Summary/Abstract Background: Neural tube defects (NTDs) are one of the commonest malformations with worldwide prevalence of 1-3 per1000 live births. They are resulted by failure of neural tube to close during neurulation in 21-28 embryonic days and it’s a multi-factorial in etiology. Currently in Zambia there is no published data regarding NTDs at Arthur Davison Children Hospital (ADCH). Therefore this study was used to assess the frequency and distribution of NTDs at ADCH and will serve as base line reference for further studies. Method: A descriptive retrospective study was conducted to review medical records of children aged 1 day to 5 years who attended ADCH between September 2018 and May 2020. Results: During the study period, there were 2365 patients admitted at the health institution. NTDs were present in 52 cases, giving a prevalence of 0.022 thus 22/1000 births congenital anomalies of this kind observed at the institution were identified from October 2018 to May 2020 patients’ registers, which constituted the study sample. The sample had more boys (61.5%) than girls (38.5%) female with the majority (78.8%) aged between one day to twenty-eight days. The Majority of the children were from Copperbelt province with 88.5%, while the minority were from Muchinga province (1.9%). However the majority of children were from Ndola district (61.5%) and the minority from Mpika district (1.9%). The study showed that many children (96.2%) presented with Spinal Bifida (SB) and lastly encephalocele (3.8%). Myelomeningocele was the most common type of SB (21.2%). Hydrocephalus was the most common associated anomaly (19.2%) while the least associated anomaly was Microcephaly (3.8). Conclusion: The study showed that the majority of children were from Ndola district on the Copperbelt province and most children were admitted between day one and twenty eight days after birth. SB was the most common type of NTDs, and among these, those with myelomeningocele were the majority. Hydrocephalus was the most common associated impairment with majority of patients not undergoing any surgical interventions.
Published in | International Journal of Neurologic Physical Therapy (Volume 7, Issue 2) |
DOI | 10.11648/j.ijnpt.20210702.12 |
Page(s) | 20-29 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Neural Tube Defects, Spinal Bifida, Meningocele, Myelomeningocele, Encephalocele, Zambia
[1] | Adeleye AO, Dairo MD, Olowookere KG (2010). Central nervous system congenital malformations in a developing country: Issues and challenges against their prevention. Child's Nervous System; 26 (7): 919-924. |
[2] | Bussuk, A. G. and Kibar, Z (2009). Genetic basis of neural tube defects. Seminars in Pediatric Neurology 16, 101–110. http://dx.doi.org/10.1016/j.spen.2009.06.001. |
[3] | Christianson, A., Howson, C. & Modell, B. March of Dimes global report on birth defects: The hidden toll of dying and disabled children, March of Dimes Birth Defects Foundation, New York. |
[4] | De Paul Djientcheu V, Njamnshi AK, Wonkam A, et al. Management of neural tube defects in a Sub-Saharan African country: the situation in Yaounde, Cameroon. Journal of the neurological sciences. 2008; 275 (1), 29-32. |
[5] | Elsheikh, G. E. A. & Ibrahim, S. A (2009). Neural tube defects in Omdurman Maternity Hospital. Sudan, Khartoum Medical Journal2 (2), 185–190. |
[6] | Farmer, P. E. & Kim, J. Y (2008). Surgery and global health: A view from beyond the OR. World Journal of Surgery 32, 533–536. http://dx.doi.org/10.1007/s00268-008-9525-9. |
[7] | Feikin DR, Nguyen LM, Adazu K, et al. The impact of distance of residence from a peripheral health facility on pediatric health utilisation in rural western Kenya. Tropical Medicine & International Health. 2009; 14 (1): 54-61. |
[8] | Githuku, J. N., Azofeifa, A., Valencia, D., Ao, T., Hamner, H., Amwayi, S. et al (2014). Assessing the prevalence of spina bifida and encephalocele in a Kenyan hospital from 2005–2010: Implications for a neural tube defects surveillance system. The Pan African Medical Journal 18, 60. http://dx.doi.org/10.11604/pamj.2014.18.60.4070. |
[9] | Greene ND, Stanier P, Moore GE (2011). The emerging role of epigenetic mechanisms in the etiology of neural tube defects. Epigenetics; 6: 875-83. |
[10] | Greene ND, Stanier P, Copp AJ (2009). Genetics of human neural tube defects. Hum Mol Genet 15; 18 (R2): R113-29. |
[11] | Houcher, B., Bourouba, R., Djabi, F. & Houcher, Z (2008). The prevalence of neural tube defects in Setif University Maternity Hospital, Algeria. 3 years review. Pteridines19 (1) 12–18. http://dx.doi.org/10.1515/pteridines.2008.19.1.2 |
[12] | Idowu O, Apemiye R (2008). Outcome of myelomeningocoele repair in sub-Saharan Africa: The Nigerian experience. Acta Neurochirurgica; 150: 911-913. doi: 10.1007/s00701-008-0002-x. |
[13] | Joel-Medewase VI, Adeleye AO (2014). The social-economic and family background of the child with a CNS birth defect in a developing country in the current era. Nigerian Journal of Paediatrics; 42 (1): 55-58. |
[14] | Kunda I, Siziya S and Mwanakasale V (2016). A Review of Congenital Anomalies Presenting at Arthur Davison Children’s Hospital. International Journal of Sciences: Basic and Applied Research (IJSBAR). Volume 29, No 1, pp 148-154. |
[15] | Kruger C, Naman N. Cranial ultrasound in neonates and infants in rural Africa. South African Journal of Child Health. 2010; 4 (3): 83-87. |
[16] | Lazareff J (2011). Neural Tube Defects. Singapore: World Scientific Publishing Company. |
[17] | Luben T, Messer L, Mendola P, Carozza S, Horel S, Langlois P. Urban–rural residence and the occurrence of neural tube defects in Texas, 1999–2003. Health & Place. 2009; 15: 863-8. |
[18] | Margaron FC, Poenaru D, Bransford R, Albright AL. Timing of ventriculoperitoneal shunt insertion following spina bifida closure in Kenya’, Child's Nervous System 2010; 26 (11): 1523-8. |
[19] | Micah Simpamba, Margaret M. Mweshi and Patricia M. Struthers (2018). Profiling Children with Neural Tube Defects at the University Teaching Hospital, Lusaka, Zambia. Journal of Preventive and Rehabilitative Medicine, Vol. 1, No. 1, pp. 12-18. doi: 10.21617/jprm.2018.0101.2. |
[20] | Mweshi MM, Amosun SL, Ngoma MP, Nkandu EM. Ethnic Pattern of Origin of Children with Spina Bifida Managed at the University Teaching Hospital and Beit Cure Hospital, Lusaka, Zambia 2001-2010. Science. 2015; 3 (6): 857-861. |
[21] | Mweshi MM, Amosun SL, Ngoma MS, Nkandu EM. Managing children with spina bifida in sub-Saharan Africa: The Zambian experience? Medical Journal of Zambia. 2011; 38 (1): 13-23. |
[22] | Mweshi, M. M., Amosun, S. L., Ngoma, M. S., Nkandu, E. M., Sichizya, K., Chikoya, L. et al., ‘Endoscopic third ventriculostomy and choroid plexus cauterization in childhood hydrocephalus in Zambia’, Medical Journal of Zambia, 2010; 37 (4), 246–252. |
[23] | Nnadi DC, Singh S (2016). The prevalence of neural tube defects in North-West Nigeria. Saudi J Health Sci; 5: 6-10. |
[24] | Padmanabhan, R (2006). Etiology, pathogenesis and prevention of neural tube defects. Congenital Anomalies (Kyoto) 46 (2), 5–67. http://dx.doi.org/10.1111/j.1741-4520.2006.00104.x. |
[25] | Padayachy L, Ochieng D (2014). Perinatal management of spina bifida. South African Medical Journal; 104 (3): 219-219. |
[26] | Rofail, D., Maguire, L., Heelis, R., Colligs, A., Lindemann, M. & Abetz, L (2012). The impact of spina bifida on caregivers. Neurology and Therapy 1 (1), 1–12. http://dx.doi.org/10.1007/s40120-012-0004-8. |
[27] | Simpamba, M. M., Struthers, P. M., & Mweshi, M. M., (2016). Access to health care for children with neural tube defects: experiences of mothers in Zambia, AfricaJournal of Disability 5 (1), a267. http://dx.doi.org/10.4102/ajod.v5i1.267. |
[28] | Salih MA, Murshid WR, Seidahmed MZ (2014). Classification, clinical features, and genetics of neural tube defects. Saudi medical journal; 35 (12): 5-14. |
[29] | Wallingford, J. B., Niswander, L. A., Shaw, G. M. & Finnell, R. H (2013). The continuing challenge of understanding, preventing and treating neural tube defects. Science 339 (6123). http://dx.doi.org/10.1126/science.1222002. |
[30] | Wang JF, Li XH, Christakos G, Liao YL, Zhang T, Gu X, Zheng XY. Geographical detectors-based health risk assessment and its application in the neural tube defects study of the Heshun Region, China. International Journal of Geographical Information Science. 2010; 24 (1): 107-27. |
[31] | Warf BC. Hydrocephalus associated with neural tube defects: Characteristics, management, and outcome in sub-Saharan Africa. Child's Nervous System. 2011; 27 (10): 1589-94. |
[32] | Zaganjor I, Sekkarie A, Tsang BL, Williams J, Razzaghi H, Mulinare J, et al. (2016) Describing the Prevalence of Neural Tube Defects Worldwide: A./Systematic Literature Review. PLoS ONE 11 (4): e0151586. doi: 10.1371/journal.pone.015158. |
APA Style
Poster Mutambo, Paul Siapiila. (2021). The Frequency and Distribution of Neural Tube Defects (NTDs) at Arthur Davison Children Hospital (ADCH), Ndola Zambia. International Journal of Neurologic Physical Therapy, 7(2), 20-29. https://doi.org/10.11648/j.ijnpt.20210702.12
ACS Style
Poster Mutambo; Paul Siapiila. The Frequency and Distribution of Neural Tube Defects (NTDs) at Arthur Davison Children Hospital (ADCH), Ndola Zambia. Int. J. Neurol. Phys. Ther. 2021, 7(2), 20-29. doi: 10.11648/j.ijnpt.20210702.12
AMA Style
Poster Mutambo, Paul Siapiila. The Frequency and Distribution of Neural Tube Defects (NTDs) at Arthur Davison Children Hospital (ADCH), Ndola Zambia. Int J Neurol Phys Ther. 2021;7(2):20-29. doi: 10.11648/j.ijnpt.20210702.12
@article{10.11648/j.ijnpt.20210702.12, author = {Poster Mutambo and Paul Siapiila}, title = {The Frequency and Distribution of Neural Tube Defects (NTDs) at Arthur Davison Children Hospital (ADCH), Ndola Zambia}, journal = {International Journal of Neurologic Physical Therapy}, volume = {7}, number = {2}, pages = {20-29}, doi = {10.11648/j.ijnpt.20210702.12}, url = {https://doi.org/10.11648/j.ijnpt.20210702.12}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnpt.20210702.12}, abstract = {Summary/Abstract Background: Neural tube defects (NTDs) are one of the commonest malformations with worldwide prevalence of 1-3 per1000 live births. They are resulted by failure of neural tube to close during neurulation in 21-28 embryonic days and it’s a multi-factorial in etiology. Currently in Zambia there is no published data regarding NTDs at Arthur Davison Children Hospital (ADCH). Therefore this study was used to assess the frequency and distribution of NTDs at ADCH and will serve as base line reference for further studies. Method: A descriptive retrospective study was conducted to review medical records of children aged 1 day to 5 years who attended ADCH between September 2018 and May 2020. Results: During the study period, there were 2365 patients admitted at the health institution. NTDs were present in 52 cases, giving a prevalence of 0.022 thus 22/1000 births congenital anomalies of this kind observed at the institution were identified from October 2018 to May 2020 patients’ registers, which constituted the study sample. The sample had more boys (61.5%) than girls (38.5%) female with the majority (78.8%) aged between one day to twenty-eight days. The Majority of the children were from Copperbelt province with 88.5%, while the minority were from Muchinga province (1.9%). However the majority of children were from Ndola district (61.5%) and the minority from Mpika district (1.9%). The study showed that many children (96.2%) presented with Spinal Bifida (SB) and lastly encephalocele (3.8%). Myelomeningocele was the most common type of SB (21.2%). Hydrocephalus was the most common associated anomaly (19.2%) while the least associated anomaly was Microcephaly (3.8). Conclusion: The study showed that the majority of children were from Ndola district on the Copperbelt province and most children were admitted between day one and twenty eight days after birth. SB was the most common type of NTDs, and among these, those with myelomeningocele were the majority. Hydrocephalus was the most common associated impairment with majority of patients not undergoing any surgical interventions.}, year = {2021} }
TY - JOUR T1 - The Frequency and Distribution of Neural Tube Defects (NTDs) at Arthur Davison Children Hospital (ADCH), Ndola Zambia AU - Poster Mutambo AU - Paul Siapiila Y1 - 2021/08/18 PY - 2021 N1 - https://doi.org/10.11648/j.ijnpt.20210702.12 DO - 10.11648/j.ijnpt.20210702.12 T2 - International Journal of Neurologic Physical Therapy JF - International Journal of Neurologic Physical Therapy JO - International Journal of Neurologic Physical Therapy SP - 20 EP - 29 PB - Science Publishing Group SN - 2575-1778 UR - https://doi.org/10.11648/j.ijnpt.20210702.12 AB - Summary/Abstract Background: Neural tube defects (NTDs) are one of the commonest malformations with worldwide prevalence of 1-3 per1000 live births. They are resulted by failure of neural tube to close during neurulation in 21-28 embryonic days and it’s a multi-factorial in etiology. Currently in Zambia there is no published data regarding NTDs at Arthur Davison Children Hospital (ADCH). Therefore this study was used to assess the frequency and distribution of NTDs at ADCH and will serve as base line reference for further studies. Method: A descriptive retrospective study was conducted to review medical records of children aged 1 day to 5 years who attended ADCH between September 2018 and May 2020. Results: During the study period, there were 2365 patients admitted at the health institution. NTDs were present in 52 cases, giving a prevalence of 0.022 thus 22/1000 births congenital anomalies of this kind observed at the institution were identified from October 2018 to May 2020 patients’ registers, which constituted the study sample. The sample had more boys (61.5%) than girls (38.5%) female with the majority (78.8%) aged between one day to twenty-eight days. The Majority of the children were from Copperbelt province with 88.5%, while the minority were from Muchinga province (1.9%). However the majority of children were from Ndola district (61.5%) and the minority from Mpika district (1.9%). The study showed that many children (96.2%) presented with Spinal Bifida (SB) and lastly encephalocele (3.8%). Myelomeningocele was the most common type of SB (21.2%). Hydrocephalus was the most common associated anomaly (19.2%) while the least associated anomaly was Microcephaly (3.8). Conclusion: The study showed that the majority of children were from Ndola district on the Copperbelt province and most children were admitted between day one and twenty eight days after birth. SB was the most common type of NTDs, and among these, those with myelomeningocele were the majority. Hydrocephalus was the most common associated impairment with majority of patients not undergoing any surgical interventions. VL - 7 IS - 2 ER -