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Immunohistopathological Profile and Biomolecular Level of Central Nerve Tumors in Kinshasa, DRC According to the Classification of the World Health Organization 2016

Received: 10 March 2021     Accepted: 29 April 2021     Published: 14 May 2021
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Abstract

The goal is to determine immunohistochemical histopathological profile and biomolecular level of Central nerve Tumors in Kinshasa, DRC. According to the classification of the World Health Organization (WHO) 2016. Our study is described on a series of cases that were studied using standard histopathological techniques, before undergoing specific immunohistochemical techniques for the detection of anti-IDH1antibodies in gliomas and biomolecular ones in the search for 1p19q deletion. Central nerve tumors account for 0.18% of all conditions, over a period of time. Meningothelial-type meningioma was the most common (60.9%). The most affected age group is over 50. The distribution of tumors by sex shows a predominance of woman (67.1%). The gliomas had constituted 29.6% of all nerve tumors recorded over the period considered and whose predominance was constituted by oligoastrocytomas with 42.1%. The immunohistochemical profile is characterized by a strong positivity with the anti-IDH1antibody in case of grade II oligoastrocytoma with 6.6%. Our study showed that central nerve tumors account for 0.18 of all conditions, gliomas are made up of 29.6% of all nerve tumors listed with a predominance of oligoastrocytomas. The immunohistochemical profile is characterized by a strong positivity with the anti-IDH1antibody in case of grade II.

Published in International Journal of Immunology (Volume 9, Issue 2)
DOI 10.11648/j.iji.20210902.12
Page(s) 29-36
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Tumors, Glioma, Histopathologic, Immunohistochemestry, Biomolecular, Classification WHO 2016

References
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  • APA Style

    Kisile Mikuo Olive, Kabongo Mpolesha Jean Marie, Claudia Manini. (2021). Immunohistopathological Profile and Biomolecular Level of Central Nerve Tumors in Kinshasa, DRC According to the Classification of the World Health Organization 2016. International Journal of Immunology, 9(2), 29-36. https://doi.org/10.11648/j.iji.20210902.12

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    ACS Style

    Kisile Mikuo Olive; Kabongo Mpolesha Jean Marie; Claudia Manini. Immunohistopathological Profile and Biomolecular Level of Central Nerve Tumors in Kinshasa, DRC According to the Classification of the World Health Organization 2016. Int. J. Immunol. 2021, 9(2), 29-36. doi: 10.11648/j.iji.20210902.12

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    AMA Style

    Kisile Mikuo Olive, Kabongo Mpolesha Jean Marie, Claudia Manini. Immunohistopathological Profile and Biomolecular Level of Central Nerve Tumors in Kinshasa, DRC According to the Classification of the World Health Organization 2016. Int J Immunol. 2021;9(2):29-36. doi: 10.11648/j.iji.20210902.12

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  • @article{10.11648/j.iji.20210902.12,
      author = {Kisile Mikuo Olive and Kabongo Mpolesha Jean Marie and Claudia Manini},
      title = {Immunohistopathological Profile and Biomolecular Level of Central Nerve Tumors in Kinshasa, DRC According to the Classification of the World Health Organization 2016},
      journal = {International Journal of Immunology},
      volume = {9},
      number = {2},
      pages = {29-36},
      doi = {10.11648/j.iji.20210902.12},
      url = {https://doi.org/10.11648/j.iji.20210902.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20210902.12},
      abstract = {The goal is to determine immunohistochemical histopathological profile and biomolecular level of Central nerve Tumors in Kinshasa, DRC. According to the classification of the World Health Organization (WHO) 2016. Our study is described on a series of cases that were studied using standard histopathological techniques, before undergoing specific immunohistochemical techniques for the detection of anti-IDH1antibodies in gliomas and biomolecular ones in the search for 1p19q deletion. Central nerve tumors account for 0.18% of all conditions, over a period of time. Meningothelial-type meningioma was the most common (60.9%). The most affected age group is over 50. The distribution of tumors by sex shows a predominance of woman (67.1%). The gliomas had constituted 29.6% of all nerve tumors recorded over the period considered and whose predominance was constituted by oligoastrocytomas with 42.1%. The immunohistochemical profile is characterized by a strong positivity with the anti-IDH1antibody in case of grade II oligoastrocytoma with 6.6%. Our study showed that central nerve tumors account for 0.18 of all conditions, gliomas are made up of 29.6% of all nerve tumors listed with a predominance of oligoastrocytomas. The immunohistochemical profile is characterized by a strong positivity with the anti-IDH1antibody in case of grade II.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Immunohistopathological Profile and Biomolecular Level of Central Nerve Tumors in Kinshasa, DRC According to the Classification of the World Health Organization 2016
    AU  - Kisile Mikuo Olive
    AU  - Kabongo Mpolesha Jean Marie
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    DO  - 10.11648/j.iji.20210902.12
    T2  - International Journal of Immunology
    JF  - International Journal of Immunology
    JO  - International Journal of Immunology
    SP  - 29
    EP  - 36
    PB  - Science Publishing Group
    SN  - 2329-1753
    UR  - https://doi.org/10.11648/j.iji.20210902.12
    AB  - The goal is to determine immunohistochemical histopathological profile and biomolecular level of Central nerve Tumors in Kinshasa, DRC. According to the classification of the World Health Organization (WHO) 2016. Our study is described on a series of cases that were studied using standard histopathological techniques, before undergoing specific immunohistochemical techniques for the detection of anti-IDH1antibodies in gliomas and biomolecular ones in the search for 1p19q deletion. Central nerve tumors account for 0.18% of all conditions, over a period of time. Meningothelial-type meningioma was the most common (60.9%). The most affected age group is over 50. The distribution of tumors by sex shows a predominance of woman (67.1%). The gliomas had constituted 29.6% of all nerve tumors recorded over the period considered and whose predominance was constituted by oligoastrocytomas with 42.1%. The immunohistochemical profile is characterized by a strong positivity with the anti-IDH1antibody in case of grade II oligoastrocytoma with 6.6%. Our study showed that central nerve tumors account for 0.18 of all conditions, gliomas are made up of 29.6% of all nerve tumors listed with a predominance of oligoastrocytomas. The immunohistochemical profile is characterized by a strong positivity with the anti-IDH1antibody in case of grade II.
    VL  - 9
    IS  - 2
    ER  - 

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Author Information
  • Pathological Anatomy Departmen, Medical School, Kinshasa University Clinics, Kinshasa, Democratic Republic of the Congo

  • Pathological Anatomy Departmen, Medical School, Kinshasa University Clinics, Kinshasa, Democratic Republic of the Congo

  • Pathological Anatomy Department, Hospital Center of San Giovanni Bosco, Turin, Italy

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