Corneal collagen cross-linking (CXL) is a therapeutic procedure that helps in increasing the corneal stiffness in the keratoconus eyes. It increases the collagen cross linking within the extracellular matrix (ECM). Ultraviolet-A (370 nm) irradiation of the cornea after saturation with the photosensitizer riboflavin is used. A minimum deepithelialized corneal thickness of 400 μm is recommended to avoid potential irradiation damage to the corneal endothelium but in advanced cases this is not achieved which limits the application of CXL in that category. Modifications have been done in the conventional CXL procedure to be applicable in thin corneas. The current review discusses different techniques employed to achieve this end and their results. The modifications in CXL halt the progression of keratectasia without postoperative complications. However, the evidence of safety and efficacy in the use of modified CXL protocols is still limited to few studies with few patients involved. Controlled studies with long-term follow-up are required to confirm the safety and efficacy of the modified protocols.
| Published in | International Journal of Ophthalmology & Visual Science (Volume 1, Issue 1) |
| DOI | 10.11648/j.ijovs.20160101.13 |
| Page(s) | 20-24 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Keratoconus, Collagen Cross Linking, Thin Cornea
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APA Style
Bhavesh Makkar, Deepak Mishra. (2017). Collagen Cross Linking in Keratoconus: A Review. International Journal of Ophthalmology & Visual Science, 1(1), 20-24. https://doi.org/10.11648/j.ijovs.20160101.13
ACS Style
Bhavesh Makkar; Deepak Mishra. Collagen Cross Linking in Keratoconus: A Review. Int. J. Ophthalmol. Vis. Sci. 2017, 1(1), 20-24. doi: 10.11648/j.ijovs.20160101.13
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Download@article{10.11648/j.ijovs.20160101.13,
author = {Bhavesh Makkar and Deepak Mishra},
title = {Collagen Cross Linking in Keratoconus: A Review},
journal = {International Journal of Ophthalmology & Visual Science},
volume = {1},
number = {1},
pages = {20-24},
doi = {10.11648/j.ijovs.20160101.13},
url = {https://doi.org/10.11648/j.ijovs.20160101.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20160101.13},
abstract = {Corneal collagen cross-linking (CXL) is a therapeutic procedure that helps in increasing the corneal stiffness in the keratoconus eyes. It increases the collagen cross linking within the extracellular matrix (ECM). Ultraviolet-A (370 nm) irradiation of the cornea after saturation with the photosensitizer riboflavin is used. A minimum deepithelialized corneal thickness of 400 μm is recommended to avoid potential irradiation damage to the corneal endothelium but in advanced cases this is not achieved which limits the application of CXL in that category. Modifications have been done in the conventional CXL procedure to be applicable in thin corneas. The current review discusses different techniques employed to achieve this end and their results. The modifications in CXL halt the progression of keratectasia without postoperative complications. However, the evidence of safety and efficacy in the use of modified CXL protocols is still limited to few studies with few patients involved. Controlled studies with long-term follow-up are required to confirm the safety and efficacy of the modified protocols.},
year = {2017}
}
TY - JOUR T1 - Collagen Cross Linking in Keratoconus: A Review AU - Bhavesh Makkar AU - Deepak Mishra Y1 - 2017/01/03 PY - 2017 N1 - https://doi.org/10.11648/j.ijovs.20160101.13 DO - 10.11648/j.ijovs.20160101.13 T2 - International Journal of Ophthalmology & Visual Science JF - International Journal of Ophthalmology & Visual Science JO - International Journal of Ophthalmology & Visual Science SP - 20 EP - 24 PB - Science Publishing Group SN - 2637-3858 UR - https://doi.org/10.11648/j.ijovs.20160101.13 AB - Corneal collagen cross-linking (CXL) is a therapeutic procedure that helps in increasing the corneal stiffness in the keratoconus eyes. It increases the collagen cross linking within the extracellular matrix (ECM). Ultraviolet-A (370 nm) irradiation of the cornea after saturation with the photosensitizer riboflavin is used. A minimum deepithelialized corneal thickness of 400 μm is recommended to avoid potential irradiation damage to the corneal endothelium but in advanced cases this is not achieved which limits the application of CXL in that category. Modifications have been done in the conventional CXL procedure to be applicable in thin corneas. The current review discusses different techniques employed to achieve this end and their results. The modifications in CXL halt the progression of keratectasia without postoperative complications. However, the evidence of safety and efficacy in the use of modified CXL protocols is still limited to few studies with few patients involved. Controlled studies with long-term follow-up are required to confirm the safety and efficacy of the modified protocols. VL - 1 IS - 1 ER -
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