| Peer-Reviewed

Clinical, Biological and Sociodemographic Profiles of Highly Active Anti-Retroviral Therapy (HAART) Naïve Patients in the Garoua Military Hospital, Cameroon

Received: 28 October 2015     Accepted: 4 November 2015     Published: 19 February 2016
Views:       Downloads:
Abstract

Knowing at what point patients are put on treatment during the clinical and biological (CD4 count) stages of HIV is important. This study investigated the clinical, biological and sociodemographic profiles of highly active antiretroviral therapy (HAART) naïve patients in the Garoua military hospital, Cameroon. This was a cross-sectional study that collected data on demographic, clinical and laboratory variables from 66HIV-infected patients aged 19 years and older from January 2013 to January 2014. Data were analysed using the Statistical Package for Social Sciences (SPSS) version 20 software program at the level 0.05. Sixty-six (66) HIV positive patients were received in the health facility during the study period, the majority of whom were female, 65.6%. Only 37.5% of their sexual partners were aware of patients’ HIV serostatus. Similarly, only 26.8% of patients’ stable sexual partners had done an HIV test, of which 73.3% tested positive. Skin diseases, weight loss and chronic fever were the commonest clinical manifestations found (33.3%, 25.4% and 17.5% respectively). About 90% of the clients had CD4 counts less than 350 cells/mm3 on clinical presentation. Hemoglobin counts less than 12g/dl were found in 72.7 % of the clients. Females were more likely than males to present with skin diseases, weight loss and fever. However, the differences were not statistically significant (p=0.159). Similarly, females (65.0%) were more likely to have CD4 counts less than 350 compared to males (35.0%) (p=0.167). More patients age less than 35 years, presented with skin diseases, weight loss and cough than those age more than 35 years. However, these differences were not statistically significant (p=0.632). In the same vein, more patients, age less than 35, had CD4 counts less than 350, than those aged more than 35 years (p=0.430). Most of our study patients had CD4 counts less than 350 cells/ml at presentation for HAART initiation. This suggests late HIV diagnosis and thus a delayed opportunity for timely access to HIV care and initiation of HAART. There is the need to intensify efforts in early routine HIV counseling and testing in health facilities in the cities, smaller towns and rural communities, so as to reduce the frequency of late HIV diagnosis with its potential implications. Encouraging clients to get their partners tested and consequently be managed appropriately is of utmost need in this area. Qualitative research to better ascertain reasons of not knowing partner status should be carried out.

Published in International Journal of HIV/AIDS Prevention, Education and Behavioural Science (Volume 1, Issue 3)
DOI 10.11648/j.ijhpebs.20150103.11
Page(s) 21-26
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

HAART Initiation, HIV Naïve Patients, Clinical and Biological Profile, Garoua, Cameroon

References
[1] UNAIDS, Report on the global AIDS epidemic 2012. Geneva, Switzerland UNAIDS, 2012.
[2] Centers for Disease Control and Prevention, Update: trends in AIDS incidence, deaths and prevalence - United States, 1996, MMWR, vol. 46(8), pp. 165-173, 1997.
[3] B. M. Ledergerber, et al, Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study – Swiss HIV Cohort Study, Lancet, 1999, vol. 353(156), pp. 863-8, 1999.
[4] S. D. Lawn, L. Myer, C. Orrell, et al, Early mortality among adults accessing a community- based antiretroviral service in South Africa: implications for programme design, AIDS, vol. 19(18), pp. 2141–8, December 2, 2005.
[5] S. D. Lawn, A. D. Harries, X. Anglaret, et al, Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa, AIDS, vol. 22(15), pp. 1897–908, 2008.
[6] M. S. Cohen, Y. Q. Chen, M. McCauley, et al, Prevention of HIV-1 infection with early antiretroviral therapy, N Engl J Med, vol. 365(6), pp. 493–505, August 11, 2011.
[7] D. L. Paterson, S. Swindellis, J. Mohr, M. Brester, E. N. Vergis, C. Squier, M. M. Wagener, and N. Singh, Adherence to Protease inhibitor therapy and outcomes in patients with HIV infection, Ann. Internal Med, vol. 133(1), pp. 21-30, 2000.
[8] G. Maartens, C. Celum, and S. R. Lewin, HIV infection: epidemiology, pathogenesis, treatment, and prevention, Lancet, vol. 384(9939), pp. 258-71, July 19, 2014.
[9] E. W. Pefura-Yone, E. Soh, A. P. Kengne, A. D. Balkissou, and C. Kuaban, Non-adherence to antiretroviral therapy in Yaounde: prevalence, determinants and the concordance of two screening criteria, J Infect Public Health, vol. 6(4), pp. 307-15, August 2013.
[10] D. C. Johnson, C. Feldacker, H. Tweya, S. Phiri, and M. C. Hosseinipour, Factors associated with timely initiation of antiretroviral therapy in two HIV clinics in Lilongwe, Malawi, Int J STD AIDS, vol. 24(1), pp. 42-9, January 2013.
[11] G. S. Cooke, F. C. Tanser, T. W. Bärnighausen, and M. L. Newell, Population uptake of antiretroviral treatment through primary care in rural South Africa, BMC Public Health, vol. 10, pp. 585, September 29, 2010.
[12] V. Vella, T. Govender, S. Dlamini, M. Taylor, I. Moodley, V. David, and C. Jinabhai, Retrospective study on the critical factors for retaining patients on antiretroviral therapy in KwaZulu-Natal, South Africa, J Acquir Immune Defic Syndr, vol. 55(1), pp. 109-16, September 2010.
[13] A. K. Salami, A. Fadeyi, J. A. Ogunmodede, and O. Desalu, Factors influencing adherence to antiretroviral medication in Ilorin, Nigeria, J Int Assoc Physicians AIDS Care (Chic), vol. 9(3), pp. 191-5, May 2010.
[14] D. Jevtović, D. Salemović, J. Ranin, B. Brmbolić, I. Pesić-Pavlović, S. Zerjav, and O. Djurković-Djaković, The prognosis of late presenters in the era of highly active antiretroviral therapy in Serbia, Open Virol J, vol. 3, pp. 84-8, October 2009.
[15] Cameroon Demographic and Health survey and Multiple Indicators Cluster Survey (DHS-MICS), 2011. http://dhsprogram.com/pubs/pdf/HF42/HF42.pdf (Accessed online, August 11, 2014).
[16] C. Ndiaye, C. Boileau, M. W. Zunzunegui, S. Koala, S. A. Aboubacrine, P. Niamba, V. K. Nguyen, and S. Rashed, Gender-related factors influencing HIV serostatus disclosure in patients receiving HAART in West Africa, World Health Popul, vol. 10(3), 43-54, 2008.
[17] World Health Organization, Interim WHO clinical staging of HIV/AIDS and HIV/AIDS case definitions for surveillance, African region. Switzerland, World Health Organization; 2005.
[18] UNAIDS, Report on the global AIDS epidemic, UNAIDS Geneva, 2010.
[19] J. B. Nachega, M. Hislop, D. W. Dowdy, et al, Adherence to highly active antiretroviral therapy assessed by pharmacy claims predicts survival in HIV-infected South African adults, J Acquir Immune Defic Syndr, vol. 43(1), pp. 78-84, 2006.
[20] A. A. Oumar, S. Dao, A. Diamoutene, S. Coulibaly, et al, Factors associated with antiretroviral treatment observance at point “G” hospital, Mali Med, vol. 22(1), pp. 18-21, 2007.
[21] K. Mojumdar, M. Vajpayee, N. K. Chauhan, and S. Mendiratta, Late presenters to HIV care and treatment, identification of associated risk factors in HIV-1 infected Indian population, BMC Public Health, vol. 10, pp. 416, 2010.
[22] H. A. Gesesew, F. A. Tesfamicheal, and B. T. Adamu, Factors affecting late presentation for HIV/AIDS care in Southwest Ethiopia: A case control study, Public Health Research, vol. 3(4), pp. 98-107, 2013.
[23] CASCADE Collaboration, Short-term risk of AIDS according to current CD4 cell count and viral load in antiretroviral drug naïve individuals and those treated in the monotherapy era, AIDS, vol. 18, pp. 51-58, 2004.
[24] M. Egger, M. May, G. Chene, A. N. Philips, B. Ledergerber, F. Dabis, et al, Prognosis of HIV-1 infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies, Lancet, vol. 360, pp. 119-129, 2002.
[25] J. M. Simoni, P. A. Frick, D. W. Pantalone, and B. J. Turner, Antiretroviral adherence interventions: a review of current literature and ongoing studies, Top HIV Med, vol. 11(6), pp. 185-98, 2003.
[26] R. Garcia, R. T. Schooley, and R. Badaro, An adherence trilogy is essential for long-term HAART success, Braz J. Infect Dis, vol. 7(5), pp. 307-14, 2003.
[27] P. Severe, M. A. Juste MA, A. Ambroise, et al, Early versus standard antiretroviral therapy for HIV-infected adults in Haiti, N Engl J Med, vol. 363(3), 257–65, July 15, 2010.
Cite This Article
  • APA Style

    Luchuo Engelbert Bain, Elvis Enowbeyang Tarkang, Sitsofe Gbogbo, Agnes Jepchoge Busienei. (2016). Clinical, Biological and Sociodemographic Profiles of Highly Active Anti-Retroviral Therapy (HAART) Naïve Patients in the Garoua Military Hospital, Cameroon. International Journal of HIV/AIDS Prevention, Education and Behavioural Science, 1(3), 21-26. https://doi.org/10.11648/j.ijhpebs.20150103.11

    Copy | Download

    ACS Style

    Luchuo Engelbert Bain; Elvis Enowbeyang Tarkang; Sitsofe Gbogbo; Agnes Jepchoge Busienei. Clinical, Biological and Sociodemographic Profiles of Highly Active Anti-Retroviral Therapy (HAART) Naïve Patients in the Garoua Military Hospital, Cameroon. Int. J. HIV/AIDS Prev. Educ. Behav. Sci. 2016, 1(3), 21-26. doi: 10.11648/j.ijhpebs.20150103.11

    Copy | Download

    AMA Style

    Luchuo Engelbert Bain, Elvis Enowbeyang Tarkang, Sitsofe Gbogbo, Agnes Jepchoge Busienei. Clinical, Biological and Sociodemographic Profiles of Highly Active Anti-Retroviral Therapy (HAART) Naïve Patients in the Garoua Military Hospital, Cameroon. Int J HIV/AIDS Prev Educ Behav Sci. 2016;1(3):21-26. doi: 10.11648/j.ijhpebs.20150103.11

    Copy | Download

  • @article{10.11648/j.ijhpebs.20150103.11,
      author = {Luchuo Engelbert Bain and Elvis Enowbeyang Tarkang and Sitsofe Gbogbo and Agnes Jepchoge Busienei},
      title = {Clinical, Biological and Sociodemographic Profiles of Highly Active Anti-Retroviral Therapy (HAART) Naïve Patients in the Garoua Military Hospital, Cameroon},
      journal = {International Journal of HIV/AIDS Prevention, Education and Behavioural Science},
      volume = {1},
      number = {3},
      pages = {21-26},
      doi = {10.11648/j.ijhpebs.20150103.11},
      url = {https://doi.org/10.11648/j.ijhpebs.20150103.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijhpebs.20150103.11},
      abstract = {Knowing at what point patients are put on treatment during the clinical and biological (CD4 count) stages of HIV is important. This study investigated the clinical, biological and sociodemographic profiles of highly active antiretroviral therapy (HAART) naïve patients in the Garoua military hospital, Cameroon. This was a cross-sectional study that collected data on demographic, clinical and laboratory variables from 66HIV-infected patients aged 19 years and older from January 2013 to January 2014. Data were analysed using the Statistical Package for Social Sciences (SPSS) version 20 software program at the level 0.05. Sixty-six (66) HIV positive patients were received in the health facility during the study period, the majority of whom were female, 65.6%. Only 37.5% of their sexual partners were aware of patients’ HIV serostatus. Similarly, only 26.8% of patients’ stable sexual partners had done an HIV test, of which 73.3% tested positive. Skin diseases, weight loss and chronic fever were the commonest clinical manifestations found (33.3%, 25.4% and 17.5% respectively). About 90% of the clients had CD4 counts less than 350 cells/mm3 on clinical presentation. Hemoglobin counts less than 12g/dl were found in 72.7 % of the clients. Females were more likely than males to present with skin diseases, weight loss and fever. However, the differences were not statistically significant (p=0.159). Similarly, females (65.0%) were more likely to have CD4 counts less than 350 compared to males (35.0%) (p=0.167). More patients age less than 35 years, presented with skin diseases, weight loss and cough than those age more than 35 years. However, these differences were not statistically significant (p=0.632). In the same vein, more patients, age less than 35, had CD4 counts less than 350, than those aged more than 35 years (p=0.430). Most of our study patients had CD4 counts less than 350 cells/ml at presentation for HAART initiation. This suggests late HIV diagnosis and thus a delayed opportunity for timely access to HIV care and initiation of HAART. There is the need to intensify efforts in early routine HIV counseling and testing in health facilities in the cities, smaller towns and rural communities, so as to reduce the frequency of late HIV diagnosis with its potential implications. Encouraging clients to get their partners tested and consequently be managed appropriately is of utmost need in this area. Qualitative research to better ascertain reasons of not knowing partner status should be carried out.},
     year = {2016}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Clinical, Biological and Sociodemographic Profiles of Highly Active Anti-Retroviral Therapy (HAART) Naïve Patients in the Garoua Military Hospital, Cameroon
    AU  - Luchuo Engelbert Bain
    AU  - Elvis Enowbeyang Tarkang
    AU  - Sitsofe Gbogbo
    AU  - Agnes Jepchoge Busienei
    Y1  - 2016/02/19
    PY  - 2016
    N1  - https://doi.org/10.11648/j.ijhpebs.20150103.11
    DO  - 10.11648/j.ijhpebs.20150103.11
    T2  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
    JF  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
    JO  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
    SP  - 21
    EP  - 26
    PB  - Science Publishing Group
    SN  - 2575-5765
    UR  - https://doi.org/10.11648/j.ijhpebs.20150103.11
    AB  - Knowing at what point patients are put on treatment during the clinical and biological (CD4 count) stages of HIV is important. This study investigated the clinical, biological and sociodemographic profiles of highly active antiretroviral therapy (HAART) naïve patients in the Garoua military hospital, Cameroon. This was a cross-sectional study that collected data on demographic, clinical and laboratory variables from 66HIV-infected patients aged 19 years and older from January 2013 to January 2014. Data were analysed using the Statistical Package for Social Sciences (SPSS) version 20 software program at the level 0.05. Sixty-six (66) HIV positive patients were received in the health facility during the study period, the majority of whom were female, 65.6%. Only 37.5% of their sexual partners were aware of patients’ HIV serostatus. Similarly, only 26.8% of patients’ stable sexual partners had done an HIV test, of which 73.3% tested positive. Skin diseases, weight loss and chronic fever were the commonest clinical manifestations found (33.3%, 25.4% and 17.5% respectively). About 90% of the clients had CD4 counts less than 350 cells/mm3 on clinical presentation. Hemoglobin counts less than 12g/dl were found in 72.7 % of the clients. Females were more likely than males to present with skin diseases, weight loss and fever. However, the differences were not statistically significant (p=0.159). Similarly, females (65.0%) were more likely to have CD4 counts less than 350 compared to males (35.0%) (p=0.167). More patients age less than 35 years, presented with skin diseases, weight loss and cough than those age more than 35 years. However, these differences were not statistically significant (p=0.632). In the same vein, more patients, age less than 35, had CD4 counts less than 350, than those aged more than 35 years (p=0.430). Most of our study patients had CD4 counts less than 350 cells/ml at presentation for HAART initiation. This suggests late HIV diagnosis and thus a delayed opportunity for timely access to HIV care and initiation of HAART. There is the need to intensify efforts in early routine HIV counseling and testing in health facilities in the cities, smaller towns and rural communities, so as to reduce the frequency of late HIV diagnosis with its potential implications. Encouraging clients to get their partners tested and consequently be managed appropriately is of utmost need in this area. Qualitative research to better ascertain reasons of not knowing partner status should be carried out.
    VL  - 1
    IS  - 3
    ER  - 

    Copy | Download

Author Information
  • Department of Military Health, Ministry of Defence, Yaounde, Cameroon

  • HIV/AIDS Prevention Research Network, Cameroon (HIVPREC), Opposite Premier Pharmacy, Common Wealth Avenue, Kumba, Cameroon

  • Department of Population and Behavioural Science, School of Public Health, University of Health and Allied Sciences (UHAS), Ho, Ghana

  • Department of Sociology and Psychology, School of Arts and Social Sciences, Moi University, Eldoret, Kenya

  • Sections