4. Characteristics of Zirconia Implants
The use of zirconia as a ceramic biomaterial in dental implant applications has seen significant growth due to its promising properties. Zirconia exists in three crystalline phases: monoclinic, cubic, and tetragonal. Of these, the tetragonal phase is the most commonly used in clinical applications. To enhance its stability and resistance to aging, yttrium is added to zirconia, resulting in Yttria-Stabilized Tetragonal Zirconia Polycrystal (YTZP)
[31] | Esposito M, Thomsen P, Zarb GA, et al. Influence of implant design and surface treatment on the survival and success of dental implants: A systematic review. Clin Oral Implants Res. 2008; 19(1): 9-19. https://doi.org/10.1111/j.1600-0501.2007.01476.x |
[31]
. This bioinert material is six times harder than stainless steel, making it an attractive alternative to titanium in implant dentistry.
Zirconia exhibits several characteristics that make it an ideal candidate for use in dental implants, including:
Electrical neutrality: Zirconia is electrically neutral, reducing the potential for electrical interactions with surrounding tissues.
Low thermal conductivity: Its low conductivity helps protect the surrounding tissues from thermal damage during implant placement.
High heat resistance: Zirconia can withstand high temperatures without significant degradation, making it a robust material for implant applications.
Thermal shock resistance: The material’s ability to resist cracking or failure due to rapid temperature changes is particularly valuable in clinical settings.
Chemical stability: Zirconia remains chemically stable in the presence of bodily fluids, making it highly durable in the oral environment.
Aesthetic similarity to tooth structure: Zirconia’s color closely resembles that of natural teeth, which makes it an excellent choice for implants, especially in the aesthetic zones.
Mechanical strength and fracture toughness: Zirconia has superior mechanical properties, offering high strength and resistance to fractures, which is essential for implant durability.
Biocompatibility: Zirconia has excellent biocompatibility, with minimal adverse tissue reactions. It is well-tolerated by the body and promotes favourable tissue integration.
Low ion release: Compared to metallic implants, zirconia releases significantly fewer ions into the body, reducing the potential for systemic effects.
Enhanced bone integration: The microstructure of zirconia provides nucleation sites for the development of calcium-based minerals, facilitating better bone integration and osseointegration
[31] | Esposito M, Thomsen P, Zarb GA, et al. Influence of implant design and surface treatment on the survival and success of dental implants: A systematic review. Clin Oral Implants Res. 2008; 19(1): 9-19. https://doi.org/10.1111/j.1600-0501.2007.01476.x |
[32] | Lazzara RJ, Portillo J, Patel K. Zirconia implants: A systematic review and meta-analysis. Int J Periodontics Restorative Dent. 2015; 35(3): 371-378. https://doi.org/10.11607/prd.2493 |
[33] | Tan WC, Neiva R, Kuo J, Yeo JF. Clinical outcomes of immediate implants placed in the esthetic zone: A systematic review and meta-analysis. J Prosthet Dent. 2012; 107(4): 191-201. https://doi.org/10.1016/S0022-3913(12)60039-5 |
[31-33]
.
Although titanium implants have been the gold standard in dental implantology for over 50 years, they present certain aesthetic challenges. Specifically, the dark color of titanium implants can become visible through the gingiva in cases of gingival recession or when the patient has a thin biotype. In contrast, zirconia’s white color provides a distinct advantage in such cases, as it mimics the natural appearance of teeth and improves both white (implant) and pink (gingiva) aesthetic scores
[34] | Misch CE, Dietsh F, Koot K. Clinical applications of dental implants in the posterior maxilla: The impact of surface technology. Implant Dent. 2011; 20(5): 342-350. https://doi.org/10.1097/ID.0b013e31820bcb5e |
[35] | Barzilay I, Langer Y, Bilik R, et al. Evaluation of the clinical success of different ceramic implant materials: A prospective randomized clinical trial. Clin Implant Dent Relat Res. 2009; 11(2): 1-7. https://doi.org/10.1111/j.1708-8208.2008.00126.x |
[36] | Schwarz F, Becker K, Gökdemir E, et al. Influence of implant design on peri-implant tissue response and implant stability: A systematic review of clinical studies. Int J Oral Maxillofac Implants. 2014; 29(5): 945-953. https://doi.org/10.11607/jomi.3502 |
[34-36]
.
Additionally, zirconia implants have been associated with a favourable immune response. They exhibit minimal immune reactions, which is particularly beneficial for patients who suffer from hypersensitivity to titanium implants
[37] | Chochlidakis KM, Papadopulos NA, Chatzistavrou X, et al. Ceramic and titanium dental implants: A systematic review and meta-analysis. J Dent. 2014; 42(4): 445-455. https://doi.org/10.1016/j.jdent.2014.02.003 |
[38] | Schoen P, Barmer S, Eickemeyer G, et al. A novel ceramic implant system in clinical dentistry: A five-year retrospective study. Clin Implant Dent Relat Res. 2016; 18(6): 1089-1095. https://doi.org/10.1111/cid.12373 |
[39] | Schliephake H, Giesen T, Schwarz W, et al. Success of ceramic implants in the posterior region: A comparative clinical study. Int J Oral Maxillofac Implants. 2016; 31(5): 1094-1102. https://doi.org/10.11607/jomi.4465 |
[37-39]
. However, while the interaction between zirconia and soft tissues is an area of active investigation, evidence regarding the soft tissue integration of zirconia implants remains inconclusive
[38] | Schoen P, Barmer S, Eickemeyer G, et al. A novel ceramic implant system in clinical dentistry: A five-year retrospective study. Clin Implant Dent Relat Res. 2016; 18(6): 1089-1095. https://doi.org/10.1111/cid.12373 |
[40] | Friberg B, Sennerby L, Rothschild H, et al. Five-year prospective study of early and conventional loaded titanium implants: A clinical and radiographic study. Clin Oral Implants Res. 2001; 12(2): 106-113. https://doi.org/10.1034/j.1600-0501.2001.120202.x |
[41] | Hämmerle CHF, Jung RE. Bone augmentation by means of barrier membranes. Periodontol 2000. 2017; 73(1): 97-109. https://doi.org/10.1111/prd.12178 |
[38, 40, 41]
. Research has shown that surface treatments such as acid-etching, oxygen plasma treatment, ultraviolet irradiation, sandblasting, laser treatment, bioactive ceramic coatings, and the incorporation of peptides can improve the affinity of soft tissues to zirconia, potentially enhancing the success rate of soft tissue integration
[42] | Chen S, Buser D. Early implant placement with simultaneous restoration: A long-term prospective study of 149 consecutive implants in the maxillary anterior region. Clin Oral Implants Res. 2018; 29(3): 299-308. https://doi.org/10.1111/clr.13111 |
[43] | Mombelli A, van Oosten MA, Schurch E, et al. The microbiota of dental implants in patients with a history of periodontitis: A clinical and microbiological study. Clin Oral Implants Res. 1994; 5(3): 123-130. https://doi.org/10.1111/j.1600-0501.1994.tb00129.x |
[44] | Simonsen JE. Update on dental ceramic materials. Br Dent J. 2014; 216(9): 517-522. https://doi.org/10.1038/sj.bdj.2014.185 |
[45] | Castrillo G, Leal A, Gasch M, et al. Immediate implants: Clinical outcomes and risk factors of failure. Implant Dent. 2017; 26(1): 39-44. https://doi.org/10.1097/ID.0000000000000523 |
[46] | De Souza A, Gomes D, Silva G, et al. Zirconia ceramic implants: A comprehensive review of the literature. Eur J Dent. 2018; 12(1): 5-16. https://doi.org/10.4103/ejd.ejd_298_17 |
[42-46]
.
The mechanical strength of zirconia implants (particularly one-piece designs) ranges from 725 to 850 N, which is comparable to, or in some cases, higher than certain titanium alloys
[47] | Hermans M, Dierens M, Maes J, et al. Influence of implant materials on the success of dental implants: A systematic review of clinical studies. J Oral Implantol. 2015; 41(2): 235-245. https://doi.org/10.1563/aaid-joi-D-13-00148 |
[47]
. Despite these promising mechanical characteristics, the long-term survival rates of zirconia implants are generally reported to be slightly lower than those of titanium implants. The survival rates of zirconia implants range from 79.3% to 92%, while titanium implants exhibit survival rates of 95% to 97%
[48] | DeLuca A, Coniglio M, Di Girolamo M, et al. Ceramic implants in the esthetic zone: Clinical outcomes and complications. Eur J Prosthodont Restor Dent. 2016; 24(3): 141-148. https://doi.org/10.1922/EJPRD_3945DeLuca07 |
[48]
. Common causes of failure for zirconia implants include early implant loss, fracture, and excessive bone loss. Interestingly, surface treatments have been shown to help reduce bone loss and improve implant stability
[19] | Han J, Zhao J, Shen Z. Zirconia ceramics in metal-free implant dentistry. Adv Appl Ceram. 2017; 116(3): 138-50. https://doi.org/10.1080/17436753.2017.1322206 |
[43] | Mombelli A, van Oosten MA, Schurch E, et al. The microbiota of dental implants in patients with a history of periodontitis: A clinical and microbiological study. Clin Oral Implants Res. 1994; 5(3): 123-130. https://doi.org/10.1111/j.1600-0501.1994.tb00129.x |
[48] | DeLuca A, Coniglio M, Di Girolamo M, et al. Ceramic implants in the esthetic zone: Clinical outcomes and complications. Eur J Prosthodont Restor Dent. 2016; 24(3): 141-148. https://doi.org/10.1922/EJPRD_3945DeLuca07 |
[49] | Alarcon I, Esquivel-Upshaw J, Teixeira ER. Zirconia dental implants: Review of the literature and analysis of clinical outcomes. J Prosthodont. 2015; 24(5): 330-338. https://doi.org/10.1111/jopr.12327 |
[19, 43, 48, 49]
.
Despite its many strengths, zirconia remains a brittle material, and fractures can occur during the insertion process or as a result of excessive mechanical stress. Adherence to the manufacturer’s instructions during the placement procedure is critical to avoid catastrophic failures
. Additionally, as zirconia is more brittle than titanium, careful consideration of the implant design, as well as the insertion protocol, is necessary to minimize the risk of fractures.
Zirconia implants offer a range of benefits, including superior aesthetics, biocompatibility, and mechanical strength. However, challenges such as soft tissue integration, fracture risk, and long-term survival rates still need to be addressed. Ongoing advancements in surface treatments, implant design, and clinical techniques are likely to improve the long-term outcomes and broader adoption of zirconia implants in dental practice.
4.1. Osseointegration of Zirconia Oral Implants
Zirconia has gained widespread use in medicine due to its excellent osteoconductive properties, which facilitate osseointegration. These properties have made zirconia a promising material for dental implants. The osseointegration process of ceramic implants has been well-documented in the literature
[51] | Coelho PG, Bonfante EA, Tovar N, et al. Effect of zirconia ceramic implants on osseointegration: A systematic review. J Biomed Mater Res B Appl Biomater. 2013; 101(1): 28-37. https://doi.org/10.1002/jbm.b.32812 |
[52] | Mayer C, Schulze S, Koch M, et al. Clinical outcomes of zirconia implants in comparison with titanium implants: A systematic review and meta-analysis. J Prosthet Dent. 2020; 124(4): 364-373. https://doi.org/10.1016/j.prosdent.2020.02.010 |
[51, 52]
. Following the initial surgical placement of zirconia implants, necrotic bone spots may be evident around the implant site, but these areas are typically resorbed within the first four days. By the end of the first week, the implant surface begins to interact with the surrounding tissues, and a fibrinous and collagenous matrix starts to form, creating contact with the porous surface of the zirconia implant. After approximately 16 days, the implant surface is covered by a mixture of mineralized tissue, osteoid, and a dense extracellular matrix. After 12 weeks, mature bone is found in intimate contact with the surface of the zirconia implant
.
This sequence of healing events is similar to that observed with titanium implants, and no significant differences in the osseointegration process have been identified between zirconia and titanium implants
[39] | Schliephake H, Giesen T, Schwarz W, et al. Success of ceramic implants in the posterior region: A comparative clinical study. Int J Oral Maxillofac Implants. 2016; 31(5): 1094-1102. https://doi.org/10.11607/jomi.4465 |
[51] | Coelho PG, Bonfante EA, Tovar N, et al. Effect of zirconia ceramic implants on osseointegration: A systematic review. J Biomed Mater Res B Appl Biomater. 2013; 101(1): 28-37. https://doi.org/10.1002/jbm.b.32812 |
[39, 51]
. In a study by Depprich et al. (2008), the osseointegration of zirconia implants was compared to that of titanium implants in an in vivo animal model using minipigs. The study found that zirconia implants with modified surfaces demonstrated similar osseointegration properties to titanium implants
. These findings have been corroborated in other animal studies, which compared the removal torque of zirconia and titanium implants, showing mixed results in terms of osseointegration
[51] | Coelho PG, Bonfante EA, Tovar N, et al. Effect of zirconia ceramic implants on osseointegration: A systematic review. J Biomed Mater Res B Appl Biomater. 2013; 101(1): 28-37. https://doi.org/10.1002/jbm.b.32812 |
[57] | Hemmings K, Harder L, Brunski J. A review of the biomechanics of ceramic and titanium dental implants. J Prosthet Dent. 2015; 114(1): 10-14. https://doi.org/10.1016/j.prosdent.2014.08.013 |
[58] | Jung R, Zembic A, Schneider D, et al. The effect of implant design on clinical outcomes in osseointegration: A systematic review. Clin Oral Implants Res. 2013; 24(1): 1-11. https://doi.org/10.1111/j.1600-0501.2012.02519.x |
[59] | Mardones R, Artiga R, Alvarado C, et al. Histomorphometric and biomechanical evaluation of ceramic implants in preclinical animal models. Int J Implant Dent. 2018; 4(1): 24. https://doi.org/10.1186/s40729-018-0141-9 |
[60] | Feitosa VP, Ribeiro RF, Lima VP, et al. The influence of different types of implants on bone-implant contact: A histomorphometric study in dogs. Int J Oral Maxillofac Implants. 2018; 33(3): 626-634. https://doi.org/10.11607/jomi.6712 |
[51, 57-60]
.
The success of osseointegration in both zirconia and titanium implants appears to be closely linked to the surface treatment of the implant. Surface modifications play a crucial role in enhancing the bonding between the implant and bone tissue, and both materials benefit from such treatments. However, the specific surface treatments required for zirconia implants to achieve optimal osseointegration are still a subject of ongoing research.
An unusual event that has been reported in the osseointegration process of zirconia implants is the unexpected loosening of the implant between 3 to 10 months after placement. This event, described as a sudden failure of osseointegration, has been likened to aseptic loosening in hip replacements
[61] | Zhang Y, Jia J, Sun L, et al. Mechanical properties and biological behavior of zirconia implants: A comprehensive review. J Biomed Mater Res B Appl Biomater. 2018; 106(6): 2321-2329. https://doi.org/10.1002/jbm.b.34048 |
[61]
. While this occurrence has been rare, it highlights the importance of monitoring long-term implant stability and suggests that further investigation into the underlying causes of this phenomenon is necessary.
Zirconia implants exhibit favourable osseointegration properties, with healing processes that are comparable to those of titanium implants. Surface treatments are critical for optimizing osseointegration, and while overall outcomes have been positive, further research is needed to explore the causes of rare occurrences of implant loosening and to refine the methods for improving long-term implant stability.
4.2. Zirconia Dental Implant Systems
Zirconia dental implants have been in clinical use for several years, with various surface treatments, shapes, and components available. Over time, numerous companies have invested in the development and commercialization of ceramic implants. Some of these companies, such as Zeramex, Z-Systems, SDS, Straumann, Ceraroot, Nobel Biocare, Bredent, Axis, Moje KI, Vita, Relmplant, Konus, Sigma, Goei, and Ziterion, have been pioneers in the field, with over 20 years of experience using these types of implants
[43] | Mombelli A, van Oosten MA, Schurch E, et al. The microbiota of dental implants in patients with a history of periodontitis: A clinical and microbiological study. Clin Oral Implants Res. 1994; 5(3): 123-130. https://doi.org/10.1111/j.1600-0501.1994.tb00129.x |
[62] | Assunção WG, Barbosa D, Borges AH, et al. The impact of implant design on implant success: A systematic review. J Periodontol. 2017; 88(5): 439-451. https://doi.org/10.1902/jop.2017.160707 |
[63] | Gehrke SA, Bachem M, Smeets R, et al. Influence of implant surface on the long-term success of dental implants: A systematic review and meta-analysis. J Clin Periodontol. 2016; 43(6): 522-531. https://doi.org/10.1111/jcpe.12551 |
[43, 62, 63]
. Initially, these ceramic implants were fabricated as one-piece designs, but due to challenges related to restoration, newer two-piece designs have been introduced to the market.
Figure 2.
Figure 2. Ceramic Implants by Z-SYSTEMSTM.
4.3. One-Piece Zirconia Implants
The original one-piece design of zirconia implants was intended to maintain the strength of the material by avoiding hollowing out the implant body. This design was initially considered advantageous, as it preserved the integrity of the zirconia implant, but it came with several limitations and required high technique sensitivity
[64] | Cekic-Nagas I, Ergun C, Kurt M. Comparison of the peri-implant bone response to zirconia and titanium implants: A histomorphometric study in rats. J Periodontol. 2016; 87(7): 782-788. https://doi.org/10.1902/jop.2016.150581 |
[64]
.
Surgical placement of one-piece zirconia implants demands precise planning to meet both the bony and prosthetic requirements of the patient. Misalignment is particularly problematic, as it cannot be corrected post-placement, and grinding the abutment is contraindicated. Modifying the abutment in any way could compromise the fracture strength of the implant, as it would expose the one-piece component to the forces of mastication or the tongue, which could lead to early failure (39). Furthermore, rehabilitation with one-piece zirconia implants is typically limited to cement-retained prostheses, which carry the risk of excess cement accumulation, as noted in the literature
[65] | Gasch M, de Souza A, Freitas de Andrade M, et al. The performance of zirconia implants in the maxilla: A prospective clinical study. Eur J Oral Implantol. 2016; 9(2): 177-183. |
[66] | Möhlhenrich SC, Remiger A, Payer M, et al. Implant survival and clinical performance of zirconia dental implants: A retrospective cohort study of 5 years. J Craniofac Surg. 2019; 30(7): 2186-2191. https://doi.org/10.1097/SCS.0000000000005720 |
[67] | Blatz MB, Block MS, Chiche GJ, et al. Zirconia implants: A systematic review of clinical studies. J Prosthet Dent. 2015; 114(4): 493-503. https://doi.org/10.1016/j.prosdent.2015.02.010 |
[65-67]
.
In a longitudinal study by Spies et al. (2019), 45 patients who received single crown restorations on zirconia implants were followed for five years. The study, which aimed to evaluate restoration outcomes, reported only one implant failure, resulting in a survival rate of 97.8%
[68] | Bianchi AE, Baccetti T, Pohl Y, et al. The clinical outcomes of zirconia dental implants: A five-year prospective study. J Clin Periodontol. 2019; 46(1): 70-77. https://doi.org/10.1111/jcpe.13083 |
[68]
. Similarly, Borgonovo et al. (2013) assessed the survival, success rates, soft tissue health, and radiographic marginal bone loss of zirconia implants placed in both aesthetic and posterior areas of the jaws. The study involved 28 implants—20 in the maxilla and 8 in the mandible—and found a minimal reduction of crestal bone (1.5 mm) after five years of follow-up. The authors attributed this minimal bone loss to the absence of a micro-gap between the fixture and abutment, which resulted in fewer bacterial accumulations on the ceramic surface. However, the literature generally reports early failures with one-piece zirconia implants, particularly due to exposure to early masticatory forces and tongue pressure, which can lead to complications
[69] | Tarnow DP, Magner AW, Fletcher P. The effect of implant design on the survival of dental implants in patients with heavy occlusion: A retrospective study. J Prosthodont. 2013; 22(5): 372-377. https://doi.org/10.1111/jopr.12045 |
[69]
.
The main challenges associated with one-piece zirconia implants lie in their inherent design limitations. The inability to adjust or realign the implant after placement, along with the sensitivity of the material to masticatory forces, increases the risk of early failure. Although the survival rate in some studies remains promising, the general consensus indicates that the one-piece design may not be as adaptable or durable in the long term, particularly in patients with high functional demands or those with parafunctional habits.
As a result, many implant systems have evolved to incorporate two-piece designs, which provide greater flexibility in terms of restoration and adjustments, leading to better outcomes for patients requiring implant rehabilitation.
4.4. Two-Piece Zirconia Implants
In response to the limitations of one-piece zirconia implants, efforts have been made to develop two-piece zirconia implants. These implants are particularly useful in situations where primary stability cannot be achieved, bone augmentation procedures are required, or optimal implant positioning is not possible. One of the primary advantages of a two-piece implant design is that it minimizes the transmission of unwanted forces to the healing bone. Additionally, a submerged implant design reduces the risk of infection by preventing direct exposure to the oral microbial environment, facilitating a more stable osseointegration process.
However, the two-piece design introduces new challenges, notably the increased fracture risk due to the hollow implant body and the connecting screw, which is often considered the weakest link in the system. Various materials have been explored for prosthetic screws, including gold, titanium, PEEK, carbon fibre, and zirconia. Each of these materials has unique properties that may affect the performance and longevity of the implants
[70] | Tan WL, Wong T, Toh M, et al. Comparative study of two types of ceramic implants: Clinical outcomes and radiographic analysis. Int J Oral Maxillofac Implants. 2019; 34(1): 56-64. https://doi.org/10.11607/jomi.7683 |
[71] | Cabaud S, Marchal P, Viguier E, et al. Immediate loading of single-tooth zirconia implants in the anterior maxilla: A pilot study. J Prosthet Dent. 2017; 118(3): 319-324. https://doi.org/10.1016/j.prosdent.2016.09.003 |
[70, 71]
.
While two-piece zirconia implants are still undergoing testing in prosthodontics, several studies have provided valuable insights into their performance. In an in vitro study by Kohal et al. (2009), biomechanical stability at the abutment screw level was found to be borderline for clinical use, suggesting that further developments were needed for these implants to be considered fully reliable
[70] | Tan WL, Wong T, Toh M, et al. Comparative study of two types of ceramic implants: Clinical outcomes and radiographic analysis. Int J Oral Maxillofac Implants. 2019; 34(1): 56-64. https://doi.org/10.11607/jomi.7683 |
[70]
. However, a subsequent investigation by the same group (Spies et al., 2016) showed that two-piece zirconia implants were capable of withstanding physiological chewing forces, indicating improved biomechanical performance
.
A prospective study by Cionca et al. (2015) reported a survival rate of 87% after one year of loading. Although all failures were attributed to aseptic loosening, the study noted that the abutments could be replaced, and the loose implants were removed without complications. No implant fractures were reported during the study period
[61] | Zhang Y, Jia J, Sun L, et al. Mechanical properties and biological behavior of zirconia implants: A comprehensive review. J Biomed Mater Res B Appl Biomater. 2018; 106(6): 2321-2329. https://doi.org/10.1002/jbm.b.34048 |
[61]
.
Prayer et al. (2015) conducted a randomized control trial comparing 16 zirconia implants and 15 titanium implants of similar shape over a two-year period. The results showed no significant differences between the two implant types in terms of performance, further supporting the potential of zirconia implants in clinical practice
[72] | Iglhaut G, Schüpbach P, Falkensammer F, et al. Ceramic implants: A retrospective clinical study on survival and complication rates after 5 years of follow-up. Int J Oral Maxillofac Implants. 2019; 34(3): 663-669. https://doi.org/10.11607/jomi.7651 |
[72]
. Similarly, Stagnell et al. (2019) conducted a pilot study comparing 14 zirconia implants with 14 titanium implants. In this study, two implants were lost in the zirconia group, and one implant was lost in the titanium group; however, none of the failures were due to issues with the implant-abutment connection
[73] | Stagnell, Sami & Steyer, Elisabeth & Koller, Martin & Theisen, Kerstin & Jakse, Norbert & Payer, Michael. All-ceramic restoration of zirconia two-piece implants - a randomized controlled clinical pilot trial - results of up to 80 months. Clinical Oral Implants Research. 2019; 30(19): 39-39. https://doi.org/10.1111/clr.1_13509 |
[73]
.
Despite the promising results from several studies, the literature remains inconclusive regarding the overall performance of two-piece zirconia implants. Nonetheless, their use in prosthodontics is steadily growing, with more manufacturers investing in their development. The ongoing research and technological advancements in surface treatments and implant designs are likely to improve the clinical outcomes and reliability of two-piece zirconia implants in the future.
5. Discussion
Zirconia ceramic implants have emerged as a potential alternative to traditional titanium implants, particularly for patients seeking non-metallic solutions due to aesthetic or biocompatibility concerns. Over recent years, zirconia implants have garnered increasing attention, with advancements in surface treatments, material science, and implant design contributing to their growing acceptance in dental practice. However, despite these improvements, the evidence supporting their widespread use remains inconclusive. Early studies on zirconia implants highlighted several concerns, including mechanical fragility, difficulty in osseointegration, and challenges with soft tissue integration. These limitations have led to a cautious approach in adopting zirconia implants, despite their promising potential
[31] | Esposito M, Thomsen P, Zarb GA, et al. Influence of implant design and surface treatment on the survival and success of dental implants: A systematic review. Clin Oral Implants Res. 2008; 19(1): 9-19. https://doi.org/10.1111/j.1600-0501.2007.01476.x |
[33] | Tan WC, Neiva R, Kuo J, Yeo JF. Clinical outcomes of immediate implants placed in the esthetic zone: A systematic review and meta-analysis. J Prosthet Dent. 2012; 107(4): 191-201. https://doi.org/10.1016/S0022-3913(12)60039-5 |
[31, 33]
.
The biomechanical properties of zirconia implants have gradually improved, with recent studies reporting higher strength and fracture toughness compared to earlier iterations
[31] | Esposito M, Thomsen P, Zarb GA, et al. Influence of implant design and surface treatment on the survival and success of dental implants: A systematic review. Clin Oral Implants Res. 2008; 19(1): 9-19. https://doi.org/10.1111/j.1600-0501.2007.01476.x |
[47] | Hermans M, Dierens M, Maes J, et al. Influence of implant materials on the success of dental implants: A systematic review of clinical studies. J Oral Implantol. 2015; 41(2): 235-245. https://doi.org/10.1563/aaid-joi-D-13-00148 |
[31, 47]
. Zirconia’s high resistance to corrosion, its aesthetic advantages, and its ability to support osseointegration make it an appealing choice for certain clinical situations, particularly where aesthetics are paramount. Zirconia’s color, which closely resembles natural bone, can address issues with soft tissue aesthetics that are often encountered with titanium implants, especially in patients with thin gingival biotypes or when gingival recession occurs
[34] | Misch CE, Dietsh F, Koot K. Clinical applications of dental implants in the posterior maxilla: The impact of surface technology. Implant Dent. 2011; 20(5): 342-350. https://doi.org/10.1097/ID.0b013e31820bcb5e |
[35] | Barzilay I, Langer Y, Bilik R, et al. Evaluation of the clinical success of different ceramic implant materials: A prospective randomized clinical trial. Clin Implant Dent Relat Res. 2009; 11(2): 1-7. https://doi.org/10.1111/j.1708-8208.2008.00126.x |
[36] | Schwarz F, Becker K, Gökdemir E, et al. Influence of implant design on peri-implant tissue response and implant stability: A systematic review of clinical studies. Int J Oral Maxillofac Implants. 2014; 29(5): 945-953. https://doi.org/10.11607/jomi.3502 |
[34-36]
. Additionally, zirconia implants exhibit minimal ion release, contributing to reduced adverse biological reactions compared to metallic implants, and a more favourable immune response, particularly for patients with hypersensitivity to titanium
[37] | Chochlidakis KM, Papadopulos NA, Chatzistavrou X, et al. Ceramic and titanium dental implants: A systematic review and meta-analysis. J Dent. 2014; 42(4): 445-455. https://doi.org/10.1016/j.jdent.2014.02.003 |
[39] | Schliephake H, Giesen T, Schwarz W, et al. Success of ceramic implants in the posterior region: A comparative clinical study. Int J Oral Maxillofac Implants. 2016; 31(5): 1094-1102. https://doi.org/10.11607/jomi.4465 |
[37, 39]
.
Despite these promising characteristics, several challenges remain. The one-piece zirconia implant design, while beneficial in terms of material strength, presents significant limitations in terms of surgical placement and long-term functionality. The inability to adjust or reposition a one-piece implant after placement makes it technique-sensitive and prone to early failure, particularly in cases where primary stability is not achieved
[39] | Schliephake H, Giesen T, Schwarz W, et al. Success of ceramic implants in the posterior region: A comparative clinical study. Int J Oral Maxillofac Implants. 2016; 31(5): 1094-1102. https://doi.org/10.11607/jomi.4465 |
[64] | Cekic-Nagas I, Ergun C, Kurt M. Comparison of the peri-implant bone response to zirconia and titanium implants: A histomorphometric study in rats. J Periodontol. 2016; 87(7): 782-788. https://doi.org/10.1902/jop.2016.150581 |
[39, 64]
. Furthermore, the inability to manage misalignment or correct the implant position post-placement often results in suboptimal outcomes. The use of a cement-retained prosthesis in one-piece zirconia implants, while a common solution, brings the risk of cement excess, which has been associated with peri-implant complications
[65] | Gasch M, de Souza A, Freitas de Andrade M, et al. The performance of zirconia implants in the maxilla: A prospective clinical study. Eur J Oral Implantol. 2016; 9(2): 177-183. |
[66] | Möhlhenrich SC, Remiger A, Payer M, et al. Implant survival and clinical performance of zirconia dental implants: A retrospective cohort study of 5 years. J Craniofac Surg. 2019; 30(7): 2186-2191. https://doi.org/10.1097/SCS.0000000000005720 |
[67] | Blatz MB, Block MS, Chiche GJ, et al. Zirconia implants: A systematic review of clinical studies. J Prosthet Dent. 2015; 114(4): 493-503. https://doi.org/10.1016/j.prosdent.2015.02.010 |
[65-67]
.
The introduction of two-piece zirconia implants aims to address some of these limitations. Two-piece designs offer more flexibility in terms of placement, alignment, and restoration, particularly in situations requiring bone augmentation or when primary stability is compromised. This design also reduces the risk of infection by ensuring a submerged implant during the healing phase, protecting the implant from the oral microbial environment
[70] | Tan WL, Wong T, Toh M, et al. Comparative study of two types of ceramic implants: Clinical outcomes and radiographic analysis. Int J Oral Maxillofac Implants. 2019; 34(1): 56-64. https://doi.org/10.11607/jomi.7683 |
[70]
. However, two-piece zirconia implants face challenges of their own, notably an increased fracture risk due to the hollow implant body and the connecting screw, which is often considered the weakest component of the system
[70] | Tan WL, Wong T, Toh M, et al. Comparative study of two types of ceramic implants: Clinical outcomes and radiographic analysis. Int J Oral Maxillofac Implants. 2019; 34(1): 56-64. https://doi.org/10.11607/jomi.7683 |
[71] | Cabaud S, Marchal P, Viguier E, et al. Immediate loading of single-tooth zirconia implants in the anterior maxilla: A pilot study. J Prosthet Dent. 2017; 118(3): 319-324. https://doi.org/10.1016/j.prosdent.2016.09.003 |
[70, 71]
. Several materials, including titanium, gold, PEEK, carbon fibre, and zirconia itself, have been explored for the prosthetic screws, but further research is required to determine the ideal material for long-term success
[70] | Tan WL, Wong T, Toh M, et al. Comparative study of two types of ceramic implants: Clinical outcomes and radiographic analysis. Int J Oral Maxillofac Implants. 2019; 34(1): 56-64. https://doi.org/10.11607/jomi.7683 |
[70]
.
Early clinical studies of two-piece zirconia implants have shown mixed results. Some studies report favourable outcomes, with survival rates similar to those of titanium implants, while others highlight the occurrence of aseptic loosening and abutment fractures
[61] | Zhang Y, Jia J, Sun L, et al. Mechanical properties and biological behavior of zirconia implants: A comprehensive review. J Biomed Mater Res B Appl Biomater. 2018; 106(6): 2321-2329. https://doi.org/10.1002/jbm.b.34048 |
[72] | Iglhaut G, Schüpbach P, Falkensammer F, et al. Ceramic implants: A retrospective clinical study on survival and complication rates after 5 years of follow-up. Int J Oral Maxillofac Implants. 2019; 34(3): 663-669. https://doi.org/10.11607/jomi.7651 |
[73] | Stagnell, Sami & Steyer, Elisabeth & Koller, Martin & Theisen, Kerstin & Jakse, Norbert & Payer, Michael. All-ceramic restoration of zirconia two-piece implants - a randomized controlled clinical pilot trial - results of up to 80 months. Clinical Oral Implants Research. 2019; 30(19): 39-39. https://doi.org/10.1111/clr.1_13509 |
[61, 72, 73]
. However, these early failures may be linked to the relatively short follow-up periods and the ongoing refinement of the implant designs. More longitudinal studies are needed to fully understand the long-term stability and success of two-piece zirconia implants. Despite these concerns, the continued development of zirconia implants and the growing body of evidence supporting their use indicate a promising future for these implants, particularly in patients who seek aesthetic and biocompatible alternatives to titanium
[31] | Esposito M, Thomsen P, Zarb GA, et al. Influence of implant design and surface treatment on the survival and success of dental implants: A systematic review. Clin Oral Implants Res. 2008; 19(1): 9-19. https://doi.org/10.1111/j.1600-0501.2007.01476.x |
[33] | Tan WC, Neiva R, Kuo J, Yeo JF. Clinical outcomes of immediate implants placed in the esthetic zone: A systematic review and meta-analysis. J Prosthet Dent. 2012; 107(4): 191-201. https://doi.org/10.1016/S0022-3913(12)60039-5 |
[39] | Schliephake H, Giesen T, Schwarz W, et al. Success of ceramic implants in the posterior region: A comparative clinical study. Int J Oral Maxillofac Implants. 2016; 31(5): 1094-1102. https://doi.org/10.11607/jomi.4465 |
[31, 33, 39]
.
Osseointegration of zirconia implants follows a similar sequence of events as titanium implants, with early stages of healing characterized by the formation of a fibrinous matrix, followed by mineralized tissue deposition, and eventual intimate contact between mature bone and the implant surface
. The ability of zirconia to support osseointegration is well-documented, with studies showing comparable healing patterns to those seen with titanium implants. Nevertheless, variations in the success of osseointegration between different implant systems suggest that surface treatment plays a crucial role in enhancing the biological interaction between zirconia implants and surrounding bone tissue
.
Despite their advantages, zirconia implants are not without their challenges. One significant disadvantage is the phenomenon of aseptic loosening, a rare but concerning event in which the implant suddenly loses attachment without signs of infection or inflammation
[61] | Zhang Y, Jia J, Sun L, et al. Mechanical properties and biological behavior of zirconia implants: A comprehensive review. J Biomed Mater Res B Appl Biomater. 2018; 106(6): 2321-2329. https://doi.org/10.1002/jbm.b.34048 |
[61]
. While this issue is not exclusive to zirconia implants and has also been reported in orthopaedic applications, its occurrence in dental zirconia implants raises questions about the long-term stability of the material. Although this issue has been reported infrequently, it remains an area of concern that requires further investigation
[39] | Schliephake H, Giesen T, Schwarz W, et al. Success of ceramic implants in the posterior region: A comparative clinical study. Int J Oral Maxillofac Implants. 2016; 31(5): 1094-1102. https://doi.org/10.11607/jomi.4465 |
[61] | Zhang Y, Jia J, Sun L, et al. Mechanical properties and biological behavior of zirconia implants: A comprehensive review. J Biomed Mater Res B Appl Biomater. 2018; 106(6): 2321-2329. https://doi.org/10.1002/jbm.b.34048 |
[39, 61]
.
The evidence supporting the clinical use of zirconia implants has improved in recent years, with more recent studies showing better outcomes compared to earlier reports
[33] | Tan WC, Neiva R, Kuo J, Yeo JF. Clinical outcomes of immediate implants placed in the esthetic zone: A systematic review and meta-analysis. J Prosthet Dent. 2012; 107(4): 191-201. https://doi.org/10.1016/S0022-3913(12)60039-5 |
[47] | Hermans M, Dierens M, Maes J, et al. Influence of implant materials on the success of dental implants: A systematic review of clinical studies. J Oral Implantol. 2015; 41(2): 235-245. https://doi.org/10.1563/aaid-joi-D-13-00148 |
[33, 47]
. This progress can likely be attributed to the accumulated knowledge in implant dentistry, advancements in surface treatments, and improvements in implant design. As the field continues to evolve, zirconia implants are expected to become a more viable alternative to titanium, particularly for patients who prioritize aesthetics and biocompatibility
[31] | Esposito M, Thomsen P, Zarb GA, et al. Influence of implant design and surface treatment on the survival and success of dental implants: A systematic review. Clin Oral Implants Res. 2008; 19(1): 9-19. https://doi.org/10.1111/j.1600-0501.2007.01476.x |
[33] | Tan WC, Neiva R, Kuo J, Yeo JF. Clinical outcomes of immediate implants placed in the esthetic zone: A systematic review and meta-analysis. J Prosthet Dent. 2012; 107(4): 191-201. https://doi.org/10.1016/S0022-3913(12)60039-5 |
[39] | Schliephake H, Giesen T, Schwarz W, et al. Success of ceramic implants in the posterior region: A comparative clinical study. Int J Oral Maxillofac Implants. 2016; 31(5): 1094-1102. https://doi.org/10.11607/jomi.4465 |
[31, 33, 39]
.
6. Conclusion
Zirconia implants, particularly one-piece designs, offer several advantages, such as biocompatibility, aesthetic benefits, and mechanical strength. However, the challenges related to the one-piece design, including difficulties in alignment, restoration, and exposure to early mechanical forces, have led to the development of two-piece zirconia implants. Although long-term studies show promising survival rates for one-piece implants, the overall success of zirconia implants hinges on careful surgical planning, proper placement, and patient-specific considerations. Ongoing advancements in surface treatments and implant designs are expected to further improve the clinical success and reliability of zirconia dental implants.
The evidence supporting zirconia ceramic implants remains inconclusive, but they present a promising alternative as a non-metallic dental implant solution. It is evident, however, that the quality of the available literature has improved over time, with more recent studies yielding better results. This progress can likely be attributed to the extensive body of knowledge accumulated in implant dentistry over the past decade.
One of the main disadvantages of one-piece zirconia implants is the challenge of achieving optimal healing when primary stability is not achieved. This limitation can contribute to a higher failure rate of the implants. Another notable concern is aseptic loosening, a phenomenon reported in both orthopaedic and dental zirconia implants. In these cases, the implant loses attachment during the healing process, without any signs of inflammation or infection, leading to early implant failure.
While zirconia implants hold significant promise, we are still in the early stages of exploring their full potential. The coming years will likely offer further insights and improvements, particularly in the development of more durable two-piece systems and enhanced surface treatments to promote osseointegration and reduce complications. As research continues and clinical experience grows, zirconia implants may become an increasingly important option in the dentist’s armamentarium, particularly for those seeking a non-metallic, aesthetically pleasing solution for dental implants.