Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes

Elka Popova; Petia Kupenova

doi:doi:10.11648/j.ijovs.20160101.11

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Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes

Elka Popova, Petia Kupenova

Published in International Journal of Ophthalmology & Visual Science (Volume 1, Issue 1)

Received: 19 August 2016 Accepted: 30 August 2016 Published: 13 September 2016

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Abstract

It is known that histamine is neurotransmitter of the retinopetal axons that originate from the tuberomamillary nucleus of the posterior hypothalamus, but its role in visual information processing in the retina is not well understood. The aim of this study was to give insight into the significance that histamine has for the distal retina function revealed by electroretinogram (ERG). The effect of 5 M histamine on the intensity – response function of the b-wave (ON response) and d-wave (OFF response) of ERG was investigated in dark adapted perfused frog eyecup preparations. Perfusion with histamine caused a significant enhancement of the amplitude of both the ON and OFF responses over the entire intensity range studied in comparison with corresponding values obtained in the control experiments. The enhancing effect of histamine was more pronounced upon the OFF than ON response in the lower intensity range, where the responses were mediated by rods. The reverse was true for the higher intensity range, where the responses were cone-dominated. The b-wave V – log I function had a steeper slope and narrower dynamic range during histamine treatment. Histamine did not alter significantly the relative sensitivity of the ON response, while it significantly increased the relative sensitivity of the OFF response. The present results clearly demonstrate that histamine has a significant effect on the intensity-response function of frog ERG b- and d-waves. This effect shows some ON/OFF asymmetries in dependence of the photoreceptor input.

Published in	International Journal of Ophthalmology & Visual Science (Volume 1, Issue 1)
DOI	10.11648/j.ijovs.20160101.11
Page(s)	1-7
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Electroretinogram, Iintensity-Response Function, Histamine, Retina

References

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[10]	Greferath U, Vessey KA, Jobling AI, Mills SA, Bui BV, He Z, Nag N, Ohtsu H, Fletcher EL. The role of histamine in the retina: studies on the Hdc knockout mouse. PLoS One 2014; 9: e116025.
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[13]	Popova E, Kupenova P Effects of dopamine D_{1_{receptor blockade on the intensity-response function of ERG b- and d-waves under different conditions of light adaptation. Vision Res. 2011; 51: 1627-36.}}
[14]	Popova E, Kupenova P. Effects of dopamine receptor blockade on the intensity-response function of ERG b- and d-waves in dark adapted eyes. Vision Res. 2013; 88: 22-29.
[15]	Kupenova P, Popova E, Vitanova L. GABAa and GABAc receptor mediated influences on the intensity-response functions of the b- and d-wave in the frog ERG. Vision Res. 2008; 48: 882-92.
[16]	Naka KI, Rushton WAH. S-potentials from colour units in the retina of fish (Cyprinidae). J Physiol. 1966; 185: 536–55.
[17]	Kupenova TN. An inductive algorithm for smooth approximation of functions. Commun JINR 2011, Dubna: E11-2011-97.
[18]	Frishman LJ. Origins of the electroretinogram. In: Heckenlively JR, Arden GB, editors. Principles and Practice of Clinical Electrophysiology of Vision. 2nd ed. London: MIT Press; 2006. p. 139–183.
[19]	Frishman LJ. Electrogenesis of the electroretinogram. In: Ryan SJ, Hinton DR, Sadda SR, Schachat AP, Wilkinson CP, Wiedemann P, editors. Retina. 5^{th^{ed. Elsevier Health Sciences; 2013, volume 1, p. 177-201.}}
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Elka Popova, Petia Kupenova. (2016). Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes. International Journal of Ophthalmology & Visual Science, 1(1), 1-7. https://doi.org/10.11648/j.ijovs.20160101.11

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ACS Style

Elka Popova; Petia Kupenova. Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes. Int. J. Ophthalmol. Vis. Sci. 2016, 1(1), 1-7. doi: 10.11648/j.ijovs.20160101.11

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AMA Style

Elka Popova, Petia Kupenova. Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes. Int J Ophthalmol Vis Sci. 2016;1(1):1-7. doi: 10.11648/j.ijovs.20160101.11

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@article{10.11648/j.ijovs.20160101.11,
  author = {Elka Popova and Petia Kupenova},
  title = {Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {1},
  number = {1},
  pages = {1-7},
  doi = {10.11648/j.ijovs.20160101.11},
  url = {https://doi.org/10.11648/j.ijovs.20160101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20160101.11},
  abstract = {It is known that histamine is neurotransmitter of the retinopetal axons that originate from the tuberomamillary nucleus of the posterior hypothalamus, but its role in visual information processing in the retina is not well understood. The aim of this study was to give insight into the significance that histamine has for the distal retina function revealed by electroretinogram (ERG). The effect of 5 M histamine on the intensity – response function of the b-wave (ON response) and d-wave (OFF response) of ERG was investigated in dark adapted perfused frog eyecup preparations. Perfusion with histamine caused a significant enhancement of the amplitude of both the ON and OFF responses over the entire intensity range studied in comparison with corresponding values obtained in the control experiments. The enhancing effect of histamine was more pronounced upon the OFF than ON response in the lower intensity range, where the responses were mediated by rods. The reverse was true for the higher intensity range, where the responses were cone-dominated. The b-wave V – log I function had a steeper slope and narrower dynamic range during histamine treatment. Histamine did not alter significantly the relative sensitivity of the ON response, while it significantly increased the relative sensitivity of the OFF response. The present results clearly demonstrate that histamine has a significant effect on the intensity-response function of frog ERG b- and d-waves. This effect shows some ON/OFF asymmetries in dependence of the photoreceptor input.},
 year = {2016}
}

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TY  - JOUR
T1  - Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes
AU  - Elka Popova
AU  - Petia Kupenova
Y1  - 2016/09/13
PY  - 2016
N1  - https://doi.org/10.11648/j.ijovs.20160101.11
DO  - 10.11648/j.ijovs.20160101.11
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20160101.11
AB  - It is known that histamine is neurotransmitter of the retinopetal axons that originate from the tuberomamillary nucleus of the posterior hypothalamus, but its role in visual information processing in the retina is not well understood. The aim of this study was to give insight into the significance that histamine has for the distal retina function revealed by electroretinogram (ERG). The effect of 5 M histamine on the intensity – response function of the b-wave (ON response) and d-wave (OFF response) of ERG was investigated in dark adapted perfused frog eyecup preparations. Perfusion with histamine caused a significant enhancement of the amplitude of both the ON and OFF responses over the entire intensity range studied in comparison with corresponding values obtained in the control experiments. The enhancing effect of histamine was more pronounced upon the OFF than ON response in the lower intensity range, where the responses were mediated by rods. The reverse was true for the higher intensity range, where the responses were cone-dominated. The b-wave V – log I function had a steeper slope and narrower dynamic range during histamine treatment. Histamine did not alter significantly the relative sensitivity of the ON response, while it significantly increased the relative sensitivity of the OFF response. The present results clearly demonstrate that histamine has a significant effect on the intensity-response function of frog ERG b- and d-waves. This effect shows some ON/OFF asymmetries in dependence of the photoreceptor input.
VL  - 1
IS  - 1
ER  -

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Author Information

Elka Popova

Department of Physiology, Medical University of Sofia, Sofia, Bulgaria
Petia Kupenova

Department of Physiology, Medical University of Sofia, Sofia, Bulgaria

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APA Style

Elka Popova, Petia Kupenova. (2016). Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes. International Journal of Ophthalmology & Visual Science, 1(1), 1-7. https://doi.org/10.11648/j.ijovs.20160101.11

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ACS Style

Elka Popova; Petia Kupenova. Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes. Int. J. Ophthalmol. Vis. Sci. 2016, 1(1), 1-7. doi: 10.11648/j.ijovs.20160101.11

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AMA Style

Elka Popova, Petia Kupenova. Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes. Int J Ophthalmol Vis Sci. 2016;1(1):1-7. doi: 10.11648/j.ijovs.20160101.11

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@article{10.11648/j.ijovs.20160101.11,
  author = {Elka Popova and Petia Kupenova},
  title = {Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {1},
  number = {1},
  pages = {1-7},
  doi = {10.11648/j.ijovs.20160101.11},
  url = {https://doi.org/10.11648/j.ijovs.20160101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20160101.11},
  abstract = {It is known that histamine is neurotransmitter of the retinopetal axons that originate from the tuberomamillary nucleus of the posterior hypothalamus, but its role in visual information processing in the retina is not well understood. The aim of this study was to give insight into the significance that histamine has for the distal retina function revealed by electroretinogram (ERG). The effect of 5 M histamine on the intensity – response function of the b-wave (ON response) and d-wave (OFF response) of ERG was investigated in dark adapted perfused frog eyecup preparations. Perfusion with histamine caused a significant enhancement of the amplitude of both the ON and OFF responses over the entire intensity range studied in comparison with corresponding values obtained in the control experiments. The enhancing effect of histamine was more pronounced upon the OFF than ON response in the lower intensity range, where the responses were mediated by rods. The reverse was true for the higher intensity range, where the responses were cone-dominated. The b-wave V – log I function had a steeper slope and narrower dynamic range during histamine treatment. Histamine did not alter significantly the relative sensitivity of the ON response, while it significantly increased the relative sensitivity of the OFF response. The present results clearly demonstrate that histamine has a significant effect on the intensity-response function of frog ERG b- and d-waves. This effect shows some ON/OFF asymmetries in dependence of the photoreceptor input.},
 year = {2016}
}

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TY  - JOUR
T1  - Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes
AU  - Elka Popova
AU  - Petia Kupenova
Y1  - 2016/09/13
PY  - 2016
N1  - https://doi.org/10.11648/j.ijovs.20160101.11
DO  - 10.11648/j.ijovs.20160101.11
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20160101.11
AB  - It is known that histamine is neurotransmitter of the retinopetal axons that originate from the tuberomamillary nucleus of the posterior hypothalamus, but its role in visual information processing in the retina is not well understood. The aim of this study was to give insight into the significance that histamine has for the distal retina function revealed by electroretinogram (ERG). The effect of 5 M histamine on the intensity – response function of the b-wave (ON response) and d-wave (OFF response) of ERG was investigated in dark adapted perfused frog eyecup preparations. Perfusion with histamine caused a significant enhancement of the amplitude of both the ON and OFF responses over the entire intensity range studied in comparison with corresponding values obtained in the control experiments. The enhancing effect of histamine was more pronounced upon the OFF than ON response in the lower intensity range, where the responses were mediated by rods. The reverse was true for the higher intensity range, where the responses were cone-dominated. The b-wave V – log I function had a steeper slope and narrower dynamic range during histamine treatment. Histamine did not alter significantly the relative sensitivity of the ON response, while it significantly increased the relative sensitivity of the OFF response. The present results clearly demonstrate that histamine has a significant effect on the intensity-response function of frog ERG b- and d-waves. This effect shows some ON/OFF asymmetries in dependence of the photoreceptor input.
VL  - 1
IS  - 1
ER  -

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