Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis

Feng Dan; He Shuxi

doi:doi:10.11648/j.ijovs.20180302.12

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Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis

Feng Dan, He Shuxi

Published in International Journal of Ophthalmology & Visual Science (Volume 3, Issue 2)

Received: 29 May 2018 Accepted: 4 July 2018 Published: 27 July 2018

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Abstract

Corneal collagen cross-linking (CXL) is a photochem therapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA, was induced to form the cross-links in corneal stroma. The purpose of this paper is to review the basic principle, therapeutic potential of corneal ulcerative disease, existing evidences from laboratory and clinical studies, and relevant limitations, then put forward the advantages of CXL in the treatment of corneal ulcerative disease, and thus provide more possibilities for the treatment of the disease.

Published in	International Journal of Ophthalmology & Visual Science (Volume 3, Issue 2)
DOI	10.11648/j.ijovs.20180302.12
Page(s)	21-26
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Corneal Collagen Cross-Linking (CXL), Ultraviolet Light A (UVA), Riboflavin, Ulcerative Disease

References

[1]	G. Wollensak, E. Spoerl, T. Seiler, Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. American Journal of Ophthalmology 135, 620-627 (2003).
[2]	E. Spoerl, M. Mrochen, D, S. Trokel, T. Seiler, Safety of UVA-riboflavin cross-linking of the cornea. Cornea 26, 385-389 (2007).
[3]	Jianghong, Xuhaiyang, Haojilong, Research progress on the mechanism of infectious corneal ulcer. Chinese Journal of Practical Ophthalmology 29, 308-311 (2011).
[4]	M. E. Fini, J. R. Cook, R. Mohan, Proteolytic mechanisms in corneal ulceration and repair. Archives of Dermatological Research 290, S12-S23 (1998).
[5]	Quxin, Haojilong, Research progress on pathological mechanism of non-infectious corneal ulcer. Jilin Medical Journal 33, 1462-1463 (2012).
[6]	Sunbingji, The theoretical basis and clinical of corneal diseases. Science and technology literature publishing house 1994.
[7]	E. Spoerl, N. Terai, F. Scholz, F. Raiskup, L. E. Pillunat, Detection of biomechanical changes after corneal cross-linking using Ocular Response Analyzer software. Journal of Refractive Surgery 27, 452-457 (2011).
[8]	Liuying, Jiangli, Wangjiangwei, Shenzhengwei, Rabbit corneal tissue resistant to in vitro enzymatic digestion after corneal collagen cross-linking. Journal of Clinical Ophthalmology 25, 165-168 (2017).
[9]	E. Spoerl, G. Wollensak, T. Seiler, Increased resistance of crosslinked cornea against enzymatic digestion. Current Eye Research 29, 35-40 (2004).
[10]	Zhaoxudong et al., Effect of collagen cross-linking on rabbit corneal stroma melting after alkali burn. Recent Advances in Ophthalmology 32, 524-527 (2012).
[11]	V. Kumar et al., Riboflavin and UV-Light Based Pathogen Reduction: Extent and Consequence of DNA Damage at the Molecular Level. Photochemistry & Photobiology 80, 15 (2004).
[12]	A. Sauer et al., In vitro efficacy of antifungal treatment using riboflavin/UV-A (365 nm) combination and amphotericin B. Investigative Ophthalmology & Visual Science 51, 3950 (2010).
[13]	Haozhaoqin et al., Management of fungal corneal ulcer by corneal collagen cross-linking technique. Chinese Journal of Experimental Ophthalmology 32, 802-806 (2014).
[14]	Y. Takami, H. Gong, T. Amemiya, Riboflavin deficiency induces ocular surface damage. Ophthalmic Research 36, 156-165 (2004).
[15]	R. Shetty, H. Nagaraja, C. Jayadev, Y. Shivanna, T. Kugar, Collagen crosslinking in the management of advanced non-resolving microbial keratitis. British Journal of Ophthalmology 98, 1033-1035 (2014).
[16]	V. Igal, Y. S. Pikkel Igal, Y. Y. Pikkel, Corneal Cross-Linking as a Treatment for Fungal Keratitis Associated with Corneal Melting. Case Reports in Ophthalmology 8, 148 (2017).
[17]	Y. A. Khan et al., Riboflavin and ultraviolet light a therapy as an adjuvant treatment for medically refractive Acanthamoeba keratitis: report of 3 cases. Ophthalmology 118, 324 (2011).
[18]	A. Panda, S. N. Krishna, S. Kumar, Photo-activated riboflavin therapy of refractory corneal ulcers. Cornea 31, 1210-1213 (2012).
[19]	D. G. Said et al., Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal melting. Ophthalmology 121, 1377-1382 (2014).
[20]	V. Igal, Y. S. P. Igal, Y. Y. Pikkel, Corneal Cross-Linking as a Treatment for Fungal Keratitis Associated with Corneal Melting. Case Reports in Ophthalmology 8, 148 (2017).
[21]	G. Ferrari, L. Iuliano, M. Viganò, P. Rama, Impending corneal perforation after collagen cross-linking for herpetic keratitis. Journal of Cataract & Refractive Surgery 39, 638-641 (2013).
[22]	J. L. Alio, A. Abbouda, D. D. Valle, J. M. B. D. Castillo, J. A. G. Fernandez, Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases. Journal of Ophthalmic Inflammation & Infection 3, 1-7 (2013).
[23]	P. Garg, S. Das, A. Roy, Collagen Cross-linking for Microbial Keratitis. Middle East African Journal of Ophthalmology 24, 18-23 (2017).
[24]	Y. Goldich et al., Clinical and corneal biomechanical changes after collagen cross-linking with riboflavin and UV irradiation in patients with progressive keratoconus: results after 2 years of follow-up. Cornea 31, 609-614 (2012).
[25]	D. S. Grewal et al., Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. Journal of Cataract & Refractive Surgery 35, 425 (2009).
[26]	M. R. Romano, G. Quaranta, M. Bregu, E. Albe, P. Vinciguerra, No retinal morphology changes after use of riboflavin and long-wavelength ultraviolet light for treatment of keratoconus. Acta Ophthalmologica 90, e79-e80 (2012).
[27]	F. Hafezi, M. Mrochen, H. P. Iseli, T. Seiler, Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas. Journal of Cataract & Refractive Surgery 35, 621-624 (2009).
[28]	F. Raiskup, K. A, E. Spoerl, P. LE, [Corneal cross-linking with hypo-osmolar riboflavin solution for keratoconus with thin corneas]. American Journal of Ophthalmology 152, 846 (2011).
[29]	G. D. Kymionis et al., Corneal collagen cross-linking with riboflavin and ultraviolet-A irradiation in patients with thin corneas. American Journal of Ophthalmology 153, 24-28 (2012).
[30]	T. Koller, M. Mrochen, T. Seiler, Complication and failure rates after corneal crosslinking. Journal of Cataract & Refractive Surgery 35, 1358-1362 (2009).
[31]	Tanja et al., Impact of crosslinking/riboflavin-UVA-photodynamic inactivation on viability, apoptosis and activation of human keratocytes in vitro. Journal of Biomedical Research 29, 321-325 (2015).
[32]	T. Stachon et al., Impact of crosslinking/riboflavin-UVA-photodynamic inactivation on viability, apoptosis and activation of human keratocytes in vitro. Journal of Biomedical Research 29, 321-325 (2015).
[33]	O. Richoz et al., Antibacterial efficacy of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL). Journal of Refractive Surgery 30, 850-854 (2014).

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APA Style

Feng Dan, He Shuxi. (2018). Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. International Journal of Ophthalmology & Visual Science, 3(2), 21-26. https://doi.org/10.11648/j.ijovs.20180302.12

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ACS Style

Feng Dan; He Shuxi. Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. Int. J. Ophthalmol. Vis. Sci. 2018, 3(2), 21-26. doi: 10.11648/j.ijovs.20180302.12

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AMA Style

Feng Dan, He Shuxi. Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. Int J Ophthalmol Vis Sci. 2018;3(2):21-26. doi: 10.11648/j.ijovs.20180302.12

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@article{10.11648/j.ijovs.20180302.12,
  author = {Feng Dan and He Shuxi},
  title = {Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {3},
  number = {2},
  pages = {21-26},
  doi = {10.11648/j.ijovs.20180302.12},
  url = {https://doi.org/10.11648/j.ijovs.20180302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20180302.12},
  abstract = {Corneal collagen cross-linking (CXL) is a photochem therapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA, was induced to form the cross-links in corneal stroma. The purpose of this paper is to review the basic principle, therapeutic potential of corneal ulcerative disease, existing evidences from laboratory and clinical studies, and relevant limitations, then put forward the advantages of CXL in the treatment of corneal ulcerative disease, and thus provide more possibilities for the treatment of the disease.},
 year = {2018}
}

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TY  - JOUR
T1  - Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis
AU  - Feng Dan
AU  - He Shuxi
Y1  - 2018/07/27
PY  - 2018
N1  - https://doi.org/10.11648/j.ijovs.20180302.12
DO  - 10.11648/j.ijovs.20180302.12
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 21
EP  - 26
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20180302.12
AB  - Corneal collagen cross-linking (CXL) is a photochem therapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA, was induced to form the cross-links in corneal stroma. The purpose of this paper is to review the basic principle, therapeutic potential of corneal ulcerative disease, existing evidences from laboratory and clinical studies, and relevant limitations, then put forward the advantages of CXL in the treatment of corneal ulcerative disease, and thus provide more possibilities for the treatment of the disease.
VL  - 3
IS  - 2
ER  -

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Author Information

Feng Dan

Department of Medical College, Hunan normal University, Changsha, China
He Shuxi

Center for Ophthalmic Optics, Hunan Provincial People's Hospital, Changsha, China

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APA Style

Feng Dan, He Shuxi. (2018). Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. International Journal of Ophthalmology & Visual Science, 3(2), 21-26. https://doi.org/10.11648/j.ijovs.20180302.12

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ACS Style

Feng Dan; He Shuxi. Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. Int. J. Ophthalmol. Vis. Sci. 2018, 3(2), 21-26. doi: 10.11648/j.ijovs.20180302.12

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AMA Style

Feng Dan, He Shuxi. Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. Int J Ophthalmol Vis Sci. 2018;3(2):21-26. doi: 10.11648/j.ijovs.20180302.12

Copy | Download

@article{10.11648/j.ijovs.20180302.12,
  author = {Feng Dan and He Shuxi},
  title = {Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {3},
  number = {2},
  pages = {21-26},
  doi = {10.11648/j.ijovs.20180302.12},
  url = {https://doi.org/10.11648/j.ijovs.20180302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20180302.12},
  abstract = {Corneal collagen cross-linking (CXL) is a photochem therapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA, was induced to form the cross-links in corneal stroma. The purpose of this paper is to review the basic principle, therapeutic potential of corneal ulcerative disease, existing evidences from laboratory and clinical studies, and relevant limitations, then put forward the advantages of CXL in the treatment of corneal ulcerative disease, and thus provide more possibilities for the treatment of the disease.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis
AU  - Feng Dan
AU  - He Shuxi
Y1  - 2018/07/27
PY  - 2018
N1  - https://doi.org/10.11648/j.ijovs.20180302.12
DO  - 10.11648/j.ijovs.20180302.12
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 21
EP  - 26
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20180302.12
AB  - Corneal collagen cross-linking (CXL) is a photochem therapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA, was induced to form the cross-links in corneal stroma. The purpose of this paper is to review the basic principle, therapeutic potential of corneal ulcerative disease, existing evidences from laboratory and clinical studies, and relevant limitations, then put forward the advantages of CXL in the treatment of corneal ulcerative disease, and thus provide more possibilities for the treatment of the disease.
VL  - 3
IS  - 2
ER  -

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