C-Reactive Protein and Aggression in Patients with Schizophrenia

Kachouchi Aymen; Zemrani Yassin; Ahroui Yassine; Salim Said; Berghalout Mohammed; Adali Imane; Manoudi Fatiha; Chabaa Laila; Asri Fatima

doi:doi:10.11648/j.ijpbs.20190402.11

C-Reactive Protein and Aggression in Patients with Schizophrenia

Kachouchi Aymen, Zemrani Yassin, Ahroui Yassine, Salim Said, Berghalout Mohammed, Adali Imane, Manoudi Fatiha, Chabaa Laila, Asri Fatima

Published in International Journal of Psychological and Brain Sciences (Volume 4, Issue 2)

Received: 24 April 2019 Accepted: 24 May 2019 Published: 10 June 2019

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Abstract

Recent studies reported firstly an association between aggression and inflammation and secondly an association between inflammation and schizophrenia. In this study, we aim to explore the association between the clinical signs of schizophrenia, aggressive behavior in patients with relapsing schizophrenia and inflammatory marker: CRP (C-reactive protein). Adult schizophrenia inpatients without affective symptoms (n = 154) were prospectively identified and categorized according to their C-reactive protein measurement at admission as either elevated (CRP > 5 mg/L; n = 52) or normal (CRP < 5 mg/L; n = 102). The following indicators of aggression were compared: PANSS excitement component (PANSS-EC), restraints, injectable treatment and suicidal behavior during hospitalization. Univariate comparisons between elevated and normal CRP levels were performed and multivariate analysis was conducted to control for relevant covariates. Inpatients with elevated C-reactive protein displayed increased aggressive behavior compared to patients with normal CRP levels (<5 mg/L). This was manifested by increased PANSS-EC score (p=0,0001), higher rates of restraint during hospitalization (p=0,0001), higher use of injectable treatment (0,0001) and existence of suicidal behavior (p=0,001). Multivariate analysis revealed that Lymphocyte count, total PANSS score, PANSS excitement score were independently associated with a CRP> 5 mg/L. These results confirm the role played by inflammation and immunity in the appearance of aggressive behavior in schizophrenic patients and highlight the interest of the CRP assay at the admission of patients as an indicator of aggression in hospitalized schizophrenic patients.

Published in	International Journal of Psychological and Brain Sciences (Volume 4, Issue 2)
DOI	10.11648/j.ijpbs.20190402.11
Page(s)	7-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Schizophrenia, Inflammation, Aggression, CRP

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APA Style

Kachouchi Aymen, Zemrani Yassin, Ahroui Yassine, Salim Said, Berghalout Mohammed, et al. (2019). C-Reactive Protein and Aggression in Patients with Schizophrenia. International Journal of Psychological and Brain Sciences, 4(2), 7-12. https://doi.org/10.11648/j.ijpbs.20190402.11

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ACS Style

Kachouchi Aymen; Zemrani Yassin; Ahroui Yassine; Salim Said; Berghalout Mohammed, et al. C-Reactive Protein and Aggression in Patients with Schizophrenia. Int. J. Psychol. Brain Sci. 2019, 4(2), 7-12. doi: 10.11648/j.ijpbs.20190402.11

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AMA Style

Kachouchi Aymen, Zemrani Yassin, Ahroui Yassine, Salim Said, Berghalout Mohammed, et al. C-Reactive Protein and Aggression in Patients with Schizophrenia. Int J Psychol Brain Sci. 2019;4(2):7-12. doi: 10.11648/j.ijpbs.20190402.11

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@article{10.11648/j.ijpbs.20190402.11,
  author = {Kachouchi Aymen and Zemrani Yassin and Ahroui Yassine and Salim Said and Berghalout Mohammed and Adali Imane and Manoudi Fatiha and Chabaa Laila and Asri Fatima},
  title = {C-Reactive Protein and Aggression in Patients with Schizophrenia},
  journal = {International Journal of Psychological and Brain Sciences},
  volume = {4},
  number = {2},
  pages = {7-12},
  doi = {10.11648/j.ijpbs.20190402.11},
  url = {https://doi.org/10.11648/j.ijpbs.20190402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpbs.20190402.11},
  abstract = {Recent studies reported firstly an association between aggression and inflammation and secondly an association between inflammation and schizophrenia. In this study, we aim to explore the association between the clinical signs of schizophrenia, aggressive behavior in patients with relapsing schizophrenia and inflammatory marker: CRP (C-reactive protein). Adult schizophrenia inpatients without affective symptoms (n = 154) were prospectively identified and categorized according to their C-reactive protein measurement at admission as either elevated (CRP > 5 mg/L; n = 52) or normal (CRP  5 mg/L. These results confirm the role played by inflammation and immunity in the appearance of aggressive behavior in schizophrenic patients and highlight the interest of the CRP assay at the admission of patients as an indicator of aggression in hospitalized schizophrenic patients.},
 year = {2019}
}

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TY  - JOUR
T1  - C-Reactive Protein and Aggression in Patients with Schizophrenia
AU  - Kachouchi Aymen
AU  - Zemrani Yassin
AU  - Ahroui Yassine
AU  - Salim Said
AU  - Berghalout Mohammed
AU  - Adali Imane
AU  - Manoudi Fatiha
AU  - Chabaa Laila
AU  - Asri Fatima
Y1  - 2019/06/10
PY  - 2019
N1  - https://doi.org/10.11648/j.ijpbs.20190402.11
DO  - 10.11648/j.ijpbs.20190402.11
T2  - International Journal of Psychological and Brain Sciences
JF  - International Journal of Psychological and Brain Sciences
JO  - International Journal of Psychological and Brain Sciences
SP  - 7
EP  - 12
PB  - Science Publishing Group
SN  - 2575-1573
UR  - https://doi.org/10.11648/j.ijpbs.20190402.11
AB  - Recent studies reported firstly an association between aggression and inflammation and secondly an association between inflammation and schizophrenia. In this study, we aim to explore the association between the clinical signs of schizophrenia, aggressive behavior in patients with relapsing schizophrenia and inflammatory marker: CRP (C-reactive protein). Adult schizophrenia inpatients without affective symptoms (n = 154) were prospectively identified and categorized according to their C-reactive protein measurement at admission as either elevated (CRP > 5 mg/L; n = 52) or normal (CRP  5 mg/L. These results confirm the role played by inflammation and immunity in the appearance of aggressive behavior in schizophrenic patients and highlight the interest of the CRP assay at the admission of patients as an indicator of aggression in hospitalized schizophrenic patients.
VL  - 4
IS  - 2
ER  -

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Author Information

Kachouchi Aymen

Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco
Zemrani Yassin

Biochemestry, Laboratory Arrazi, CHU Marrakech, Morocco
Ahroui Yassine

Biochemestry, Laboratory Arrazi, CHU Marrakech, Morocco
Salim Said

Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco
Berghalout Mohammed

Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco
Adali Imane

Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco
Manoudi Fatiha

Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco
Chabaa Laila

Biochemestry, Laboratory Arrazi, CHU Marrakech, Morocco
Asri Fatima

Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco

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Plain Text BibTeX RIS

APA Style

Kachouchi Aymen, Zemrani Yassin, Ahroui Yassine, Salim Said, Berghalout Mohammed, et al. (2019). C-Reactive Protein and Aggression in Patients with Schizophrenia. International Journal of Psychological and Brain Sciences, 4(2), 7-12. https://doi.org/10.11648/j.ijpbs.20190402.11

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ACS Style

Kachouchi Aymen; Zemrani Yassin; Ahroui Yassine; Salim Said; Berghalout Mohammed, et al. C-Reactive Protein and Aggression in Patients with Schizophrenia. Int. J. Psychol. Brain Sci. 2019, 4(2), 7-12. doi: 10.11648/j.ijpbs.20190402.11

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AMA Style

Kachouchi Aymen, Zemrani Yassin, Ahroui Yassine, Salim Said, Berghalout Mohammed, et al. C-Reactive Protein and Aggression in Patients with Schizophrenia. Int J Psychol Brain Sci. 2019;4(2):7-12. doi: 10.11648/j.ijpbs.20190402.11

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@article{10.11648/j.ijpbs.20190402.11,
  author = {Kachouchi Aymen and Zemrani Yassin and Ahroui Yassine and Salim Said and Berghalout Mohammed and Adali Imane and Manoudi Fatiha and Chabaa Laila and Asri Fatima},
  title = {C-Reactive Protein and Aggression in Patients with Schizophrenia},
  journal = {International Journal of Psychological and Brain Sciences},
  volume = {4},
  number = {2},
  pages = {7-12},
  doi = {10.11648/j.ijpbs.20190402.11},
  url = {https://doi.org/10.11648/j.ijpbs.20190402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpbs.20190402.11},
  abstract = {Recent studies reported firstly an association between aggression and inflammation and secondly an association between inflammation and schizophrenia. In this study, we aim to explore the association between the clinical signs of schizophrenia, aggressive behavior in patients with relapsing schizophrenia and inflammatory marker: CRP (C-reactive protein). Adult schizophrenia inpatients without affective symptoms (n = 154) were prospectively identified and categorized according to their C-reactive protein measurement at admission as either elevated (CRP > 5 mg/L; n = 52) or normal (CRP  5 mg/L. These results confirm the role played by inflammation and immunity in the appearance of aggressive behavior in schizophrenic patients and highlight the interest of the CRP assay at the admission of patients as an indicator of aggression in hospitalized schizophrenic patients.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - C-Reactive Protein and Aggression in Patients with Schizophrenia
AU  - Kachouchi Aymen
AU  - Zemrani Yassin
AU  - Ahroui Yassine
AU  - Salim Said
AU  - Berghalout Mohammed
AU  - Adali Imane
AU  - Manoudi Fatiha
AU  - Chabaa Laila
AU  - Asri Fatima
Y1  - 2019/06/10
PY  - 2019
N1  - https://doi.org/10.11648/j.ijpbs.20190402.11
DO  - 10.11648/j.ijpbs.20190402.11
T2  - International Journal of Psychological and Brain Sciences
JF  - International Journal of Psychological and Brain Sciences
JO  - International Journal of Psychological and Brain Sciences
SP  - 7
EP  - 12
PB  - Science Publishing Group
SN  - 2575-1573
UR  - https://doi.org/10.11648/j.ijpbs.20190402.11
AB  - Recent studies reported firstly an association between aggression and inflammation and secondly an association between inflammation and schizophrenia. In this study, we aim to explore the association between the clinical signs of schizophrenia, aggressive behavior in patients with relapsing schizophrenia and inflammatory marker: CRP (C-reactive protein). Adult schizophrenia inpatients without affective symptoms (n = 154) were prospectively identified and categorized according to their C-reactive protein measurement at admission as either elevated (CRP > 5 mg/L; n = 52) or normal (CRP  5 mg/L. These results confirm the role played by inflammation and immunity in the appearance of aggressive behavior in schizophrenic patients and highlight the interest of the CRP assay at the admission of patients as an indicator of aggression in hospitalized schizophrenic patients.
VL  - 4
IS  - 2
ER  -

Copy | Download