI was higher in patients with clinical hypothyroidism compared to other groups with significant difference (p: 0.04). A statistically significant decrease in FEV1, FVC, and increase in FEV1/FVC were seen in children with clinical hypothyroidism compared to other children (p: 0.0001). Significant negative correlation was seen between TSH and FEV1 (r:-0.36, p: 0.02), FVC (r:-0.64, p: 0.0001), and positive correlation with FEV1/FVC (r: 0.44, p: 0.004). Positive correlation was found between FT4 and FEV1 (r: 0.88, p: 0.04), FVC (r: 0.49, p: 0.001) and negative correlation with FEV1/FVC (r: -0.43, p: 0.006).},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - The Effect of Hypothyroidism on Pulmonary Function in School-age Children
AU  - Rahaf Sleman
AU  - Ahmed Chreitah
AU  - Maamoun Hakim
Y1  - 2021/12/24
PY  - 2021
N1  - https://doi.org/10.11648/j.jfmhc.20210704.15
DO  - 10.11648/j.jfmhc.20210704.15
T2  - Journal of Family Medicine and Health Care
JF  - Journal of Family Medicine and Health Care
JO  - Journal of Family Medicine and Health Care
SP  - 108
EP  - 111
PB  - Science Publishing Group
SN  - 2469-8342
UR  - https://doi.org/10.11648/j.jfmhc.20210704.15
AB  - Background: Hypothyroidism is a relative public health problem in pediatric, associated with increased morbidity due to multisystemic impairment including deleterious changes in lung function. Objective: The aim of this study is to assess lung function in children affected by hypothyroidism. In addition to, comparison lung function between clinical and subclinical hypothyroidism. Materials and Methods: An Observational Comparative Cross-Sectional study was conducted in 40 patients with newly diagnosed hypothyroidism and 40 healthy children aged 6-14 years. They are selected from Endocrinology and General Pediatric Clinic, Tishreen University Hospital between August 2020 and August 2021. Weight and height were measured and body mass index BMI was calculated. Blood samples were taken and TSH, FT4 were measured. Results: A total of 80 children, 30 males (37.5%) and 50 females (62.5%) with mean age 10.4±2.1 years were included in the study. Out of the 80 children, 40 (50%) were euthyroidism, 20 (25%) were with subclinical hypothyroidism, and 20 (25%) were with clinical hypothyroidism. BMI was higher in patients with clinical hypothyroidism compared to other groups with significant difference (p: 0.04). A statistically significant decrease in FEV1, FVC, and increase in FEV1/FVC were seen in children with clinical hypothyroidism compared to other children (p: 0.0001). Significant negative correlation was seen between TSH and FEV1 (r:-0.36, p: 0.02), FVC (r:-0.64, p: 0.0001), and positive correlation with FEV1/FVC (r: 0.44, p: 0.004). Positive correlation was found between FT4 and FEV1 (r: 0.88, p: 0.04), FVC (r: 0.49, p: 0.001) and negative correlation with FEV1/FVC (r: -0.43, p: 0.006).
VL  - 7
IS  - 4
ER  -

Copy | Download