Mathematical modeling of disease has been an indispensable tool in accounting for disease transmission dynamics as well as disease spread. Epidemiological disease models have been used to explain the dynamics of HIV/AIDS in the population from the early 1900s. The models developed however faced considerable challenges ranging from inaccurate representation of natural data for deterministic models, to methods of forecasting such as statistical extrapolation which assumes that current conditions will prevail which is not always the case. Despite the spread of HIV/AIDS having been explored widely, not much literature is available on the Gillespie Algorithm based SIR model. This algorithm is able to give a statistically correct of the course of a disease with initial conditions to begin with and propensity functions to update the system. The purpose of this paper is to build on the concept of Gillespie's Algorithm based SIR models by developing a stochastic SIR model to simulate disease evolution in the population setting. The values produced through simulation by the model developed in this paper using a tau value as the time step of the model were compared to HIV/AIDS data from 1985 to 2018, given by NACC. We conclude that the simulated model reflects reality.
Published in | International Journal of Data Science and Analysis (Volume 5, Issue 6) |
DOI | 10.11648/j.ijdsa.20190506.12 |
Page(s) | 117-122 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Stochastic, Simulation, Deterministic, SIR Model, Continuous-Time Markov Chain, Gillespie's Algorithm Models
[1] | F. C. J.-C. R. F. N. M. T. C. S. G. J. D. C. A.-B. C. V.-B. F. R. C. o. Barré-Sinoussi, "Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)," Science, vol. 220, no. 4599, pp. 868-871, 1983. |
[2] | W. A. M. S. R. T. D. O. T. R. S. J. V. N. L. P. N. B. J. F. K. D. P. W. S. M. o. Paxton, "Relative resistance to HIV--1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high--risk sexual exposures," Nature medicine, vol. 2, no. 4, p. 412, 1996. |
[3] | W. A. N. G. R. K. H. J. L. U. O. C.-p. Z. N. W. A. N. G. Jun-jie, "Dynamic mathematical models of HIV/AIDS transmission in China," Chinese medical journal, vol. 123, no. 15, p. 2120, 2010. |
[4] | A. I. D. S. Council, "Working Committee Office UN Theme Group on AIDS in China," A joint assessment of HIV/AIDS prevention, treatment and care in China. Beijing: Ministry of Health, China, 2007. |
[5] | H. S. Rodrigues, "Application of SIR epidemiological model: new trends," arXiv preprint arXiv: 1611.02565, 2016. |
[6] | L. S. J. A. B. T. R. A. E. a. H. D. R. Bao, "Modelling national HIV/AIDS epidemics: revised approach in the UNAIDS Estimation and Projection Package 2011," BMJ Publishing Group Limited, no. 88, pp. 3-18, 2012. |
[7] | J. A. K. S. E. G. C. S. K. V. Stover, "Updates to the spectrum model to estimate key hiv indicators," wolter Kluwer Health, vol. 28, no. 4, 2014. |
[8] | D. L. Y. a. M. X. Greenhalgh, "Sde sis epidemic model with demographic stochasticity and varying population size.," Applied Mathematics and Computation,, vol. 276, p. 218–238, 2016. |
[9] | A. M. N. DURAD MUHAMMAD HANIF, "Analysis Of Sir Epidemic Models," VFAST Transactions on Software Engineering, vol. 6, no. 1, pp. 1-6, 2015. |
[10] | S. a. C. B. Ryu, "Development of epidemic model using the stochastic method," Journal of the Korean Data and Information Science Society, vol. 26, no. 2, pp. 301-312, 2015. |
[11] | J. S. C. S. E. S. C. P. R. C. S. J. G. Koopman, "Stochastic effects on endemic infection levels of disseminating versus local contacts," Mathematical biosciences, vol. 180, no. 1-2, pp. 49-71, 2002. |
[12] | R. P. Dobrow, "Introduction to stochastic processes with R," 2016. |
[13] | W. O. M. A. G. Kermack, "A contribution to the mathematical theory of epidemics," Proceedings of the royal society of london. Series A, Containing papers of a mathematical and physical character, vol. 115, no. 772, pp. 700-721, 1927. |
[14] | W. O. M. A. G. Kermack, "Contributions to the mathematical theory of epidemics. II.—The problem of endemicity," Proceedings of the Royal Society of London. Series A, containing papers of a mathematical and physical character, vol. 138, no. 834, pp. 55-83, 1932. |
[15] | W. O. M. A. G. Kermack, "Contributions to the mathematical theory of epidemics. III.—Further studies of the problem of endemicity," Proceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical Character, vol. 141, no. 843, pp. 94-122, 1933. |
[16] | D. T. Gillespie, "A general method for numerically simulating the stochastic time evolution of coupled chemical reactions," Journal of computational physics, vol. 22, no. 4, pp. 403-434, 1976. |
[17] | D. T. Gillespie, "Exact stochastic simulation of coupled chemical reactions," The journal of physical chemistry, vol. 81, no. 25, pp. 2340-2361, 1977. |
[18] | L. A. S. D. C. J. E. R. L. A. Waller, "Monte Carlo assessments of goodness-of-fit for ecological simulation models," Ecological Modelling, vol. 164, no. 1, pp. 49-63, 2003. |
[19] | G. H. K. R. S. Friedland, "Transmission of the human immunodeficiency virus," New England Journal of Medicine, vol. 317, no. 18, pp. 1125-1135, 1987. |
[20] | V. Isham, "Mathematical modelling of the transmission dynamics of HIV infection and AIDS: a review," Journal of the Royal Statistical Society: Series A (Statistics in Society), vol. 151, no. 1, pp. 5-30, 1988. |
[21] | R. G. M. H. Brookmeyer, "A method for obtaining short-term projections and lower bounds on the size of the AIDS epidemic," Journal of the American Statistical Association, vol. 83, no. 402, pp. 301-308, 1988. |
APA Style
Kavyu Mary Kamina, Samuel Mwalili, Anthony Wanjoya. (2019). The Modeling of a Stochastic SIR Model for HIV/AIDS Epidemic Using Gillespie's Algorithm. International Journal of Data Science and Analysis, 5(6), 117-122. https://doi.org/10.11648/j.ijdsa.20190506.12
ACS Style
Kavyu Mary Kamina; Samuel Mwalili; Anthony Wanjoya. The Modeling of a Stochastic SIR Model for HIV/AIDS Epidemic Using Gillespie's Algorithm. Int. J. Data Sci. Anal. 2019, 5(6), 117-122. doi: 10.11648/j.ijdsa.20190506.12
AMA Style
Kavyu Mary Kamina, Samuel Mwalili, Anthony Wanjoya. The Modeling of a Stochastic SIR Model for HIV/AIDS Epidemic Using Gillespie's Algorithm. Int J Data Sci Anal. 2019;5(6):117-122. doi: 10.11648/j.ijdsa.20190506.12
@article{10.11648/j.ijdsa.20190506.12, author = {Kavyu Mary Kamina and Samuel Mwalili and Anthony Wanjoya}, title = {The Modeling of a Stochastic SIR Model for HIV/AIDS Epidemic Using Gillespie's Algorithm}, journal = {International Journal of Data Science and Analysis}, volume = {5}, number = {6}, pages = {117-122}, doi = {10.11648/j.ijdsa.20190506.12}, url = {https://doi.org/10.11648/j.ijdsa.20190506.12}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijdsa.20190506.12}, abstract = {Mathematical modeling of disease has been an indispensable tool in accounting for disease transmission dynamics as well as disease spread. Epidemiological disease models have been used to explain the dynamics of HIV/AIDS in the population from the early 1900s. The models developed however faced considerable challenges ranging from inaccurate representation of natural data for deterministic models, to methods of forecasting such as statistical extrapolation which assumes that current conditions will prevail which is not always the case. Despite the spread of HIV/AIDS having been explored widely, not much literature is available on the Gillespie Algorithm based SIR model. This algorithm is able to give a statistically correct of the course of a disease with initial conditions to begin with and propensity functions to update the system. The purpose of this paper is to build on the concept of Gillespie's Algorithm based SIR models by developing a stochastic SIR model to simulate disease evolution in the population setting. The values produced through simulation by the model developed in this paper using a tau value as the time step of the model were compared to HIV/AIDS data from 1985 to 2018, given by NACC. We conclude that the simulated model reflects reality.}, year = {2019} }
TY - JOUR T1 - The Modeling of a Stochastic SIR Model for HIV/AIDS Epidemic Using Gillespie's Algorithm AU - Kavyu Mary Kamina AU - Samuel Mwalili AU - Anthony Wanjoya Y1 - 2019/11/04 PY - 2019 N1 - https://doi.org/10.11648/j.ijdsa.20190506.12 DO - 10.11648/j.ijdsa.20190506.12 T2 - International Journal of Data Science and Analysis JF - International Journal of Data Science and Analysis JO - International Journal of Data Science and Analysis SP - 117 EP - 122 PB - Science Publishing Group SN - 2575-1891 UR - https://doi.org/10.11648/j.ijdsa.20190506.12 AB - Mathematical modeling of disease has been an indispensable tool in accounting for disease transmission dynamics as well as disease spread. Epidemiological disease models have been used to explain the dynamics of HIV/AIDS in the population from the early 1900s. The models developed however faced considerable challenges ranging from inaccurate representation of natural data for deterministic models, to methods of forecasting such as statistical extrapolation which assumes that current conditions will prevail which is not always the case. Despite the spread of HIV/AIDS having been explored widely, not much literature is available on the Gillespie Algorithm based SIR model. This algorithm is able to give a statistically correct of the course of a disease with initial conditions to begin with and propensity functions to update the system. The purpose of this paper is to build on the concept of Gillespie's Algorithm based SIR models by developing a stochastic SIR model to simulate disease evolution in the population setting. The values produced through simulation by the model developed in this paper using a tau value as the time step of the model were compared to HIV/AIDS data from 1985 to 2018, given by NACC. We conclude that the simulated model reflects reality. VL - 5 IS - 6 ER -