Isolation of Mycotoxigenic Fungi, Detection and Quantification of Ochratoxin A from Coffee (<i>Coffea arabica</i> L.)

Legese Hagos; Nagassa Dechassa; Kifle Belachew; Demelash Teferi; Solomon Yilma; Gabisa Gidisa

doi:doi:10.11648/j.jddmc.20200604.12

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Isolation of Mycotoxigenic Fungi, Detection and Quantification of Ochratoxin A from Coffee (Coffea arabica L.)

Legese Hagos, Nagassa Dechassa, Kifle Belachew, Demelash Teferi, Solomon Yilma, Gabisa Gidisa

Published in Journal of Drug Design and Medicinal Chemistry (Volume 6, Issue 4)

Received: 30 December 2020 Accepted: 12 January 2021 Published: 22 January 2021

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Abstract

Introduction. Successful prevention of mother-to-child transmission (PMTCT) of the human immunodeficiency virus (HIV) requires early diagnosis, consistent access to antiretroviral therapy (ART), and regular health care during and after pregnancy. This study assessed the determinants of early HIV diagnosis by children born to HIV-positive (HIV+) mothers in the Kongo Central Province, Democratic Republic of the Congo (DRC). Methodology. Data from 230 HIV+ mothers screened under the PMTCT program between July 2015 and December 2017 were extracted from the databases of 31 Health Zones (HZ) of Kongo Central province. Data detailing laboratory and anthropometric findings, morbidity, and mortality were collected from each exposed child. The determinants of inaccessibility to early diagnosis were identified using logistic regression. Results. The mothers' mean age was 32.4 years, and 90.9% were on ART; 68.8% of children were older than 12 months at diagnosis. Diagnosis during the first 6 months of the child’s life was critical. Malnutrition was found in almost 90% of the children. Determinants of non-access to an early diagnosis were mothers who attained a primary education level and did not disclose their HIV status. Conclusion. All possible interventions should be considered to prevent mother-to-child HIV transmission. To ensure a child’s survival to their first birthday, early diagnosis should be performed soon after birth to an HIV+ mother and ART should be initiated.

Published in	Journal of Drug Design and Medicinal Chemistry (Volume 6, Issue 4)
DOI	10.11648/j.jddmc.20200604.12
Page(s)	47-52
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Coffee, Ethiopia, Mycotoxigenic Fungi, Ochratoxin A

References

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APA Style

Legese Hagos, Nagassa Dechassa, Kifle Belachew, Demelash Teferi, Solomon Yilma, et al. (2021). Isolation of Mycotoxigenic Fungi, Detection and Quantification of Ochratoxin A from Coffee (Coffea arabica L.). Journal of Drug Design and Medicinal Chemistry, 6(4), 47-52. https://doi.org/10.11648/j.jddmc.20200604.12

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ACS Style

Legese Hagos; Nagassa Dechassa; Kifle Belachew; Demelash Teferi; Solomon Yilma, et al. Isolation of Mycotoxigenic Fungi, Detection and Quantification of Ochratoxin A from Coffee (Coffea arabica L.). J. Drug Des. Med. Chem. 2021, 6(4), 47-52. doi: 10.11648/j.jddmc.20200604.12

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AMA Style

Legese Hagos, Nagassa Dechassa, Kifle Belachew, Demelash Teferi, Solomon Yilma, et al. Isolation of Mycotoxigenic Fungi, Detection and Quantification of Ochratoxin A from Coffee (Coffea arabica L.). J Drug Des Med Chem. 2021;6(4):47-52. doi: 10.11648/j.jddmc.20200604.12

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@article{10.11648/j.jddmc.20200604.12,
  author = {Legese Hagos and Nagassa Dechassa and Kifle Belachew and Demelash Teferi and Solomon Yilma and Gabisa Gidisa},
  title = {Isolation of Mycotoxigenic Fungi, Detection and Quantification of Ochratoxin A from Coffee (Coffea arabica L.)},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {6},
  number = {4},
  pages = {47-52},
  doi = {10.11648/j.jddmc.20200604.12},
  url = {https://doi.org/10.11648/j.jddmc.20200604.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20200604.12},
  abstract = {Introduction. Successful prevention of mother-to-child transmission (PMTCT) of the human immunodeficiency virus (HIV) requires early diagnosis, consistent access to antiretroviral therapy (ART), and regular health care during and after pregnancy. This study assessed the determinants of early HIV diagnosis by children born to HIV-positive (HIV+) mothers in the Kongo Central Province, Democratic Republic of the Congo (DRC). Methodology. Data from 230 HIV+ mothers screened under the PMTCT program between July 2015 and December 2017 were extracted from the databases of 31 Health Zones (HZ) of Kongo Central province. Data detailing laboratory and anthropometric findings, morbidity, and mortality were collected from each exposed child. The determinants of inaccessibility to early diagnosis were identified using logistic regression. Results. The mothers' mean age was 32.4 years, and 90.9% were on ART; 68.8% of children were older than 12 months at diagnosis. Diagnosis during the first 6 months of the child’s life was critical. Malnutrition was found in almost 90% of the children. Determinants of non-access to an early diagnosis were mothers who attained a primary education level and did not disclose their HIV status. Conclusion. All possible interventions should be considered to prevent mother-to-child HIV transmission. To ensure a child’s survival to their first birthday, early diagnosis should be performed soon after birth to an HIV+ mother and ART should be initiated.},
 year = {2021}
}

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TY - JOUR
T1 - Isolation of Mycotoxigenic Fungi, Detection and Quantification of Ochratoxin A from Coffee (Coffea arabica L.)
AU - Legese Hagos
AU - Nagassa Dechassa
AU - Kifle Belachew
AU - Demelash Teferi
AU - Solomon Yilma
AU - Gabisa Gidisa
Y1 - 2021/01/22
PY - 2021
N1 - https://doi.org/10.11648/j.jddmc.20200604.12
DO - 10.11648/j.jddmc.20200604.12
T2 - Journal of Drug Design and Medicinal Chemistry
JF - Journal of Drug Design and Medicinal Chemistry
JO - Journal of Drug Design and Medicinal Chemistry
SP - 47
EP - 52
PB - Science Publishing Group
SN - 2472-3576
UR - https://doi.org/10.11648/j.jddmc.20200604.12
AB - Introduction. Successful prevention of mother-to-child transmission (PMTCT) of the human immunodeficiency virus (HIV) requires early diagnosis, consistent access to antiretroviral therapy (ART), and regular health care during and after pregnancy. This study assessed the determinants of early HIV diagnosis by children born to HIV-positive (HIV+) mothers in the Kongo Central Province, Democratic Republic of the Congo (DRC). Methodology. Data from 230 HIV+ mothers screened under the PMTCT program between July 2015 and December 2017 were extracted from the databases of 31 Health Zones (HZ) of Kongo Central province. Data detailing laboratory and anthropometric findings, morbidity, and mortality were collected from each exposed child. The determinants of inaccessibility to early diagnosis were identified using logistic regression. Results. The mothers' mean age was 32.4 years, and 90.9% were on ART; 68.8% of children were older than 12 months at diagnosis. Diagnosis during the first 6 months of the child’s life was critical. Malnutrition was found in almost 90% of the children. Determinants of non-access to an early diagnosis were mothers who attained a primary education level and did not disclose their HIV status. Conclusion. All possible interventions should be considered to prevent mother-to-child HIV transmission. To ensure a child’s survival to their first birthday, early diagnosis should be performed soon after birth to an HIV+ mother and ART should be initiated.
VL - 6
IS - 4
ER -

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Author Information

Legese Hagos

Ethiopian Institute of Agricultural Research, Jimma Agricultural Research Center, Jimma, Ethiopia
Nagassa Dechassa

Ethiopian Institute of Agricultural Research, Ambo Plant Protection Research Center, Ambo, Ethiopia
Kifle Belachew

Ethiopian Institute of Agricultural Research, Jimma Agricultural Research Center, Jimma, Ethiopia
Demelash Teferi

Ethiopian Institute of Agricultural Research, Jimma Agricultural Research Center, Jimma, Ethiopia
Solomon Yilma

Ethiopian Institute of Agricultural Research, Ambo Plant Protection Research Center, Ambo, Ethiopia
Gabisa Gidisa

Ethiopian Institute of Agricultural Research, Jimma Agricultural Research Center, Jimma, Ethiopia

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Legese Hagos, Nagassa Dechassa, Kifle Belachew, Demelash Teferi, Solomon Yilma, et al. (2021). Isolation of Mycotoxigenic Fungi, Detection and Quantification of Ochratoxin A from Coffee (Coffea arabica L.). Journal of Drug Design and Medicinal Chemistry, 6(4), 47-52. https://doi.org/10.11648/j.jddmc.20200604.12

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ACS Style

Legese Hagos; Nagassa Dechassa; Kifle Belachew; Demelash Teferi; Solomon Yilma, et al. Isolation of Mycotoxigenic Fungi, Detection and Quantification of Ochratoxin A from Coffee (Coffea arabica L.). J. Drug Des. Med. Chem. 2021, 6(4), 47-52. doi: 10.11648/j.jddmc.20200604.12

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AMA Style

Legese Hagos, Nagassa Dechassa, Kifle Belachew, Demelash Teferi, Solomon Yilma, et al. Isolation of Mycotoxigenic Fungi, Detection and Quantification of Ochratoxin A from Coffee (Coffea arabica L.). J Drug Des Med Chem. 2021;6(4):47-52. doi: 10.11648/j.jddmc.20200604.12

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@article{10.11648/j.jddmc.20200604.12,
  author = {Legese Hagos and Nagassa Dechassa and Kifle Belachew and Demelash Teferi and Solomon Yilma and Gabisa Gidisa},
  title = {Isolation of Mycotoxigenic Fungi, Detection and Quantification of Ochratoxin A from Coffee (Coffea arabica L.)},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {6},
  number = {4},
  pages = {47-52},
  doi = {10.11648/j.jddmc.20200604.12},
  url = {https://doi.org/10.11648/j.jddmc.20200604.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20200604.12},
  abstract = {Introduction. Successful prevention of mother-to-child transmission (PMTCT) of the human immunodeficiency virus (HIV) requires early diagnosis, consistent access to antiretroviral therapy (ART), and regular health care during and after pregnancy. This study assessed the determinants of early HIV diagnosis by children born to HIV-positive (HIV+) mothers in the Kongo Central Province, Democratic Republic of the Congo (DRC). Methodology. Data from 230 HIV+ mothers screened under the PMTCT program between July 2015 and December 2017 were extracted from the databases of 31 Health Zones (HZ) of Kongo Central province. Data detailing laboratory and anthropometric findings, morbidity, and mortality were collected from each exposed child. The determinants of inaccessibility to early diagnosis were identified using logistic regression. Results. The mothers' mean age was 32.4 years, and 90.9% were on ART; 68.8% of children were older than 12 months at diagnosis. Diagnosis during the first 6 months of the child’s life was critical. Malnutrition was found in almost 90% of the children. Determinants of non-access to an early diagnosis were mothers who attained a primary education level and did not disclose their HIV status. Conclusion. All possible interventions should be considered to prevent mother-to-child HIV transmission. To ensure a child’s survival to their first birthday, early diagnosis should be performed soon after birth to an HIV+ mother and ART should be initiated.},
 year = {2021}
}

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