Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear

Wei Liping; He Guiyun

doi:doi:10.11648/j.ijovs.20200501.13

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Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear

Wei Liping, He Guiyun

Published in International Journal of Ophthalmology & Visual Science (Volume 5, Issue 1)

Received: 24 November 2019 Accepted: 24 December 2019 Published: 7 January 2020

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Abstract

Various eye diseases can cause retinal pigment epithelium (RPE) tear. RPE tear is common in neovascular age-related macular degeneration (nAMD). The injection of anti-vascular endothelial growth factor (VEGF) increases the risk of PRE tear, the mechanism of which is a sudden change in intraocular pressure during drug injection, vitreous macular traction, destruction of the RPE tight junction barrier and secondary contraction and fibrosis of the choroidal neovascular membrane. The height of pigment epithelial detachment (PED) is an important risk factor for RPE tear in patients with nAMD after injection of anti-VEGF drugs. The diagnosis of RPE tears primarily relies on imaging studies，such as fundus photography、fundus autofluorescence、optical coherence tomography and so on. Regarding treatment, we must first determine whether the patient has a RPE tear, or whether there are risk factors related to the RPE tear, and then perform the corresponding personalized treatment. If possible, consider stem cell transplant alternatives. There is no proven method to prevent RPE tear so far. This article will review and summarize the research progress in the pathogenesis, risk factors, diagnosis, treatment and prevention of RPE tear caused by anti-VEGF drugs, and further improve the understanding of RPE tears，in order to provide reference for clinical work.

Published in	International Journal of Ophthalmology & Visual Science (Volume 5, Issue 1)
DOI	10.11648/j.ijovs.20200501.13
Page(s)	15-20
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Anti-vascular Endothelial Growth Factor, Retinal Pigment Epithelium Tear, Neovascular Age-related Macular Degeneration

References

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Wei Liping, He Guiyun. (2020). Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear. International Journal of Ophthalmology & Visual Science, 5(1), 15-20. https://doi.org/10.11648/j.ijovs.20200501.13

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ACS Style

Wei Liping; He Guiyun. Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear. Int. J. Ophthalmol. Vis. Sci. 2020, 5(1), 15-20. doi: 10.11648/j.ijovs.20200501.13

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AMA Style

Wei Liping, He Guiyun. Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear. Int J Ophthalmol Vis Sci. 2020;5(1):15-20. doi: 10.11648/j.ijovs.20200501.13

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@article{10.11648/j.ijovs.20200501.13,
  author = {Wei Liping and He Guiyun},
  title = {Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {5},
  number = {1},
  pages = {15-20},
  doi = {10.11648/j.ijovs.20200501.13},
  url = {https://doi.org/10.11648/j.ijovs.20200501.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20200501.13},
  abstract = {Various eye diseases can cause retinal pigment epithelium (RPE) tear. RPE tear is common in neovascular age-related macular degeneration (nAMD). The injection of anti-vascular endothelial growth factor (VEGF) increases the risk of PRE tear, the mechanism of which is a sudden change in intraocular pressure during drug injection, vitreous macular traction, destruction of the RPE tight junction barrier and secondary contraction and fibrosis of the choroidal neovascular membrane. The height of pigment epithelial detachment (PED) is an important risk factor for RPE tear in patients with nAMD after injection of anti-VEGF drugs. The diagnosis of RPE tears primarily relies on imaging studies，such as fundus photography、fundus autofluorescence、optical coherence tomography and so on. Regarding treatment, we must first determine whether the patient has a RPE tear, or whether there are risk factors related to the RPE tear, and then perform the corresponding personalized treatment. If possible, consider stem cell transplant alternatives. There is no proven method to prevent RPE tear so far. This article will review and summarize the research progress in the pathogenesis, risk factors, diagnosis, treatment and prevention of RPE tear caused by anti-VEGF drugs, and further improve the understanding of RPE tears，in order to provide reference for clinical work.},
 year = {2020}
}

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TY  - JOUR
T1  - Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear
AU  - Wei Liping
AU  - He Guiyun
Y1  - 2020/01/07
PY  - 2020
N1  - https://doi.org/10.11648/j.ijovs.20200501.13
DO  - 10.11648/j.ijovs.20200501.13
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 15
EP  - 20
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20200501.13
AB  - Various eye diseases can cause retinal pigment epithelium (RPE) tear. RPE tear is common in neovascular age-related macular degeneration (nAMD). The injection of anti-vascular endothelial growth factor (VEGF) increases the risk of PRE tear, the mechanism of which is a sudden change in intraocular pressure during drug injection, vitreous macular traction, destruction of the RPE tight junction barrier and secondary contraction and fibrosis of the choroidal neovascular membrane. The height of pigment epithelial detachment (PED) is an important risk factor for RPE tear in patients with nAMD after injection of anti-VEGF drugs. The diagnosis of RPE tears primarily relies on imaging studies，such as fundus photography、fundus autofluorescence、optical coherence tomography and so on. Regarding treatment, we must first determine whether the patient has a RPE tear, or whether there are risk factors related to the RPE tear, and then perform the corresponding personalized treatment. If possible, consider stem cell transplant alternatives. There is no proven method to prevent RPE tear so far. This article will review and summarize the research progress in the pathogenesis, risk factors, diagnosis, treatment and prevention of RPE tear caused by anti-VEGF drugs, and further improve the understanding of RPE tears，in order to provide reference for clinical work.
VL  - 5
IS  - 1
ER  -

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Author Information

Wei Liping

Department of Medical College, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
He Guiyun

Hunan Provincial People's Hospital, Changsha, China

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Plain Text BibTeX RIS

APA Style

Wei Liping, He Guiyun. (2020). Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear. International Journal of Ophthalmology & Visual Science, 5(1), 15-20. https://doi.org/10.11648/j.ijovs.20200501.13

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ACS Style

Wei Liping; He Guiyun. Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear. Int. J. Ophthalmol. Vis. Sci. 2020, 5(1), 15-20. doi: 10.11648/j.ijovs.20200501.13

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AMA Style

Wei Liping, He Guiyun. Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear. Int J Ophthalmol Vis Sci. 2020;5(1):15-20. doi: 10.11648/j.ijovs.20200501.13

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@article{10.11648/j.ijovs.20200501.13,
  author = {Wei Liping and He Guiyun},
  title = {Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {5},
  number = {1},
  pages = {15-20},
  doi = {10.11648/j.ijovs.20200501.13},
  url = {https://doi.org/10.11648/j.ijovs.20200501.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20200501.13},
  abstract = {Various eye diseases can cause retinal pigment epithelium (RPE) tear. RPE tear is common in neovascular age-related macular degeneration (nAMD). The injection of anti-vascular endothelial growth factor (VEGF) increases the risk of PRE tear, the mechanism of which is a sudden change in intraocular pressure during drug injection, vitreous macular traction, destruction of the RPE tight junction barrier and secondary contraction and fibrosis of the choroidal neovascular membrane. The height of pigment epithelial detachment (PED) is an important risk factor for RPE tear in patients with nAMD after injection of anti-VEGF drugs. The diagnosis of RPE tears primarily relies on imaging studies，such as fundus photography、fundus autofluorescence、optical coherence tomography and so on. Regarding treatment, we must first determine whether the patient has a RPE tear, or whether there are risk factors related to the RPE tear, and then perform the corresponding personalized treatment. If possible, consider stem cell transplant alternatives. There is no proven method to prevent RPE tear so far. This article will review and summarize the research progress in the pathogenesis, risk factors, diagnosis, treatment and prevention of RPE tear caused by anti-VEGF drugs, and further improve the understanding of RPE tears，in order to provide reference for clinical work.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear
AU  - Wei Liping
AU  - He Guiyun
Y1  - 2020/01/07
PY  - 2020
N1  - https://doi.org/10.11648/j.ijovs.20200501.13
DO  - 10.11648/j.ijovs.20200501.13
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 15
EP  - 20
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20200501.13
AB  - Various eye diseases can cause retinal pigment epithelium (RPE) tear. RPE tear is common in neovascular age-related macular degeneration (nAMD). The injection of anti-vascular endothelial growth factor (VEGF) increases the risk of PRE tear, the mechanism of which is a sudden change in intraocular pressure during drug injection, vitreous macular traction, destruction of the RPE tight junction barrier and secondary contraction and fibrosis of the choroidal neovascular membrane. The height of pigment epithelial detachment (PED) is an important risk factor for RPE tear in patients with nAMD after injection of anti-VEGF drugs. The diagnosis of RPE tears primarily relies on imaging studies，such as fundus photography、fundus autofluorescence、optical coherence tomography and so on. Regarding treatment, we must first determine whether the patient has a RPE tear, or whether there are risk factors related to the RPE tear, and then perform the corresponding personalized treatment. If possible, consider stem cell transplant alternatives. There is no proven method to prevent RPE tear so far. This article will review and summarize the research progress in the pathogenesis, risk factors, diagnosis, treatment and prevention of RPE tear caused by anti-VEGF drugs, and further improve the understanding of RPE tears，in order to provide reference for clinical work.
VL  - 5
IS  - 1
ER  -

Copy | Download