Association Between Platelet Count and Other Factors in Patients with Stage-IV Non-Small Cell Lung Cancer

Beauty Saha; Muhammad Rafiqul Islam; Nazma Azim; Salman Bashar Al Aub; Rashedul Islam; Ahmed Jabeer

doi:doi:10.11648/j.ijcocr.20230803.14

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Association Between Platelet Count and Other Factors in Patients with Stage-IV Non-Small Cell Lung Cancer

Beauty Saha, Muhammad Rafiqul Islam, Nazma Azim, Salman Bashar Al Aub, Rashedul Islam, Ahmed Jabeer

Published in International Journal of Clinical Oncology and Cancer Research (Volume 8, Issue 3)

Received: 22 July 2023 Accepted: 21 August 2023 Published: 18 September 2023

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Abstract

Background: Stage IV non-small-cell lung cancer (NSCLC) means a disease that has spread from the lungs to distant areas of the body like the liver, brain, or bones. An increased platelet count can accompany various cancers including lung cancer. This finding has recently been suggested to indicate a poor prognosis. Preconception on the relation between platelet count and other associated factors in patients with stage-IV non-small cell lung cancer may be a potential associated indicator in managing such patients. Aim of the study: This study aimed to evaluate the relationship between platelet count and other associated factors in patients with stage-IV non-small cell lung cancer (NSCLC). Methods: This prospective observational study was conducted at the National Institute of Cancer Research & Hospital (NICRH), Dhaka, Bangladesh during the period from September 2019 to August 2020. A total of 108 patients were enrolled purposively. Detailed history taking and thorough physical examination was done along with relevant investigations. Data were collected by semi-structured questionnaire and analysis was done by SPSS, version 21.0. Results: The mean age of the patients was found 56.4±12.2 years and the majority (79.6%) of patients were male. The highest number of participants (40.7%) were symptomatic; in bed, >50% of the day, almost two-thirds (59.3%) had <5% weight loss, and almost three fourth (69.4%) had squamous cell carcinoma. At the time of the first assessment, 75 (69.4%) patients had normal and 33 (30.6%) had elevated platelet count levels, age, sex, and histological type were statistically not significant between normal and elevated platelet count level groups. But performance status and weight loss were statistically significant (p<0.05) between the two groups. According to univariate analysis, age, performance status at presentation, weight loss of more than 10% for 3 months and platelet count before the start of treatment were all significant predictors for overall survival. Conclusion: As per the findings of this study we can conclude that there has no significant correlation of platelet count with age, sex or histological types of NSCLC patients. But with performance status and weight loss, there may have a statistically significant correlation in such patients.

Published in	International Journal of Clinical Oncology and Cancer Research (Volume 8, Issue 3)
DOI	10.11648/j.ijcocr.20230803.14
Page(s)	64-71
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Non-Small Cell Lung Cancer, Platelet Count, Prognostic Factor, Stage-IV NSCLC

References

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APA Style

Beauty Saha, Muhammad Rafiqul Islam, Nazma Azim, Salman Bashar Al Aub, Rashedul Islam, et al. (2023). Association Between Platelet Count and Other Factors in Patients with Stage-IV Non-Small Cell Lung Cancer. International Journal of Clinical Oncology and Cancer Research, 8(3), 64-71. https://doi.org/10.11648/j.ijcocr.20230803.14

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ACS Style

Beauty Saha; Muhammad Rafiqul Islam; Nazma Azim; Salman Bashar Al Aub; Rashedul Islam, et al. Association Between Platelet Count and Other Factors in Patients with Stage-IV Non-Small Cell Lung Cancer. Int. J. Clin. Oncol. Cancer Res. 2023, 8(3), 64-71. doi: 10.11648/j.ijcocr.20230803.14

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AMA Style

Beauty Saha, Muhammad Rafiqul Islam, Nazma Azim, Salman Bashar Al Aub, Rashedul Islam, et al. Association Between Platelet Count and Other Factors in Patients with Stage-IV Non-Small Cell Lung Cancer. Int J Clin Oncol Cancer Res. 2023;8(3):64-71. doi: 10.11648/j.ijcocr.20230803.14

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@article{10.11648/j.ijcocr.20230803.14,
  author = {Beauty Saha and Muhammad Rafiqul Islam and Nazma Azim and Salman Bashar Al Aub and Rashedul Islam and Ahmed Jabeer},
  title = {Association Between Platelet Count and Other Factors in Patients with Stage-IV Non-Small Cell Lung Cancer},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {8},
  number = {3},
  pages = {64-71},
  doi = {10.11648/j.ijcocr.20230803.14},
  url = {https://doi.org/10.11648/j.ijcocr.20230803.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20230803.14},
  abstract = {Background: Stage IV non-small-cell lung cancer (NSCLC) means a disease that has spread from the lungs to distant areas of the body like the liver, brain, or bones. An increased platelet count can accompany various cancers including lung cancer. This finding has recently been suggested to indicate a poor prognosis. Preconception on the relation between platelet count and other associated factors in patients with stage-IV non-small cell lung cancer may be a potential associated indicator in managing such patients. Aim of the study: This study aimed to evaluate the relationship between platelet count and other associated factors in patients with stage-IV non-small cell lung cancer (NSCLC). Methods: This prospective observational study was conducted at the National Institute of Cancer Research & Hospital (NICRH), Dhaka, Bangladesh during the period from September 2019 to August 2020. A total of 108 patients were enrolled purposively. Detailed history taking and thorough physical examination was done along with relevant investigations. Data were collected by semi-structured questionnaire and analysis was done by SPSS, version 21.0. Results: The mean age of the patients was found 56.4±12.2 years and the majority (79.6%) of patients were male. The highest number of participants (40.7%) were symptomatic; in bed, >50% of the day, almost two-thirds (59.3%) had <5% weight loss, and almost three fourth (69.4%) had squamous cell carcinoma. At the time of the first assessment, 75 (69.4%) patients had normal and 33 (30.6%) had elevated platelet count levels, age, sex, and histological type were statistically not significant between normal and elevated platelet count level groups. But performance status and weight loss were statistically significant (p<0.05) between the two groups. According to univariate analysis, age, performance status at presentation, weight loss of more than 10% for 3 months and platelet count before the start of treatment were all significant predictors for overall survival. Conclusion: As per the findings of this study we can conclude that there has no significant correlation of platelet count with age, sex or histological types of NSCLC patients. But with performance status and weight loss, there may have a statistically significant correlation in such patients.},
 year = {2023}
}

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TY - JOUR
T1 - Association Between Platelet Count and Other Factors in Patients with Stage-IV Non-Small Cell Lung Cancer
AU - Beauty Saha
AU - Muhammad Rafiqul Islam
AU - Nazma Azim
AU - Salman Bashar Al Aub
AU - Rashedul Islam
AU - Ahmed Jabeer
Y1 - 2023/09/18
PY - 2023
N1 - https://doi.org/10.11648/j.ijcocr.20230803.14
DO - 10.11648/j.ijcocr.20230803.14
T2 - International Journal of Clinical Oncology and Cancer Research
JF - International Journal of Clinical Oncology and Cancer Research
JO - International Journal of Clinical Oncology and Cancer Research
SP - 64
EP - 71
PB - Science Publishing Group
SN - 2578-9511
UR - https://doi.org/10.11648/j.ijcocr.20230803.14
AB - Background: Stage IV non-small-cell lung cancer (NSCLC) means a disease that has spread from the lungs to distant areas of the body like the liver, brain, or bones. An increased platelet count can accompany various cancers including lung cancer. This finding has recently been suggested to indicate a poor prognosis. Preconception on the relation between platelet count and other associated factors in patients with stage-IV non-small cell lung cancer may be a potential associated indicator in managing such patients. Aim of the study: This study aimed to evaluate the relationship between platelet count and other associated factors in patients with stage-IV non-small cell lung cancer (NSCLC). Methods: This prospective observational study was conducted at the National Institute of Cancer Research & Hospital (NICRH), Dhaka, Bangladesh during the period from September 2019 to August 2020. A total of 108 patients were enrolled purposively. Detailed history taking and thorough physical examination was done along with relevant investigations. Data were collected by semi-structured questionnaire and analysis was done by SPSS, version 21.0. Results: The mean age of the patients was found 56.4±12.2 years and the majority (79.6%) of patients were male. The highest number of participants (40.7%) were symptomatic; in bed, >50% of the day, almost two-thirds (59.3%) had <5% weight loss, and almost three fourth (69.4%) had squamous cell carcinoma. At the time of the first assessment, 75 (69.4%) patients had normal and 33 (30.6%) had elevated platelet count levels, age, sex, and histological type were statistically not significant between normal and elevated platelet count level groups. But performance status and weight loss were statistically significant (p<0.05) between the two groups. According to univariate analysis, age, performance status at presentation, weight loss of more than 10% for 3 months and platelet count before the start of treatment were all significant predictors for overall survival. Conclusion: As per the findings of this study we can conclude that there has no significant correlation of platelet count with age, sex or histological types of NSCLC patients. But with performance status and weight loss, there may have a statistically significant correlation in such patients.
VL - 8
IS - 3
ER -

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Author Information

Beauty Saha

Department of Radiotherapy, Mymensingh Medical College Hospital, Mymensingh, Bangladesh
Muhammad Rafiqul Islam

Department of Medical Oncology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh
Nazma Azim

National Institute of Cancer Research and Hospital, Dhaka, Bangladesh
Salman Bashar Al Aub

Department of Medical Oncology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh
Rashedul Islam

Department of Medical Oncology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh
Ahmed Jabeer

Department of Medical Oncology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh

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APA Style

Beauty Saha, Muhammad Rafiqul Islam, Nazma Azim, Salman Bashar Al Aub, Rashedul Islam, et al. (2023). Association Between Platelet Count and Other Factors in Patients with Stage-IV Non-Small Cell Lung Cancer. International Journal of Clinical Oncology and Cancer Research, 8(3), 64-71. https://doi.org/10.11648/j.ijcocr.20230803.14

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ACS Style

Beauty Saha; Muhammad Rafiqul Islam; Nazma Azim; Salman Bashar Al Aub; Rashedul Islam, et al. Association Between Platelet Count and Other Factors in Patients with Stage-IV Non-Small Cell Lung Cancer. Int. J. Clin. Oncol. Cancer Res. 2023, 8(3), 64-71. doi: 10.11648/j.ijcocr.20230803.14

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AMA Style

Beauty Saha, Muhammad Rafiqul Islam, Nazma Azim, Salman Bashar Al Aub, Rashedul Islam, et al. Association Between Platelet Count and Other Factors in Patients with Stage-IV Non-Small Cell Lung Cancer. Int J Clin Oncol Cancer Res. 2023;8(3):64-71. doi: 10.11648/j.ijcocr.20230803.14

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@article{10.11648/j.ijcocr.20230803.14,
  author = {Beauty Saha and Muhammad Rafiqul Islam and Nazma Azim and Salman Bashar Al Aub and Rashedul Islam and Ahmed Jabeer},
  title = {Association Between Platelet Count and Other Factors in Patients with Stage-IV Non-Small Cell Lung Cancer},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {8},
  number = {3},
  pages = {64-71},
  doi = {10.11648/j.ijcocr.20230803.14},
  url = {https://doi.org/10.11648/j.ijcocr.20230803.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20230803.14},
  abstract = {Background: Stage IV non-small-cell lung cancer (NSCLC) means a disease that has spread from the lungs to distant areas of the body like the liver, brain, or bones. An increased platelet count can accompany various cancers including lung cancer. This finding has recently been suggested to indicate a poor prognosis. Preconception on the relation between platelet count and other associated factors in patients with stage-IV non-small cell lung cancer may be a potential associated indicator in managing such patients. Aim of the study: This study aimed to evaluate the relationship between platelet count and other associated factors in patients with stage-IV non-small cell lung cancer (NSCLC). Methods: This prospective observational study was conducted at the National Institute of Cancer Research & Hospital (NICRH), Dhaka, Bangladesh during the period from September 2019 to August 2020. A total of 108 patients were enrolled purposively. Detailed history taking and thorough physical examination was done along with relevant investigations. Data were collected by semi-structured questionnaire and analysis was done by SPSS, version 21.0. Results: The mean age of the patients was found 56.4±12.2 years and the majority (79.6%) of patients were male. The highest number of participants (40.7%) were symptomatic; in bed, >50% of the day, almost two-thirds (59.3%) had <5% weight loss, and almost three fourth (69.4%) had squamous cell carcinoma. At the time of the first assessment, 75 (69.4%) patients had normal and 33 (30.6%) had elevated platelet count levels, age, sex, and histological type were statistically not significant between normal and elevated platelet count level groups. But performance status and weight loss were statistically significant (p<0.05) between the two groups. According to univariate analysis, age, performance status at presentation, weight loss of more than 10% for 3 months and platelet count before the start of treatment were all significant predictors for overall survival. Conclusion: As per the findings of this study we can conclude that there has no significant correlation of platelet count with age, sex or histological types of NSCLC patients. But with performance status and weight loss, there may have a statistically significant correlation in such patients.},
 year = {2023}
}

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