The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone

Mahmoud Abdel Aziz El Fadly; Heba Abdel Wahed Selim; Salah Abdel Fattah Ahmed

doi:doi:10.11648/j.ijcoms.20200602.11

| Peer-Reviewed

The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone

Mahmoud Abdel Aziz El Fadly, Heba Abdel Wahed Selim, Salah Abdel Fattah Ahmed

Published in International Journal of Clinical Oral and Maxillofacial Surgery (Volume 6, Issue 2)

Received: 5 August 2019 Accepted: 9 September 2019 Published: 15 June 2020

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

The aim of this study was to examine the evidence behind the use of the composite of bone marrow concentrate and Nano-hydroxyapatite as an alternative to autologous bone graft in the repair of bony defects. The study was conducted on 14 residual surgical non-continuity defects resulting from enucleation of benign odontogenic cysts. The defects were randomly allocated into two groups according to defect filling as follows: Group A (n=7), the defects were grafted using a composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules; Group B (n=7), the defects were grafted using autologous bone graft. Radiographic evaluation was done using Cone beam C. T. scan, immediate, six and twelve months post-operatively to assess the volumetric changes of the grafts along the follow-up period. The results of this study revealed that there was no statistically significant difference (p>0.05) between the two groups regarding the percentage of reduction of the graft volume along the follow-up period. In the light of the radiographic results of this study it can be concluded that the use of composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules to reconstruct surgical defects is a reliable alternative to autogenous bone graft.

Published in	International Journal of Clinical Oral and Maxillofacial Surgery (Volume 6, Issue 2)
DOI	10.11648/j.ijcoms.20200602.11
Page(s)	20-25
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Bone Marrow Concentrate, Autogenous Bone Graft, Nano-hydroxyapatite, Surgical Defects

References

[1]	Packer JW, Colditz JC. Bone injuries: treatment and rehabilitation. Hand Clin. 1986; 2: 81–91.
[2]	Hall HD, Phillips RM, Chase DC. Bone grafts of large cystic defects in the mandible. J Oral Surg. 1971; 29: 146-150.
[3]	Giannoudis PV, Dinopoulos H, Tsiridis E. Bone substitutes: an update. Injury. 2005; 36: S20-S27.
[4]	Pradel W, Eckelt U, Lauer G. Bone regeneration after enucleation of mandibular cysts: comparing autogenous grafts from tissue- engineered bone and iliac bone. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101: 285-290.
[5]	Younger EM, Chapman MW. Morbidity at bone graft donor sites. J Orthop Trauma. 1989; 3: 192-195.
[6]	Jager M, Hernigou P, Zilkens C, Herten M, Fischer J, et al. Cell therapy in bone-healing disorders. Orthopade. 2010; 39: 449–462; quiz 463.
[7]	Rosset P, Deschaseaux F, Layrolle P. Cell therapy for bone repair Orthopaedics & traumatology, surgery & research: OTSR 2014; 100: S107–S112.
[8]	P. Kasten, I. Beyen, M. Instant stem cell therapy: characterization and concentration of human mesenchymal stem cells in vitro. European Cells & Materials, vol. 16. 2008; 47–55.
[9]	Chahla J, Mannava S, Cinque ME, Geeslin AG, Codina D, LaPrade RF. Bone Marrow Aspirate Concentrate Harvesting and Processing Technique. Arthrosc Tech. 2017; 6: 441-45.
[10]	Al Battah F, De Kock J, Ramboer E, Heymans A, Vanhaecke T. Evaluation of the multipotent character of human adipose tissue- derived stem cells isolated by Ficoll gradient centrifugation and red blood cell lysis treatment. Toxicol in Vitro. 2011; 25: 1224–1230.
[11]	Ettl T, Gosau M, Sader R, Reichert TE. Jaw cysts - filling or no filling after enucleation? A review. J Craniomaxillofac Surg. 2012; 40: 485-93.
[12]	Kitoh H, Kitakoji T, Tsuchiya H, Katoh M, Ishiguro N Transplantation of culture expanded bone marrow cells and platelet rich plasma in distraction osteogenesis of the long bones. Bone 2007: 40: 522–528.
[13]	Jager M, Herten M, Fochtmann U, Fischer J, Hernigou P. Bridging the gap: bone marrow aspiration concentrate reduces autologous bone grafting in osseous defects. J Orthop Res 2011; 29: 173–180.
[14]	Hatzokos I, Stavridis SI, Iosifidou E, Karataglis D, Christodoulou A. Autologous bone marrow grafting combined with demineralized bone matrix improves consolidation of docking site after distraction osteogenesis. J Bone Joint Surg Am 2011; 93: 671–678.
[15]	Peterbauer-Scherb A, van Griensven M, Meinl A, Gabriel C, Redl H. Isolation of pig bone marrow mesenchymal stem cells suitable for one-step procedures in chondrogenic regeneration. J Tissue Eng Regen Med. 2010; 4: 485–490.
[16]	Horn P, Bork S, Diehlmann A, Walenda T, Eckstein V. Isolation of human mesenchymal stromal cells is more efficient by red blood cell lysis. Cytotherapy. 2008; 10: 676–685.
[17]	Marx RE, Garg AK. Bone structure, metabolism, and physiology: its impact on dental implantology. Implant Dent 1998; 7: 267-276.
[18]	El Hadidi YN, El Kassaby M, El Fatah Ahmed SA, Khamis NS. Effect of Mesenchymal Stem Cell Application on the Distracted Bone Microstructure: An Experimental Study. J Oral Maxillofac Surg. 2016; 74: 1463. e1-1463. e11.
[19]	Rosenstein SW, Long Jr RE, Dado DV, Vinson B, Alder ME. Comparison of 2-D calculations from periapical and occlusal radiographs versus 3-D calculations from CAT scans in determining bone support for cleft-adjacent teeth following early alveolar bone grafts. The Cleft palate-craniofacial journal. 1997; 34: 199-205.
[20]	Zhang W, Shen G, Wang X, Yu H, Fan L. Evaluation of alveolar bone grafting using limited cone beam computed tomography. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012; 113: 542-8.
[21]	El Badawy F, Hamed W, Farid M, El Kassaby M. Volumetric Analysis of Alveolar Bone Grafts using Cone Beam Computed Tomography. Egypt Dent J. 2015; 62 (3).
[22]	Jensen SS, Bornstein MM, Dard M, Bosshardt DD, Buser D: Comparative study of biphasic calcium phosphates with different HA/TCP ratios in mandibular bone defects. A long-term histomorphometric study in minipigs. J Biomed Mater Res B Appl Biomater. 2009; 90: 171e181.
[23]	Lorenz J, Eichler K, Barbeck M. Volumetric analysis of bone substitute material performance within the human sinus cavity of former head and neck cancer patients: A prospective, randomized clinical trial. Ann Maxillofac Surg. 2016; 6: 175–181.

Cite This Article

Plain Text BibTeX RIS

APA Style

Mahmoud Abdel Aziz El Fadly, Heba Abdel Wahed Selim, Salah Abdel Fattah Ahmed. (2020). The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone. International Journal of Clinical Oral and Maxillofacial Surgery, 6(2), 20-25. https://doi.org/10.11648/j.ijcoms.20200602.11

Copy | Download

ACS Style

Mahmoud Abdel Aziz El Fadly; Heba Abdel Wahed Selim; Salah Abdel Fattah Ahmed. The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone. Int. J. Clin. Oral Maxillofac. Surg. 2020, 6(2), 20-25. doi: 10.11648/j.ijcoms.20200602.11

Copy | Download

AMA Style

Mahmoud Abdel Aziz El Fadly, Heba Abdel Wahed Selim, Salah Abdel Fattah Ahmed. The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone. Int J Clin Oral Maxillofac Surg. 2020;6(2):20-25. doi: 10.11648/j.ijcoms.20200602.11

Copy | Download

@article{10.11648/j.ijcoms.20200602.11,
  author = {Mahmoud Abdel Aziz El Fadly and Heba Abdel Wahed Selim and Salah Abdel Fattah Ahmed},
  title = {The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone},
  journal = {International Journal of Clinical Oral and Maxillofacial Surgery},
  volume = {6},
  number = {2},
  pages = {20-25},
  doi = {10.11648/j.ijcoms.20200602.11},
  url = {https://doi.org/10.11648/j.ijcoms.20200602.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcoms.20200602.11},
  abstract = {The aim of this study was to examine the evidence behind the use of the composite of bone marrow concentrate and Nano-hydroxyapatite as an alternative to autologous bone graft in the repair of bony defects. The study was conducted on 14 residual surgical non-continuity defects resulting from enucleation of benign odontogenic cysts. The defects were randomly allocated into two groups according to defect filling as follows: Group A (n=7), the defects were grafted using a composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules; Group B (n=7), the defects were grafted using autologous bone graft. Radiographic evaluation was done using Cone beam C. T. scan, immediate, six and twelve months post-operatively to assess the volumetric changes of the grafts along the follow-up period. The results of this study revealed that there was no statistically significant difference (p>0.05) between the two groups regarding the percentage of reduction of the graft volume along the follow-up period. In the light of the radiographic results of this study it can be concluded that the use of composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules to reconstruct surgical defects is a reliable alternative to autogenous bone graft.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone
AU  - Mahmoud Abdel Aziz El Fadly
AU  - Heba Abdel Wahed Selim
AU  - Salah Abdel Fattah Ahmed
Y1  - 2020/06/15
PY  - 2020
N1  - https://doi.org/10.11648/j.ijcoms.20200602.11
DO  - 10.11648/j.ijcoms.20200602.11
T2  - International Journal of Clinical Oral and Maxillofacial Surgery
JF  - International Journal of Clinical Oral and Maxillofacial Surgery
JO  - International Journal of Clinical Oral and Maxillofacial Surgery
SP  - 20
EP  - 25
PB  - Science Publishing Group
SN  - 2472-1344
UR  - https://doi.org/10.11648/j.ijcoms.20200602.11
AB  - The aim of this study was to examine the evidence behind the use of the composite of bone marrow concentrate and Nano-hydroxyapatite as an alternative to autologous bone graft in the repair of bony defects. The study was conducted on 14 residual surgical non-continuity defects resulting from enucleation of benign odontogenic cysts. The defects were randomly allocated into two groups according to defect filling as follows: Group A (n=7), the defects were grafted using a composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules; Group B (n=7), the defects were grafted using autologous bone graft. Radiographic evaluation was done using Cone beam C. T. scan, immediate, six and twelve months post-operatively to assess the volumetric changes of the grafts along the follow-up period. The results of this study revealed that there was no statistically significant difference (p>0.05) between the two groups regarding the percentage of reduction of the graft volume along the follow-up period. In the light of the radiographic results of this study it can be concluded that the use of composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules to reconstruct surgical defects is a reliable alternative to autogenous bone graft.
VL  - 6
IS  - 2
ER  -

Copy | Download

Author Information

Mahmoud Abdel Aziz El Fadly

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University, Cairo, Egypt
Heba Abdel Wahed Selim

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University, Cairo, Egypt
Salah Abdel Fattah Ahmed

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University, Cairo, Egypt

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Mahmoud Abdel Aziz El Fadly, Heba Abdel Wahed Selim, Salah Abdel Fattah Ahmed. (2020). The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone. International Journal of Clinical Oral and Maxillofacial Surgery, 6(2), 20-25. https://doi.org/10.11648/j.ijcoms.20200602.11

Copy | Download

ACS Style

Mahmoud Abdel Aziz El Fadly; Heba Abdel Wahed Selim; Salah Abdel Fattah Ahmed. The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone. Int. J. Clin. Oral Maxillofac. Surg. 2020, 6(2), 20-25. doi: 10.11648/j.ijcoms.20200602.11

Copy | Download

AMA Style

Mahmoud Abdel Aziz El Fadly, Heba Abdel Wahed Selim, Salah Abdel Fattah Ahmed. The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone. Int J Clin Oral Maxillofac Surg. 2020;6(2):20-25. doi: 10.11648/j.ijcoms.20200602.11

Copy | Download

@article{10.11648/j.ijcoms.20200602.11,
  author = {Mahmoud Abdel Aziz El Fadly and Heba Abdel Wahed Selim and Salah Abdel Fattah Ahmed},
  title = {The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone},
  journal = {International Journal of Clinical Oral and Maxillofacial Surgery},
  volume = {6},
  number = {2},
  pages = {20-25},
  doi = {10.11648/j.ijcoms.20200602.11},
  url = {https://doi.org/10.11648/j.ijcoms.20200602.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcoms.20200602.11},
  abstract = {The aim of this study was to examine the evidence behind the use of the composite of bone marrow concentrate and Nano-hydroxyapatite as an alternative to autologous bone graft in the repair of bony defects. The study was conducted on 14 residual surgical non-continuity defects resulting from enucleation of benign odontogenic cysts. The defects were randomly allocated into two groups according to defect filling as follows: Group A (n=7), the defects were grafted using a composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules; Group B (n=7), the defects were grafted using autologous bone graft. Radiographic evaluation was done using Cone beam C. T. scan, immediate, six and twelve months post-operatively to assess the volumetric changes of the grafts along the follow-up period. The results of this study revealed that there was no statistically significant difference (p>0.05) between the two groups regarding the percentage of reduction of the graft volume along the follow-up period. In the light of the radiographic results of this study it can be concluded that the use of composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules to reconstruct surgical defects is a reliable alternative to autogenous bone graft.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone
AU  - Mahmoud Abdel Aziz El Fadly
AU  - Heba Abdel Wahed Selim
AU  - Salah Abdel Fattah Ahmed
Y1  - 2020/06/15
PY  - 2020
N1  - https://doi.org/10.11648/j.ijcoms.20200602.11
DO  - 10.11648/j.ijcoms.20200602.11
T2  - International Journal of Clinical Oral and Maxillofacial Surgery
JF  - International Journal of Clinical Oral and Maxillofacial Surgery
JO  - International Journal of Clinical Oral and Maxillofacial Surgery
SP  - 20
EP  - 25
PB  - Science Publishing Group
SN  - 2472-1344
UR  - https://doi.org/10.11648/j.ijcoms.20200602.11
AB  - The aim of this study was to examine the evidence behind the use of the composite of bone marrow concentrate and Nano-hydroxyapatite as an alternative to autologous bone graft in the repair of bony defects. The study was conducted on 14 residual surgical non-continuity defects resulting from enucleation of benign odontogenic cysts. The defects were randomly allocated into two groups according to defect filling as follows: Group A (n=7), the defects were grafted using a composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules; Group B (n=7), the defects were grafted using autologous bone graft. Radiographic evaluation was done using Cone beam C. T. scan, immediate, six and twelve months post-operatively to assess the volumetric changes of the grafts along the follow-up period. The results of this study revealed that there was no statistically significant difference (p>0.05) between the two groups regarding the percentage of reduction of the graft volume along the follow-up period. In the light of the radiographic results of this study it can be concluded that the use of composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules to reconstruct surgical defects is a reliable alternative to autogenous bone graft.
VL  - 6
IS  - 2
ER  -

Copy | Download