Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats

Veronica Inyamu Ochigbo; Joseph Olusegun Ayo; Tagang Aluwong

doi:doi:10.11648/j.ja.20170503.11

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Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats

Veronica Inyamu Ochigbo, Joseph Olusegun Ayo, Tagang Aluwong

Published in Journal of Anesthesiology (Volume 5, Issue 3)

Received: 15 May 2017 Accepted: 24 May 2017 Published: 17 July 2017

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Abstract

Ascorbic acid modulates the central nervous system either physiologically or pharmacologically, and has been proposed to function as a neuromodulator. The effect of ascorbic acid (AA, vitamin C) on some physiological parameters, onset and duration of anaesthesia following propofol anaesthesia was evaluated in goats. A total of 24 goats divided into four groups, comprising five goats each in groups I and II, and seven goats each in groups III and IV were used for the experiment. Groups I and II served as control for AA (200 mg/kg) and propofol (5 mg/kg) intravenous treatments, respectively; while groups III and IV received AA at 200 mg/kg and 300 mg/kg, respectively before propofol anaesthesia. The result showed that AA significantly (P < 0.05) decreased the onset of anaesthesia and increased the duration of propofol anaesthesia in goats. AA (300 mg/kg) induced a decrease (P < 0.05) in respiratory rate during anaesthesia, but there were no significant changes in heart rate and rectal temperature in the groups. In conclusion, AA potentiated the effect of propofol – induced anaesthesia in goats without alteration in heart rate and rectal temperature.

Published in	Journal of Anesthesiology (Volume 5, Issue 3)
DOI	10.11648/j.ja.20170503.11
Page(s)	19-23
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Propofol, Ascorbic Acid, Goat, Physiological Parameters, General Anaesthesia

References

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APA Style

Veronica Inyamu Ochigbo, Joseph Olusegun Ayo, Tagang Aluwong. (2017). Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats. International Journal of Anesthesia and Clinical Medicine, 5(3), 19-23. https://doi.org/10.11648/j.ja.20170503.11

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ACS Style

Veronica Inyamu Ochigbo; Joseph Olusegun Ayo; Tagang Aluwong. Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats. Int. J. Anesth. Clin. Med. 2017, 5(3), 19-23. doi: 10.11648/j.ja.20170503.11

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AMA Style

Veronica Inyamu Ochigbo, Joseph Olusegun Ayo, Tagang Aluwong. Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats. Int J Anesth Clin Med. 2017;5(3):19-23. doi: 10.11648/j.ja.20170503.11

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@article{10.11648/j.ja.20170503.11,
  author = {Veronica Inyamu Ochigbo and Joseph Olusegun Ayo and Tagang Aluwong},
  title = {Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {5},
  number = {3},
  pages = {19-23},
  doi = {10.11648/j.ja.20170503.11},
  url = {https://doi.org/10.11648/j.ja.20170503.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20170503.11},
  abstract = {Ascorbic acid modulates the central nervous system either physiologically or pharmacologically, and has been proposed to function as a neuromodulator. The effect of ascorbic acid (AA, vitamin C) on some physiological parameters, onset and duration of anaesthesia following propofol anaesthesia was evaluated in goats. A total of 24 goats divided into four groups, comprising five goats each in groups I and II, and seven goats each in groups III and IV were used for the experiment. Groups I and II served as control for AA (200 mg/kg) and propofol (5 mg/kg) intravenous treatments, respectively; while groups III and IV received AA at 200 mg/kg and 300 mg/kg, respectively before propofol anaesthesia. The result showed that AA significantly (P < 0.05) decreased the onset of anaesthesia and increased the duration of propofol anaesthesia in goats. AA (300 mg/kg) induced a decrease (P < 0.05) in respiratory rate during anaesthesia, but there were no significant changes in heart rate and rectal temperature in the groups. In conclusion, AA potentiated the effect of propofol – induced anaesthesia in goats without alteration in heart rate and rectal temperature.},
 year = {2017}
}

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TY  - JOUR
T1  - Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats
AU  - Veronica Inyamu Ochigbo
AU  - Joseph Olusegun Ayo
AU  - Tagang Aluwong
Y1  - 2017/07/17
PY  - 2017
N1  - https://doi.org/10.11648/j.ja.20170503.11
DO  - 10.11648/j.ja.20170503.11
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 19
EP  - 23
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ja.20170503.11
AB  - Ascorbic acid modulates the central nervous system either physiologically or pharmacologically, and has been proposed to function as a neuromodulator. The effect of ascorbic acid (AA, vitamin C) on some physiological parameters, onset and duration of anaesthesia following propofol anaesthesia was evaluated in goats. A total of 24 goats divided into four groups, comprising five goats each in groups I and II, and seven goats each in groups III and IV were used for the experiment. Groups I and II served as control for AA (200 mg/kg) and propofol (5 mg/kg) intravenous treatments, respectively; while groups III and IV received AA at 200 mg/kg and 300 mg/kg, respectively before propofol anaesthesia. The result showed that AA significantly (P < 0.05) decreased the onset of anaesthesia and increased the duration of propofol anaesthesia in goats. AA (300 mg/kg) induced a decrease (P < 0.05) in respiratory rate during anaesthesia, but there were no significant changes in heart rate and rectal temperature in the groups. In conclusion, AA potentiated the effect of propofol – induced anaesthesia in goats without alteration in heart rate and rectal temperature.
VL  - 5
IS  - 3
ER  -

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Author Information

Veronica Inyamu Ochigbo

Department of Physiology, Pharmacology and Biochemistry, University of Agriculture, Makurdi, Nigeria
Joseph Olusegun Ayo

Department of Veterinary Physiology, Ahmadu Bello University, Zaria, Nigeria
Tagang Aluwong

Department of Veterinary Physiology, Ahmadu Bello University, Zaria, Nigeria

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Plain Text BibTeX RIS

APA Style

Veronica Inyamu Ochigbo, Joseph Olusegun Ayo, Tagang Aluwong. (2017). Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats. International Journal of Anesthesia and Clinical Medicine, 5(3), 19-23. https://doi.org/10.11648/j.ja.20170503.11

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ACS Style

Veronica Inyamu Ochigbo; Joseph Olusegun Ayo; Tagang Aluwong. Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats. Int. J. Anesth. Clin. Med. 2017, 5(3), 19-23. doi: 10.11648/j.ja.20170503.11

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AMA Style

Veronica Inyamu Ochigbo, Joseph Olusegun Ayo, Tagang Aluwong. Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats. Int J Anesth Clin Med. 2017;5(3):19-23. doi: 10.11648/j.ja.20170503.11

Copy | Download

@article{10.11648/j.ja.20170503.11,
  author = {Veronica Inyamu Ochigbo and Joseph Olusegun Ayo and Tagang Aluwong},
  title = {Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {5},
  number = {3},
  pages = {19-23},
  doi = {10.11648/j.ja.20170503.11},
  url = {https://doi.org/10.11648/j.ja.20170503.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20170503.11},
  abstract = {Ascorbic acid modulates the central nervous system either physiologically or pharmacologically, and has been proposed to function as a neuromodulator. The effect of ascorbic acid (AA, vitamin C) on some physiological parameters, onset and duration of anaesthesia following propofol anaesthesia was evaluated in goats. A total of 24 goats divided into four groups, comprising five goats each in groups I and II, and seven goats each in groups III and IV were used for the experiment. Groups I and II served as control for AA (200 mg/kg) and propofol (5 mg/kg) intravenous treatments, respectively; while groups III and IV received AA at 200 mg/kg and 300 mg/kg, respectively before propofol anaesthesia. The result showed that AA significantly (P < 0.05) decreased the onset of anaesthesia and increased the duration of propofol anaesthesia in goats. AA (300 mg/kg) induced a decrease (P < 0.05) in respiratory rate during anaesthesia, but there were no significant changes in heart rate and rectal temperature in the groups. In conclusion, AA potentiated the effect of propofol – induced anaesthesia in goats without alteration in heart rate and rectal temperature.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats
AU  - Veronica Inyamu Ochigbo
AU  - Joseph Olusegun Ayo
AU  - Tagang Aluwong
Y1  - 2017/07/17
PY  - 2017
N1  - https://doi.org/10.11648/j.ja.20170503.11
DO  - 10.11648/j.ja.20170503.11
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 19
EP  - 23
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ja.20170503.11
AB  - Ascorbic acid modulates the central nervous system either physiologically or pharmacologically, and has been proposed to function as a neuromodulator. The effect of ascorbic acid (AA, vitamin C) on some physiological parameters, onset and duration of anaesthesia following propofol anaesthesia was evaluated in goats. A total of 24 goats divided into four groups, comprising five goats each in groups I and II, and seven goats each in groups III and IV were used for the experiment. Groups I and II served as control for AA (200 mg/kg) and propofol (5 mg/kg) intravenous treatments, respectively; while groups III and IV received AA at 200 mg/kg and 300 mg/kg, respectively before propofol anaesthesia. The result showed that AA significantly (P < 0.05) decreased the onset of anaesthesia and increased the duration of propofol anaesthesia in goats. AA (300 mg/kg) induced a decrease (P < 0.05) in respiratory rate during anaesthesia, but there were no significant changes in heart rate and rectal temperature in the groups. In conclusion, AA potentiated the effect of propofol – induced anaesthesia in goats without alteration in heart rate and rectal temperature.
VL  - 5
IS  - 3
ER  -

Copy | Download