The Purpose of the study was to evaluate the association between thyroid -stimulating hormone (TSH), free tri-iodothyronine (T3), free thyroxine (T4), hypothyroidism, hyperthyroidism and age related macular degeneration (ARMD) incidence. Nine hundred and fifty patients with thyroid disorders versus five hundred and thirty eu-thyroid subjects were included in the study during the period from January 2014 to February 2019. Blood pressure, blood sugar level and cholesterol, smoking state were estimated. TSH, T3&T4 were measured. Retinal photography and optical coherence tomography were performed. Patients with hyperthyroidism had increased incidence of ARMD. Patients using thyroxine had also increased incidence of ARMD than non using of thyroxine. There were statistically higher significant percent of marriage, educational level and smoking in patients with thyroid disorders with ARMD than euthyroid (p=0.03. 0.06, 0.001 respectively). In thyroid disorders patients, there were a significant differences between patients had ARMD or had not as regard diabetes, hypertension and cholesterol level (p=0.04, 0.09, 0.03 respectively). We concluded that there were increased incidence of ARMD in both hyperthyroidism, and patients use the thyroxine.
Published in |
International Journal of Ophthalmology & Visual Science (Volume 4, Issue 4)
This article belongs to the Special Issue The Relation Between Age Related Macular Degeneration and Thyroid Disorders |
DOI | 10.11648/j.ijovs.20190404.18 |
Page(s) | 101-105 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
TSH, T4, T3, ARMD
[1] | Naidoo K, Gichuhi S, Basanez MG, Flaxman SR, Jonas JB, Keeffe J. Prevalence and causes of vision loss in sub-Saharan Africa: 1990–2010. British J Ophthalmol. 2014; 98: 612–8. |
[2] | Wong TY, Zheng YF, Jonas JB, Flaxman SR, Keeffe J, Leasher J. Prevalence and causes of vision loss in East Asia: 1990–2010. British J Ophthalmol. 2014; 98: 599–604. |
[3] | Ittermann T, Dorr M, Volzke H, Tost F, Lehmphul I, Kohrle J. High serum thyrotropin levels are associated with retinal arteriolar narrowing in the general population. Thyroid. 2014; 24: 1473–8. |
[4] | Ma H, Thapa A, Morris L, Redmond TM, Baehr W, Ding XQ. Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration. Proc Natl Acad Sci U S A. 2014; 111: 3602–7. |
[5] | Aoki Y, Belin RM, Clickner R, Jeffries R, Phillips L, Mahaffey KR. Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999–2002) Thyroid. 2007; 17: 1211–23. |
[6] | Garmendia Madariaga A, Santos Palacios S, Guillen-Grima F, Galofre JC. The incidence and prevalence of thyroid dysfunction in Europe: a meta-analysis. J Clin Endocrinol Metabol. 2014; 99: 923–31. |
[7] | Gao N, Zhang W, Zhang YZ, Yang Q, Chen SH. Carotid intima-media thickness in patients with subclinical hypothyroidism: a meta-analysis. Atherosclerosis. 2013; 227: 18–25. |
[8] | Klein R, Klein BE, Jensen SC, et al. Medication use and the 5-year incidence of early age-related maculopathy: the Beaver Dam Eye Study. Arch Ophthalmol. 2001; 119: 1354–1359. |
[9] | Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: Age-Related Eye Disease Study Report Number 3. Ophthalmology. 2000; 107: 2224–2232. |
[10] | Douglas IJ, Cook C, Chakravarthy U, et al. A case-control study of drug risk factors for age-related macular degeneration. Ophthalmology. 2007; 114: 1164–1169. |
[11] | Bromfield S, Keenan J, Jolly P, McGwin G., Jr A suggested association between hypothyroidism and age-related macular degeneration. Curr Eye Res. 2012; 37: 549–52. |
[12] | Klein R, Klein BE, Jensen SC, Cruickshanks KJ, Lee KE, Danforth LG, et al. Medication use and the 5-year incidence of early age-related maculopathy: the Beaver Dam Eye Study. Arch Ophthalmol. 2001; 119: 1354–9. |
[13] | Chaker L, Buitendijk GH, Dehghan A,. Thyroid function and age-related macular degeneration: a prospective population-based cohort study--the Rotterdam Study. BMC Med. 2015; 13: 94. |
[14] | Chatziralli I. A, Mitropoulos B Thyroidopathy and Age-Related Macular Degeneration: Is There Any Correlation. Biomed Hub 2017; 2: 454706. |
[15] | Ding X Q, Malek, G. Thyroid Hormone Signaling Regulation of Retinal Pigment Epithelium Viability by BrightFocus Foundation 2018. |
[16] | Gopinath B; Liew G; Kifley A; Mitchell P. Thyroid Dysfunction and Ten-Year Incidence of Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science 2016, 57, 5273-5277. |
[17] | Ng L, Lyubarsky A, Nikonov SS, Ma M, Srinivas M, Kefas B. Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors. J Neurosci. 2010; 30: 3347–57. |
[18] | Ma, H., Thapa, A., Morris, L., Redmond, T. M., Baehr, W., and Ding, X. Q. Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration. Proc. Natl. Acad. Sci. USA 2014, 111, 3602–3607. |
[19] | Nguyen-Legros J, Hicks D. Renewal of photoreceptor outer segments and their phagocytosis by the retinal pigment epithelium. Int Rev Cytol. 2000; 196: 245–313. |
[20] | Klein R, Cruickshanks KJ, Myers CE, Sivakumaran TA, Iyengar SK, Meuer SM, The relationship of atherosclerosis to the 10-year cumulative incidence of age-related macular degeneration: the Beaver Dam studies. Ophthalmology 2013: 120; 1012-9.36. |
[21] | Ittermann T, Jurgens C. Thyroid function: a new road to understanding age-related macular degeneration? BMC Med. 2015; 13: 95. |
[22] | Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000; 45: 115–134. |
APA Style
Mona Abdelkader, Naglaa Abass. (2019). The Relation Between Age Related Macular Degeneration and Thyroid Disorders. International Journal of Ophthalmology & Visual Science, 4(4), 101-105. https://doi.org/10.11648/j.ijovs.20190404.18
ACS Style
Mona Abdelkader; Naglaa Abass. The Relation Between Age Related Macular Degeneration and Thyroid Disorders. Int. J. Ophthalmol. Vis. Sci. 2019, 4(4), 101-105. doi: 10.11648/j.ijovs.20190404.18
AMA Style
Mona Abdelkader, Naglaa Abass. The Relation Between Age Related Macular Degeneration and Thyroid Disorders. Int J Ophthalmol Vis Sci. 2019;4(4):101-105. doi: 10.11648/j.ijovs.20190404.18
@article{10.11648/j.ijovs.20190404.18, author = {Mona Abdelkader and Naglaa Abass}, title = {The Relation Between Age Related Macular Degeneration and Thyroid Disorders}, journal = {International Journal of Ophthalmology & Visual Science}, volume = {4}, number = {4}, pages = {101-105}, doi = {10.11648/j.ijovs.20190404.18}, url = {https://doi.org/10.11648/j.ijovs.20190404.18}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20190404.18}, abstract = {The Purpose of the study was to evaluate the association between thyroid -stimulating hormone (TSH), free tri-iodothyronine (T3), free thyroxine (T4), hypothyroidism, hyperthyroidism and age related macular degeneration (ARMD) incidence. Nine hundred and fifty patients with thyroid disorders versus five hundred and thirty eu-thyroid subjects were included in the study during the period from January 2014 to February 2019. Blood pressure, blood sugar level and cholesterol, smoking state were estimated. TSH, T3&T4 were measured. Retinal photography and optical coherence tomography were performed. Patients with hyperthyroidism had increased incidence of ARMD. Patients using thyroxine had also increased incidence of ARMD than non using of thyroxine. There were statistically higher significant percent of marriage, educational level and smoking in patients with thyroid disorders with ARMD than euthyroid (p=0.03. 0.06, 0.001 respectively). In thyroid disorders patients, there were a significant differences between patients had ARMD or had not as regard diabetes, hypertension and cholesterol level (p=0.04, 0.09, 0.03 respectively). We concluded that there were increased incidence of ARMD in both hyperthyroidism, and patients use the thyroxine.}, year = {2019} }
TY - JOUR T1 - The Relation Between Age Related Macular Degeneration and Thyroid Disorders AU - Mona Abdelkader AU - Naglaa Abass Y1 - 2019/11/20 PY - 2019 N1 - https://doi.org/10.11648/j.ijovs.20190404.18 DO - 10.11648/j.ijovs.20190404.18 T2 - International Journal of Ophthalmology & Visual Science JF - International Journal of Ophthalmology & Visual Science JO - International Journal of Ophthalmology & Visual Science SP - 101 EP - 105 PB - Science Publishing Group SN - 2637-3858 UR - https://doi.org/10.11648/j.ijovs.20190404.18 AB - The Purpose of the study was to evaluate the association between thyroid -stimulating hormone (TSH), free tri-iodothyronine (T3), free thyroxine (T4), hypothyroidism, hyperthyroidism and age related macular degeneration (ARMD) incidence. Nine hundred and fifty patients with thyroid disorders versus five hundred and thirty eu-thyroid subjects were included in the study during the period from January 2014 to February 2019. Blood pressure, blood sugar level and cholesterol, smoking state were estimated. TSH, T3&T4 were measured. Retinal photography and optical coherence tomography were performed. Patients with hyperthyroidism had increased incidence of ARMD. Patients using thyroxine had also increased incidence of ARMD than non using of thyroxine. There were statistically higher significant percent of marriage, educational level and smoking in patients with thyroid disorders with ARMD than euthyroid (p=0.03. 0.06, 0.001 respectively). In thyroid disorders patients, there were a significant differences between patients had ARMD or had not as regard diabetes, hypertension and cholesterol level (p=0.04, 0.09, 0.03 respectively). We concluded that there were increased incidence of ARMD in both hyperthyroidism, and patients use the thyroxine. VL - 4 IS - 4 ER -