Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020

Dawit Mulugeta; Emeru Adeba; Belachew Etana; Amanuel Lamesa

doi:doi:10.11648/j.ijhpebs.20220801.13

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Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020

Dawit Mulugeta, Emeru Adeba, Belachew Etana, Amanuel Lamesa

Published in International Journal of HIV/AIDS Prevention, Education and Behavioural Science (Volume 8, Issue 1)

Received: 14 January 2022 Accepted: 5 February 2022 Published: 16 February 2022

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Abstract

Purpose: A key goal of anti-retro viral treatment is to achieve and maintain durable viral load suppression. Viral load is the concentration of HIV RNA in the blood. Viral load suppressed clients have low HIV transmission to sexual partner and important in HIV/AIDS epidemic control. Challenges in providing rapid and comprehensive care to patient with high viral load lead to poor or limited response among PLHIV with viremia. Viral load suppression at different Africa countries is low when compared to globally given target. Person with high viral load have recurrent opportunistic infection and higher transmission of HIV/AIDS. So the aim of this study to assess viral load suppression and associated factors among high viral load ART clients at public health facilities of Nekemte town. Patient and Methods: an institutional based cross sectional study was conducted among 418 proportionally selected high viral load ART clients (VL ≥ 1000copies/ml) from July 3, 2017 to September 26, 2019. Study participants were selected through simple random sampling technique. The association between dependent and independent variable was tested by binary logistic regression and those candidate with P value < 0.2 was selected and multiple binary logistic regression was conducted to identify the independent predictors of viral load suppression and AOR with its 95% CI and value of P < 0.05 was declared as statistical significance. Result: Of 418 high viral loads ART clients, 64% had suppressed viral load result. The probability of viral load suppression was higher among 1^st line ARV regimen (AOR=3.86, 95% CI: 1.04-3.11), annual viral load test (AOR=6.1, 95 CI: 3.4-10.6), and CD4 count ≥ 200 (AOR=3.64, 95% CI: 1.98-6.7). The probability of viral load suppression was lower among clients with history of hospitalization (AOR=0.43, 95% CI: 0.21-0.89) and receiving CPT (AOR=0.56, 95% CI: 0.32-0.97). Conclusion: This study showed that viral load suppression was near to the WHO target (70%). Clients with CD4 cell count ≥ 200, discontinued CPT, 1^st line ARV regimen, annual viral load test had higher probability of viral load suppression while clients with bedridden functional status and history of hospitalization had lower probability of viral load suppression. Clients on 2^nd line had low viral load suppression as compared to 1^st line and enhanced adherence counseling had no association in viral load suppression which need further research.

Published in	International Journal of HIV/AIDS Prevention, Education and Behavioural Science (Volume 8, Issue 1)
DOI	10.11648/j.ijhpebs.20220801.13
Page(s)	12-18
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Enhancive Adherence Counseling, Viral Load, High Viral Load, Viral Load Suppression, Nekemte Town, Ethiopia

References

[1]	ICAP’s clinical and training unit, “Standard Operating Procedures on Viral Load Monitoring for ICAP Clinical Staff and Health Care Workers: A Template Document for Country Adaptation, July 2015.”
[2]	M. C. Pearson Jennifer, Vraso Alex, Tumwikirize Juliet, Ahimbisibwe Allan, Balachandra Shirish, “Managing Viral Load Results,” pp. 1–26.
[3]	Federal Ministry of heath of Ethiopia, National Consolidated Guideline for Comprehensive HIV Prevention, Care and treatment 2018 (August).
[4]	UNAIDS 2019, “Global AIDS Monitoring,” 2020.
[5]	I. G. Family, welfare,Health Ministry, “National Operational Guideline for Viral Load Testing.”
[6]	L. E. Bain, C. Nkoke, and J. J. N. Noubiap, “UNAIDS 90 – 90 – 90 targets to end the AIDS epidemic by 2020 are not realistic: comment on ‘Can the UNAIDS 90 – 90 – 90 target be achieved? A systematic analysis of national HIV treatment cascades,’” pp. 2016–2018, 2020.
[7]	G. Ayele, B. Tessema, A. Amsalu, G. Ferede, and G. Yismaw, “Prevalence and associated factors of treatment failure among HIV / AIDS patients on HAART attending University of Gondar Referral Hospital Northwest Ethiopia,” pp. 1–13, 2018.
[8]	B. Maryland, University of, “Viremia Clinics in Kenya: Enhanced Monitoring and Management of HIV- Positive Individuals on Antiretroviral Treatment with High Viral Load.” pp. 1–9.
[9]	H. Sunpath, “Clinical guidelines for the management of HIV / AIDS in adults and adolescents ≥ 15 years What is NEW Co Infections Monitoring VL and DR Drug.”
[10]	G. Ali, Jemal Hassen,Yirtaw, Tewodros, “Time to viral load suppression and its associated factors in cohort of patients taking antiretroviral treatment in East,” pp. 1–6, 2019.
[11]	T. B. Id, S. S. Id, K. C. Takarinda, and H. Bara, “Enhanced adherence counselling and viral load suppression in HIV seropositive patients with an initial high viral load in Harare, Zimbabwe: Operational issues,” vol. 444, pp. 1–13, 2019.
[12]	G. Diress, S. Dagne, B. Alemnew, S. Adane, and A. Addisu, “Viral Load Suppression after Enhanced Adherence Counseling and Its Predictors among High Viral Load HIV Seropositive People in North Wollo Zone Public Hospitals, Northeast Ethiopia, 2019: Retrospective Cohort Study,” vol. 2020, 2020.
[13]	K. Bonner, A. Mezochow, T. Roberts, N. Ford, and J. Cohn, “Viral Load Monitoring as a Tool to Reinforce Adherence: A Systematic Review Authors Viral Load Monitoring as a Tool to Reinforce Adherence: A Systematic Review,” 2020.
[14]	E. Nasuuna, J. Kigozi, L. Babirye, A. Muganzi, and N. K. Sewankambo, “Low HIV viral suppression rates following the intensive adherence counseling (IAC) program for children and adolescents with viral failure in public health facilities in Uganda,” pp. 1–9, 2018.
[15]	A. A. Desta, T. W. Woldearegay, N. Futwi, G. T. Gebrehiwot, G. G. Gebru, A. A. Berhe, and H. Godefay, “HIV virological non-suppression and factors associated with non-suppression among adolescents and adults on antiretroviral therapy in northern Ethiopia : a retrospective study,” pp. 1–10, 2020.
[16]	S. Abebaw, Addisu, Taddele, Mekuanint, Alem, Girma, Birlew, Tesfa, Berihun, “Magnitude of virologic failure and associated factors among adult patients on antiretroviral therapy at Debre,” pp. 1–31, 2020.
[17]	S. Rangarajan, D. J. Colby, G. Le Truong, B. D. Duong, H. N. Huu, T. P. Broh, and D. T. Tri, “Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam,” pp. 94–101, 2016.
[18]	B. Castelnuovo, J. Sempa, K. N. Agnes, M. R. Kamya, and Y. C. Manabe, “Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings,” no. April, 2011.
[19]	J. De Dieu, N. Ntwali, T. Decroo, M. Ribakare, and A. Kiromera, “Viral load detection and management on first line ART in rural Rwanda,” pp. 1–9, 2019.
[20]	Y. A. Melsew, M. W. Terefe, G. A. Tessema, and T. A. Ayele, “Rate of Immunological Failure and its Predictors among Patients on Highly Active Antiretroviral Therapy at Debremarkos Hospital, Northwest Ethiopia: A Retrospective Follow up Study AIDS & Clinical Research,” vol. 4, no. 5, 2013.
[21]	H. Sultan, S. Hussen, M. Mama, B. Mekonnen, M. Shegaze, N. Boti, and M. Shure, “Predictors of Time to Viral Load Suppression of Adult PLWHIV on ART in Arba Minch General Hospital: A Follow up Study,” pp. 6–13.
[22]	B. A. Yihun, G. D. Kibret, C. Tesema, and L. Id, “Incidence and predictors of treatment failure among children on first-line antiretroviral therapy in Amhara Region Referral Hospitals, northwest Ethiopia 2018: A retrospective study,” pp. 1–15, 2019.

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Dawit Mulugeta, Emeru Adeba, Belachew Etana, Amanuel Lamesa. (2022). Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020. International Journal of HIV/AIDS Prevention, Education and Behavioural Science, 8(1), 12-18. https://doi.org/10.11648/j.ijhpebs.20220801.13

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ACS Style

Dawit Mulugeta; Emeru Adeba; Belachew Etana; Amanuel Lamesa. Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020. Int. J. HIV/AIDS Prev. Educ. Behav. Sci. 2022, 8(1), 12-18. doi: 10.11648/j.ijhpebs.20220801.13

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AMA Style

Dawit Mulugeta, Emeru Adeba, Belachew Etana, Amanuel Lamesa. Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020. Int J HIV/AIDS Prev Educ Behav Sci. 2022;8(1):12-18. doi: 10.11648/j.ijhpebs.20220801.13

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@article{10.11648/j.ijhpebs.20220801.13,
  author = {Dawit Mulugeta and Emeru Adeba and Belachew Etana and Amanuel Lamesa},
  title = {Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020},
  journal = {International Journal of HIV/AIDS Prevention, Education and Behavioural Science},
  volume = {8},
  number = {1},
  pages = {12-18},
  doi = {10.11648/j.ijhpebs.20220801.13},
  url = {https://doi.org/10.11648/j.ijhpebs.20220801.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijhpebs.20220801.13},
  abstract = {Purpose: A key goal of anti-retro viral treatment is to achieve and maintain durable viral load suppression. Viral load is the concentration of HIV RNA in the blood. Viral load suppressed clients have low HIV transmission to sexual partner and important in HIV/AIDS epidemic control. Challenges in providing rapid and comprehensive care to patient with high viral load lead to poor or limited response among PLHIV with viremia. Viral load suppression at different Africa countries is low when compared to globally given target. Person with high viral load have recurrent opportunistic infection and higher transmission of HIV/AIDS. So the aim of this study to assess viral load suppression and associated factors among high viral load ART clients at public health facilities of Nekemte town. Patient and Methods: an institutional based cross sectional study was conducted among 418 proportionally selected high viral load ART clients (VL ≥ 1000copies/ml) from July 3, 2017 to September 26, 2019. Study participants were selected through simple random sampling technique. The association between dependent and independent variable was tested by binary logistic regression and those candidate with P value st line ARV regimen (AOR=3.86, 95% CI: 1.04-3.11), annual viral load test (AOR=6.1, 95 CI: 3.4-10.6), and CD4 count ≥ 200 (AOR=3.64, 95% CI: 1.98-6.7). The probability of viral load suppression was lower among clients with history of hospitalization (AOR=0.43, 95% CI: 0.21-0.89) and receiving CPT (AOR=0.56, 95% CI: 0.32-0.97). Conclusion: This study showed that viral load suppression was near to the WHO target (70%). Clients with CD4 cell count ≥ 200, discontinued CPT, 1st line ARV regimen, annual viral load test had higher probability of viral load suppression while clients with bedridden functional status and history of hospitalization had lower probability of viral load suppression. Clients on 2nd line had low viral load suppression as compared to 1st line and enhanced adherence counseling had no association in viral load suppression which need further research.},
 year = {2022}
}

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TY  - JOUR
T1  - Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020
AU  - Dawit Mulugeta
AU  - Emeru Adeba
AU  - Belachew Etana
AU  - Amanuel Lamesa
Y1  - 2022/02/16
PY  - 2022
N1  - https://doi.org/10.11648/j.ijhpebs.20220801.13
DO  - 10.11648/j.ijhpebs.20220801.13
T2  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
JF  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
JO  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
SP  - 12
EP  - 18
PB  - Science Publishing Group
SN  - 2575-5765
UR  - https://doi.org/10.11648/j.ijhpebs.20220801.13
AB  - Purpose: A key goal of anti-retro viral treatment is to achieve and maintain durable viral load suppression. Viral load is the concentration of HIV RNA in the blood. Viral load suppressed clients have low HIV transmission to sexual partner and important in HIV/AIDS epidemic control. Challenges in providing rapid and comprehensive care to patient with high viral load lead to poor or limited response among PLHIV with viremia. Viral load suppression at different Africa countries is low when compared to globally given target. Person with high viral load have recurrent opportunistic infection and higher transmission of HIV/AIDS. So the aim of this study to assess viral load suppression and associated factors among high viral load ART clients at public health facilities of Nekemte town. Patient and Methods: an institutional based cross sectional study was conducted among 418 proportionally selected high viral load ART clients (VL ≥ 1000copies/ml) from July 3, 2017 to September 26, 2019. Study participants were selected through simple random sampling technique. The association between dependent and independent variable was tested by binary logistic regression and those candidate with P value st line ARV regimen (AOR=3.86, 95% CI: 1.04-3.11), annual viral load test (AOR=6.1, 95 CI: 3.4-10.6), and CD4 count ≥ 200 (AOR=3.64, 95% CI: 1.98-6.7). The probability of viral load suppression was lower among clients with history of hospitalization (AOR=0.43, 95% CI: 0.21-0.89) and receiving CPT (AOR=0.56, 95% CI: 0.32-0.97). Conclusion: This study showed that viral load suppression was near to the WHO target (70%). Clients with CD4 cell count ≥ 200, discontinued CPT, 1st line ARV regimen, annual viral load test had higher probability of viral load suppression while clients with bedridden functional status and history of hospitalization had lower probability of viral load suppression. Clients on 2nd line had low viral load suppression as compared to 1st line and enhanced adherence counseling had no association in viral load suppression which need further research.
VL  - 8
IS  - 1
ER  -

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Author Information

Dawit Mulugeta

Nekemte Specialized Hospital, Nekemte, Ethiopia
Emeru Adeba

Institute of Public Health, Wollega University, Nekemte, Ethiopia
Belachew Etana

Institute of Public Health, Wollega University, Nekemte, Ethiopia
Amanuel Lamesa

Nekemte Town Health Office, Nekemte, Ethiopia

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APA Style

Dawit Mulugeta, Emeru Adeba, Belachew Etana, Amanuel Lamesa. (2022). Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020. International Journal of HIV/AIDS Prevention, Education and Behavioural Science, 8(1), 12-18. https://doi.org/10.11648/j.ijhpebs.20220801.13

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ACS Style

Dawit Mulugeta; Emeru Adeba; Belachew Etana; Amanuel Lamesa. Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020. Int. J. HIV/AIDS Prev. Educ. Behav. Sci. 2022, 8(1), 12-18. doi: 10.11648/j.ijhpebs.20220801.13

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AMA Style

Dawit Mulugeta, Emeru Adeba, Belachew Etana, Amanuel Lamesa. Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020. Int J HIV/AIDS Prev Educ Behav Sci. 2022;8(1):12-18. doi: 10.11648/j.ijhpebs.20220801.13

Copy | Download

@article{10.11648/j.ijhpebs.20220801.13,
  author = {Dawit Mulugeta and Emeru Adeba and Belachew Etana and Amanuel Lamesa},
  title = {Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020},
  journal = {International Journal of HIV/AIDS Prevention, Education and Behavioural Science},
  volume = {8},
  number = {1},
  pages = {12-18},
  doi = {10.11648/j.ijhpebs.20220801.13},
  url = {https://doi.org/10.11648/j.ijhpebs.20220801.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijhpebs.20220801.13},
  abstract = {Purpose: A key goal of anti-retro viral treatment is to achieve and maintain durable viral load suppression. Viral load is the concentration of HIV RNA in the blood. Viral load suppressed clients have low HIV transmission to sexual partner and important in HIV/AIDS epidemic control. Challenges in providing rapid and comprehensive care to patient with high viral load lead to poor or limited response among PLHIV with viremia. Viral load suppression at different Africa countries is low when compared to globally given target. Person with high viral load have recurrent opportunistic infection and higher transmission of HIV/AIDS. So the aim of this study to assess viral load suppression and associated factors among high viral load ART clients at public health facilities of Nekemte town. Patient and Methods: an institutional based cross sectional study was conducted among 418 proportionally selected high viral load ART clients (VL ≥ 1000copies/ml) from July 3, 2017 to September 26, 2019. Study participants were selected through simple random sampling technique. The association between dependent and independent variable was tested by binary logistic regression and those candidate with P value st line ARV regimen (AOR=3.86, 95% CI: 1.04-3.11), annual viral load test (AOR=6.1, 95 CI: 3.4-10.6), and CD4 count ≥ 200 (AOR=3.64, 95% CI: 1.98-6.7). The probability of viral load suppression was lower among clients with history of hospitalization (AOR=0.43, 95% CI: 0.21-0.89) and receiving CPT (AOR=0.56, 95% CI: 0.32-0.97). Conclusion: This study showed that viral load suppression was near to the WHO target (70%). Clients with CD4 cell count ≥ 200, discontinued CPT, 1st line ARV regimen, annual viral load test had higher probability of viral load suppression while clients with bedridden functional status and history of hospitalization had lower probability of viral load suppression. Clients on 2nd line had low viral load suppression as compared to 1st line and enhanced adherence counseling had no association in viral load suppression which need further research.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Viral Load Suppression and Associated Factors Among High Viral Load Antiretroviral Treatment Client at Public Health Facilities of Nekemte Town, Nekemte, Ethiopia, 2020
AU  - Dawit Mulugeta
AU  - Emeru Adeba
AU  - Belachew Etana
AU  - Amanuel Lamesa
Y1  - 2022/02/16
PY  - 2022
N1  - https://doi.org/10.11648/j.ijhpebs.20220801.13
DO  - 10.11648/j.ijhpebs.20220801.13
T2  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
JF  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
JO  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
SP  - 12
EP  - 18
PB  - Science Publishing Group
SN  - 2575-5765
UR  - https://doi.org/10.11648/j.ijhpebs.20220801.13
AB  - Purpose: A key goal of anti-retro viral treatment is to achieve and maintain durable viral load suppression. Viral load is the concentration of HIV RNA in the blood. Viral load suppressed clients have low HIV transmission to sexual partner and important in HIV/AIDS epidemic control. Challenges in providing rapid and comprehensive care to patient with high viral load lead to poor or limited response among PLHIV with viremia. Viral load suppression at different Africa countries is low when compared to globally given target. Person with high viral load have recurrent opportunistic infection and higher transmission of HIV/AIDS. So the aim of this study to assess viral load suppression and associated factors among high viral load ART clients at public health facilities of Nekemte town. Patient and Methods: an institutional based cross sectional study was conducted among 418 proportionally selected high viral load ART clients (VL ≥ 1000copies/ml) from July 3, 2017 to September 26, 2019. Study participants were selected through simple random sampling technique. The association between dependent and independent variable was tested by binary logistic regression and those candidate with P value st line ARV regimen (AOR=3.86, 95% CI: 1.04-3.11), annual viral load test (AOR=6.1, 95 CI: 3.4-10.6), and CD4 count ≥ 200 (AOR=3.64, 95% CI: 1.98-6.7). The probability of viral load suppression was lower among clients with history of hospitalization (AOR=0.43, 95% CI: 0.21-0.89) and receiving CPT (AOR=0.56, 95% CI: 0.32-0.97). Conclusion: This study showed that viral load suppression was near to the WHO target (70%). Clients with CD4 cell count ≥ 200, discontinued CPT, 1st line ARV regimen, annual viral load test had higher probability of viral load suppression while clients with bedridden functional status and history of hospitalization had lower probability of viral load suppression. Clients on 2nd line had low viral load suppression as compared to 1st line and enhanced adherence counseling had no association in viral load suppression which need further research.
VL  - 8
IS  - 1
ER  -

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