Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates

Barbara Picone; Alan Christoffels

doi:doi:10.11648/j.ijgg.20140204.12

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Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates

Barbara Picone, Alan Christoffels

Published in International Journal of Genetics and Genomics (Volume 2, Issue 4)

Received: 25 July 2014 Accepted: 6 August 2014 Published: 20 August 2014

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Abstract

African primates remain an unexplored source of information required to complete the origin and evolution of many human pathogens. Current studies have shown the importance of several receptor human genes implicated in host resistance or susceptibility to tuberculosis. The validation of these genes in Mycobacterium tuberculosis infection makes them an excellent model system to investigate the mode of selective pressures that may act on pathogen defense genes. To trace the evolutionary history of these genes, the report describes preliminary results for eight receptors human genes having either a significant or a possible association with Tuberculosis (TB). By using a combination of maximum likelihood approaches, evidence of positive selection were detected for four genes. The analysis between species, nevertheless, shows a clear pattern of nucleotide variation mostly compatible with purifying selection.

Published in	International Journal of Genetics and Genomics (Volume 2, Issue 4)
DOI	10.11648/j.ijgg.20140204.12
Page(s)	57-61
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Receptor Genes, Tuberculosis, Phylogeny, Non-Human Primates, Adaptive Evolution

References

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APA Style

Barbara Picone, Alan Christoffels. (2014). Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates. International Journal of Genetics and Genomics, 2(4), 57-61. https://doi.org/10.11648/j.ijgg.20140204.12

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ACS Style

Barbara Picone; Alan Christoffels. Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates. Int. J. Genet. Genomics 2014, 2(4), 57-61. doi: 10.11648/j.ijgg.20140204.12

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AMA Style

Barbara Picone, Alan Christoffels. Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates. Int J Genet Genomics. 2014;2(4):57-61. doi: 10.11648/j.ijgg.20140204.12

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@article{10.11648/j.ijgg.20140204.12,
  author = {Barbara Picone and Alan Christoffels},
  title = {Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates},
  journal = {International Journal of Genetics and Genomics},
  volume = {2},
  number = {4},
  pages = {57-61},
  doi = {10.11648/j.ijgg.20140204.12},
  url = {https://doi.org/10.11648/j.ijgg.20140204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20140204.12},
  abstract = {African primates remain an unexplored source of information required to complete the origin and evolution of many human pathogens. Current studies have shown the importance of several receptor human genes implicated in host resistance or susceptibility to tuberculosis. The validation of these genes in Mycobacterium tuberculosis infection makes them an excellent model system to investigate the mode of selective pressures that may act on pathogen defense genes. To trace the evolutionary history of these genes, the report describes preliminary results for eight receptors human genes having either a significant or a possible association with Tuberculosis (TB). By using a combination of maximum likelihood approaches, evidence of positive selection were detected for four genes. The analysis between species, nevertheless, shows a clear pattern of nucleotide variation mostly compatible with purifying selection.},
 year = {2014}
}

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TY  - JOUR
T1  - Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates
AU  - Barbara Picone
AU  - Alan Christoffels
Y1  - 2014/08/20
PY  - 2014
N1  - https://doi.org/10.11648/j.ijgg.20140204.12
DO  - 10.11648/j.ijgg.20140204.12
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 57
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PB  - Science Publishing Group
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UR  - https://doi.org/10.11648/j.ijgg.20140204.12
AB  - African primates remain an unexplored source of information required to complete the origin and evolution of many human pathogens. Current studies have shown the importance of several receptor human genes implicated in host resistance or susceptibility to tuberculosis. The validation of these genes in Mycobacterium tuberculosis infection makes them an excellent model system to investigate the mode of selective pressures that may act on pathogen defense genes. To trace the evolutionary history of these genes, the report describes preliminary results for eight receptors human genes having either a significant or a possible association with Tuberculosis (TB). By using a combination of maximum likelihood approaches, evidence of positive selection were detected for four genes. The analysis between species, nevertheless, shows a clear pattern of nucleotide variation mostly compatible with purifying selection.
VL  - 2
IS  - 4
ER  -

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Author Information

Barbara Picone

Department of Genetics, University of Stellenbosch, Stellenbosch, 7602, South Africa
Alan Christoffels

South African National Bioinformatics Institute (SANBI), SA Medical Research Council Bioinformatics Unit, University Western Cape, Bellville, 7535, South Africa

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APA Style

Barbara Picone, Alan Christoffels. (2014). Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates. International Journal of Genetics and Genomics, 2(4), 57-61. https://doi.org/10.11648/j.ijgg.20140204.12

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ACS Style

Barbara Picone; Alan Christoffels. Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates. Int. J. Genet. Genomics 2014, 2(4), 57-61. doi: 10.11648/j.ijgg.20140204.12

Copy | Download

AMA Style

Barbara Picone, Alan Christoffels. Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates. Int J Genet Genomics. 2014;2(4):57-61. doi: 10.11648/j.ijgg.20140204.12

Copy | Download

@article{10.11648/j.ijgg.20140204.12,
  author = {Barbara Picone and Alan Christoffels},
  title = {Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates},
  journal = {International Journal of Genetics and Genomics},
  volume = {2},
  number = {4},
  pages = {57-61},
  doi = {10.11648/j.ijgg.20140204.12},
  url = {https://doi.org/10.11648/j.ijgg.20140204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20140204.12},
  abstract = {African primates remain an unexplored source of information required to complete the origin and evolution of many human pathogens. Current studies have shown the importance of several receptor human genes implicated in host resistance or susceptibility to tuberculosis. The validation of these genes in Mycobacterium tuberculosis infection makes them an excellent model system to investigate the mode of selective pressures that may act on pathogen defense genes. To trace the evolutionary history of these genes, the report describes preliminary results for eight receptors human genes having either a significant or a possible association with Tuberculosis (TB). By using a combination of maximum likelihood approaches, evidence of positive selection were detected for four genes. The analysis between species, nevertheless, shows a clear pattern of nucleotide variation mostly compatible with purifying selection.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates
AU  - Barbara Picone
AU  - Alan Christoffels
Y1  - 2014/08/20
PY  - 2014
N1  - https://doi.org/10.11648/j.ijgg.20140204.12
DO  - 10.11648/j.ijgg.20140204.12
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 57
EP  - 61
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20140204.12
AB  - African primates remain an unexplored source of information required to complete the origin and evolution of many human pathogens. Current studies have shown the importance of several receptor human genes implicated in host resistance or susceptibility to tuberculosis. The validation of these genes in Mycobacterium tuberculosis infection makes them an excellent model system to investigate the mode of selective pressures that may act on pathogen defense genes. To trace the evolutionary history of these genes, the report describes preliminary results for eight receptors human genes having either a significant or a possible association with Tuberculosis (TB). By using a combination of maximum likelihood approaches, evidence of positive selection were detected for four genes. The analysis between species, nevertheless, shows a clear pattern of nucleotide variation mostly compatible with purifying selection.
VL  - 2
IS  - 4
ER  -

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