Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats

Mahmoud Ibrahim El-Sayed; Sameh Awad; Mokhtar Yousef; Abdelmonem Wahba; Aisha El Attar; Mostafa Zedan

doi:doi:10.11648/j.ijhnm.20190501.14

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Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats

Mahmoud Ibrahim El-Sayed, Sameh Awad, Mokhtar Yousef, Abdelmonem Wahba, Aisha El Attar, Mostafa Zedan

Published in International Journal of Homeopathy & Natural Medicines (Volume 5, Issue 1)

Received: 8 March 2019 Accepted: 13 April 2019 Published: 20 May 2019

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Abstract

Milk protein-derived bioactive peptides could be used in human nutrition in both newborns and adults, since they are claimed to be health-improving components that can be used to reduce the risk of disease or to enhance certain physiological functions. This study investigated the effect of oral intake of milk protein concentrate (MPC) and milk protein concentrate hydrolysate (MPCH) on body weight, organ relative weight, and hematological parameters in alloxan-induced diabetes rats. The animals were divided into six major groups after stabilization of diabetes for one week. Diabetic and non-diabetic rats groups were received intra-gastric dose of MPC or MPCH (150mg/kg B.W) for six weeks. Feed treatment by MPC and MPCH significantly (P<0.05) increased the final body weight of normal rats and improved the body weight of diabetic rats and significantly protective (P<0.05) the liver, kidney, heart and lung of normal rats and reduced the fallers of these organs in diabetic rats. The diabetes groups treated by MPCH showed improvement in RBC, Hb, Ht and PLT values. Meanwhile WBC not affected. The oral intake of MPCH protected the normal range of Lymphocytes and S. Nutrophils in healthy and diabetic rats. The oral intake of MPCH caused significant (P<0.05) decrease of Monocytes in diabetic and non-diabetic rats, while the oral intake of MPC had no affected on Monocytes of diabetic and non-diabetic rats. MPC and MPCH reduced the harmful effect of T2D on body weight, organs weights of rats, and improvement most hematological parameters of normal and diabetes rats.

Published in	International Journal of Homeopathy & Natural Medicines (Volume 5, Issue 1)
DOI	10.11648/j.ijhnm.20190501.14
Page(s)	18-29
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Milk Protein, Protein Hydrolysate, Bioactive Peptides, T2 Diabetes

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APA Style

Mahmoud Ibrahim El-Sayed, Sameh Awad, Mokhtar Yousef, Abdelmonem Wahba, Aisha El Attar, et al. (2019). Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats. International Journal of Homeopathy & Natural Medicines, 5(1), 18-29. https://doi.org/10.11648/j.ijhnm.20190501.14

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ACS Style

Mahmoud Ibrahim El-Sayed; Sameh Awad; Mokhtar Yousef; Abdelmonem Wahba; Aisha El Attar, et al. Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats. Int. J. Homeopathy Nat. Med. 2019, 5(1), 18-29. doi: 10.11648/j.ijhnm.20190501.14

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AMA Style

Mahmoud Ibrahim El-Sayed, Sameh Awad, Mokhtar Yousef, Abdelmonem Wahba, Aisha El Attar, et al. Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats. Int J Homeopathy Nat Med. 2019;5(1):18-29. doi: 10.11648/j.ijhnm.20190501.14

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@article{10.11648/j.ijhnm.20190501.14,
  author = {Mahmoud Ibrahim El-Sayed and Sameh Awad and Mokhtar Yousef and Abdelmonem Wahba and Aisha El Attar and Mostafa Zedan},
  title = {Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats},
  journal = {International Journal of Homeopathy & Natural Medicines},
  volume = {5},
  number = {1},
  pages = {18-29},
  doi = {10.11648/j.ijhnm.20190501.14},
  url = {https://doi.org/10.11648/j.ijhnm.20190501.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijhnm.20190501.14},
  abstract = {Milk protein-derived bioactive peptides could be used in human nutrition in both newborns and adults, since they are claimed to be health-improving components that can be used to reduce the risk of disease or to enhance certain physiological functions. This study investigated the effect of oral intake of milk protein concentrate (MPC) and milk protein concentrate hydrolysate (MPCH) on body weight, organ relative weight, and hematological parameters in alloxan-induced diabetes rats. The animals were divided into six major groups after stabilization of diabetes for one week. Diabetic and non-diabetic rats groups were received intra-gastric dose of MPC or MPCH (150mg/kg B.W) for six weeks. Feed treatment by MPC and MPCH significantly (PPP<0.05) decrease of Monocytes in diabetic and non-diabetic rats, while the oral intake of MPC had no affected on Monocytes of diabetic and non-diabetic rats. MPC and MPCH reduced the harmful effect of T2D on body weight, organs weights of rats, and improvement most hematological parameters of normal and diabetes rats.},
 year = {2019}
}

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TY  - JOUR
T1  - Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats
AU  - Mahmoud Ibrahim El-Sayed
AU  - Sameh Awad
AU  - Mokhtar Yousef
AU  - Abdelmonem Wahba
AU  - Aisha El Attar
AU  - Mostafa Zedan
Y1  - 2019/05/20
PY  - 2019
N1  - https://doi.org/10.11648/j.ijhnm.20190501.14
DO  - 10.11648/j.ijhnm.20190501.14
T2  - International Journal of Homeopathy & Natural Medicines
JF  - International Journal of Homeopathy & Natural Medicines
JO  - International Journal of Homeopathy & Natural Medicines
SP  - 18
EP  - 29
PB  - Science Publishing Group
SN  - 2472-2316
UR  - https://doi.org/10.11648/j.ijhnm.20190501.14
AB  - Milk protein-derived bioactive peptides could be used in human nutrition in both newborns and adults, since they are claimed to be health-improving components that can be used to reduce the risk of disease or to enhance certain physiological functions. This study investigated the effect of oral intake of milk protein concentrate (MPC) and milk protein concentrate hydrolysate (MPCH) on body weight, organ relative weight, and hematological parameters in alloxan-induced diabetes rats. The animals were divided into six major groups after stabilization of diabetes for one week. Diabetic and non-diabetic rats groups were received intra-gastric dose of MPC or MPCH (150mg/kg B.W) for six weeks. Feed treatment by MPC and MPCH significantly (PPP<0.05) decrease of Monocytes in diabetic and non-diabetic rats, while the oral intake of MPC had no affected on Monocytes of diabetic and non-diabetic rats. MPC and MPCH reduced the harmful effect of T2D on body weight, organs weights of rats, and improvement most hematological parameters of normal and diabetes rats.
VL  - 5
IS  - 1
ER  -

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Author Information

Mahmoud Ibrahim El-Sayed

Department of Dairy Technology Research, Food Technology Research Institute, ARC, Giza, Egypt
Sameh Awad

Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt
Mokhtar Yousef

Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
Abdelmonem Wahba

Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt
Aisha El Attar

Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt
Mostafa Zedan

Department of Dairy Technology Research, Food Technology Research Institute, ARC, Giza, Egypt

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APA Style

Mahmoud Ibrahim El-Sayed, Sameh Awad, Mokhtar Yousef, Abdelmonem Wahba, Aisha El Attar, et al. (2019). Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats. International Journal of Homeopathy & Natural Medicines, 5(1), 18-29. https://doi.org/10.11648/j.ijhnm.20190501.14

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ACS Style

Mahmoud Ibrahim El-Sayed; Sameh Awad; Mokhtar Yousef; Abdelmonem Wahba; Aisha El Attar, et al. Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats. Int. J. Homeopathy Nat. Med. 2019, 5(1), 18-29. doi: 10.11648/j.ijhnm.20190501.14

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AMA Style

Mahmoud Ibrahim El-Sayed, Sameh Awad, Mokhtar Yousef, Abdelmonem Wahba, Aisha El Attar, et al. Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats. Int J Homeopathy Nat Med. 2019;5(1):18-29. doi: 10.11648/j.ijhnm.20190501.14

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@article{10.11648/j.ijhnm.20190501.14,
  author = {Mahmoud Ibrahim El-Sayed and Sameh Awad and Mokhtar Yousef and Abdelmonem Wahba and Aisha El Attar and Mostafa Zedan},
  title = {Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats},
  journal = {International Journal of Homeopathy & Natural Medicines},
  volume = {5},
  number = {1},
  pages = {18-29},
  doi = {10.11648/j.ijhnm.20190501.14},
  url = {https://doi.org/10.11648/j.ijhnm.20190501.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijhnm.20190501.14},
  abstract = {Milk protein-derived bioactive peptides could be used in human nutrition in both newborns and adults, since they are claimed to be health-improving components that can be used to reduce the risk of disease or to enhance certain physiological functions. This study investigated the effect of oral intake of milk protein concentrate (MPC) and milk protein concentrate hydrolysate (MPCH) on body weight, organ relative weight, and hematological parameters in alloxan-induced diabetes rats. The animals were divided into six major groups after stabilization of diabetes for one week. Diabetic and non-diabetic rats groups were received intra-gastric dose of MPC or MPCH (150mg/kg B.W) for six weeks. Feed treatment by MPC and MPCH significantly (PPP<0.05) decrease of Monocytes in diabetic and non-diabetic rats, while the oral intake of MPC had no affected on Monocytes of diabetic and non-diabetic rats. MPC and MPCH reduced the harmful effect of T2D on body weight, organs weights of rats, and improvement most hematological parameters of normal and diabetes rats.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats
AU  - Mahmoud Ibrahim El-Sayed
AU  - Sameh Awad
AU  - Mokhtar Yousef
AU  - Abdelmonem Wahba
AU  - Aisha El Attar
AU  - Mostafa Zedan
Y1  - 2019/05/20
PY  - 2019
N1  - https://doi.org/10.11648/j.ijhnm.20190501.14
DO  - 10.11648/j.ijhnm.20190501.14
T2  - International Journal of Homeopathy & Natural Medicines
JF  - International Journal of Homeopathy & Natural Medicines
JO  - International Journal of Homeopathy & Natural Medicines
SP  - 18
EP  - 29
PB  - Science Publishing Group
SN  - 2472-2316
UR  - https://doi.org/10.11648/j.ijhnm.20190501.14
AB  - Milk protein-derived bioactive peptides could be used in human nutrition in both newborns and adults, since they are claimed to be health-improving components that can be used to reduce the risk of disease or to enhance certain physiological functions. This study investigated the effect of oral intake of milk protein concentrate (MPC) and milk protein concentrate hydrolysate (MPCH) on body weight, organ relative weight, and hematological parameters in alloxan-induced diabetes rats. The animals were divided into six major groups after stabilization of diabetes for one week. Diabetic and non-diabetic rats groups were received intra-gastric dose of MPC or MPCH (150mg/kg B.W) for six weeks. Feed treatment by MPC and MPCH significantly (PPP<0.05) decrease of Monocytes in diabetic and non-diabetic rats, while the oral intake of MPC had no affected on Monocytes of diabetic and non-diabetic rats. MPC and MPCH reduced the harmful effect of T2D on body weight, organs weights of rats, and improvement most hematological parameters of normal and diabetes rats.
VL  - 5
IS  - 1
ER  -

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