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Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report

Received: 4 October 2016     Accepted: 21 April 2017     Published: 26 September 2017
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Abstract

Purpose: To evaluate the effect of targeted exercises in phenytoin toxicity induced cereballar motor dysfunction. Method: A 45 years old female with simple partial epilepsy under medication phenytoin sodium 200mg/day since seven years. Subject presented with the increased serum phenytoin level around 40.00 more than the normal range 10.00-20.00 all cerebellar test were positive including balance and coordination test. Four weeks physiotherapy management was conducted using coordination exercises, PNF and balance exercises. Result: Four weeks of physiotherapy management along with medical management patients improved balance, coordination and ADL function. Conclusion: Acute reversible Phenytoin toxicity induced cerebellar dysfunction can be managed by providing specific balance, coordination and PNF for upper limb and lower limb.

Published in International Journal of Neurologic Physical Therapy (Volume 3, Issue 4)
DOI 10.11648/j.ijnpt.20170304.11
Page(s) 25-27
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Phenytoin Toxicity, Cerebellar Dysfunction, Epilepsy

References
[1] Villa A. M. Sica RE. Persistent cerebellar ataxia after toxic administration of diphenylhydantion. Arq Neuropsiquiatr 1994; 52 (4): 572-4.
[2] Ghatak NR. Santoso RA. Mckinney WM. Cerebellar degeneration following long term phenytoin therapy. Neurology 1995; 10 (3): 305-11.
[3] Benabou R. Carpenter S. Adermann F Dubeau F, Sherwin A. Progressive irreversible ataxia after long term phenytoing therapy. Neurology 1995; 45 (suppl 4): A368.
[4] Meena Gupta et. al persistent cerebellar ataxia with cerebellar cognitive affective syndrome due to acute phenytoin intoxication: A case report, Neurology Asia, 3013: 18 (1): 107-111.
[5] S. Ahmad, John Laidlaw, G. W. Houghton A. Richens, Involuntary movement caused by phenytoin intoxication in epileptic patients, 1975, 38, 22-231, Journal of Neurology, Neurosurgery and Psychiatry.
[6] Archnana Thakral, Radha Shenoy, Drik Deleu, Acute visual dysfunction following phenytoin-induced toxicity, Acta neurol belg, 2003 103, 218-220.
[7] Imamura T, Ejima A, Sahara M, Saito H, Tsuburaya K. Cerebellar atrophy and persistent cerebellar ataxia after acute intoxication of phenytoin. Brain Nerve 1992; 44 (2): 149-53.
[8] Nitin Kumar, Annaya Chakraborthy, Anand L Betdur, Phenytoin-Induced Cerebellar atrophy and epileptic boy, In Journal of Pharmacology, 2013: 45 (6): 636-637.
[9] Ahuja SR, Karade S, Kulkarni MV, Cerebellar atrophy in an epileptic child: Is it due to phenytoin? Journal of Postgraduate Medicine, 2000; 46: 278-9.
[10] DP Holschneider, J Yang Y Guo, J-M I Maarek, Reorganization of Functional Brain Maps After exercise Training: Importance of cerebellar- Thalamic- Cortical Pathway, Brain Res. 2007 December 12; 1184: 96-107.
[11] David Drijkoningen et. al, Training –induced improvement in postural control are accompanied by alteration in cerebellar white matter in brain injured patients, Neurolmage: Clinical 7 (2015) 240-251.
[12] Kadriye Armutlu, Rana Karabudak and Gulay Nurlu Physiotherapy Approaches in the treatment of Ataxic Multiple Sclerosis: A pilot study, neurorehabilitation and Neural Repair: 2001: 15; 203-211.
[13] Vaclav Marcian, Pavel Filip, Martin Bares Milan Brazdil, Cerebellar Dysfunction and Atxai in Patients with Epilepsy: Coincidence, Consequence, or Cause?, Tremor Other Hyperkinetic Movement (NY) 2016, 6: 376.
[14] Matthis Synozik, Winfried Tlg, Motor Training in Degenerative Spinocerebellar Disease: Ataxia-Specific Improvements by Intensive Physiotherapy and Exergames, BioMed Research International, 2014, 10.1155/583507.
[15] U. Bultmann, D Pierscianek, E. R. Gizewski et. al, Functional recovery and rehabilitation of postural impairment and gait ataxia in patient with acute cerebellar stroke, Gait and Posture, 2004, Vol. 39, no. 1, 563-569.
[16] Thach WT, Bastian AJ, Role of the cerebellum in the control and adaptation of gait in health disease, Progress Brain Research, 2004: 143: 353-66.
[17] V R patel, D. S. Zee, The cerebellum in eye movement control: nystagmus, coordinate frames and disconjugacy, The scientific journal of the royal college of opthalmoplegia, 2015 Feb: 29 (2): 191-195.
[18] Richard V Abadi, Mechanisms underlying nystagmus, Journal of the royal society of medicine, 2002 May: 95 (5): 231-234.
[19] Byung In Han, Hyun Seok Song, Ji Soo Kim, Vestibular rehabilitation therapy: Review of indications, mechanism and key exercises, Journal of Clinical Neurology, 2011 Dec: 7 (4): 184-196.
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  • APA Style

    Tenzing Norbu Lama, Smita K. C. (2017). Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report. International Journal of Neurologic Physical Therapy, 3(4), 25-27. https://doi.org/10.11648/j.ijnpt.20170304.11

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    ACS Style

    Tenzing Norbu Lama; Smita K. C. Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report. Int. J. Neurol. Phys. Ther. 2017, 3(4), 25-27. doi: 10.11648/j.ijnpt.20170304.11

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    AMA Style

    Tenzing Norbu Lama, Smita K. C. Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report. Int J Neurol Phys Ther. 2017;3(4):25-27. doi: 10.11648/j.ijnpt.20170304.11

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  • @article{10.11648/j.ijnpt.20170304.11,
      author = {Tenzing Norbu Lama and Smita K. C.},
      title = {Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report},
      journal = {International Journal of Neurologic Physical Therapy},
      volume = {3},
      number = {4},
      pages = {25-27},
      doi = {10.11648/j.ijnpt.20170304.11},
      url = {https://doi.org/10.11648/j.ijnpt.20170304.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnpt.20170304.11},
      abstract = {Purpose: To evaluate the effect of targeted exercises in phenytoin toxicity induced cereballar motor dysfunction. Method: A 45 years old female with simple partial epilepsy under medication phenytoin sodium 200mg/day since seven years. Subject presented with the increased serum phenytoin level around 40.00 more than the normal range 10.00-20.00 all cerebellar test were positive including balance and coordination test. Four weeks physiotherapy management was conducted using coordination exercises, PNF and balance exercises. Result: Four weeks of physiotherapy management along with medical management patients improved balance, coordination and ADL function. Conclusion: Acute reversible Phenytoin toxicity induced cerebellar dysfunction can be managed by providing specific balance, coordination and PNF for upper limb and lower limb.},
     year = {2017}
    }
    

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    T1  - Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report
    AU  - Tenzing Norbu Lama
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    T2  - International Journal of Neurologic Physical Therapy
    JF  - International Journal of Neurologic Physical Therapy
    JO  - International Journal of Neurologic Physical Therapy
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    PB  - Science Publishing Group
    SN  - 2575-1778
    UR  - https://doi.org/10.11648/j.ijnpt.20170304.11
    AB  - Purpose: To evaluate the effect of targeted exercises in phenytoin toxicity induced cereballar motor dysfunction. Method: A 45 years old female with simple partial epilepsy under medication phenytoin sodium 200mg/day since seven years. Subject presented with the increased serum phenytoin level around 40.00 more than the normal range 10.00-20.00 all cerebellar test were positive including balance and coordination test. Four weeks physiotherapy management was conducted using coordination exercises, PNF and balance exercises. Result: Four weeks of physiotherapy management along with medical management patients improved balance, coordination and ADL function. Conclusion: Acute reversible Phenytoin toxicity induced cerebellar dysfunction can be managed by providing specific balance, coordination and PNF for upper limb and lower limb.
    VL  - 3
    IS  - 4
    ER  - 

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Author Information
  • Manual Therapy and Pain Relief Centre, Lalitpur, Nepal

  • School of Medical Sciences, Department of Physiotherapy, Kathmandu University, Dhulikhel, Nepal

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