Recently, cancer progression has been linked to a trans-membrane receptor, neuropilin. Studies show that neuropilins are widely distributed in the body and these receptors appear to control the vasculirization of tumors. Neuropilins 1 and 2 are known to be involved in angiogenesis and vascular development and are receptors for vascular endothelial growth factor (VEGF) and the class 3 semaphorins. Angiogenesis, which is a feature of many malignancies, is aided by increased neuropilin expression. Hence, high neuropilin expression correlates with tumor progression and poor prognosis. Attempts are being made to suppress tumor growth and invasion by employing agents that suppress angiogenesis. This is of great interest, because blockade or inhibition of these molecules may be used as therapeutic agents in cancer therapy. In this review, the molecular biology and current knowledge of neuropilins are explored with a view to identifying their therapeutic potentials. In conclusion, neuropilin targeted intervention may be relevant as anti-cancer therapy.
| Published in | Journal of Anesthesiology (Volume 6, Issue 1) |
| DOI | 10.11648/j.ja.20180601.13 |
| Page(s) | 10-14 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2018. Published by Science Publishing Group |
Neuropilin, Semaphorins, Angiogenesis, VEGF, Malignancy, Receptor, Therapy
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APA Style
Ekpe E. L., Okorie Elsie, Emin Emin, Ekpe Victor. (2018). Neuropilins - Past, Present and Future: A Review of Its Anti-Neoplastic Potential. International Journal of Anesthesia and Clinical Medicine, 6(1), 10-14. https://doi.org/10.11648/j.ja.20180601.13
ACS Style
Ekpe E. L.; Okorie Elsie; Emin Emin; Ekpe Victor. Neuropilins - Past, Present and Future: A Review of Its Anti-Neoplastic Potential. Int. J. Anesth. Clin. Med. 2018, 6(1), 10-14. doi: 10.11648/j.ja.20180601.13
AMA Style
Ekpe E. L., Okorie Elsie, Emin Emin, Ekpe Victor. Neuropilins - Past, Present and Future: A Review of Its Anti-Neoplastic Potential. Int J Anesth Clin Med. 2018;6(1):10-14. doi: 10.11648/j.ja.20180601.13
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Download@article{10.11648/j.ja.20180601.13,
author = {Ekpe E. L. and Okorie Elsie and Emin Emin and Ekpe Victor},
title = {Neuropilins - Past, Present and Future: A Review of Its Anti-Neoplastic Potential},
journal = {International Journal of Anesthesia and Clinical Medicine},
volume = {6},
number = {1},
pages = {10-14},
doi = {10.11648/j.ja.20180601.13},
url = {https://doi.org/10.11648/j.ja.20180601.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20180601.13},
abstract = {Recently, cancer progression has been linked to a trans-membrane receptor, neuropilin. Studies show that neuropilins are widely distributed in the body and these receptors appear to control the vasculirization of tumors. Neuropilins 1 and 2 are known to be involved in angiogenesis and vascular development and are receptors for vascular endothelial growth factor (VEGF) and the class 3 semaphorins. Angiogenesis, which is a feature of many malignancies, is aided by increased neuropilin expression. Hence, high neuropilin expression correlates with tumor progression and poor prognosis. Attempts are being made to suppress tumor growth and invasion by employing agents that suppress angiogenesis. This is of great interest, because blockade or inhibition of these molecules may be used as therapeutic agents in cancer therapy. In this review, the molecular biology and current knowledge of neuropilins are explored with a view to identifying their therapeutic potentials. In conclusion, neuropilin targeted intervention may be relevant as anti-cancer therapy.},
year = {2018}
}
TY - JOUR T1 - Neuropilins - Past, Present and Future: A Review of Its Anti-Neoplastic Potential AU - Ekpe E. L. AU - Okorie Elsie AU - Emin Emin AU - Ekpe Victor Y1 - 2018/04/03 PY - 2018 N1 - https://doi.org/10.11648/j.ja.20180601.13 DO - 10.11648/j.ja.20180601.13 T2 - International Journal of Anesthesia and Clinical Medicine JF - International Journal of Anesthesia and Clinical Medicine JO - International Journal of Anesthesia and Clinical Medicine SP - 10 EP - 14 PB - Science Publishing Group SN - 2997-2698 UR - https://doi.org/10.11648/j.ja.20180601.13 AB - Recently, cancer progression has been linked to a trans-membrane receptor, neuropilin. Studies show that neuropilins are widely distributed in the body and these receptors appear to control the vasculirization of tumors. Neuropilins 1 and 2 are known to be involved in angiogenesis and vascular development and are receptors for vascular endothelial growth factor (VEGF) and the class 3 semaphorins. Angiogenesis, which is a feature of many malignancies, is aided by increased neuropilin expression. Hence, high neuropilin expression correlates with tumor progression and poor prognosis. Attempts are being made to suppress tumor growth and invasion by employing agents that suppress angiogenesis. This is of great interest, because blockade or inhibition of these molecules may be used as therapeutic agents in cancer therapy. In this review, the molecular biology and current knowledge of neuropilins are explored with a view to identifying their therapeutic potentials. In conclusion, neuropilin targeted intervention may be relevant as anti-cancer therapy. VL - 6 IS - 1 ER -
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